Editorial: Vascular Protection of Herbal Medicine: Roles and Mechanisms.
PMID: 29022508 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - October 13, 2017 Category: Drugs & Pharmacology Authors: Liu Y, Liu Y Tags: Curr Vasc Pharmacol Source Type: research

Editorial: Relationship between Vitamin D and Metalloproteinases (MMPs) in Acute Myocardial Infarction (AMI).
PMID: 28982337 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - October 4, 2017 Category: Drugs & Pharmacology Authors: Perovic M, Obradovic M, Resanovic I, Isenovic ER Tags: Curr Vasc Pharmacol Source Type: research

Thalidomide Improves Psoriasis-like Lesions and Inhibits Cutaneous VEGF Expression without Alteration of Microvessel Density in Imiquimod-induced Psoriatic Mouse Model.
Abstract Background Psoriasis is a chronic inflammatory skin disorder of unknown etiology. Increasing evidence suggests that psoriasis is probably an angiogenesis-dependent disease. Thalidomide has been reported being able to inhibit the effects of fibroblast growth factor 2 and vascular endothelial growth factor (VEGF), and inhibit tumour necrosis factor-alpha synthesis, and suppress tumour necrosis factor-induced nuclear factor-kappa B activation in Jurkat cells, resulting in suppression of proliferation inflammation, angiogenesis, and the immune system, which are related to the pathogenesis of psoriasis. Object...
Source: Current Vascular Pharmacology - October 4, 2017 Category: Drugs & Pharmacology Authors: Liu JH, Wu HH, Zhao YK, Wang F, Gao Q, Luo DQ Tags: Curr Vasc Pharmacol Source Type: research

The Role of Xanthine Oxidase Inhibitors in Patients with History of Stroke: A Systematic Review.
CONCLUSION: Based on the reviewed literature, allopurinol appears to be a promising therapy to improve vascular function and reduce disability in patients who have had a stroke. The benefits seen are in combination with current standard of care treatments with aspirin and lipid-lowering therapy. Larger trials are necessary to better understand the role of allopurinol in patients with history of stroke. PMID: 28933307 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 19, 2017 Category: Drugs & Pharmacology Authors: Britnell SR, Chillari KA, Brown JN Tags: Curr Vasc Pharmacol Source Type: research

Polymorphism Gln27Glu of β2 adrenergic receptors in patients with ischaemic cardiomyopathy.
CONCLUSION: The present study shows that the Gln27Gln genotype of β2-AR is the most predominant while the Glu27Glu is the least prevalent in our HF population. There was no difference in the prevalence of polymorphism Gln27Glu between HF patients and control subjects. However, the presence of Glu allele was associated with lower myocardial infarction rate. PMID: 28933308 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 19, 2017 Category: Drugs & Pharmacology Authors: Metaxa S, Missouris C, Mavrogianni D, Miliou A, Oikonomou E, Vlismas A, Toli E, Kormali L, Drakakis P, Tousoulis D Tags: Curr Vasc Pharmacol Source Type: research

Cigarette smoking is associated with decreased Bone Gla-protein (BGP) levels in hemodialysis patients.
CONCLUSION: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health. PMID: 28933309 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 19, 2017 Category: Drugs & Pharmacology Authors: Fusaro M, Gallieni M, Aghi A, Iervasi G, Rizzo MA, Stucchi A, Noale M, Tripepi G, Nickolas T, Veronese N, Fabris F, Giannini S, Calò L, Piccoli A, Mereu MC, Cosmai L, Ferraro A, Magonara F, Spinello M, Sella S, Plebani M Tags: Curr Vasc Pharmacol Source Type: research

Pulmonary Hypertension secondary to Left Heart Disease.
Abstract BACKGROUND: Pulmonary hypertension (PH) related to left heart disease (LHD) is the most common form of PH, accounting for more than two third of all PH cases. The hemodynamic abnormalities seen in PH-LHD are complex, and there are currently minimal evidence-based recommendations for the management of PH-LHD. While it is accepted that PH in the context of left heart disease is a marker of worse prognosis, it remains unclear whether its primary treatment is beneficial or harmful. In this article, we discuss the prevalence and significance of PH in patients with heart failure (HF) with reduced ejection fract...
Source: Current Vascular Pharmacology - September 12, 2017 Category: Drugs & Pharmacology Authors: Kabbach G, Mukherjee D Tags: Curr Vasc Pharmacol Source Type: research

