Hepatoprotective effects of a ruthenium(II) Schiff base complex in diet-induced pre-diabetic rats
ConclusionThe ruthenium(II) complex showed beneficial effects as it ameliorated and prevented the progression of diabetes-related liver derangements while eliminating the hepatotoxicity associated with the use of metal compounds. However, further studies are still required to further determine the physiological mechanisms behind this effect. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Factors Associated with Compliance with World Health Organization-Recommended Infant-Feeding Practices by Mothers with HIV Infection in Northwest Ethiopia
ConclusionsThe prevalence of recommended infant feeding practices among HIV-exposed infants in the study area was suboptimal compared with the ≥90% recommended by the World Health Organization. Higher educational status of the mother, antenatal and postnatal follow-ups, and disclosure of HIV status to spouses were predictors of adherence to the recommended infant-feeding practices. Although not yet proven in a prospective clinical trial, providing more education for women, improving attendance at antenatal and postnatal follow-up visits, encouraging the disclosure of HIV status to spouses, and educating mothers about pr...
Source: Current Therapeutic Research - November 7, 2019 Category: Drugs & Pharmacology Source Type: research

Injections intra articulaires (IA) d'acide hyaluronique (AH) dans le traitement symptomatique de la gonarthrose : une méta-analyse des injections uniques (mono-injections)
Publication date: Available online 6 November 2019Source: Current Therapeutic ResearchAuthor(s): Patrice VINCENT, Ingénieur ENSAMRésuméIntroductionLa viscosupplémentation du liquide synovial par injections intra articulaires (IA) d'acide hyaluronique (AH), est un traitement symptomatique bien connu dans la gonarthrose. La question se pose de savoir si les traitements par injection unique (mono-injection) peuvent présenter autant d'efficacité que les multi-injections (3 à 5).MéthodesUne méta-analyse des résultats publiés pour les essais de mono-inj...
Source: Current Therapeutic Research - November 7, 2019 Category: Drugs & Pharmacology Source Type: research

An evidence based review of Dupilumab in the treatment of moderate to severe asthma
ConclusionConcomitant use of Dupilumab with ICS/LABA, improves clinical outcomes and quality of life in moderate to severe asthmatic patients. Though Dupilumab has a promising role in the asthma treatment, it is still in the emerging stage for its acceptance globally. Ongoing studies will help to determine Dupilumab's long-term efficacy and safety for its future extensive use. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 30, 2019 Category: Drugs & Pharmacology Source Type: research

Factors associated with compliance to the WHO recommended infant feeding practices in mothers with HIV infection Northwest, Ethiopia
ConclusionThe prevalence of recommended infant feeding practices among HIV exposed infants in the study area was sub-optimal compared to the ≥90% recommended by WHO . Higher educational status of the mother, antenatal and postnatal follow ups and disclosure of HIV status to spouses were predictors of adherence to the recommended infant feeding practices. While not yet proven in a prospective clinical trial, providing more education for women, improving attejndance at antenatal and postnatal follow-up visits, encouraging disclosing HIV status to spouses, and educating mothers about proper infant feeding options during fo...
Source: Current Therapeutic Research - October 20, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach
ConclusionsThe study findings suggest that clinical interventions aimed at enhancing the safety and tolerance of quinine might be achieved by a rational decrease in dose size and/or dosing interval, post-48 hours of chronic quinine administration, in malaria-infected patients. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 17, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics of quinine in healthy Nigerian subjects and in patients with uncomplicated malaria: analysis of data using a population approach
ConclusionsThe study findings suggest that clinical interventions aimed at enhancing the safety and tolerance of quinine might be achieved by a rational decrease in dose size and/or dosing interval, post-48 h of chronic quinine administration, in malaria-infected subjects. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 12, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of glutamatergic modulators on extracellular glutamate: How does this information contribute to the discovery of novel antidepressants?
ConclusionsThe strategy of using glutamatergic modulators as therapeutic agents requires a better understanding of the role of glutamate in the pathophysiology of depression. Gaining such understanding is a challenge because it entails evaluating different targets as well as the effects of these modulators on the kinetics of glutamate uptake. Essentially, glutamate transport is a dynamic process and, currently, it is still necessary to develop new approaches to assay glutamate in the synaptic cleft. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 11, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy of Periodic Intensive Insulin Therapy on secondary complications of diabetes warrants larger prospective randomized clinical trials
Publication date: Available online 20 August 2019Source: Current Therapeutic ResearchAuthor(s): Jonathan Lakey (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 21, 2019 Category: Drugs & Pharmacology Source Type: research

