The Mechanisms Involved in Mesenchymal Stem Cell Alleviation of Sepsis-Induced Acute Lung Injury in Mice: A Pilot Study
Publication date: 2020Source: Current Therapeutic Research, Volume 93Author(s): Feng Luo, Wei Jiang, Yan Xu, Xue-mei Liu, Wei Wang, Wei Zhang, Congjuan Luo (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 28, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy and tolerability of a fixed dose combination of Rosuvastatin and Ezetimibe, compared to a fixed dose combination of Simvastatin and Ezetimibe in Brazilian patients with primary hypercholesterolemia or mixed dyslipidemia: A multicenter, randomized trial
Publication date: Available online 28 July 2020Source: Current Therapeutic ResearchAuthor(s): Antonio Carlos Amedeo Vattimo, Francisco Antonio Helfestein Fonseca, Douglas Costa Morais, Larissa Fontes Generoso, Renata Herrera, Cristiane Moraes Barbosa, Maria Cristina de Oliveira Izar, Rita Antonelli Cardoso, Stevin Zung (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 28, 2020 Category: Drugs & Pharmacology Source Type: research

The Effect of Dipeptidyl Peptidase-4 Inhibitors on Macrovascular and Microvascular Complications of Diabetes Mellitus: A Systematic Review
Publication date: Available online 25 July 2020Source: Current Therapeutic ResearchAuthor(s): Olesya Taylor, Christine Lam (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 26, 2020 Category: Drugs & Pharmacology Source Type: research

Comparing the efficacy of apple peels and a sodium-glucose cotransporter 2 inhibitor (Ipragliflozin) on interstitial glucose levels: A pilot case study
Publication date: Available online 25 July 2020Source: Current Therapeutic ResearchAuthor(s): Junichi Okada, Eijiro Yamada, Kazuya Okada, Shuichi Okada, Masanobu Yamada (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 26, 2020 Category: Drugs & Pharmacology Source Type: research

A pilot study to investigate the mechanisms involved in mesenchymal stem cell alleviation of sepsis-induced acute lung injury in mice
Publication date: Available online 8 July 2020Source: Current Therapeutic ResearchAuthor(s): Feng Luo, Wei Jiang, Yan Xu, Xue-mei Liu, Wei Wang, Wei Zhang, Congjuan Luo (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

The Effect of Propofol on a Forced Swim Test in Mice at 24 Hours
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): David G. Daniel, Noah G. Daniel, Donald T. Daniel, Laura Copeland Flynn, Michael H. Allen (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 1, 2020 Category: Drugs & Pharmacology Source Type: research

Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): Marwa Houssein, Widian Abi Saab, Mahmoud Khalil, Hala Khalife, Maamoun Fatfat (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 28, 2020 Category: Drugs & Pharmacology Source Type: research

Parental experience of potential adverse drug reactions related to their oral administration of antipyretic analgesics in children in Saudi Arabia
Publication date: Available online 20 June 2020Source: Current Therapeutic ResearchAuthor(s): Mansour Tobaiqy, Katie MacLure, Mansoor Radwi, Ashwaq M. Almalki, Ahmed Hassan Alhasan, Maya Tannoury, Zouhair Attieh (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical evaluation of the use of ginger extract in the preventive management of motion sickness
Publication date: Available online 15 June 2020Source: Current Therapeutic ResearchAuthor(s): Carlos Pereira Nunes, Claudio de Campos Rodrigues, Carlos Alfredo Franco Cardoso, Natasha Cytrynbaum, Renato Kaufman, Helio Rzetelna, Gerson Goldwasser, Alessandra Santos, Lisa Oliveira, Mauro Geller (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 16, 2020 Category: Drugs & Pharmacology Source Type: research

The Effect of Propofol on the Forced Swim Test in Mice at 24 Hours
Publication date: Available online 14 June 2020Source: Current Therapeutic ResearchAuthor(s): David G Daniel, Noah G Daniel, Donald T Daniel, Laura Copeland Flynn, Michael H Allen (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 15, 2020 Category: Drugs & Pharmacology Source Type: research

