Effect of Osteoporosis Treatments on Osteoarthritis Progression in Postmenopausal Women: A Review of the Literature
AbstractPurpose of ReviewThe purpose of this literature review was to determine if medications used to treat osteoporosis are also effective for treating osteoarthritis (OA).Recent FindingsA total of 40 relevant articles were identified. Studies were categorized into those (1) discussing estrogen and selective estrogen receptor modulators (SERMs), (2) bisphosphonates, (3) parathyroid hormone (PTH) analogs, and (4) denosumab, and (5) prior review articles. A large amount of evidence suggests that estrogen and SERMs are effective at reducing OA symptoms and disease progression. Evidence suggests that bisphosphonates, the mos...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
How to Monitor Disease Activity of Axial Spondyloarthritis in Clinical Practice
AbstractPurpose of ReviewTreatment guided by periodic and quantitative data assessment results in better outcomes compared to using clinical gestalt. While validated generic as well as specific disease activity measures for axial spondyloarthritis (axSpA) are available, there is vast scope to improve their actual utilization in routine clinical practice. In this review, we discuss available disease activity measures for axSpA, describe results from the survey conducted among general rheumatologists as well as Spondyloarthritis Research and Treatment Network (SPARTAN) members about disease activity measurement in daily prac...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives
AbstractPurpose of the ReviewThrombotic risk assessment in antiphospholipid positive (aPL +) subjects is a major challenge, and the study of in vitro thrombin generation (thrombin generation assays (TGA)) could provide useful information. Activated protein C (APC) sensitivity is involved in thrombotic events in antiphospholipid syndrome patients. We summarized methods used to assess A PC sensitivity with TGA and evaluated the prognostic role of APC resistance through literature search.Recent FindingsAPC resistance induced by aPL is a complex pathway. Several cross-sectional studies assessed APC sensitivity to understand...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
Effect of Osteoporosis Treatments on Osteoarthritis Progression in Postmenopausal Women: A Review of the Literature
AbstractPurpose of ReviewThe purpose of this literature review was to determine if medications used to treat osteoporosis are also effective for treating osteoarthritis (OA).Recent FindingsA total of 40 relevant articles were identified. Studies were categorized into those (1) discussing estrogen and selective estrogen receptor modulators (SERMs), (2) bisphosphonates, (3) parathyroid hormone (PTH) analogs, and (4) denosumab, and (5) prior review articles. A large amount of evidence suggests that estrogen and SERMs are effective at reducing OA symptoms and disease progression. Evidence suggests that bisphosphonates, the mos...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
How to Monitor Disease Activity of Axial Spondyloarthritis in Clinical Practice
AbstractPurpose of ReviewTreatment guided by periodic and quantitative data assessment results in better outcomes compared to using clinical gestalt. While validated generic as well as specific disease activity measures for axial spondyloarthritis (axSpA) are available, there is vast scope to improve their actual utilization in routine clinical practice. In this review, we discuss available disease activity measures for axSpA, describe results from the survey conducted among general rheumatologists as well as Spondyloarthritis Research and Treatment Network (SPARTAN) members about disease activity measurement in daily prac...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives
AbstractPurpose of the ReviewThrombotic risk assessment in antiphospholipid positive (aPL +) subjects is a major challenge, and the study of in vitro thrombin generation (thrombin generation assays (TGA)) could provide useful information. Activated protein C (APC) sensitivity is involved in thrombotic events in antiphospholipid syndrome patients. We summarized methods used to assess A PC sensitivity with TGA and evaluated the prognostic role of APC resistance through literature search.Recent FindingsAPC resistance induced by aPL is a complex pathway. Several cross-sectional studies assessed APC sensitivity to understand...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
Year in Review in Axial Spondyloarthritis Clinical Research and Guidelines: SPARTAN 2023 Annual Meeting Proceedings
AbstractPurpose of ReviewTo highlight high impact clinical publications in spondyloarthritis from May 2022 to April 2023 that were summarized and presented at the SPARTAN annual meeting in May 2023.Recent FindingsPublications included updated guidelines on management of axial spondyloarthritis (axSpA) by ASAS-EULAR and development of a modified Juvenile Spondyloarthritis Disease Activity Index (JSpADA). Definitions were published for MRI lesions of the spine in axSpA and active and structural sacroiliac (SI) joint lesions in juvenile spondyloarthritis (JSpA). Anatomic variants of the sacroiliac joint were commonly detected...
Source: Current Rheumatology Reports - February 10, 2024 Category: Rheumatology Source Type: research
Dose Tapering and Discontinuation of Biologic DMARDs in Axial Spondyloarthritis: A Narrative Review (2023 SPARTAN Annual Meeting Proceedings)
AbstractPurpose of ReviewLimited data is available for tapering or discontinuation of biologic therapy in patients with axSpA who are in disease remission. The current review concentrates on published studies regarding dose tapering or withdrawal of biologics in axSpA.Recent FindingsRecent evidence in light of randomized controlled trials suggests that tapering of b-DMARDs is a feasible strategy to maintain remission or low disease activity in axSpA patients. TNF inhibitors were the studied biologics in most of these trials. The disease flare rates were comparable to those maintained on standard dose in most of these studi...
Source: Current Rheumatology Reports - February 9, 2024 Category: Rheumatology Source Type: research
Sequence of Events in the Pathogenesis of Axial Spondyloarthritis: A Current Review —2023 SPARTAN Meeting Proceedings
AbstractPurpose of ReviewOver the past two decades, significant progress has been made to untangle the etiology of inflammation and new bone formation (NBF) associated with axial spondyloarthritis (axSpA). However, exact mechanisms as to how the disease initiates and develops remain elusive.Recent FindingsType 3 immunity, centered around the IL-23/IL-17 axis, has been recognized as a key player in the pathogenesis of axSpA. Multiple hypotheses associated with HLA-B*27 have been proposed to account for disease onset and progression of axSpA, potentially by driving downstream T cell responses. However, HLA-B*27 alone is not ...
Source: Current Rheumatology Reports - February 7, 2024 Category: Rheumatology Source Type: research
Microbial Mechanisms of Rheumatoid Arthritis Pathogenesis
AbstractPurpose of ReviewHost-microbiome interactions have been implicated in the pathophysiology of rheumatoid arthritis (RA), but the data linking specific microbes to RA is largely associative. Here, we review recent studies that have interrogated specific mechanistic links between microbes and host in the setting of RA.Recent FindingsSeveral candidate bacterial species and antigens that may trigger the conversion of an anti-bacterial to an autoimmune response have been recently identified. Additional studies have identified microbial metabolic pathways that are altered in RA. Some of these microbial species and metabol...
Source: Current Rheumatology Reports - February 1, 2024 Category: Rheumatology Source Type: research
Broadening the Scope of Resilience in Chronic Pain: Methods, Social Context, and Development
AbstractPurpose of ReviewA wellspring of new research has offered varying models of resilience in chronic pain populations; however, resilience is a multifaceted and occasionally nebulous construct. The current review explores definitional and methodological issues in existing observational and clinical studies and offers new directions for future studies of pain resilience.Recent FindingsDefinitions of pain resilience have historically relied heavily upon self-report and from relatively narrow scientific domains (e.g., positive psychology) and in narrow demographic groups (i.e., Caucasian, affluent, or highly educated adu...
Source: Current Rheumatology Reports - January 25, 2024 Category: Rheumatology Source Type: research