Periodic Intensive Insulin Therapy Remains Experimental
Publication date: Available online 20 August 2019Source: Current Therapeutic ResearchAuthor(s): Amy Chang, Athena Philis-Tsimikas (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 20, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery
ConclusionsThe results of the current study support those of earlier studies that suggest that palonosetron was statistically more effective than the other 2 formulations in the prevention of PONV in patients who have undergone middle ear surgery. (Curr Ther Res Clin Exp. 2019; 80:XXXXXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Bioequivalence Study of 100-mg Cilostazol Tablets in Healthy Thai Adult Volunteers
ConclusionsBestazol 100-mg tablet was bioequivalent to Pletaal 100-mg tablet. Thus, the formulations can be used interchangeably in clinical practice. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

Bioequivalence Study of 100 mg Cilostazol Tablets in Healthy Thai Adult Volunteers
This study was conducted at the Siriraj Clinical Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Each volunteer was initially treated according to either the Test-Reference (TR) or the Reference-Test (RT) sequence, after which each subject was switched to the other study sequence after a two-week washout period. Pharmacokinetic analysis was performed using log-transformed ratios (test/reference) for Cmax, AUC0-tlast, AUC0-∞, Tmax, t1/2, and λZ for both cilostazol and 3,4-dehydro-cilostazol (its active metabolite) with 90% confidence interval. Physical examination, ...
Source: Current Therapeutic Research - July 16, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison Of Ondansetron, Tropisetron And Palonosetron For The Prevention Of Postoperative Nausea And Vomiting After Middle Ear Surgery
Conclusion: The results of the current study support those of earlier studies that suggest that palonosetron was statistically more effective than the other two formulations in the prevention of PONV in patients who have undergone middle ear surgery. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Erythrocyte partitioning profile of Isosteviol in human and rat blood
ConclusionsThe findings suggest that isosteviol preferentially partitions into plasma compartments in man and rat. The significance of this profile for the efficacy, tissue uptake and retention of isosteviol will, however, have to be further studied. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Schistosomiasis: Life Cycle, Diagnosis, and Control
Publication date: Available online 22 June 2019Source: Current Therapeutic ResearchAuthor(s): Martin L. NelwanAbstractHuman schistosomiasis is a parasitic disease caused by blood-worms that infect multiple organs, including the liver, intestine, bladder, and urethra. The life cycle of these parasites involves two hosts: snails and mammals. Manifestations of schistosomiasis can be acute or chronic. Clinical manifestations of acute schistosomiasis can include fever and headache. Symptoms of chronic infections can include dysuria and hyperplasia. Infections can occur in several sites, including the bile ducts, intestine, and ...
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Inyección Intraarticular Única de Ácido Hialurónico en la Artrosis de Rodilla: Estudio Multicéntrico Prospectivo Abierto (ART-ONE 75) mediante Comparación Post-Hoc con Placebo
Publication date: 2019Source: Current Therapeutic Research, Volume 90Author(s): Dominique BARON, Christian FLIN, Jérôme PORTERIE, Jacques DESPAUX, Patrice VINCENTResumenIntroducciónLa viscosuplementación del líquido sinovial mediante la inyección intraarticular (IA) de ácido hialurónico (AH) es un tratamiento sintomático ampliamente utilizado en la artrosis de rodilla (AR). Además de los productos diseñados para realizar inyecciones múltiples (normalmente de 3 a 5 inyecciones, en intervalos de 1 semana), se presta especial atención a ...
Source: Current Therapeutic Research - May 23, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Periodic Intensive Insulin Therapy: An Updated Review
ConclusionsRecent advancements show that IIT is an effective option for both type 1 diabetes mellitus and type 2 diabetes mellitus patient populations. This treatment resembles normal pancreatic function so closely that it has significantly reduced the effects of relatively common complications of diabetes in comparison to standard treatments. Thus, this new treatment is a promising advancement in the management of diabetes. (Curr Ther Res Clin Exp. 2019; 80:XXX–XXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model
This study aimed to determine the health-related quality of life among patients with type II diabetes mellitus (T2DM) using insulin therapy.MethodsCross-sectional observational study design was used to collect data from Malaysian patients with T2DM. Subjective and objective assessments were made either by using several questionnaires or each patient's specific medication profile registered to care sites. Study participants were recruited from both public hospitals and community health clinics located in Kuala Lumpur, Malaysia.ResultsA total of 430 patients with T2DM were recruited in this study with a response rate of 94.7...
Source: Current Therapeutic Research - May 10, 2019 Category: Drugs & Pharmacology Source Type: research

