Neutrophil to Lymphocyte (N/L) and Platelet to Lymphocyte (P/L) Ratios in Differentiating Acute Heart Failure from Respiratory Infection.
Abstract BACKGROUND: The clinical manifestations of acute heart failure (AHF) and respiratory infection (RI) frequently overlap in patients presenting with dyspnoea at the emergency department (ED). The neutrophil to lymphocyte (N/L) and platelet to lymphocyte (P/L) ratios have been proposed as diagnostic and prognostic indices in this setting. OBJECTIVE: To evaluate the ability of N/L and P/L ratios to discriminate the cause of dyspnoea in patients admitted with an initial diagnosis of AHF-RI. METHOD: 100 consecutive dyspnoeic CHF patients diagnosed as AHF-RI in the ED of Sotiria Chest Diseases General ...
Source: Current Vascular Pharmacology - January 26, 2017 Category: Drugs & Pharmacology Authors: Siniorakis EE, Tsarouhas K, Tsitsimpikou C, Batila TC, Panta S, Zampelis KG, Rentoukas E, Triposkiadis F, Limberi SJ Tags: Curr Vasc Pharmacol Source Type: research

Beneficial effects of sildenafil on tissue perfusion and inflammation in a murine model of limb ischemia and atherosclerosis.
CONCLUSIONS: Sildenafil exerts significant beneficial effects on tissue perfusion and inflammatory status after limb ischemia, a finding implying neovascularization and potential vascular protective properties of sildenafil. PMID: 28128066 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 26, 2017 Category: Drugs & Pharmacology Authors: Valatsou A, Briasoulis A, Vogiatzi G, Pantopoulou A, Oikonomou E, Miliou A, Perrea D, Tousoulis D Tags: Curr Vasc Pharmacol Source Type: research

Indicators of cardiovascular risk in metabolic syndrome: long term follow-up in Italian patients.
CONCLUSION: The follow-up data of a series of Italian patients with and without MetS, clearly indicates that the former have a raised cIMT and their arterial IMT progression is greater and the presence of a larger WHtR is apparently linked to a higher incidence of CV events. PMID: 28128067 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 26, 2017 Category: Drugs & Pharmacology Authors: Mombelli G, Pavanello C, Castelnuovo S, Bosisio R, Simonelli S, Pazzucconi F, Sirtori CR Tags: Curr Vasc Pharmacol Source Type: research

Comparison of biolimus versus everolimus for drug-eluting stents in the percutaneous treatment of infra-inguinal arterial disease.
In conclusion, EES appear superior to BES for endovascular therapy of infra-inguinal artery disease. Dedicated randomized trials are required to definitely confirm or disprove these findings. PMID: 28117007 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 22, 2017 Category: Drugs & Pharmacology Authors: Giordano A, Ferraro P, Corcione N, Messina S, Maresca G, Coscioni E, Avellino R, Giordano G, Peruzzi M, Marullo AG, Napolitano G, Romano MF, Biondi-Zoccai G Tags: Curr Vasc Pharmacol Source Type: research

Common therapeutic modalities against diabetes and associated cardiovascular disease.
Abstract Despite recent advances in medical research, the incidence of diabetes and cardiovascular disease (CVD)-induced fatal events is increasing. The literature point towards several co-occurring pathways that could lead to terminal complications related with these diseases. Different pathophysiological alterations such as hyperglycaemia, hyperinsulinaemia, insulin resistance, obesity, endothelial dysfunction and oxidative stress lead to the initiation and progression of atherosclerotic plaques. In view of the continuous rise in fatal events and overlapping pathological conditions associated with CVD and diabet...
Source: Current Vascular Pharmacology - January 5, 2017 Category: Drugs & Pharmacology Authors: Jabir NR, Firoz CK, Ashraf GM, Zaidi SK, Shakil S, Kamal MA, Tabrez S Tags: Curr Vasc Pharmacol Source Type: research

Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges.
Abstract Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies to manage the growth and metastasis of cancers. The functional and proliferative status of blood vessels is regulated by the balance between various key molecules that either stimulate or inhibit angiogenesis. During quiescence, the "angiogenic switch" is "off". However, during tumour development pro-angiogenic factors such as vascular endothelial growth factor (VEG...
Source: Current Vascular Pharmacology - January 5, 2017 Category: Drugs & Pharmacology Authors: Siveen KS, Prabhu K, Krishnankutty R, Kuttikrishnan S, Tsakou M, Alali FQ, Dermime S, Mohammad RM, Uddin S Tags: Curr Vasc Pharmacol Source Type: research

Phytochemical Therapies in Vascular Functioning: A Molecular Approach.
Abstract There has been an increasing interest in the usage of natural products for the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). Regular consumption of fruits, vegetables and whole grains has been shown to be negatively correlated with the risk of CVDs. These foods provide a diversity of nutrients and different bioactive compounds including phytochemicals, vitamins, minerals and fibers which play critical roles in the sustainability of optimal cardiovascular health. Plant-based foods or a nutritional cure are gradually being integrated into medical practice for CVD managem...
Source: Current Vascular Pharmacology - January 5, 2017 Category: Drugs & Pharmacology Authors: Gencoglu H, Orhan C, Sahin K Tags: Curr Vasc Pharmacol Source Type: research

Thrombotic management of antiphospholipid syndrome: Towards novel targeted therapies.
Abstract Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis and/or pregnancy morbidity with persistent levels of antiphospholipid antibodies (aPLs). The development of thrombosis in APS is mediated by aPLs and contributes to the high mortality rate in APS patients. However, although APS has been reported for more than 30 years, there has been no optimal regimen for its prevention or for the management of thrombosis, mainly because the mainstay treatment strategies for managing APS are not targeted towards aPL-mediated thrombotic pathophysiology. Instead, the treatments com...
Source: Current Vascular Pharmacology - January 5, 2017 Category: Drugs & Pharmacology Authors: Asiful Islam M, Alam F, Wong KK, Kamal MA, Gan SH Tags: Curr Vasc Pharmacol Source Type: research

Should we be concerned about the inflammatory response to endovascular procedures?
Abstract Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction. Additiona...
Source: Current Vascular Pharmacology - January 5, 2017 Category: Drugs & Pharmacology Authors: Radak D, Djukic N, Tanaskovic S, Obradovic M, Cenic-Milosevic D, Isenovic ER Tags: Curr Vasc Pharmacol Source Type: research

Gut microbiota in vascular disease: Therapeutic target?
Abstract Gut microbiota is increasingly recognized as a powerful regulator of host physiology. Most of effects are mediated through metabolites acting as energy sources, signaling molecules, receptor ligands and substrates for host enzymes. Owing to the meta-stability and high amenability of the gut microbiota to modification by diet and environment, predicting specific gut microbes or its metabolites responsible for different host metabolic states is often confounded. However, through animal models and human studies a direct role of gut microbes in cardiovascular disorders (CVD) has emerged. The interaction among...
Source: Current Vascular Pharmacology - January 4, 2017 Category: Drugs & Pharmacology Authors: Anbazhagan AN, Priyamvada S, Priyadarshini M Tags: Curr Vasc Pharmacol Source Type: research

Preface.
PMID: 28029087 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 29, 2016 Category: Drugs & Pharmacology Authors: Mikhailidis DP Tags: Curr Vasc Pharmacol Source Type: research

Glucagon-like peptide-1 (GLP-1) receptor agonists in the treatment of obese women with polycystic ovary syndrome.
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females and is often associated with a number of cardiometabolic disorders such as central obesity, dyslipidaemia, hypertension, insulin resistance, hyperinsulinaemia, glucose intolerance and type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 (GLP-1), a gut hormone secreted after a meal, enhances glucose-stimulated insulin secretion and additionally suppresses appetite and gastric motility. Most studies found impaired GLP-1 kinetics in obese individuals, whereas small studies in PCOS reported reduced, normal or even elevated G...
Source: Current Vascular Pharmacology - December 21, 2016 Category: Drugs & Pharmacology Authors: Tzotzas T, Karras SN, Katsiki N Tags: Curr Vasc Pharmacol Source Type: research

