Defining the fate trajectory of eccrine gland formation
Dev Cell. 2024 Jan 8;59(1):1-3. doi: 10.1016/j.devcel.2023.12.004.ABSTRACTEccrine glands secrete water onto the surface of human skin to regulate body temperature. In this issue of Developmental Cell, Dingwall et al. dissect the transcriptional signature of developing eccrine glands, and they also uncover a unique dermal niche that is responsible for promoting eccrine gland developmental progression.PMID:38194909 | DOI:10.1016/j.devcel.2023.12.004 (Source: Developmental Cell)
Source: Developmental Cell - January 9, 2024 Category: Cytology Authors: Meagan C Branch Elena Ezhkova Source Type: research
Temporal regulation of vegetative phase change in plants
Dev Cell. 2024 Jan 8;59(1):4-19. doi: 10.1016/j.devcel.2023.11.010.ABSTRACTDuring their vegetative growth, plants reiteratively produce leaves, buds, and internodes at the apical end of the shoot. The identity of these organs changes as the shoot develops. Some traits change gradually, but others change in a coordinated fashion, allowing shoot development to be divided into discrete juvenile and adult phases. The transition between these phases is called vegetative phase change. Historically, vegetative phase change has been studied because it is thought to be associated with an increase in reproductive competence. However...
Source: Developmental Cell - January 9, 2024 Category: Cytology Authors: R Scott Poethig Jim Fouracre Source Type: research
MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement
Dev Cell. 2023 Dec 23:S1534-5807(23)00651-2. doi: 10.1016/j.devcel.2023.12.001. Online ahead of print.ABSTRACTMicrotubule doublets (MTDs) comprise an incomplete microtubule (B-tubule) attached to the side of a complete cylindrical microtubule. These compound microtubules are conserved in cilia across the tree of life; however, the mechanisms by which MTDs form and are maintained in vivo remain poorly understood. Here, we identify microtubule-associated protein 9 (MAP9) as an MTD-associated protein. We demonstrate that C. elegans MAPH-9, a MAP9 homolog, is present during MTD assembly and localizes exclusively to MTDs, a pre...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Michael V Tran Daria Khuntsariya Richard D Fetter James W Ferguson Jennifer T Wang Alexandra F Long Lauren E Cote Stephen R Wellard Nabor V ázquez-Martínez Maria D Sallee Mariya Genova Maria M Magiera Sani Eskinazi Jessica D Lee Nina Peel Carsten Janke Source Type: research
Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids
Dev Cell. 2023 Dec 26:S1534-5807(23)00653-6. doi: 10.1016/j.devcel.2023.12.003. Online ahead of print.ABSTRACTEctodermal appendages, such as the mammary gland (MG), are thought to have evolved from hair-associated apocrine glands to serve the function of milk secretion. Through the directed differentiation of mouse embryonic stem cells (mESCs), here, we report the generation of multilineage ESC-derived mammary organoids (MEMOs). We adapted the skin organoid model, inducing the dermal mesenchyme to transform into mammary-specific mesenchyme via the sequential activation of Bone Morphogenetic Protein 4 (BMP4) and Parathyroid...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Sounak Sahu Sarthak Sahoo Teresa Sullivan T Norene O'Sullivan Sevilay Turan Mary E Albaugh Sandra Burkett Bao Tran David S Salomon Serguei V Kozlov Karl R Koehler Mohit Kumar Jolly Shyam K Sharan Source Type: research
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
Dev Cell. 2023 Dec 23:S1534-5807(23)00652-4. doi: 10.1016/j.devcel.2023.12.002. Online ahead of print.ABSTRACTThe molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a selective regulator of lymphatic but not of blood endothelial contact inhibition. Conditional deletion of Pde2a in mouse embryos reveals severe lymphatic dysplasia, whereas blood vessel architecture remains unaltered. In the absence of PDE2A, human lymphatic endothelial cells fail to induce mature junctions and cell cycle arrest, whereas cGMP l...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Claudia Carlantoni Leon M H Liekfeld Sandra A Hemkemeyer Danny Schreier Ceren Saygi Roberta Kurelic Silvia Cardarelli Joanna Kalucka Christian Schulte Manu Beerens Reiner K Mailer Tilman E Sch äffer Fabio Naro Manuela Pellegrini Viacheslav O Nikolaev Tho Source Type: research
MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement
Dev Cell. 2023 Dec 23:S1534-5807(23)00651-2. doi: 10.1016/j.devcel.2023.12.001. Online ahead of print.ABSTRACTMicrotubule doublets (MTDs) comprise an incomplete microtubule (B-tubule) attached to the side of a complete cylindrical microtubule. These compound microtubules are conserved in cilia across the tree of life; however, the mechanisms by which MTDs form and are maintained in vivo remain poorly understood. Here, we identify microtubule-associated protein 9 (MAP9) as an MTD-associated protein. We demonstrate that C. elegans MAPH-9, a MAP9 homolog, is present during MTD assembly and localizes exclusively to MTDs, a pre...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Michael V Tran Daria Khuntsariya Richard D Fetter James W Ferguson Jennifer T Wang Alexandra F Long Lauren E Cote Stephen R Wellard Nabor V ázquez-Martínez Maria D Sallee Mariya Genova Maria M Magiera Sani Eskinazi Jessica D Lee Nina Peel Carsten Janke Source Type: research
Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids
Dev Cell. 2023 Dec 26:S1534-5807(23)00653-6. doi: 10.1016/j.devcel.2023.12.003. Online ahead of print.ABSTRACTEctodermal appendages, such as the mammary gland (MG), are thought to have evolved from hair-associated apocrine glands to serve the function of milk secretion. Through the directed differentiation of mouse embryonic stem cells (mESCs), here, we report the generation of multilineage ESC-derived mammary organoids (MEMOs). We adapted the skin organoid model, inducing the dermal mesenchyme to transform into mammary-specific mesenchyme via the sequential activation of Bone Morphogenetic Protein 4 (BMP4) and Parathyroid...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Sounak Sahu Sarthak Sahoo Teresa Sullivan T Norene O'Sullivan Sevilay Turan Mary E Albaugh Sandra Burkett Bao Tran David S Salomon Serguei V Kozlov Karl R Koehler Mohit Kumar Jolly Shyam K Sharan Source Type: research
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
Dev Cell. 2023 Dec 23:S1534-5807(23)00652-4. doi: 10.1016/j.devcel.2023.12.002. Online ahead of print.ABSTRACTThe molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a selective regulator of lymphatic but not of blood endothelial contact inhibition. Conditional deletion of Pde2a in mouse embryos reveals severe lymphatic dysplasia, whereas blood vessel architecture remains unaltered. In the absence of PDE2A, human lymphatic endothelial cells fail to induce mature junctions and cell cycle arrest, whereas cGMP l...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Claudia Carlantoni Leon M H Liekfeld Sandra A Hemkemeyer Danny Schreier Ceren Saygi Roberta Kurelic Silvia Cardarelli Joanna Kalucka Christian Schulte Manu Beerens Reiner K Mailer Tilman E Sch äffer Fabio Naro Manuela Pellegrini Viacheslav O Nikolaev Tho Source Type: research
MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement
Dev Cell. 2023 Dec 23:S1534-5807(23)00651-2. doi: 10.1016/j.devcel.2023.12.001. Online ahead of print.ABSTRACTMicrotubule doublets (MTDs) comprise an incomplete microtubule (B-tubule) attached to the side of a complete cylindrical microtubule. These compound microtubules are conserved in cilia across the tree of life; however, the mechanisms by which MTDs form and are maintained in vivo remain poorly understood. Here, we identify microtubule-associated protein 9 (MAP9) as an MTD-associated protein. We demonstrate that C. elegans MAPH-9, a MAP9 homolog, is present during MTD assembly and localizes exclusively to MTDs, a pre...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Michael V Tran Daria Khuntsariya Richard D Fetter James W Ferguson Jennifer T Wang Alexandra F Long Lauren E Cote Stephen R Wellard Nabor V ázquez-Martínez Maria D Sallee Mariya Genova Maria M Magiera Sani Eskinazi Jessica D Lee Nina Peel Carsten Janke Source Type: research
Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids
Dev Cell. 2023 Dec 26:S1534-5807(23)00653-6. doi: 10.1016/j.devcel.2023.12.003. Online ahead of print.ABSTRACTEctodermal appendages, such as the mammary gland (MG), are thought to have evolved from hair-associated apocrine glands to serve the function of milk secretion. Through the directed differentiation of mouse embryonic stem cells (mESCs), here, we report the generation of multilineage ESC-derived mammary organoids (MEMOs). We adapted the skin organoid model, inducing the dermal mesenchyme to transform into mammary-specific mesenchyme via the sequential activation of Bone Morphogenetic Protein 4 (BMP4) and Parathyroid...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Sounak Sahu Sarthak Sahoo Teresa Sullivan T Norene O'Sullivan Sevilay Turan Mary E Albaugh Sandra Burkett Bao Tran David S Salomon Serguei V Kozlov Karl R Koehler Mohit Kumar Jolly Shyam K Sharan Source Type: research
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