Inyección intraarticular única de ácido hialurónico en la artrosis de rodilla: estudio multicéntrico prospectivo abierto (ART-ONE 75) mediante Comparación Post-Hoc con Placebo
Publication date: Available online 2 May 2019Source: Current Therapeutic ResearchAuthor(s): Dominique BARON, Christian FLIN, Jérôme PORTERIE, Jacques DESPAUX, Patrice VINCENTResumenIntroducciónLa viscosuplementación del líquido sinovial mediante la inyección intraarticular (IA) de ácido hialurónico (AH) es un tratamiento sintomático ampliamente utilizado en la artrosis de rodilla (AR). Además de los productos diseñados para realizar inyecciones múltiples (normalmente de 3 a 5 inyecciones, en intervalos de 1 semana), se presta especial atenci...
Source: Current Therapeutic Research - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

An Updated Review on the Effects of Periodic Intensive Insulin Therapy
ConclusionsRecent advancements have proven that Intensive Insulin Therapy is an effective option for both T1DM and T2DM patient populations. This treatment resembles normal pancreatic function so closely that it has significantly reduced the effects of relatively common diabetic complications in comparison to standard treatments. Thus, this new treatment is a promising advancement in the management of diabetes. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Predictors of Health-related Quality of Life (HRQoL) among Insulin Users of Type II Diabetes Mellitus Patients; a Multidimensional Model
This study aimed to determine the Health-related Quality of Life (HRQoL) among type II diabetes mellitus (T2DM) patients using insulin therapy.MethodsCross-sectional observational study design was used to collect data from Malaysian patients with T2DM. Subjective & objective assessments were made either by using several questionnaires or patient's specific medication profile registered to care sites. Study participants were recruited from both public hospitals and community health clinics located in Kuala Lumpur, Malaysia.ResultsA total of 430 T2DM patients was recruited in this study with a response rate of 94.7%. The...
Source: Current Therapeutic Research - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Intra-Articular Hyaluronic Acid in the Symptomatic Treatment of Knee Osteoarthritis: A Meta-Analysis of Single-Injection Products
Publication date: 2019Source: Current Therapeutic Research, Volume 90Author(s): Patrice VincentABSTRACTBackgroundViscosupplementation of the synovial fluid with intra-articular hyaluronic acid (IA HA) is a well-known symptomatic treatment of knee osteoarthritis. The question arises whether a monoinjection (ie, single injection) could be as efficient as multi-injection (ie, 3–5 injections) regimens.MethodsA meta-analysis of published studies relating to IA HA monoinjection trials was performed. The efficacy criterion was the Western Ontario and MacMaster Universities pain subscore. Any study design was accepted, from ...
Source: Current Therapeutic Research - April 2, 2019 Category: Drugs & Pharmacology Source Type: research

Concurrent Quinidine and Phenobarbital in the Treatment of a Patient with 2 KCNT1 Mutations
We report the case of an infant with 2 KCNT1 mutations who experienced minor relief with quinidine and discuss the drug's important interaction with phenobarbital. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 12, 2019 Category: Drugs & Pharmacology Source Type: research

Intra-articular (IA) hyaluronic acid (HA) in the symptomatic treatment of knee osteoarthritis (OA): a meta-analysis of single injection products (IA HA mono-injections)
DiscussionThere are certainly limits to the post-hoc placebo comparison method, for individual studies. But for each synthesis per subgroup or group, the results were properly confirmed using multiple statistical approaches and weighing methods. This meta-analysis suggests that mono-injections produce results similar to multi-injections of intra articular hyaluronic acid in terms of pain relief in the treatment of knee OA. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 7, 2019 Category: Drugs & Pharmacology Source Type: research