Oral Glucose-lowering Drugs and Cardiovascular Outcomes: From the Negative RECORD and ACCORD to Neutral TECOS and Promising EMPA-REG.
Abstract Cardiovascular (CV) morbidity and mortality are higher among patients with diabetes mellitus type 2 (T2DM), particularly those with concomitant CV diseases, compared with other populations. In patients with T2DM, intensive glucose lowering reduces microvascular disease, but has a smaller and debated effect on CV events or mortality. In this setting, the US Food and Drug Administration (FDA) required in 2008 that all new agents for the treatment of T2DM should be evaluated in terms of CV safety. Metformin has long been established as first-line pharmacological therapy in patients with T2DM, due to its prov...
Source: Current Vascular Pharmacology - December 8, 2016 Category: Drugs & Pharmacology Authors: Tsioufis C, Andrikou E, Thomopoulos C, Papanas N, Tousoulis D Tags: Curr Vasc Pharmacol Source Type: research

Apoptosis and Acute Brain Ischemia in Ischemic Stroke.
Abstract Apoptosis may contribute to a significant proportion of neuron death following acute brain ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia may lead to stroke, which is one of the main causes of long-term morbidity and mortality in both developed and developing countries. Therefore, stroke prevention and treatment is clinically important. There are two important separate areas of the brain during ABI: the ischemic core and the ischemic penumbra. The ischemic core of the brain experiences a sudden reduction of blood flow, just minutes after ischemic attack with i...
Source: Current Vascular Pharmacology - November 3, 2016 Category: Drugs & Pharmacology Authors: Radak D, Katsiki N, Resanovic I, Jovanovic A, Sudar-Milovanovic E, Zafirovic S, Mousa SA, Isenovic ER Tags: Curr Vasc Pharmacol Source Type: research

Editorial (Thematic Issue: Sex, Environment, Physical Activity, Diet, and Obesity in Cardiovascular Disease Risk).
PMID: 27809757 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - November 1, 2016 Category: Drugs & Pharmacology Authors: Mukherjee D, Whayne TF Tags: Curr Vasc Pharmacol Source Type: research

Influence of a high-fat diet on cardiac iNOS in female rats.
Abstract Overexpression of inducible nitric oxide synthase (iNOS) is a key link between high-fat (HF) diet induced obesity and cardiovascular disease. Oestradiol has cardioprotective effects that may be mediated through reduction of iNOS activity/expression. In the present study, female Wistar rats were fed a standard diet or a HF diet (42% fat) for 10 weeks. iNOS gene and protein expressions were measured in heart tissue. HF-fed rats exhibited a significant increase in cardiac iNOS mRNA by 695% (p
Source: Current Vascular Pharmacology - October 25, 2016 Category: Drugs & Pharmacology Authors: Isenovic ER, Jovanovic A, Milovanovic ES, Milovanovic S, Pitt SJ, Stewart AJ, Zafirovic S, Stanimirovic J, Radak D Tags: Curr Vasc Pharmacol Source Type: research

Valsartan Protects against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis.
Abstract Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration of iodinated contrast media (CM) for diagnostic and interventional cardiovascular procedures and is associated with substantial morbidity and mortality. While the preventative measures can mitigate the risk of CI-AKI, there remains a need for novel and effective therapeutic approaches. The pathogenesis of CI-AKI is complex and not completely understood. CM-induced renal tubular cell apoptosis caused by the activation of endoplasmic reticulum (ER) stress is involved in CI-AKI. We previously demonstrated that valsa...
Source: Current Vascular Pharmacology - October 25, 2016 Category: Drugs & Pharmacology Authors: Sun Y, Peng PA, Ma Y, Liu X, Yu Y, Jia S, Xu X, Wu S, Zhou Y Tags: Curr Vasc Pharmacol Source Type: research

Metalloproteinases activity in epicardial adipose tissue of patients with coronary artery disease.
CONCLUSION: EAT from CABG presents higher gelatinases activity than No CABG. This finding reveals a potential role of MMPs in EAT expansion making their activity a potential treatment goal. PMID: 27781958 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - October 24, 2016 Category: Drugs & Pharmacology Authors: Berg G, Miksztowicz V, Morales C, Barchuk M, López G, Póveda R, Gelpi R, Schreier L, Rubio M Tags: Curr Vasc Pharmacol Source Type: research