Cell death by Gallotannin is associated with inhibition of JAK/STAT pathway in human colon cancer cells
Publication date: Available online 13 June 2020Source: Current Therapeutic ResearchAuthor(s): Marwa Houssein, Widian Abi Saab, Mahmoud Khalil, Hala Khalife, Maamoun Fatfat (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 14, 2020 Category: Drugs & Pharmacology Source Type: research

Acide hyaluronique intra articulaire dans la gonarthrose: une étude long-terme, ouverte, de Phase IV, avec analyse détaillée par stade de Kellgren-Lawrence
Publication date: Available online 27 May 2020Source: Current Therapeutic ResearchAuthor(s): Patrice VINCENT (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 28, 2020 Category: Drugs & Pharmacology Source Type: research

Association Between the Level of Reported Good Medication Adherence and the Geographic Location of a Patient's Residence and Presence of a Glucometer Among Adult Diabetic Patients in Ethiopia: A Systematic Review and Meta-analysis
Publication date: Available online 27 May 2020Source: Current Therapeutic ResearchAuthor(s): Getenet Dessie, Fasil Wagnew, Henok Mulugeta, Amare Belachew, Ayenew Negesse, Getachew Mulu Kassa, Tesfa Dejenie Habtewold, Kaley Parchinski (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 28, 2020 Category: Drugs & Pharmacology Source Type: research

Potential Protective Effects of Naringin on Oculo-Pulmonary Injury Induced by PM10 (Wood Smoke) Exposure by Modulation of Oxidative Damage and Acetylcholine Esterase Activity in a Rat Model
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): Jacob K. Akintunde, Joseph B. Abioye, Owen N. Ebinama (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 9, 2020 Category: Drugs & Pharmacology Source Type: research

Healthcare Resource Utilization and Costs Among Patients With Schizophrenia Switching From Oral Risperidone/Paliperidone to Once-Monthly Paliperidone Palmitate: A Veterans Health Administration Claims Analysis
Publication date: Available online 19 April 2020Source: Current Therapeutic ResearchAuthor(s): Charmi Patel, Antoine El Khoury, Ahong Huang, Li Wang, Richa Bashyal (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 21, 2020 Category: Drugs & Pharmacology Source Type: research

Potential protective effects of naringin on oculo-pulmonary injury induced by wood smoke PM10 exposure by modulation of oxidative damage and acetylcholine esterase activity in a rat model
Publication date: Available online 20 April 2020Source: Current Therapeutic ResearchAuthor(s): J.K. Akintunde, J.B. Abioye, O.N. Ebinama (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 21, 2020 Category: Drugs & Pharmacology Source Type: research

Multiple Relapses of Visceral Leishmaniasis in HIV Co-Infected Patients: A Case Series from Ethiopia
Publication date: Available online 8 April 2020Source: Current Therapeutic ResearchAuthor(s): Rezika Mohammed, Helina Fikre, Angela Schuster, Tigist Mekonnen, Johan van Griensven, Ermias Diro (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Drug-Induced Liver Injury in Critically Ill Children Taking Antiepileptic Drugs: A Retrospective Study
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): Kannan Sridharan, Amal Al Daylami, Reema Ajjawi, Husain A.M. Al Ajooz (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 6, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley Rats
Publication date: Available online 19 March 2020Source: Current Therapeutic ResearchAuthor(s): Li Shan Chiu, Ryan S. Anderton, Vince W. Clark, Jane L. Cross, Neville W. Knuckey, Bruno P. Meloni (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Drug-induced liver injury in critically ill children on anti-epileptic drugs: A retrospective study
Publication date: Available online 9 March 2020Source: Current Therapeutic ResearchAuthor(s): Kannan Sridharan, Amal Al Daylami, Reema Ajjawi, Husain AM Al Ajooz (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 11, 2020 Category: Drugs & Pharmacology Source Type: research

The Effects of Clinical Pharmacist Education on Lifestyle Modifications of Postmyocardial Infarction Patients in South India: A Prospective Interventional Study
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): Sarumathy Sundararajan, Shanmugarajan Thukani Sathanantham, Shanmugasundaram Palani (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 27, 2020 Category: Drugs & Pharmacology Source Type: research