Concurrent quinidine & phenobarbital in the treatment of a patient with two KCNT1 mutations
We report the case of an infant with two KCNT1 mutations who experienced minor relief with quinidine and discuss the drug's important interaction with phenobarbital. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Global Pediatric Drug Development
ConclusionsGlobal pediatric drug development is a evolving field, and with recent initiatives from the European Medicines Agency and US Food and Drug Administration, this goal is definitively attainable. (Curr Ther Res Clin Exp. 2019; 80:XXX–XXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

Bioequivalence of 2 Naproxen Sodium Tablet Formulations in Healthy Male and Female Volunteers
ConclusionsThis single-dose study found that the test product (RB naproxen sodium tablets) and reference product (Aleve naproxen sodium tablets) met the regulatory criteria for bioequivalence in these fasted male and female volunteers; both test and reference products were found to be safe and well tolerated.Graphical Abstract (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 21, 2019 Category: Drugs & Pharmacology Source Type: research

Global paediatric drug development
ConclusionsGlobal paediatric drug development is a constantly evolving field, and with recent initiatives from EMA and FDA this goal is definitively attainable. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris
ConclusionsThe association of isotretinoin exposure with prenatal developmental toxicity is well established. Though numerous reports also link isotretinoin treatment with psychiatric side effects, this association remains controversial. The extent to which isotretinoin influences pediatric and adult development and cognition, and whether and why certain individuals may be susceptible to psychiatric side effects, remains to be clarified. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 10, 2019 Category: Drugs & Pharmacology Source Type: research

North Polar Tube Reduces the Risk of Epistaxis during Nasotracheal Intubation: A prospective, Randomized Clinical Trial
In this study, a north polar tube (Portex® North Polar tube [Ivory PVC Portex tube; Smiths Medical International, Hythe, United Kingdom]) (NPT) and spiral tube (ST) were compared for their ability to provide a nasal airway in patients during maxillofacial surgery.MethodsPatients who were aged 18 to 65 years with American Society of Anaesthesiologists score 1 to 2 and Mallampati score 1 to 2 were included in the study. The anesthesia technique was standardized in all patients. Patients were divided into 2 groups randomly: the NPT (n = 35) and ST groups (n = 35). Anesthesia was administered with 1% to 2% sevoflur...
Source: Current Therapeutic Research - February 9, 2019 Category: Drugs & Pharmacology Source Type: research

Questionable Industry-Sponsored Postneonatal Pediatric Studies in Slovenia
ConclusionsPediatric studies triggered by US and EU regulatory demands are a serious abuse of nonneonatal children and adolescents in Slovenia and worldwide. They are medically redundant at best and often deter patients from effective innovative personalized therapy. They also exclude young patients from reasonable studies. Institutional review boards/ethics committees should be alerted, should critically review all ongoing pediatric studies, should suspend those found to be questionable, and should reject newly submitted questionable ones. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 2, 2019 Category: Drugs & Pharmacology Source Type: research

Global Harmonization of Pediatric Drug Development: Critical for Progress for Developing Safe and Effective Therapeutics for Children
Publication date: Available online 26 January 2019Source: Current Therapeutic ResearchAuthor(s): Andrew E. Mulberg, Timothy CrippsAbstractThe evaluation of "Questionable Industry-Sponsored Studies in children and adolescents in Slovenia" published by XXXX in this issue of Current Therapeutic Research provides an opportunity to discuss evolving US and EU legislative measures to improve available clinical trialderived pediatric data and provide coherent labeling for pediatric providers in dosing of drugs for children. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 26, 2019 Category: Drugs & Pharmacology Source Type: research

The Challenges of Pediatric Drug Development
Publication date: Available online 26 January 2019Source: Current Therapeutic ResearchAuthor(s): Klaus Rose (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 26, 2019 Category: Drugs & Pharmacology Source Type: research

Are Regulatory Age Limits in Pediatric Melanoma Justified?
Publication date: Available online 18 January 2019Source: Current Therapeutic ResearchAuthor(s): Klaus Rose, Philip D Walson (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 18, 2019 Category: Drugs & Pharmacology Source Type: research