Relationships between alcohol consumption, smoking status and food habits in Greek adolescents: Vascular implications for the future.
Abstract We assessed the prevalence of alcohol consumption and smoking in Greek adolescents and evaluated their association with food habits. Adolescents (495 boys and 508 girls) aged 15 ± 1 years old and 15 ± 2 years old respectively, completed questionnaires regarding smoking, alcohol and food habits. Tobacco use and alcohol consumption were reported by 9.2% and 48.1% of them, respectively. Of those that drank alcohol, 13.9% were also smokers. Older adolescents were more likely to consume foods high in fat and sugar, low in vitamins and minerals as well as foods, considered by them to be less healt...
Source: Current Vascular Pharmacology - October 24, 2016 Category: Drugs & Pharmacology Authors: Hassapidou MN, Fachantidou AI, Papadopoulou SK, Katsiki N, Fachantidis P, Daskalou E, Deligiannis AP Tags: Curr Vasc Pharmacol Source Type: research

Lipoprotein subfractions, uric acid and cardiovascular risk in end-stage renal disease (ESRD) patients.
CONCLUSIONS: Our study demonstrated that higher SUA level was associated with lower prevalence of CVD among hemodialysis patients. The association between higher SUA and lower CVD risk may be explained by the fact that elevated uric acid concentration in haemodialysis population is a marker for better nutritional status and by antioxidant properties SUA. PMID: 27774887 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - October 21, 2016 Category: Drugs & Pharmacology Authors: Gluba-Brzózka A, Franczyk B, Bartnicki P, Rysz-Górzyńska M, Rysz J Tags: Curr Vasc Pharmacol Source Type: research

The effect of treatments for rheumatoid arthritis on endothelial dysfunction evaluated by flow-mediated vasodilation in patients with rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease with a potential cardiovascular (CV) risk. Flow-mediated vasodilation (FMD) is an ultrasonic method to evaluate endothelial function. RA is a contributor to endothelial dysfunction, a CV risk. Relevant insights on the improvement of the CV outcomes in RA patients may be obtained by a systematic review of trials that investigated the effects of RA treatment on FMD in RA patients. This review found that treatments with antirheumatic drugs and some non-antirheumatic drugs could improve the FMD in RA patients. Treatment with anti-tumour necrosis fact...
Source: Current Vascular Pharmacology - October 13, 2016 Category: Drugs & Pharmacology Authors: Kotani K, Miyamoto M, Ando H Tags: Curr Vasc Pharmacol Source Type: research

Heart Score estimation by specialized nurses in a Greek urban population.
CONCLUSIONS: In the present study, specialized nurses estimated the HeartScore in a Greek urban population. The majority of the studied population was undiagnosed and untreated. These results highlight the necessity for both primary and secondary prevention programs that can be carried out by specialized nurses. Such programs may improve the diagnosis and treatment of CVD risk factors; early initiation and optimization of therapy as well as management of drug intolerance (e.g. statins) can contribute to CVD risk reduction. PMID: 27633454 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 14, 2016 Category: Drugs & Pharmacology Authors: Papadopoulou E, Meidani M, Boutsikou M, Papaspiropoulou P, Kelaiditou T, Koukouzli A, Tapola A, Voudoufianaki I, Mavrogeni S, Katsiki N, Kolovou G, Lekakis I Tags: Curr Vasc Pharmacol Source Type: research

Application of dual-source CT coronary angiography in type 2 diabetic patients with symptomatic coronary heart disease.
CONCLUSION: DSCT showed that coronary arteries of diabetic patients with symptomatic CHD were more prone to calcification. There was more non-obstructive than obstructive lumen narrowing; obstructive stenosis and calcification score was positively correlated; coronary plaques were widely distributed, and mainly located in multiple diseased vessels. PMID: 27633455 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 14, 2016 Category: Drugs & Pharmacology Authors: He C, Wang P, Du FZ, Gu JW, Yang ZG Tags: Curr Vasc Pharmacol Source Type: research

