Understanding the microenvironment and how this controls cell fate
Dev Cell. 2023 Dec 18;58(24):2819-2821. doi: 10.1016/j.devcel.2023.11.025.ABSTRACTThe microenvironment influences cell fate. In this collection of voices, researchers from the fields of cancer and regeneration highlight approaches to establish the importance of the microenvironment and discuss future directions to understand the complex interaction between cells and their surrounding environment and how this impacts on disease and regeneration.PMID:38113847 | DOI:10.1016/j.devcel.2023.11.025 (Source: Developmental Cell)
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Elaine Fuchs Erik Sahai Ashani T Weeraratna Benjamin Deneen Carmen Chak-Lui Wong Andr ás Simon Source Type: research
What approaches are needed to understand human development and disease?
Dev Cell. 2023 Dec 18;58(24):2822-2825. doi: 10.1016/j.devcel.2023.11.026.ABSTRACTResearchers are leveraging what we have learned from model organisms to understand if the same principles arise in human physiology, development, and disease. In this collection of Voices, we asked researchers from different fields to discuss what tools and insights they are using to answer fundamental questions in human biology.PMID:38113848 | DOI:10.1016/j.devcel.2023.11.026 (Source: Developmental Cell)
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Berna Sozen Richard A Flavell Dudley W Lamming Debra L Silver Simona Parrinello Cory Abate-Shen Franziska Michor Vijay G Sankaran Source Type: research
Human embryonic and fetal biobanking: Establishing the Dutch Fetal Biobank and a framework for standardization
Dev Cell. 2023 Dec 18;58(24):2826-2835. doi: 10.1016/j.devcel.2023.11.019.ABSTRACTRecent studies of human embryos and fetuses have advanced our understanding not only of basic biology but also of health and disease, through a combination of detailed three-dimensional (3D) morphology and processes such as gene expression, cellular decision-making and differentiation, and epigenetics during the various phases of human development and growth. Large-scale research initiatives focusing on these topics have been initiated during the last decade, all of which depend on biobanks that provide high-quality images of human embryonic ...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Yousif Dawood Marieke F J Buijtendijk Doriane Bohly Quinn D Gunst Daniel Docter Eva Pajkrt Roelof-Jan Oostra Raoul C Hennekam Maurice J B van den Hoff Bernadette S de Bakker Source Type: research
Shaping the brain: The emergence of cortical structure and folding
Dev Cell. 2023 Dec 18;58(24):2836-2849. doi: 10.1016/j.devcel.2023.11.004.ABSTRACTThe cerebral cortex-the brain's covering and largest region-has increased in size and complexity in humans and supports higher cognitive functions such as language and abstract thinking. There is a growing understanding of the human cerebral cortex, including the diversity and number of cell types that it contains, as well as of the developmental mechanisms that shape cortical structure and organization. In this review, we discuss recent progress in our understanding of molecular and cellular processes, as well as mechanical forces, that regu...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Shyam K Akula David Exposito-Alonso Christopher A Walsh Source Type: research
The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis
Dev Cell. 2023 Dec 18;58(24):2850-2866. doi: 10.1016/j.devcel.2023.11.003.ABSTRACTThe emergence of tissue form in multicellular organisms results from the complex interplay between genetics and physics. In both plants and animals, cells must act in concert to pattern their behaviors. Our understanding of the factors sculpting multicellular form has increased dramatically in the past few decades. From this work, common themes have emerged that connect plant and animal morphogenesis-an exciting connection that solidifies our understanding of the developmental basis of multicellular life. In this review, we will discuss the t...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Isabella Burda Adam C Martin Adrienne H K Roeder Mary Ann Collins Source Type: research
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice
Dev Cell. 2023 Dec 18;58(24):2914-2929.e7. doi: 10.1016/j.devcel.2023.11.013.ABSTRACTLow-grade chronic inflammation is a hallmark of ageing, associated with impaired tissue function and disease development. However, how cell-intrinsic and -extrinsic factors collectively establish this phenotype, termed inflammaging, remains poorly understood. We addressed this question in the mouse intestinal epithelium, using mouse organoid cultures to dissect stem cell-intrinsic and -extrinsic sources of inflammaging. At the single-cell level, we found that inflammaging is established differently along the crypt-villus axis, with aged in...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Maja C Funk Jan G Gleixner Florian Heigwer Dominik Vonficht Erica Valentini Zeynep Aydin Elena Tonin Stefania Del Prete Sylvia Mahara Yannick Throm Jenny Hetzer Danijela Heide Oliver Stegle Duncan T Odom Angelika Feldmann Simon Haas Mathias Heikenwalder M Source Type: research
Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
Dev Cell. 2023 Dec 8:S1534-5807(23)00621-4. doi: 10.1016/j.devcel.2023.11.023. Online ahead of print.ABSTRACTAutophagy is a conserved cellular degradation process. While autophagy-related proteins were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the relevance of this during cancer development is unclear. Here, we identify a role for autophagy in regulating platelet-derived growth factor receptor alpha (PDGFRA) signaling and levels. We find that PDGFRA can be targeted for autophagic degradation through the activity of the autophagy cargo receptor p62. As a result, short-term autophagy...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Joanne E Simpson Morwenna T Muir Martin Lee Catherine Naughton Nick Gilbert Steven M Pollard Noor Gammoh Source Type: research
Understanding the microenvironment and how this controls cell fate
Dev Cell. 2023 Dec 18;58(24):2819-2821. doi: 10.1016/j.devcel.2023.11.025.ABSTRACTThe microenvironment influences cell fate. In this collection of voices, researchers from the fields of cancer and regeneration highlight approaches to establish the importance of the microenvironment and discuss future directions to understand the complex interaction between cells and their surrounding environment and how this impacts on disease and regeneration.PMID:38113847 | DOI:10.1016/j.devcel.2023.11.025 (Source: Developmental Cell)
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Elaine Fuchs Erik Sahai Ashani T Weeraratna Benjamin Deneen Carmen Chak-Lui Wong Andr ás Simon Source Type: research
What approaches are needed to understand human development and disease?