Prevalence of Chronic Kidney Disease and Associated Factors among Patients with Diabetes in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Hailemaryam Alemu, Workagegnehu Hailu, Aynshet Adane (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 27, 2020 Category: Drugs & Pharmacology Source Type: research

Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Postmarket, Open-Label, Long-Term Historical Control Study with Analysis Detailed per Krellgren-Lawrence Radiologic Osteoarthritis Scale Grade
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Patrice Vincent, Thibaut Lucas de Couville, Thierry Thomas (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 27, 2020 Category: Drugs & Pharmacology Source Type: research

Medical reversals in family practice: a review
ConclusionWhile these practices were implemented because of sound biologic plausibility or encouraging observational data, well-done RCTs have failed to show evidence of effectiveness. These examples raise caution in introducing new clinical interventions into widespread clinical practice without sufficient high quality evidence demonstrating efficacy. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 23, 2020 Category: Drugs & Pharmacology Source Type: research

Synergistic Effect of 1,3,6-Trihydroxy-4,5,7-Trichloroxanthone in Combination with Doxorubicin on B-Cell Lymphoma Cells and Its Mechanism of Action Through Molecular Docking
ConclusionsThe xanthone-doxorubicin combination showed promising in vitro activity against lymphoma cells. The results also indicate that the TTX and doxorubicin combination's effect was due to the interaction between TTX with Raf-1 and c-Jun N-kinase receptors, 2 determinants of doxorubicin resistance progression. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 21, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical Pharmacist Education on Lifestyle modifications of Post Myocardial Infarction Patients of South India- A Prospective Interventional Study
ConclusionClinical Pharmacist counseling improved the medication adherence and lifestyle modifications in post MI patients with the reduction in blood glucose, blood pressure and total cholesterol levels among the study population. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Potential use of 1,3,6-trihydroxy-4,5,7-trichloroxanthone and doxorubicin combination on B-cell lymphoma and its mechanism of actions through molecular docking study
ConclusionsThe xanthone-doxorubicin combination showed promising in vitro activity against lymphoma cells. The results also indicate that the TTX and doxorubicin combination's effect was due to the interaction between TTX with Raf-1 and JNK receptors, two determinants of doxorubicin resistance progression. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Intra-Articular Hyaluronic Acid and Chondroitin Sulfate: Pharmacokinetic Investigation in Osteoarthritic Rat Models
ConclusionsDespite differences in their molecular size, HA and CS showed PK behavior similarly characterized by prolonged residence inside the joint and slow release in plasma, favoring long-term beneficial effects. (Curr Ther Res Clin Exp. 2020; 92:XXX–XXX) (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 12, 2020 Category: Drugs & Pharmacology Source Type: research

Gonadotropin versus Follicle-Stimulating Hormone for Ovarian Response in Patients Undergoing in vitro Fertilization: A Retrospective Cohort Comparison
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in patients with poor ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection with a gonadotropin-releasing hormone antagonist protocol, although significantly higher serum insulin-like growth factor-1 level and insignificantly lower serum insulin-like growth factor binding protein-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Curr Ther Res Clin Exp. 2020; 81:XXX–XXX) (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 3, 2020 Category: Drugs & Pharmacology Source Type: research

Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1
ConclusionsIn contrast to PSNCBAM-1, the synthesized compounds are analogs with fewer rings. The compounds LDK1317 (12a) and LDK1321 (6a) contained only 2 or 3 rings, respectively, and showed the binding parameters (KB = 110 nM, α = 2.3, and KB = 85 nM, α = 5.9). Further, the computationally predicted drug-like properties and solubility suggest these compounds are acceptable new lead compounds for further development of CB1 allosteric modulators. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 25, 2019 Category: Drugs & Pharmacology Source Type: research

Intra Articular (IA) Hyaluronic Acid (HA) and Chondroitin Sulfate (CS): Pharmacokinetic (PK) investigation in rat osteoarthritic model
ConclusionDespite differences in their molecular size, HA and CS showed PK behavior similarly characterized by prolonged residence inside the joint and slow release in plasma, favoring long term beneficial effects. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 9, 2019 Category: Drugs & Pharmacology Source Type: research