Animal Models of Focal Cerebral Ischaemia and Haemorrhagic Transformation: Considerations in Experimental Stroke Study Design.
Abstract Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation treatments are highly effective, some of the benefit is lost because of haemorrhagic complications and consequential neurological deterioration of the patients. A number of mechanisms have been described that mediate the haemorrhagic changes and several agents have been tested in experimental models for inhibiting post stroke haemorrhage. Here, we review and discuss the small animal models of focal...
Source: Current Vascular Pharmacology - September 5, 2017 Category: Drugs & Pharmacology Authors: Shearer JA, Douglas AS, Kirby BP, Tatlisumak T, Doyle KM Tags: Curr Vasc Pharmacol Source Type: research

Is There An Association Between Periodontitis And Atherosclerosis In Adults? A Systematic Review.
CONCLUSION: The available evidence indicates an association between the 2 diseases, with elevated levels of inflammatory markers, mainly C-reactive protein and interleukin 6. PMID: 28875830 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 30, 2017 Category: Drugs & Pharmacology Authors: Almeida APCPSC, Fagundes NCF, Maia LC, Lima RR Tags: Curr Vasc Pharmacol Source Type: research

Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators.
CONCLUSION: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators. PMID: 28828979 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 21, 2017 Category: Drugs & Pharmacology Authors: Stokic E, Romani A, Ilincic B, Kupusinac A, Stosic Z, Isenovic ER Tags: Curr Vasc Pharmacol Source Type: research

Single-pill triple fixed dose combination therapy with single component drug monitoring in treatment-resistant hypertension: a pilot study.
CONCLUSION: Our results support the use of single-pill triple FDC therapy in combination with TDM for the management of patients with suspected treatment-resistant hypertension and further testing in clinical studies. PMID: 28828980 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 21, 2017 Category: Drugs & Pharmacology Authors: Kreutz R, Scholze J, Douros A Tags: Curr Vasc Pharmacol Source Type: research

Impact of angiotensin converting enzyme inhibitors/angiotensin receptors blockers on mortality in acute heart failure patients with left ventricular systolic dysfunction in the Middle East: Observations from the Gulf Acute Heart Failure Registry (Gulf CARE).
CONCLUSIONS: ACEIs and ARBs treatments were associated with lower mortality risk during admission and up to 12-month of follow-up in Middle East AHF patients with left ventricular systolic dysfunction. PMID: 28820057 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 17, 2017 Category: Drugs & Pharmacology Authors: Al-Zakwani I, Sulaiman K, Al-Lawati JA, Alsheikh-Ali AA, Panduranga P, AlHabib KF, Al Suwaidi J, Al-Mahmeed W, AlFaleh H, Elasfar A, Al-Motarreb A, Ridha M, Bulbanat B, Al-Jarallah M, Bazargani N, Asaad N, Amin H Tags: Curr Vasc Pharmacol Source Type: research

Oxidative stress and inflammation: their role in the pathogenesis of peripheral artery disease with or without type 2 diabetes mellitus.
Abstract Peripheral artery disease (PAD), a common vascular disease, has been associated with increased cardiovascular (CV) morbidity and mortality as well as all-cause death. Type 2 diabetes mellitus (T2DM) predisposes to PAD development. In T2DM patients, PAD further increases the risk for CV disease and death as well as foot morbidity and microvascular complications. The present narrative review discusses the role of oxidative stress and inflammation in the pathophysiology of PAD with or without the presence of T2DM. The effects of lifestyle measures (i.e. diet, physical activity and smoking cessation) and drug...
Source: Current Vascular Pharmacology - July 31, 2017 Category: Drugs & Pharmacology Authors: Signorelli SS, Katsiki N Tags: Curr Vasc Pharmacol Source Type: research

Nitroxyl anion mediates relaxation in mesenteric arteries from angiotensin II hypertensive mice.
CONCLUSIONS: We reveal that exogenous HNO-mediated relaxation, via Angeli's Salt, is impaired in mesenteric arteries from AngII-treated mice, yet endogenous HNO-mediated relaxation may be more important during hypertension. PMID: 28745215 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 25, 2017 Category: Drugs & Pharmacology Authors: Wynne BM, Labazi H, Tostes RC, Webb RC Tags: Curr Vasc Pharmacol Source Type: research

Editorial: Cures of Vascular Disease - The State.
PMID: 28697721 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 14, 2017 Category: Drugs & Pharmacology Authors: Tabrez S Tags: Curr Vasc Pharmacol Source Type: research

