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Cytoplasmic Polyadenylation Element Binding Protein 1 and Atherosclerosis: Prospective Target and New Insights
Curr Vasc Pharmacol. 2024 Jan 26. doi: 10.2174/0115701611258090231221082502. Online ahead of print.ABSTRACTThe ribonucleic acid (RNA)-binding protein Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1), a key member of the CPEB family, is essential in controlling gene expression involved in both healthy physiological and pathological processes. CPEB1 can bind to the 3'- untranslated regions (UTR) of substrate messenger ribonucleic acid (mRNA) and regulate its translation. There is increasing evidence that CPEB1 is closely related to the pathological basis of atherosclerosis. According to recent investigations, ma...
Source: Current Vascular Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Authors: Jing Zhou Chao-Ke Tang Source Type: research

Hyperparathyroidism and Peripheral Arterial Disease
Curr Vasc Pharmacol. 2024 Jan 26. doi: 10.2174/0115701611280905231227045826. Online ahead of print.ABSTRACTPrimary hyperparathyroidism (PHPT) is presented in various forms, including classic PHPT, characterised by increased parathyroid hormone (PTH) secretion, normohormonal PHPT, and normocalcaemic PHPT. Secondary hyperparathyroidism is characterised by increased PTH secretion triggered by factors such as vitamin D deficiency and kidney failure. This review aims to discuss the involvement of hyperparathyroidism (HPT) in atherosclerosis, including peripheral arterial disease (PAD). The increased level of PTH is involved in ...
Source: Current Vascular Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Authors: Pier Luigi Antignani Mateja K Jezovnik Ales Blinc Dimitri P Mikhailidis Panagiotis Anagnostis Gerit Holger Schernthaner Mojca Jensterle Katica Bajuk Studen Miso Sabovic Pavel Poredos Source Type: research

Sedation with Ketamine-Propofol in Patients Undergoing Transcatheter Aortic Valve Implantation: A Comparative Retrospective Study on General Anesthesia
CONCLUSION: There was no significant difference in mortality in terms of anesthesia management. Anemia was a risk factor for mortality (only in univariate analysis) in the whole study population. We concluded that conscious sedation with ketamine and propofol is effective and safe for TAVI procedures compared to general anesthesia.PMID:38284695 | DOI:10.2174/0115701611274790231221044147 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Authors: Nurdan Yilmaz Yasar Gokhan Gul Murat Ugurlucan Source Type: research

Utilizing Pharmacogenomic Data for a Safer Use of Statins among the Emirati Population
CONCLUSION: Among the sparse studies available, the present one demonstrates all SLCO1B1 and CYP2C9 function-impairing alleles among Emiratis. We highlighted how population-specific pharmacogenomic data can predict safer choices of statins, especially in understudied populations.PMID:38284696 | DOI:10.2174/0115701611283841231227064343 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Authors: Mais N Alqasrawi Zeina N Al-Mahayri Hiba Alblooshi Habiba Alsafar Bassam R Ali Source Type: research

Cardiac Radiofrequency Ablation Exacerbates Myocardial Injury through Pro-Inflammatory Response and Pro-Oxidative Stress in Elderly Patients with Persistent Atrial Fibrillation
CONCLUSION: Monopolar radiofrequency ablation methods could result in more myocardial injury than bipolar radiofrequency ablation. Oxidative stress and inflammatory response may be involved in cardiac radiofrequency ablation-induced myocardial injury, resulting in myocardial ischemia in elderly patients with PAF.PMID:38213173 | DOI:10.2174/0115701611257644231215071611 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 12, 2024 Category: Drugs & Pharmacology Authors: Xia Li Wenhang Zhou Dianxuan Guo Youdong Hu Hualan Zhou Ying Chen Source Type: research

Management of peripheral arterial disease after menopause
Curr Vasc Pharmacol. 2023 Dec 26. doi: 10.2174/0115701611288783231212062901. Online ahead of print.NO ABSTRACTPMID:38151850 | DOI:10.2174/0115701611288783231212062901 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: Theofanis Papas Source Type: research