Unusual route of buprenorphine administration: an alternative approach for bypassing adverse drug reactions
Publication date: Available online 18 January 2019Source: Current Therapeutic ResearchAuthor(s): Azadeh Nazari, Shahram Naderi Mazjin, Mansour ShamsipourAbstractTramadol abuse is a critical and growing health concern in Asia. In Iran, tramadol abuse arises most commonly as a result of self-medicating that leads to tramadol dependence. Buprenorphine, a partial agonist of mu opioid receptors approved for the treatment of tramadol dependence, is administered sublingually due to its extensive first-pass metabolism and resulting low oral bioavailability. A 50-year-old man presenting with tramadol dependence after self-medicatin...
Source: Current Therapeutic Research - January 18, 2019 Category: Drugs & Pharmacology Source Type: research

Bioequivalence of Two Naproxen Sodium Tablet Formulations in Healthy Male and Female Subjects
ConclusionsThis single-dose study found that the Test product (RB naproxen sodium tablets) and Reference product (Aleve® naproxen sodium tablets) met the regulatory criteria for bioequivalence in these fasted male and female volunteers; both Test and Reference products were found to be safe and well tolerated.Graphical abstract (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 18, 2019 Category: Drugs & Pharmacology Source Type: research

Questionable Industry-Sponsored Post-Neonatal Pediatric Studies in Slovenia
ConclusionsPediatric studies triggered by US and EU regulatory demands are a serious abuse of non-neonatal children and adolescents in Slovenia and worldwide. They are medically redundant at best and often deter patients from effective innovative personalized therapy. They also exclude young patients from reasonable studies. Institutional Review Boards/ ethics committees should be alerted, should critically review all ongoing pediatric studies, should suspend those found to be questionable, and should reject newly submitted questionable ones. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 18, 2019 Category: Drugs & Pharmacology Source Type: research

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Paediatric Sickle Cell Disease Patients Treated with Artesunate-Amodiaquine
ConclusionsThe data shows a tendency towards lower DEAQ concentration in this limited population of SCD patients and the exploratory population PK estimates suggest altered DEAQ disposition in SCD patients with acute UM. These findings, which if confirmed, may reflect pathophysiological changes associated with SCD, have implications for therapeutic response to amodiaquine in SCD patients. The limited number of recruited SCD patients and sparse sampling approach however, limits extrapolation of the data, and calls for further studies in a larger population. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 12, 2019 Category: Drugs & Pharmacology Source Type: research

Pediatric Drug Development: Challenges and Opportunities
Publication date: Available online 28 December 2018Source: Current Therapeutic ResearchAuthor(s): Cesare Spadoni (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 28, 2018 Category: Drugs & Pharmacology Source Type: research

From Research to the Bedside: Challenges for Pediatric Academic Researchers
ConclusionChanges are needed if academicians are to maximize their involvement in pediatric drug and device development. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 28, 2018 Category: Drugs & Pharmacology Source Type: research

Effectiveness and Tolerability of 3-Day Mebendazole Treatment of Giardia duodenalis Infection in Adults and Children: Two Prospective, Open-Label Phase IV Trials
ConclusionsMebendazole may be an effective alternative treatment of G. duodenalis infections in both children and adults. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Effectiveness and tolerability of 3 day mebendazole treatment of Giardia duodenalis infections in adults and children: two prospective, open-label Phase IV trials
ConclusionsMBZ may be an effective alternative treatment of G. duodenalis infections in both children and adults. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time
ConclusionsPrevious studies have shown that DPD status should be determined before treatment with fluoropyrimidine agents to prevent unnecessary side effects with possible fatal consequences. Our study in combination with literature shows that there is a discrepancy between the DPD enzyme activity and the presence of clinically relevant single nucleotide polymorphisms. At this moment, a combination of a genetic and enzyme test is preferable for diagnostic testing. (Curr Ther Res Clin Exp. 2018; 79:XXX–XXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 27, 2018 Category: Drugs & Pharmacology Source Type: research