Therapy Of Cardiac Arrhythmias In Children: An Emerging Role Of Electroanatomical Mapping Systems.
DISCUSSION: Management of cardiac arrhythmias could be very difficult in several scenarios, especially in children with body weight
Source: Current Vascular Pharmacology - July 5, 2017 Category: Drugs & Pharmacology Authors: Matteo C, Maurizio M, Viviana T, Scarano M, Paolo B, Giuseppe D Tags: Curr Vasc Pharmacol Source Type: research

The management of dyslipidaemia in patients with type 2 diabetes mellitus receiving lipid-lowering drugs: a sub-analysis of the CEPHEUS findings.
CONCLUSION: The results of this study highlight the suboptimal management of dyslipidaemia in T2DM patients at high and very high risk of CVD. PMID: 28677510 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 5, 2017 Category: Drugs & Pharmacology Authors: Shehab A, Al-Rasadi K, Arafah M, Al-Hinai AT, Al Mahmeed W, Bhagavathula AS, Al Tamimi O, Al Herz S, Al Anazi F, Al Nemer K, Metwally O, Alkhadra A, Fakhry M, Elghetany H, Medani AR, Yusufali AH, Al Jassim O, Al Hallaq O, Baslaib FOAS, Alawadhi M, Amin H, Tags: Curr Vasc Pharmacol Source Type: research

Effect of low (5 mg) vs high (20-40 mg) rosuvastatin dose on 24h arterial stiffness, central haemodynamics, and non-alcoholic fatty liver disease in patients with optimally controlled arterial hypertension.
CONCLUSIONS: Both doses of rosuvastatin had a beneficial effect on AS; the high dose was more efficient in reducing PWVs and central haemodynamics, and also the high dose was more effective in ameliorating NAFLD. Given that AH control was optimal and lipid values attained targets, 4 other CVD predictors were also addressed. Larger and longer term studies are needed to demonstrate the clinical benefit of such treatment preference. PMID: 28669329 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 30, 2017 Category: Drugs & Pharmacology Authors: Mitsiou E, Boutari C, Kotsis V, Georgianou E, Doumas M, Karagiannis A, Athyros VG Tags: Curr Vasc Pharmacol Source Type: research

Is Nonalcoholic fatty liver disease indeed the hepatic manifestation of metabolic syndrome?
Abstract Metabolic syndrome (MetS) is a cluster of central obesity, dyslipidaemia, insulin resistance and hypertension. MetS frequently co-exists with non-alcoholic fatty liver disease (NAFLD), which is characterized by fat accumulation in the liver in the absence of alcohol abuse, viral hepatitis and other causes of chronic liver diseases. Both MetS and NAFLD are associated with an increased risk for cardiovascular disease and type 2 diabetes mellitus. There are also other associations between MetS and NAFLD. In the present narrative review, we discuss the links between MetS and NAFLD in terms of prevalence, risk...
Source: Current Vascular Pharmacology - June 20, 2017 Category: Drugs & Pharmacology Authors: Katsiki N, Perez-Martinez P, Anagnostis P, Mikhailidis DP, Karagiannis A Tags: Curr Vasc Pharmacol Source Type: research

Lifestyle modifications in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide, affecting more than 30% of general population. High-fat diets, physical inactivity and obesity, all prevalent in the western societies, are strongly associated with the development and progression of NAFLD. Current drug therapies have not consistently shown substantial beneficial effects. Thus, lifestyle modification appears to be the optimal intervention in combating the disease. Accordingly, several studies have concluded that weight loss, via increase in physical activity, and dietary interventions could potential a...
Source: Current Vascular Pharmacology - June 20, 2017 Category: Drugs & Pharmacology Authors: Stavropoulos K, Imprialos K, Pittaras A, Faselis C, Narayan P, Kokkinos P Tags: Curr Vasc Pharmacol Source Type: research

Vitamin D is related to markers of vulnerable plaque in acute myocardial infarction.
CONCLUSIONS: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients. PMID: 28595560 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 9, 2017 Category: Drugs & Pharmacology Authors: Machulsky NF, Barchuk M, Gagliardi J, González D, Lombardo M, Escudero AG, Gigena G, Blanco F, Schreier L, Fabre B, Berg G Tags: Curr Vasc Pharmacol Source Type: research