Retrospective Cohort Comparison of Gonadotropin versus follicle-stimulating hormone for in ovarian response patients undergoing in vitro fertilization
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in POR patients undergoing IVF/ISCI with a GnRH antagonist protocol, although significantly higher serum IGF-1 level and insignificantly lower serum IGFBP-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 3, 2019 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective Effects of a Ruthenium(II) Schiff Base Complex in Rats with Diet-Induced Prediabetes
ConclusionsThe ruthenium(II) complex showed beneficial effects as it ameliorated and prevented the progression of diabetes-related liver derangements while eliminating the hepatotoxicity associated with the use of metal compounds. However, further studies are still required to further determine the physiological mechanisms behind this effect. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 23, 2019 Category: Drugs & Pharmacology Source Type: research

Dupilumab in the Treatment of Moderate to Severe Asthma: An Evidence-Based Review
ConclusionsConcomitant use of dupilumab with long-acting beta agonists used in combination with inhaled corticosteroids, improves clinical outcomes and quality of life in patients with moderate to severe asthma. Although dupilumab has a promising role in treatment of patients with asthma, it is still in the emerging stage for its acceptance globally. Ongoing studies will help to determine dupilumab's long-term efficacy and safety for its future extensive use. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective effects of a ruthenium(II) Schiff base complex in diet-induced pre-diabetic rats
ConclusionThe ruthenium(II) complex showed beneficial effects as it ameliorated and prevented the progression of diabetes-related liver derangements while eliminating the hepatotoxicity associated with the use of metal compounds. However, further studies are still required to further determine the physiological mechanisms behind this effect. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Factors Associated with Compliance with World Health Organization-Recommended Infant-Feeding Practices by Mothers with HIV Infection in Northwest Ethiopia
ConclusionsThe prevalence of recommended infant feeding practices among HIV-exposed infants in the study area was suboptimal compared with the ≥90% recommended by the World Health Organization. Higher educational status of the mother, antenatal and postnatal follow-ups, and disclosure of HIV status to spouses were predictors of adherence to the recommended infant-feeding practices. Although not yet proven in a prospective clinical trial, providing more education for women, improving attendance at antenatal and postnatal follow-up visits, encouraging the disclosure of HIV status to spouses, and educating mothers about pr...
Source: Current Therapeutic Research - November 7, 2019 Category: Drugs & Pharmacology Source Type: research

Injections intra articulaires (IA) d'acide hyaluronique (AH) dans le traitement symptomatique de la gonarthrose : une méta-analyse des injections uniques (mono-injections)
Publication date: Available online 6 November 2019Source: Current Therapeutic ResearchAuthor(s): Patrice VINCENT, Ingénieur ENSAMRésuméIntroductionLa viscosupplémentation du liquide synovial par injections intra articulaires (IA) d'acide hyaluronique (AH), est un traitement symptomatique bien connu dans la gonarthrose. La question se pose de savoir si les traitements par injection unique (mono-injection) peuvent présenter autant d'efficacité que les multi-injections (3 à 5).MéthodesUne méta-analyse des résultats publiés pour les essais de mono-inj...
Source: Current Therapeutic Research - November 7, 2019 Category: Drugs & Pharmacology Source Type: research

An evidence based review of Dupilumab in the treatment of moderate to severe asthma
ConclusionConcomitant use of Dupilumab with ICS/LABA, improves clinical outcomes and quality of life in moderate to severe asthmatic patients. Though Dupilumab has a promising role in the asthma treatment, it is still in the emerging stage for its acceptance globally. Ongoing studies will help to determine Dupilumab's long-term efficacy and safety for its future extensive use. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 30, 2019 Category: Drugs & Pharmacology Source Type: research