The mir-221/222 cluster is a key player in vascular biology via the fine-tuning of endothelial cell physiology.
Abstract The discovery of small RNAs has shed new light on microRNA (mRNA) regulation and a range of biological processes. The recognition that miRNAs-221 and -222 are sensitive regulators in the endothelium may enable the identification of novel biomarkers and therapeutic targets. Given that endothelial dysfunction precedes the development of atherosclerosis and contributes to the development of cardiovascular damage, circulating miRNAs produced by endothelial cells (ECs) are putative biomarkers for a wide range of cardiovascular diseases. Furthermore, EC proliferation and migration have a critical role in the fo...
Source: Current Vascular Pharmacology - September 14, 2016 Category: Drugs & Pharmacology Authors: Celic T, Meuth VM, Massy IS, Metzinger L Tags: Curr Vasc Pharmacol Source Type: research

Cocaine and Acute Basilar Artery Occlusion: What we Know to Date?
PMID: 27633287 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Authors: Siniscalchi A, Sztajzel R, Malferrari G, De Sarro G, Saletti A, Gallelli L Tags: Curr Vasc Pharmacol Source Type: research

"Ah, Wherefore with Infection Should he Live?": Microbial Virulence Factors in Diabetic Foot Ulceration.
"Ah, Wherefore with Infection Should he Live?": Microbial Virulence Factors in Diabetic Foot Ulceration. Curr Vasc Pharmacol. 2016 Sep 9; Authors: Vas P, Panagopoulos P, Papanas N PMID: 27633288 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Authors: Vas P, Panagopoulos P, Papanas N Tags: Curr Vasc Pharmacol Source Type: research

Can Glucagon Like Peptide 1 (GLP1) Agonists or Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors Ameliorate Non-Alcoholic Steatohepatitis in People with or Without Diabetes?
PMID: 27633289 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Authors: Athyros VG, Katsiki N, Karagiannis A Tags: Curr Vasc Pharmacol Source Type: research

Do Some Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) Reduce Macrovascular Complications of Type 2 Diabetes Mellitus? A Commentary on the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) Trial.
PMID: 27633290 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Authors: Athyros VG, Katsiki N, Tentolouris N Tags: Curr Vasc Pharmacol Source Type: research

Time for Earlier and More Intensive Preventive Therapy.
PMID: 27633291 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Authors: Paraskevas KI, Spence JD Tags: Curr Vasc Pharmacol Source Type: research

Vascular Risk Estimation by Specialist Nurses.
PMID: 27633292 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Authors: Jayne Z, Jain A, Nair DR Tags: Curr Vasc Pharmacol Source Type: research

Impaired Insulin Sensitivity And Secretion In Patients With Alzheimer's Disease: The Relationship With Other Atherosclerosis Risk Factors.
Abstract OBJECTIVE: We analysed: (a) insulin sensitivity, (b) insulin secretion capacity, (c) plasma insulin, (d) adiponectin levels, and, (e) lipid parameters in normoglycaemic, nonobese patients with Alzheimer's disease (AD) (group A, n=62), mild cognitive impairment (MCI) (group B, n=41), and healthy controls (group C, n=25). METHOD: Insulin sensitivity was determined both by euglycemic hyperinsulinaemic clamp (M value) and homeostasis model assessment (HOMA-IR), insulin secretion capacity by acute insulin response and first-phase insulin response (FPIR), plasma insulin by RIA and adiponectin by ELISA meth...
Source: Current Vascular Pharmacology - September 5, 2016 Category: Drugs & Pharmacology Authors: Macesic M, Lalic NM, Kostic VS, Jotic A, Lalic K, Stefanova E, Milicic T, Lukic L, Gajovic JS, Krako N Tags: Curr Vasc Pharmacol Source Type: research

Beta-blockers are associated with decreased in-hospital mortality and stroke in acute decompensated heart failure: Findings from a retrospective analysis of a 22-year registry in the Middle East (1991-2013).
CONCLUSIONS: Previous beta-blockade therapy in patients presenting with ADHF decreases intra-hospital mortality and the incidence of CV events and transient ischemic attacks. Moreover, non-withdrawal of beta-blockers during hospitalization has a favorable outcome. PMID: 27550053 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 22, 2016 Category: Drugs & Pharmacology Authors: Khalil CA, Al Suwaidi J, Singh R, Asaad N, Abushahba G, Kunju U, Al-Qahtani A, AlBinali HA Tags: Curr Vasc Pharmacol Source Type: research