Sexual dysfunction, cardiovascular risk and effects of pharmacotherapy.
Abstract Sexual dysfunction affects millions of people with an increasing prevalence, worldwide. The pathophysiology of the disease shares several similarities with cardiovascular disease (CVD), including atherosclerosis, endothelial dysfunction, structural vascular damage and subclinical inflammation. Erectile dysfunction (ED) and female sexual dysfunction are common among patients with CVD and risk factors such as hypertension, diabetes, obesity and metabolic syndrome. Given the common pathogenesis of the diseases, ED is an independent prognostic factor of future ED events. Patients with overt ED or risk factors...
Source: Current Vascular Pharmacology - June 9, 2017 Category: Drugs & Pharmacology Authors: Imprialos KP, Stavropoulos K, Doumas M, Tziomalos K, Karagiannis A, Athyros VG Tags: Curr Vasc Pharmacol Source Type: research

Lipid metabolism in patients with end-stage renal disease: A five year follow-up study.
CONCLUSIONS: 1. HV-HDF patients exhibit specific lipid profiles with elevated triacylglycerol, low HDL and LDL and higher content of cholesterol in remnant particles (VLDL and IDL) at the expense of large LDL. HDL subfractions were linked to the number of risk factors for CVD in the control group only. 2. Baseline lipoprotein profiles did not differ between survivors and non-survivors. Non-survivors had higher CRP and lower HDL-C. 3. During the 5 year follow-up period, cholesterol in HDL particles and lipoproteins carrying apolipoprotein B redistributed in survivors towards smaller particles, thus resembling the profile of...
Source: Current Vascular Pharmacology - May 29, 2017 Category: Drugs & Pharmacology Authors: Dušejovská M, Staňková B, Vecka M, Rychlíková J, Mokrejšová M, Rychlík I, Žák A Tags: Curr Vasc Pharmacol Source Type: research

Lifestyle Changes among ACS Survivors in Arabian Gulf Countries (Gulf COAST Registry).
We described lifestyle changes one year after acute coronary syndrome (ACS) among patients in Arabian Gulf countries. Data of patients admitted to 29 hospitals in 4 countries with the diagnosis of ACS were analysed from Gulf citizens with ACS events (Gulf COAST) registry. A total of 3565 ACS patients recruited in the Gulf COAST registry had a one-year follow up available. There was a significant correlation between return to work and the age of patient (p
Source: Current Vascular Pharmacology - May 28, 2017 Category: Drugs & Pharmacology Authors: Al-Roomi F, Khesroh A, Al-Zakwani I, Attur S, Rashed W, Zubaid M Tags: Curr Vasc Pharmacol Source Type: research

Vitamin D levels in middle-aged patients with obstructive sleep apnoea syndrome.
Abstract BACKGROUND: Vitamin D (Vit D) insufficiency has been implicated in the pathophysiology of numerous diseases. Obstructive sleep apnoea syndrome (OSAS), a disorder associated with increased cardiovascular and cerebrovascular morbidity, has been associated with lowered Vit D levels, but reports are inconclusive. AIM: To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D], a marker of Vit D status, and anthropometric and sleep characteristics of OSAS patients and to compare those levels between OSAS patients and non-apnoeic controls. METHOD: Consecutive subjects who had undergone po...
Source: Current Vascular Pharmacology - May 28, 2017 Category: Drugs & Pharmacology Authors: Archontogeorgis K, Nena E, Papanas N, Zissimopoulos A, Voulgaris A, Xanthoudaki M, Manolopoulos E, Froudarakis M, Steiropoulos P Tags: Curr Vasc Pharmacol Source Type: research

Alterations in Plasma Triglyceride Concentrations following Two Oral Meals with Different Fat Content in Patients with Type 2 Diabetes Mellitus.
CONCLUSION: An oral fat tolerance test (OFTT), which contains 75g fat, and represents the everyday habits of Western societies, could provide additional information regarding the postprandial state of the individuals with well-controlled T2DM. The consumption of meals with very high fat content may lead to over diagnosing PPL. TG differences after the consumption of a high fat meal correlated with HOMA-IR. This may be useful to evaluate the role of HOMA-IR in T2DM patients. A standardized the OFTT will help clinicians to better define postprandial TG abnormalities, leading to more appropriate therapeutic options to improve...
Source: Current Vascular Pharmacology - May 28, 2017 Category: Drugs & Pharmacology Authors: Gavra P, Mellidonis A, Iraklianou S, Mihas C, Kolovou V, Mavrogeni S, Dimitriadis G, Rallidis L, Vasaramva K, Boutati E, Katsiki N, Kolovou G Tags: Curr Vasc Pharmacol Source Type: research

Endovascular vs. Open Repair of Abdominal Aortic Aneurysms and Renal Function.
PMID: 28472917 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 8, 2017 Category: Drugs & Pharmacology Authors: Paraskevas KI, Veith FJ Tags: Curr Vasc Pharmacol Source Type: research