Special Meeting Report: Keystone Symposia on Molecular and Cellular Biology, Hannover, Germany, June 4-8, 2018
Publication date: Available online 14 November 2018Source: Current Therapeutic ResearchAuthor(s): Philip D. Walson (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Evolution of dihydropyrimidine dehydrogenase diagnostics in a single center in a time-period of eight years
Publication date: Available online 31 October 2018Source: Current Therapeutic ResearchAuthor(s): Marieke J.H. Coenen, Aimée D.C. Paulussen, Marc Breuer, Martijn Lindhout, Demis C.J. Tserpelis, Anja Steyls, Jörgen Bierau, Bianca J.C. van den BoschAbstractPurposeFluoropyrimidine treatment can be optimized based on DPD (dihydropyrimidine dehydrogenase) activity. DPD dysfunction leads to an increased exposure to active metabolites, which can result in severe or even fatal toxicity.MethodsWe provide an overview of eight years DPD diagnostics (n=1194).ResultsWithin the study period our diagnostic test has evolved fro...
Source: Current Therapeutic Research - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

PORTEX® North Polar tube reduces the risk of epistaxis during nasotracheal intubation: A prospective, randomized clinical trial
In this study, the PORTEX® North Polar tube(NPT) and spiral tube(ST) were compared for their ability to provide a nasal airway in patients during maxillofacial surgery.MethodsPatients who were aged 18-65 years with ASA 1-2 and MP 1-2 were included in the study. The anesthesia technique was standardized in all patients. Patients were divided into two groups randomly: the NPT(n=35) and ST groups(n=35). Anesthesia was administered with 1-2% sevoflurane and a mixture of 50% O2 + 50% air in both groups. The MAP and HR values of pre-induction, pre-intubation, and the 1st, 2nd, 3rd and 5th minutes of intubation were recor...
Source: Current Therapeutic Research - October 9, 2018 Category: Drugs & Pharmacology Source Type: research

Intensification of basal insulin therapy with Lixisenatide in patients with type 2 diabetes in a real-world setting: the BASAL-LIXI Study
Publication date: Available online 9 October 2018Source: Current Therapeutic ResearchAuthor(s): Diego Bellido, Pablo Abellán, José Manuel Ruiz Palomar, Rogelio Álvarez Sintes, Andreu Nubiola, Virginia Bellido, Gracia Romero, Basal Lixi Study investigatorsABSTRACTPurposeBasal insulin reduces fasting blood glucose (FBG), but postprandial blood glucose (PPG) may remain higher. Traditional strategies with rapid insulin intensification can cause hypoglycemic episodes and weight gain. Glucagon-like peptide-1 receptor agonists, such as the short-acting lixisenatide, are able to control postprandial excursions...
Source: Current Therapeutic Research - October 9, 2018 Category: Drugs & Pharmacology Source Type: research

Antipsychotic Drug Dispensations in Older Adults, Including Continuation After a Fall-Related Hospitalization: Identifying Adherence to Screening Tool of Older Persons’ Potentially Inappropriate Prescriptions Criteria Using the Nova Scotia Seniors' Pharmacare Program and Canadian Institute for Health's Discharge Databases
Publication date: 2018Source: Current Therapeutic Research, Volume 89Author(s): Shanna C. Trenaman, Barbara J. Hill-Taylor, Kara J. Matheson, David M. Gardner, Ingrid S. SketrisABSTRACT PurposeDespite well-established concerns regarding adverse drug effects, antipsychotics are frequently prescribed for older adults. Our first objective was to identify trends in antipsychotic dispensations to older Nova Scotians. STOPP (Screening Tool of Older Persons’ Potentially Inappropriate Prescriptions) criteria identify antipsychotic use in those with a history of falls as potentially inappropriate. Our second objective was to ...
Source: Current Therapeutic Research - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Antipsychotic dispensations in older adults, including continuation after a fall-related hospitalization: Identifying adherence to STOPP criteria using the Nova Scotia Seniors' Pharmacare and Canadian Institute for Health's Discharge Databases
Publication date: Available online 31 August 2018Source: Current Therapeutic ResearchAuthor(s): Shanna C. Trenaman, Barbara J. Hill-Taylor, Kara J. Matheson, David M. Gardner, Ingrid S. Sketris (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 1, 2018 Category: Drugs & Pharmacology Source Type: research