Type 2 diabetes mellitus and the elderly: an update on drugs used to treat glycaemia.
Abstract Type 2 diabetes mellitus (T2DM) and its complications are more prevalent in the elderly. As the general population worldwide is ageing, effective and safe treatment of older T2DM patients is becoming more important in clinical practice. Elderly T2DM patients should be carefully evaluated for functional, mental, geriatric and medical disorders before the initiation of antidiabetic drug therapy and regularly monitored thereafter. Treatment strategy and goals should be individualized based on patient co-morbidities and drug pharmacokinetic and pharmacodynamic properties. This narrative review discusses the u...
Source: Current Vascular Pharmacology - August 22, 2016 Category: Drugs & Pharmacology Authors: Mitrakou A, Katsiki N, Lalic NM Tags: Curr Vasc Pharmacol Source Type: research

Why not to use the handgrip test in the assessment of cardiovascular autonomic neuropathy among patients with diabetes mellitus?
CONCLUSIONS: Our data confirm that the handgrip test should no longer be part of the cardiovascular autonomic testing being highly dependent on hypertensive status and baseline diastolic BP. Exaggerated exercise pressor response is proposed as putative mechanism for the inverse association between abnormal results of the handgrip test and hypertension. Adequate CARTs important to allow their use in clinical trials and for the prevention of DM-associated complications by initiating early treatment. PMID: 27550055 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 22, 2016 Category: Drugs & Pharmacology Authors: Körei AE, Kempler M, Istenes I, Vági OE, Putz Z, Horváth VJ, Keresztes K, Lengyel C, Tabák ÁG, Spallone V, Kempler P Tags: Curr Vasc Pharmacol Source Type: research

Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events: A Systematic Pharmacoepidemiological Review.
CONCLUSION: Further research is needed in order to devise new guidelines for safer use of NSAIDs. PMID: 27468710 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 27, 2016 Category: Drugs & Pharmacology Authors: Kontogiorgis C, Valikeserlis I, Hadjipavlou-Litina D, Nena E, Constantinidis TC Tags: Curr Vasc Pharmacol Source Type: research

Chronic Kidney Disease and Cardiovascular Risk Modification.
CONCLUSION: Cardio-renal interaction involves multiple risk factors that contribute significantly to the CKD-induced development of accelerated atherosclerosis, an inflammatory state that causes cardiovascular events. PMID: 27456102 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Fan J, Salameh H Tags: Curr Vasc Pharmacol Source Type: research

Increased Exercise Favorably Modifies Coronary Artery Disease and Peripheral Arterial Disease Outcomes.
Abstract Exercise therapy, especially when supervised on-site in a clinical facility or directed off-site for a home-based program, is an essential component of the management of coronary artery disease (CAD) and peripheral arterial disease (PAD). In the case of both atherosclerotic diseases, it can decrease adverse cardiovascular (CV) events. There has been a recent push toward invasive management of both CAD and PAD but accumulating clinical experience has shown the limitation of invasive management and emphasized the importance of medications, CV risk reduction, conditioning, and exercise, especially when super...
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Whayne TF, Mukherjee D Tags: Curr Vasc Pharmacol Source Type: research

The Mediterranean and other Dietary Patterns in Secondary Cardiovascular.
Abstract Cardiovascular Disease (CVD) remains the leading cause of death and disability worldwide, with increased hospital discharge rates, causing a serious public health issue and an economic burden. Recent demographic transitions, including ageing of the population, low fertility, urbanization and shift towards unhealthy behaviours have resulted in an increase in the prevalence of cardiometabolic disorders (i.e. hypertension, obesity, diabetes). According to the reports of international organisations, a substantial number of heart attacks could have been prevented through lifestyle modifications (i.e. diet, phy...
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Panagiotakos DB, Notara V, Kouvari M, Pitsavos C Tags: Curr Vasc Pharmacol Source Type: research