Re: 'Re. Renal Function Impairment in Patients Undergoing Elective EVAR vs Elective Open Repair During Follow up Period: A Systematic Review of the Literature'.
PMID: 28472918 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 8, 2017 Category: Drugs & Pharmacology Authors: Spanos K, Karathanos C, Athanasoulas A, Saleptsis V, Vasilopoulos I, Xhepa S, Matsagkas M, Giannoukas AD Tags: Curr Vasc Pharmacol Source Type: research

Renoprotection by direct renin inhibition: a systematic review and meta-analysis.
In conclusion, inhibiting renin and prorenin with aliskiren is a more promising renoprotective treatment compared with blocking the renin/prorenin receptors (RPR). One of the main mechanisms by which aliskiren may confer renoprotection is by decreasing albuminuria and proteinuria. However, it does not seem to change sCr and eGFR in patients at risk of developing renal disease. Furthermore, co-administration of an angiotensin-converting-enzyme inhibitor (ACEI) or an angiotensin II receptor blockers (ARB) and aliskiren was shown to decrease albuminuria and proteinuria to a greater extent compared with monotherapy with these ...
Source: Current Vascular Pharmacology - May 1, 2017 Category: Drugs & Pharmacology Authors: Louvis N, Coulson J Tags: Curr Vasc Pharmacol Source Type: research

Non-pharmacological Modulation of the Autonomic Nervous System for Heart Failure Treatment: where do we stand?
Abstract An imbalance in the autonomic nervous system (ANS) is a central pathophysiologic mechanism in heart failure (HF) and has been a principal target of treatment in these patients. Traditional pharmacologic agents do not provide specific modulation of discrete arms of the ANS, while side effects may lead to poor tolerance. Technological advances have provided a series of invasive methods that may provide a focused effect on the ANS in selected patient groups. Renal denervation, initially targeted for patients with resistant hypertension, has given positive preliminary results in terms of heart structure and f...
Source: Current Vascular Pharmacology - April 28, 2017 Category: Drugs & Pharmacology Authors: Tsioufis C, Iliakis P, Kasiakogias A, Konstantinidis D, Lovic D, Petras D, Doumas M, Tsiamis E, Papademetriou V, Tousoulis D Tags: Curr Vasc Pharmacol Source Type: research

Capillary degeneration and right ventricular remodeling due to hypoxic stress with Sugen5416.
CONCLUSION: Capillary degeneration and activation of VEGF/ERK signaling pathway might be crucial to accelerate the cardiac remodeling due to hypoxic stress with Sugen5416. PMID: 28460626 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - April 27, 2017 Category: Drugs & Pharmacology Authors: Woo E, Kato R, Imano H, Fujiwara Y, Ijiri Y, Okada Y, Yamaguchi T, Izumi Y, Yoshiyama M, Katsumata T, Hayashi T Tags: Curr Vasc Pharmacol Source Type: research

Renal denervation therapy: Can it contribute to better blood pressure control in hypertension?
Abstract Although the first results from studies suggested important benefits regarding blood pressure (BP) control in resistant hypertension by the use of diverse systems of renal denervation (RDN) in the setting of resistant hypertension, the Symplicity HTN-3, randomized sham-controlled trial reduced the enthusiasm and led to a more critical approach towards this neuromodulation innovative therapy. Nowadays there is an ongoing research attempt to justify the pathophysiological background of RDN since overdrive of the sympathetic nervous system is one of the key mechanisms leading to the development and progressi...
Source: Current Vascular Pharmacology - April 26, 2017 Category: Drugs & Pharmacology Authors: Tsioufis C, Dimitriadis K, Kordalis A, Doumas M, Konstantinidis D, Kalos T, Mahfoud F, Papademetriou V, Tousoulis D Tags: Curr Vasc Pharmacol Source Type: research

Clinical value of measuring the renin/aldosterone levels: Optimising the management of uncontrolled/resistant hypertension.
Abstract Resistant hypertension (HT) is a common clinical entity with debilitating cardiovascular consequences. The highly heterogeneous nature of resistant HT requires a meticulous work-up to exclude 'pseudo-resistance' and secondary forms of arterial HT. Resistant HT has recently gained wide scientific interest due to the introduction of interventional methods (renal sympathetic denervation and carotid baroreceptor stimulation) for blood pressure (BP) reduction in this patient population. Despite however the recent advances in understanding the pathophysiology and the clinical characteristics of the disease, the...
Source: Current Vascular Pharmacology - April 26, 2017 Category: Drugs & Pharmacology Authors: Doumas M, Boutari C, Tsioufis C, Dimitriadis K, Triantafyllou A, Douma S Tags: Curr Vasc Pharmacol Source Type: research

