Intra Articular (IA) Hyaluronic Acid (HA) and Chondroitin Sulfate (CS): Pharmacokinetic (PK) investigation in rat osteoarthritic model
ConclusionDespite differences in their molecular size, HA and CS showed PK behavior similarly characterized by prolonged residence inside the joint and slow release in plasma, favoring long term beneficial effects. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
Retrospective Cohort Comparison of Gonadotropin versus follicle-stimulating hormone for in ovarian response patients undergoing in vitro fertilization
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in POR patients undergoing IVF/ISCI with a GnRH antagonist protocol, although significantly higher serum IGF-1 level and insignificantly lower serum IGFBP-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 3, 2019 Category: Drugs & Pharmacology Source Type: research
Hepatoprotective Effects of a Ruthenium(II) Schiff Base Complex in Rats with Diet-Induced Prediabetes
ConclusionsThe ruthenium(II) complex showed beneficial effects as it ameliorated and prevented the progression of diabetes-related liver derangements while eliminating the hepatotoxicity associated with the use of metal compounds. However, further studies are still required to further determine the physiological mechanisms behind this effect. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 23, 2019 Category: Drugs & Pharmacology Source Type: research
Dupilumab in the Treatment of Moderate to Severe Asthma: An Evidence-Based Review
ConclusionsConcomitant use of dupilumab with long-acting beta agonists used in combination with inhaled corticosteroids, improves clinical outcomes and quality of life in patients with moderate to severe asthma. Although dupilumab has a promising role in treatment of patients with asthma, it is still in the emerging stage for its acceptance globally. Ongoing studies will help to determine dupilumab's long-term efficacy and safety for its future extensive use. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 14, 2019 Category: Drugs & Pharmacology Source Type: research
Hepatoprotective effects of a ruthenium(II) Schiff base complex in diet-induced pre-diabetic rats
ConclusionThe ruthenium(II) complex showed beneficial effects as it ameliorated and prevented the progression of diabetes-related liver derangements while eliminating the hepatotoxicity associated with the use of metal compounds. However, further studies are still required to further determine the physiological mechanisms behind this effect. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 14, 2019 Category: Drugs & Pharmacology Source Type: research
Factors Associated with Compliance with World Health Organization-Recommended Infant-Feeding Practices by Mothers with HIV Infection in Northwest Ethiopia
ConclusionsThe prevalence of recommended infant feeding practices among HIV-exposed infants in the study area was suboptimal compared with the ≥90% recommended by the World Health Organization. Higher educational status of the mother, antenatal and postnatal follow-ups, and disclosure of HIV status to spouses were predictors of adherence to the recommended infant-feeding practices. Although not yet proven in a prospective clinical trial, providing more education for women, improving attendance at antenatal and postnatal follow-up visits, encouraging the disclosure of HIV status to spouses, and educating mothers about pro...
Source: Current Therapeutic Research - November 7, 2019 Category: Drugs & Pharmacology Source Type: research
Injections intra articulaires (IA) d'acide hyaluronique (AH) dans le traitement symptomatique de la gonarthrose : une méta-analyse des injections uniques (mono-injections)
DiscussionIl existe certainement des limites à la méthode de comparaison post-hoc versus placebo, appliquée à des essais individuels. Mais pour chaque synthèse par sous-groupe ou groupe, les résultats ont été confirmés en utilisant plusieurs approches statistiques et différentes méthodes de pondération. Cette méta-analyse suggère que les résultats des mono-injections sont similaires à ceux des multi-injections d'acide hyaluronique intra articulaire en termes de soulagement de la douleur, dans le traitement de la gonarthrose. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 7, 2019 Category: Drugs & Pharmacology Source Type: research
An evidence based review of Dupilumab in the treatment of moderate to severe asthma
ConclusionConcomitant use of Dupilumab with ICS/LABA, improves clinical outcomes and quality of life in moderate to severe asthmatic patients. Though Dupilumab has a promising role in the asthma treatment, it is still in the emerging stage for its acceptance globally. Ongoing studies will help to determine Dupilumab's long-term efficacy and safety for its future extensive use. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 30, 2019 Category: Drugs & Pharmacology Source Type: research
Factors associated with compliance to the WHO recommended infant feeding practices in mothers with HIV infection Northwest, Ethiopia
ConclusionThe prevalence of recommended infant feeding practices among HIV exposed infants in the study area was sub-optimal compared to the ≥90% recommended by WHO . Higher educational status of the mother, antenatal and postnatal follow ups and disclosure of HIV status to spouses were predictors of adherence to the recommended infant feeding practices. While not yet proven in a prospective clinical trial, providing more education for women, improving attejndance at antenatal and postnatal follow-up visits, encouraging disclosing HIV status to spouses, and educating mothers about proper infant feeding options during fol...
Source: Current Therapeutic Research - October 19, 2019 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach
ConclusionsThe study findings suggest that clinical interventions aimed at enhancing the safety and tolerance of quinine might be achieved by a rational decrease in dose size and/or dosing interval, post-48 hours of chronic quinine administration, in malaria-infected patients. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 16, 2019 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics of quinine in healthy Nigerian subjects and in patients with uncomplicated malaria: analysis of data using a population approach
ConclusionsThe study findings suggest that clinical interventions aimed at enhancing the safety and tolerance of quinine might be achieved by a rational decrease in dose size and/or dosing interval, post-48 h of chronic quinine administration, in malaria-infected subjects. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 12, 2019 Category: Drugs & Pharmacology Source Type: research
The effect of glutamatergic modulators on extracellular glutamate: How does this information contribute to the discovery of novel antidepressants?
ConclusionsThe strategy of using glutamatergic modulators as therapeutic agents requires a better understanding of the role of glutamate in the pathophysiology of depression. Gaining such understanding is a challenge because it entails evaluating different targets as well as the effects of these modulators on the kinetics of glutamate uptake. Essentially, glutamate transport is a dynamic process and, currently, it is still necessary to develop new approaches to assay glutamate in the synaptic cleft. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
Efficacy of Periodic Intensive Insulin Therapy on secondary complications of diabetes warrants larger prospective randomized clinical trials
Publication date: Available online 20 August 2019Source: Current Therapeutic ResearchAuthor(s): Jonathan Lakey (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 21, 2019 Category: Drugs & Pharmacology Source Type: research
Periodic Intensive Insulin Therapy Remains Experimental
Publication date: Available online 20 August 2019Source: Current Therapeutic ResearchAuthor(s): Amy Chang, Athena Philis-Tsimikas (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 20, 2019 Category: Drugs & Pharmacology Source Type: research
Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery
ConclusionsThe results of the current study support those of earlier studies that suggest that palonosetron was statistically more effective than the other 2 formulations in the prevention of PONV in patients who have undergone middle ear surgery. (Curr Ther Res Clin Exp. 2019; 80:XXXXXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 26, 2019 Category: Drugs & Pharmacology Source Type: research