Interrelationships with Metabolic Syndrome, Obesity and Cardiovascular.
Abstract Cardiovascular (CV) disease is the most common cause of morbidity and mortality worldwide, particularly in the presence of the metabolic syndrome (MetS). Classifications and treatment of the MetS have recently been redefined. While the majority of the cardiac components such as hypertension, diabetes mellitus (DM) and dyslipidemia are objectively measurable elements, a few disparities among the definitions have to be considered that can variably modify diagnosis, treatment and prevention. Noncardiac factors such as liver disease (including, but not limited to, alcoholic and non-alcoholic steatosis/hepatit...
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Said S, Mukherjee D, Whayne TF Tags: Curr Vasc Pharmacol Source Type: research

Use of Chronic Disease Registries to Optimize Cardiovascular Health.
Abstract : Cardiovascular disease remains a significant cause of mortality and morbidity despite relentless ongoing research all over the world. The different cardiovascular societies and research organizations are in a constant effort to improve overall cardiovascular (CV) outcome by conducting trials and establishment of guidelines. The ever growing health care costs have enforced governmental agencies to develop quality performance measures which are addressed towards increasing quality, safety, efficiency of patient care and to curtail the cost of health care. Clinical registries are observational databases wh...
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Gosavi S, Bhagavat A Tags: Curr Vasc Pharmacol Source Type: research

Cardiovascular Risk Factors: Does Sex Matter?
Abstract Coronary heart disease (CHD) is the leading cause of death for women worldwide, most of which is believed to be preventable. Numerous risk factors for CHD are well described, and understanding these risk factors is the first step to reducing the burden of CHD. There are clear differences in risk factors between women and men. The incidence of myocardial infarction is much lower among women under the age of 50 years compared with men, but after menopause, the incidence in women dramatically increases to approach that of men. For this reason, estrogen is postulated to be cardioprotective but results of rece...
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Wells GL Tags: Curr Vasc Pharmacol Source Type: research

Abnormal Peri-Organ or Intra-organ Fat (APIFat) Deposition: An Underestimated Predictor of Vascular Risk?
Abstract Adipose tissue, a major endocrine organ, consists of brown and white adipocytes. Brown fatmay play a beneficialrole in cardiometabolic disordersBrown adipose tissue can also improve glucose and lipid metabolism. In contrast, the expansion of white adipose tissue has been related to obesity, type 2 diabetes mellitus and cardiovascular disease (CVD). Both the quantity and the quality of the white adipose tissue as well as its distribution may affect CVD risk. In this context, the link between adiposity and CVD risk is greater for visceral than subcutaneous fat. Apart from these fat depots, there are other a...
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Katsiki N, Athyros VG, Mikhailidis DP Tags: Curr Vasc Pharmacol Source Type: research

Efficacy and Safety Assessment of Hypertension Management with Coveram (Perindopril/Amlodipine Fixed Combination) in Patients with Previous Angiotensin Receptor Blocker (ARB) Treatment: Arabian Gulf Strong Study.
CONCLUSIONS: The perindopril/amlodipine combination is an effective and well tolerated anti-hypertensive option in patients on previous ARB treatment. PMID: 27456109 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 22, 2016 Category: Drugs & Pharmacology Authors: Ahmed M, Alanbaei M, El Tamimi H, Al-Wahshi Y, Al-Zakwani I Tags: Curr Vasc Pharmacol Source Type: research

Clopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Study.
Abstract OBJECTIVES: A considerable number of patients do not achieve an adequate response to clopidogrel. Our study aimed to evaluate genetic and non-genetic factors as possible risks for clopidogrel high on-treatment platelet reactivity (HTPR) in patients (n=112) with carotid artery stenosis undergoing endarterectomy (CEA). METHODS: Using multiple-electrode impedance aggregometry (MEA) the antiplatelet effectiveness of clopidogrel was measured after 24 h, 7 and 30 days of clopidogrel treatment, which was introduced after elective CEA at a dose of 75 mg daily, for at least 30 days. RESULTS: HTPR was obs...
Source: Current Vascular Pharmacology - July 13, 2016 Category: Drugs & Pharmacology Authors: Backovic D, Ignjatovic S, Rakicevic L, Novkovic M, Kusic-Tisma J, Radojkovic D, Strugarevic E, Calija B, Radak D, Kovac M Tags: Curr Vasc Pharmacol Source Type: research