The clinical problems of hypertension treatment in hemodialysis patients.
Abstract Hypertension (HT) is present in >80% of patients undergoing haemodialysis (HD). Elevated blood pressure (BP) in hemodialysis patients is associated with cardiovascular events and mortality only when BP is recorded with home or ambulatory monitoring, since pre- and post-dialysis measurements are not valid estimates of BP levels during the inter-interval. Sodium and water overload is the most important of several mechanisms involved in HT development in HD. In this context, non-pharmacologic measures to ensure water and sodium balance by achieving patient dry weight and decreasing daily sodium intake...
Source: Current Vascular Pharmacology - April 14, 2017 Category: Drugs & Pharmacology Authors: Loutradis CN, Tsioufis C, Sarafidis PA Tags: Curr Vasc Pharmacol Source Type: research

Uncontrolled Hypertension and Oncology: Clinical Τips.
Uncontrolled Hypertension and Oncology: Clinical Τips. Curr Vasc Pharmacol. 2017 Apr 14;: Authors: Kalaitzidis RG, Elisaf MS Abstract Angiogenesis is fundamental for tumour development and progression. Thus, anti-angiogenic agents have been developed and are mainly vascular endothelial growth factor (VEGF) pathway inhibitors. However, these agents commonly exhibit cardiac and renal toxicity, proteinuria and hypertension (HT). In fact, with the use of anti-angiogenic agents a rapiddose-dependent increaseof blood pressure (BP) is observed. Thepossible mechanisms of VEGF inhibitors-induced HTinclude ...
Source: Current Vascular Pharmacology - April 14, 2017 Category: Drugs & Pharmacology Authors: Kalaitzidis RG, Elisaf MS Tags: Curr Vasc Pharmacol Source Type: research

Hypertension and heart failure with preserved ejection fraction: connecting the dots.
Abstract Heart failure (HF) with preserved ejection fraction (EF) (HFpEF) accounts for approximately 50% of HF cases and its prevalence relative to HF with reduced EF is rising. Hypertension (HT) is the most common co-morbidity in HFpEF patients and it is implicated in both the pathogenesis and the prognosis of the disease. Therefore, HT is a modifiable risk factor of high yield in HFpEF. We reviewed the literature for epidemiologic data supporting the co-aggregation of the two entities as well as patho-physiologic mechanisms linking HT to HFpEF. Most importantly, we focused on treatment options targeting HT as a ...
Source: Current Vascular Pharmacology - April 14, 2017 Category: Drugs & Pharmacology Authors: Tsioufis C, Georgiopoulos G, Oikonomou D, Thomopoulos C, Katsiki N, Kasiakogias A, Chrysochoou C, Konstantinidis D, Kalos T, Tousoulis D Tags: Curr Vasc Pharmacol Source Type: research

Optimizing the management of uncontrolled hypertension: what do triple fixed- dose drug combinations add?
Abstract Fixed-dose triple drug combinations represent one of the latest innovations of pharmacotherapy for hypertension (HT). They combine a traditional renin-angiotensin system blocker, a diuretic and a calcium channel blocker. The main benefit is the simplification of treatment regimen because 3 different agents are combined at different doses in a single pill. Improving adherence to treatment partly explains why this kind of combination may effectively reduce blood pressure (BP). BP lowering by a single-pill triple-drug combination can be approximately predicted, by using appropriate formulas described in prev...
Source: Current Vascular Pharmacology - April 14, 2017 Category: Drugs & Pharmacology Authors: Thomopoulos C, Katsimagklis G, Archontakis S, Skalis G, Makris T Tags: Curr Vasc Pharmacol Source Type: research

Pharmacological Therapy of Abdominal Aortic Aneurysm: An Update.
Abstract Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation, is associated with high mortality. AAA is characterized by inflammation, smooth muscle cell (SMC) depletion and extracellular matrix (ECM) degradation. Surgical intervention and endovascular therapy are recommended to prevent rupture of large AAAs. Unfortunately, there is no reliable pharmacological agent available to limit AAA expansion. In the past decades, extensive investigations and a body of ongoing clinical trials aimed at defining potent treatments to inhibit and even regress AAA growth. In this review, we summariz...
Source: Current Vascular Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Wang YD, Liu ZJ, Ren J, Xiang MX Tags: Curr Vasc Pharmacol Source Type: research