Factors associated with compliance to the WHO recommended infant feeding practices in mothers with HIV infection Northwest, Ethiopia
ConclusionThe prevalence of recommended infant feeding practices among HIV exposed infants in the study area was sub-optimal compared to the ≥90% recommended by WHO . Higher educational status of the mother, antenatal and postnatal follow ups and disclosure of HIV status to spouses were predictors of adherence to the recommended infant feeding practices. While not yet proven in a prospective clinical trial, providing more education for women, improving attejndance at antenatal and postnatal follow-up visits, encouraging disclosing HIV status to spouses, and educating mothers about proper infant feeding options during fo...
Source: Current Therapeutic Research - October 20, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach
ConclusionsThe study findings suggest that clinical interventions aimed at enhancing the safety and tolerance of quinine might be achieved by a rational decrease in dose size and/or dosing interval, post-48 hours of chronic quinine administration, in malaria-infected patients. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 17, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics of quinine in healthy Nigerian subjects and in patients with uncomplicated malaria: analysis of data using a population approach
ConclusionsThe study findings suggest that clinical interventions aimed at enhancing the safety and tolerance of quinine might be achieved by a rational decrease in dose size and/or dosing interval, post-48 h of chronic quinine administration, in malaria-infected subjects. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 12, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of glutamatergic modulators on extracellular glutamate: How does this information contribute to the discovery of novel antidepressants?
ConclusionsThe strategy of using glutamatergic modulators as therapeutic agents requires a better understanding of the role of glutamate in the pathophysiology of depression. Gaining such understanding is a challenge because it entails evaluating different targets as well as the effects of these modulators on the kinetics of glutamate uptake. Essentially, glutamate transport is a dynamic process and, currently, it is still necessary to develop new approaches to assay glutamate in the synaptic cleft. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 11, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy of Periodic Intensive Insulin Therapy on secondary complications of diabetes warrants larger prospective randomized clinical trials
Publication date: Available online 20 August 2019Source: Current Therapeutic ResearchAuthor(s): Jonathan Lakey (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 21, 2019 Category: Drugs & Pharmacology Source Type: research

Periodic Intensive Insulin Therapy Remains Experimental
Publication date: Available online 20 August 2019Source: Current Therapeutic ResearchAuthor(s): Amy Chang, Athena Philis-Tsimikas (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 20, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery
ConclusionsThe results of the current study support those of earlier studies that suggest that palonosetron was statistically more effective than the other 2 formulations in the prevention of PONV in patients who have undergone middle ear surgery. (Curr Ther Res Clin Exp. 2019; 80:XXXXXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Bioequivalence Study of 100-mg Cilostazol Tablets in Healthy Thai Adult Volunteers
ConclusionsBestazol 100-mg tablet was bioequivalent to Pletaal 100-mg tablet. Thus, the formulations can be used interchangeably in clinical practice. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

Bioequivalence Study of 100 mg Cilostazol Tablets in Healthy Thai Adult Volunteers
This study was conducted at the Siriraj Clinical Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Each volunteer was initially treated according to either the Test-Reference (TR) or the Reference-Test (RT) sequence, after which each subject was switched to the other study sequence after a two-week washout period. Pharmacokinetic analysis was performed using log-transformed ratios (test/reference) for Cmax, AUC0-tlast, AUC0-∞, Tmax, t1/2, and λZ for both cilostazol and 3,4-dehydro-cilostazol (its active metabolite) with 90% confidence interval. Physical examination, ...
Source: Current Therapeutic Research - July 16, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison Of Ondansetron, Tropisetron And Palonosetron For The Prevention Of Postoperative Nausea And Vomiting After Middle Ear Surgery
Conclusion: The results of the current study support those of earlier studies that suggest that palonosetron was statistically more effective than the other two formulations in the prevention of PONV in patients who have undergone middle ear surgery. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Erythrocyte partitioning profile of Isosteviol in human and rat blood
ConclusionsThe findings suggest that isosteviol preferentially partitions into plasma compartments in man and rat. The significance of this profile for the efficacy, tissue uptake and retention of isosteviol will, however, have to be further studied. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Schistosomiasis: Life Cycle, Diagnosis, and Control
Publication date: Available online 22 June 2019Source: Current Therapeutic ResearchAuthor(s): Martin L. NelwanAbstractHuman schistosomiasis is a parasitic disease caused by blood-worms that infect multiple organs, including the liver, intestine, bladder, and urethra. The life cycle of these parasites involves two hosts: snails and mammals. Manifestations of schistosomiasis can be acute or chronic. Clinical manifestations of acute schistosomiasis can include fever and headache. Symptoms of chronic infections can include dysuria and hyperplasia. Infections can occur in several sites, including the bile ducts, intestine, and ...
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research