Dev Cell. 2023 Dec 23:S1534-5807(23)00652-4. doi: 10.1016/j.devcel.2023.12.002. Online ahead of print.ABSTRACTThe molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a selective regulator of lymphatic but not of blood endothelial contact inhibition. Conditional deletion of Pde2a in mouse embryos reveals severe lymphatic dysplasia, whereas blood vessel architecture remains unaltered. In the absence of PDE2A, human lymphatic endothelial cells fail to induce mature junctions and cell cycle arrest, whereas cGMP l...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Claudia Carlantoni Leon M H Liekfeld Sandra A Hemkemeyer Danny Schreier Ceren Saygi Roberta Kurelic Silvia Cardarelli Joanna Kalucka Christian Schulte Manu Beerens Reiner K Mailer Tilman E Sch äffer Fabio Naro Manuela Pellegrini Viacheslav O Nikolaev Tho Source Type: research
MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement
Dev Cell. 2023 Dec 23:S1534-5807(23)00651-2. doi: 10.1016/j.devcel.2023.12.001. Online ahead of print.ABSTRACTMicrotubule doublets (MTDs) comprise an incomplete microtubule (B-tubule) attached to the side of a complete cylindrical microtubule. These compound microtubules are conserved in cilia across the tree of life; however, the mechanisms by which MTDs form and are maintained in vivo remain poorly understood. Here, we identify microtubule-associated protein 9 (MAP9) as an MTD-associated protein. We demonstrate that C. elegans MAPH-9, a MAP9 homolog, is present during MTD assembly and localizes exclusively to MTDs, a pre...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Michael V Tran Daria Khuntsariya Richard D Fetter James W Ferguson Jennifer T Wang Alexandra F Long Lauren E Cote Stephen R Wellard Nabor V ázquez-Martínez Maria D Sallee Mariya Genova Maria M Magiera Sani Eskinazi Jessica D Lee Nina Peel Carsten Janke Source Type: research
Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids
Dev Cell. 2023 Dec 26:S1534-5807(23)00653-6. doi: 10.1016/j.devcel.2023.12.003. Online ahead of print.ABSTRACTEctodermal appendages, such as the mammary gland (MG), are thought to have evolved from hair-associated apocrine glands to serve the function of milk secretion. Through the directed differentiation of mouse embryonic stem cells (mESCs), here, we report the generation of multilineage ESC-derived mammary organoids (MEMOs). We adapted the skin organoid model, inducing the dermal mesenchyme to transform into mammary-specific mesenchyme via the sequential activation of Bone Morphogenetic Protein 4 (BMP4) and Parathyroid...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Sounak Sahu Sarthak Sahoo Teresa Sullivan T Norene O'Sullivan Sevilay Turan Mary E Albaugh Sandra Burkett Bao Tran David S Salomon Serguei V Kozlov Karl R Koehler Mohit Kumar Jolly Shyam K Sharan Source Type: research
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
Dev Cell. 2023 Dec 23:S1534-5807(23)00652-4. doi: 10.1016/j.devcel.2023.12.002. Online ahead of print.ABSTRACTThe molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a selective regulator of lymphatic but not of blood endothelial contact inhibition. Conditional deletion of Pde2a in mouse embryos reveals severe lymphatic dysplasia, whereas blood vessel architecture remains unaltered. In the absence of PDE2A, human lymphatic endothelial cells fail to induce mature junctions and cell cycle arrest, whereas cGMP l...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Claudia Carlantoni Leon M H Liekfeld Sandra A Hemkemeyer Danny Schreier Ceren Saygi Roberta Kurelic Silvia Cardarelli Joanna Kalucka Christian Schulte Manu Beerens Reiner K Mailer Tilman E Sch äffer Fabio Naro Manuela Pellegrini Viacheslav O Nikolaev Tho Source Type: research
MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement
Dev Cell. 2023 Dec 23:S1534-5807(23)00651-2. doi: 10.1016/j.devcel.2023.12.001. Online ahead of print.ABSTRACTMicrotubule doublets (MTDs) comprise an incomplete microtubule (B-tubule) attached to the side of a complete cylindrical microtubule. These compound microtubules are conserved in cilia across the tree of life; however, the mechanisms by which MTDs form and are maintained in vivo remain poorly understood. Here, we identify microtubule-associated protein 9 (MAP9) as an MTD-associated protein. We demonstrate that C. elegans MAPH-9, a MAP9 homolog, is present during MTD assembly and localizes exclusively to MTDs, a pre...
Source: Developmental Cell - December 30, 2023 Category: Cytology Authors: Michael V Tran Daria Khuntsariya Richard D Fetter James W Ferguson Jennifer T Wang Alexandra F Long Lauren E Cote Stephen R Wellard Nabor V ázquez-Martínez Maria D Sallee Mariya Genova Maria M Magiera Sani Eskinazi Jessica D Lee Nina Peel Carsten Janke Source Type: research