Anagliptin, a Dipeptidyl Peptidase-4 Inhibitor Ameliorates Arterial Stiffness in Association with Reduction of Remnant-Like Particle Cholesterol and Alanine Transaminase Levels in Type 2 Diabetic Patients.
CONCLUSION: The present study suggests that anagliptin may exert a beneficial effect on arterial stiffness in patients with T2DM, which is independent of its blood glucose-lowering property. Anagliptin may ameliorate arterial stiffness partly via reduction of RLP cholesterol and improvement of liver function. PMID: 27357182 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Tahara N, Yamagishi SI, Bekki M, Kodama N, Nakamura T, Sugiyama Y, Oshige T, Kumashiro Y, Honda A, Tahara A, Igata S, Fukumoto Y Tags: Curr Vasc Pharmacol Source Type: research

Lack of Evidence for Deterioration in Endothelial Function Following Ticagrelor Treatment Cessation.
Abstract BACKGROUND: Ticagrelor may exert pleiotropic actions, beyond platelet inhibition, which are possibly adenosine-mediated. It has been suggested that in patients with coronary artery disease (CAD) ticagrelor may influence endothelial function. OBJECTIVE: We aimed to assess the possibility of endothelial function deterioration following ticagrelor treatment cessation. METHODS: This was a prospective, observational study, in stable CAD patients with prior percutaneous coronary intervention (PCI) for acute coronary syndrome manifested 1 year earlier, under ticagrelor maintenance dose (90 mg bid) and ...
Source: Current Vascular Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Xanthopoulou I, Vogiatzi C, Bampouri T, Chasapi A, Bei I, Davlouros P, Hahalis G, Alexopoulos D Tags: Curr Vasc Pharmacol Source Type: research

Virulence Potential of Staphylococcus Aureus Strains Isolated From Diabetic Foot Ulcers Among Patients From Southern Poland.
wska-Mach J Abstract The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was investigated among infected diabetic foot ulcers in hospitalized and non-hospitalized patients in southern Poland to assess the virulence patterns and antimicrobial resistance among these strains. MRSA was detected in 10.3% of all studied isolates, from the hospitalized patients only. The rest of the isolates was methicillin susceptible. The minimal inhibitory concentration that inhibits 50% of bacterial isolates (MIC50) for vancomycin was 1.0 mg/mL. The mupA gene was detected in six (8.8%) isolates, in one MRSA strain an...
Source: Current Vascular Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Pobiega M, Myjak I, Pomorska-Wesolowska M, Romaniszyn D, Ziólkowski G, Chmielarczyk A, Maciag J, Szczyptaf A, Wójkowska-Mach J Tags: Curr Vasc Pharmacol Source Type: research

The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Abstract The estimation of risk for atherosclerotic cardiovascular (CV) events based only on the presence of classical risk factors is often insufficient. Therefore, efforts have been made to find markers that indicate the presence of preclinical or clinical disease. Inflammation mediates all stages of the disease, from initiation to the thrombotic complications of atherosclerosis. Raised levels of several circulating markers, particularly inflammatory mediators, have been reported in subjects with atherosclerosis. Increased risk for CV events is associated with increased levels of cytokines, cell-adhesion molecul...
Source: Current Vascular Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Poredos P, Jezovnik MK Tags: Curr Vasc Pharmacol Source Type: research

The Effect of Nicotine and Tobacco on Aortic Matrix Metalloproteinases in the Production of Aortic Aneurysm.
CONCLUSION: Nicotine and tobacco constituents translate the exposure to cigarette smoke into increased MMP expression through various molecular mechanisms whose interruption can form the basis for pharmacologic management of AAs. PMID: 27363715 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Rabkin SW Tags: Curr Vasc Pharmacol Source Type: research

Editorial: Resolution of Non-Alcoholic-Steatohepatitis. More than One Drug Needed?
PMID: 27173023 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 13, 2016 Category: Drugs & Pharmacology Authors: Athyros VG, Katsiki N, Mikhailidis DP Tags: Curr Vasc Pharmacol Source Type: research