The socioeconomic effects of uncontrolled hypertension.
Abstract Hypertension (HT), albeit a modifiable risk factor of cardiovascular morbidity and mortality, remains one of the main contributors to the total disease burden internationally and, thus, inevitably one of the basic cost drivers in healthcare systems. Taking the above into account, this brief narrative review aims at presenting the main findings of the international health economics literature on HTwith regards to four key areas: a) the costs attributable to HT, b) the effects of HTon patient well-being, c) the cost-effectiveness of pharmaceutical interventions against high blood pressure, and, d) the costs...
Source: Current Vascular Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Athanasakis K Tags: Curr Vasc Pharmacol Source Type: research

Antithrombotic Therapy for Transcatheter Valvular Interventions: A Revisit.
Abstract The optimal antithrombotic therapies for transcatheter aortic valve implantation (TAVI) and MitraClip implantation have not been well established. We conducted a narrative review from currently available studies between January 2002 and May 2016 to highlight the advantages and disadvantages of antithrombotic therapy use in cardiac catheter-based therapeutic techniques. Recently, these techniques have dramatically altered the approach towards valvular heart diseases management. The introduction into clinical practice, of TAVI for severe aortic stenosis and MitraClip for mitral regurgitation, has revolution...
Source: Current Vascular Pharmacology - April 6, 2017 Category: Drugs & Pharmacology Authors: Mohammed S, El-Menyar A, Al-Janubi H, Shabana A, Alanazi Z Tags: Curr Vasc Pharmacol Source Type: research

Ultrasound-Assisted Catheter-Directed Thrombolysis in High-Risk and Intermediate-High-Risk Pulmonary Embolism: A Meta-analysis.
ml;zdemir N, Konstantinides S Abstract Catheter-directed Ultrasound-Assisted Thrombolysis (USAT) is a novel technology providing a high efficacy with a reduced bleeding risk in patients with pulmonary embolism (PE). We performed a meta-analysis based on presented or published PE series in which USAT was utilized. We searched the MEDLINE, EMBASE and the Cochrane Library for trials published up to December 2015. The primary outcomes were mean pulmonary artery pressure (PAMP), right to left ventricle diameter ratio (RV/LV ratio) and computed tomography (CT) obstruction score. The secondary outcomes were all-cause and...
Source: Current Vascular Pharmacology - April 4, 2017 Category: Drugs & Pharmacology Authors: Kaymaz C, Akbal ÖY, Tanboğa IH, Hakgör A, Yilmaz F, Öztürk S, Poçi N, Türkday S, Özdemir N, Konstantinides S Tags: Curr Vasc Pharmacol Source Type: research

Relationship of high-sensitivity C-reactive protein concentrations and systolic heart failure.
Abstract Objective Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF. Methods In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed. The questionnaires were completed by professional interviews. Results In 2236 subjec...
Source: Current Vascular Pharmacology - April 4, 2017 Category: Drugs & Pharmacology Authors: Kang S, Fan LY, Chen M, Li J, Liu ZM Tags: Curr Vasc Pharmacol Source Type: research

A glycation angle to look into the Diabetic Vasculopathy: Cause and Cure.
Abstract The process of advanced glycation, which is accelerated in diabetes as a result of chronic hyperglycemia and increased oxidative stress, has been suggested to play a vital role in the diabetic complications. Extensive intracellular and extracellular generation and accumulation of advanced glycation end products (AGEs) have been linked to increased risk for microvascular and macrovascular injuries in diabetes. AGEs result from the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids, potentially altering their function. AGEs act directly to induce cross-linking of long-lived pr...
Source: Current Vascular Pharmacology - March 27, 2017 Category: Drugs & Pharmacology Authors: Ahmad S, Siddiqui Z, Rehman S, Khan MY, Khan H, Khanum S, Alouffi S, Saeed M Tags: Curr Vasc Pharmacol Source Type: research

Klotho-FGF23, cardiovascular disease, and vascular calcification: black or white?
Abstract Patients affected by Chronic Kidney Disease and Mineral Bone Disorder (CKD-MBD) have a high risk of cardiovascular (CV) mortality that is poorly explained by traditional risk factors. The newest medical treatments for CKD-MBD have been associated with encouraging, but still inconsistent, improvement in CV disease complications and patient survival. A better understanding of the biomarkers and mechanisms of left ventricular hypertrophy (LVH), atherosclerosis, and vascular calcification (VC) may help with diagnosis and treatment of the organ damage that occurs secondary to CKD-MBD, thus improving survival. ...
Source: Current Vascular Pharmacology - March 8, 2017 Category: Drugs & Pharmacology Authors: Cozzolino M, Cianciolo G, Galassi A, Capelli I, Schillaci R, Lamanna G Tags: Curr Vasc Pharmacol Source Type: research