Dev Cell. 2023 Dec 18;58(24):2822-2825. doi: 10.1016/j.devcel.2023.11.026.ABSTRACTResearchers are leveraging what we have learned from model organisms to understand if the same principles arise in human physiology, development, and disease. In this collection of Voices, we asked researchers from different fields to discuss what tools and insights they are using to answer fundamental questions in human biology.PMID:38113848 | DOI:10.1016/j.devcel.2023.11.026 (Source: Developmental Cell)
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Berna Sozen Richard A Flavell Dudley W Lamming Debra L Silver Simona Parrinello Cory Abate-Shen Franziska Michor Vijay G Sankaran Source Type: research
Human embryonic and fetal biobanking: Establishing the Dutch Fetal Biobank and a framework for standardization
Dev Cell. 2023 Dec 18;58(24):2826-2835. doi: 10.1016/j.devcel.2023.11.019.ABSTRACTRecent studies of human embryos and fetuses have advanced our understanding not only of basic biology but also of health and disease, through a combination of detailed three-dimensional (3D) morphology and processes such as gene expression, cellular decision-making and differentiation, and epigenetics during the various phases of human development and growth. Large-scale research initiatives focusing on these topics have been initiated during the last decade, all of which depend on biobanks that provide high-quality images of human embryonic ...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Yousif Dawood Marieke F J Buijtendijk Doriane Bohly Quinn D Gunst Daniel Docter Eva Pajkrt Roelof-Jan Oostra Raoul C Hennekam Maurice J B van den Hoff Bernadette S de Bakker Source Type: research
Shaping the brain: The emergence of cortical structure and folding
Dev Cell. 2023 Dec 18;58(24):2836-2849. doi: 10.1016/j.devcel.2023.11.004.ABSTRACTThe cerebral cortex-the brain's covering and largest region-has increased in size and complexity in humans and supports higher cognitive functions such as language and abstract thinking. There is a growing understanding of the human cerebral cortex, including the diversity and number of cell types that it contains, as well as of the developmental mechanisms that shape cortical structure and organization. In this review, we discuss recent progress in our understanding of molecular and cellular processes, as well as mechanical forces, that regu...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Shyam K Akula David Exposito-Alonso Christopher A Walsh Source Type: research
The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis
Dev Cell. 2023 Dec 18;58(24):2850-2866. doi: 10.1016/j.devcel.2023.11.003.ABSTRACTThe emergence of tissue form in multicellular organisms results from the complex interplay between genetics and physics. In both plants and animals, cells must act in concert to pattern their behaviors. Our understanding of the factors sculpting multicellular form has increased dramatically in the past few decades. From this work, common themes have emerged that connect plant and animal morphogenesis-an exciting connection that solidifies our understanding of the developmental basis of multicellular life. In this review, we will discuss the t...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Isabella Burda Adam C Martin Adrienne H K Roeder Mary Ann Collins Source Type: research
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice
Dev Cell. 2023 Dec 18;58(24):2914-2929.e7. doi: 10.1016/j.devcel.2023.11.013.ABSTRACTLow-grade chronic inflammation is a hallmark of ageing, associated with impaired tissue function and disease development. However, how cell-intrinsic and -extrinsic factors collectively establish this phenotype, termed inflammaging, remains poorly understood. We addressed this question in the mouse intestinal epithelium, using mouse organoid cultures to dissect stem cell-intrinsic and -extrinsic sources of inflammaging. At the single-cell level, we found that inflammaging is established differently along the crypt-villus axis, with aged in...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Maja C Funk Jan G Gleixner Florian Heigwer Dominik Vonficht Erica Valentini Zeynep Aydin Elena Tonin Stefania Del Prete Sylvia Mahara Yannick Throm Jenny Hetzer Danijela Heide Oliver Stegle Duncan T Odom Angelika Feldmann Simon Haas Mathias Heikenwalder M Source Type: research
Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
Dev Cell. 2023 Dec 8:S1534-5807(23)00621-4. doi: 10.1016/j.devcel.2023.11.023. Online ahead of print.ABSTRACTAutophagy is a conserved cellular degradation process. While autophagy-related proteins were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the relevance of this during cancer development is unclear. Here, we identify a role for autophagy in regulating platelet-derived growth factor receptor alpha (PDGFRA) signaling and levels. We find that PDGFRA can be targeted for autophagic degradation through the activity of the autophagy cargo receptor p62. As a result, short-term autophagy...
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Joanne E Simpson Morwenna T Muir Martin Lee Catherine Naughton Nick Gilbert Steven M Pollard Noor Gammoh Source Type: research
Understanding the microenvironment and how this controls cell fate
Dev Cell. 2023 Dec 18;58(24):2819-2821. doi: 10.1016/j.devcel.2023.11.025.ABSTRACTThe microenvironment influences cell fate. In this collection of voices, researchers from the fields of cancer and regeneration highlight approaches to establish the importance of the microenvironment and discuss future directions to understand the complex interaction between cells and their surrounding environment and how this impacts on disease and regeneration.PMID:38113847 | DOI:10.1016/j.devcel.2023.11.025 (Source: Developmental Cell)
Source: Developmental Cell - December 19, 2023 Category: Cytology Authors: Elaine Fuchs Erik Sahai Ashani T Weeraratna Benjamin Deneen Carmen Chak-Lui Wong Andr ás Simon Source Type: research