Wounds difficult to heal: a social problem still rising. Effective strategies of treatment.
CONCLUSIONS: These results suggest that healing was promoted not only by limiting bacterial infections but also by the release of chemiotatic and proangiogenetic factors from leukocytes and platelets, improving the neoformation of capillaries. PMID: 28260516 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - February 28, 2017 Category: Drugs & Pharmacology Authors: Capoano R, Businaro R, Tesori MC, Donello C, Lombardo F, Lo Vasco VR, Capriotti L, Corsi M, Di Raimo T, Leopizzi M, Salvati B, Ricci S Tags: Curr Vasc Pharmacol Source Type: research

Structure of atherosclerotic plaques in different vascular territories: clinical relevance.
Abstract Atherosclerosis is a systemic disease with different faces. Despite similar, or even identical, risk factors and pathogenesis, atherosclerotic lesions and their clinical manifestations vary in different parts of the vasculature. Peripheral arterial disease (PAD) in the superficial femoral artery (SFA) represents a frequent clinical manifestations of atherosclerotic disease. The pathohistological characteristics of plaques in PAD differ from lesions in the coronary arteries. Plaques in the SFA have more fibrotic elements with less lipid and degenerative tissue elements; this makes them more stable and less...
Source: Current Vascular Pharmacology - February 25, 2017 Category: Drugs & Pharmacology Authors: Poredos P, Poredos P, Jezovnik MK Tags: Curr Vasc Pharmacol Source Type: research

Low-Density Lipoprotein Cholesterol (LDL-C): How Low?
Abstract Low-density lipoprotein cholesterol (LDL-C) is a well-established major cardiovascular (CV) risk factor supported by clinical evidence showing decreased atherosclerotic disease events when LDL-C is therapeutically lowered. A reasonable approach is to tailor each patient's LDL-C target level depending on the initial LDL-C level and the perceived risk. Multiple clinical entities such as the newborn, hypobetalipoproteinemia, proprotein convertase subtilisin/kexin type 9 (PCSK9) missense mutations, and an unexpected excess response to a statin or other medications, are associated with very low LDL-C levels in...
Source: Current Vascular Pharmacology - February 25, 2017 Category: Drugs & Pharmacology Authors: Whayne TF Tags: Curr Vasc Pharmacol Source Type: research

Blood infusion and the risk of haemorrhage in patients undergoing cardiac surgery with extracorporeal circulation.
CONCLUSION: The optimum thresholds for autologous processed blood and red blood cells reinfused into the patient were 1800 and 580 ml, respectively. Increasing these thresholds augmented the risk of haemorrhage as an immediate postoperative period complication. PMID: 28201958 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - February 12, 2017 Category: Drugs & Pharmacology Authors: Luque-Oliveros M, García-Carpintero MÁ, Cauli O Tags: Curr Vasc Pharmacol Source Type: research

Hypothyroidism and nephrotic syndrome: why, when and how to treat.
Abstract Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions. However, with a low thyroid reserve the tra...
Source: Current Vascular Pharmacology - February 6, 2017 Category: Drugs & Pharmacology Authors: Di Mario F, Pofi R, Gigante A, Rivoli L, Rosato E, Isidori AM, Cianci R, Barbano B Tags: Curr Vasc Pharmacol Source Type: research

Ethnic and Geographical Differences in Ischaemic Stroke Among Young Adults.
Abstract Ischaemic stroke in young adults encompasses approximately 5 - 15% of all ischaemic strokes, depending on the selected upper age limit. The key features of the disease, including incidence, risk factors, underlying causes, mortality, outcomes, as well as long-term risks of recurrent events are different from those for elderly patients. There is also evidence indicating that these characteristics may differ ethnically and geographically. It is clinically important to recognize such differences not only for correct diagnosis and treatment, but also for introducing accurate preventive measures. Ethnic differ...
Source: Current Vascular Pharmacology - February 1, 2017 Category: Drugs & Pharmacology Authors: Yesilot N, Putaala J, Bahar SZ, Tatlısumak T Tags: Curr Vasc Pharmacol Source Type: research