A brief report of plexiform neurofibroma
Plexiform neurofibroma (PNF) is a rare variant of neurofibromatosis type1 (NF-1), which histopathologically, is a subtype of benign nerve sheath tumors, neurofibromas (NF). It develops as a result of proliferation in all parts of peripheral nervous system and can cause the functional damage, deformities, pain, considerable mortality, and morbidity and even the increasing risk of malignant transformation in some critical cases. Currently, the surgical intervention is the treatment of choice for PNF patients, which due to the tumor invasion, massive growth, and the chance of postoperative regrowth is not possible. (Source: C...
Source: Current Problems in Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Mahdi Khajavi(MD), Shahrokh Khoshsirat(MD), Lida Ahangarnazari(MD), Niloofar Majdinasab(MD) Source Type: research
High expression of CC chemokine receptor 5 (CCR5) promotes disease progression in patients with B-cell non-Hodgkin lymphomas
Chemokines are small proteins, that regulate cell migration in many physiological and pathologic processes in human body. They are also responsible for cancer progression. CC chemokine receptor 5 (CCR5) is responsible for cell recruitment in inflammation and may be involved in antitumor immune response controlling. Aberrant CCR5 can be found in different kind of cancers, not only hematological, but also solid tumors. Non-Hodgkin lymphomas consist of many lymphoma subtypes. They predominantly derive from B cells and can have very heterogenous clinical course. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Aleksandra Butrym, Ilona Kryczek, Dorota Dlubek, Emilia Jaskula, Andrzej Lange, Artur Jurczyszyn, Grzegorz Mazur Source Type: research
IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages
Pro-carboxypeptidase B2 (pro-CPB2) or thrombin-activatable fibrinolysis inhibitor (TAFI) is a glycoprotein encoded by the CPB2 gene and deregulated in several cancer types, including breast cancer. Thrombin binding to thrombomodulin (TM), encoded by THBD, is important for TAFI activation. CPB2 gene expression is influenced by genetic polymorphism and cytokines such as interleukin 10 (IL-10). Our previous results showed that tumor infiltrating monocytes/macrophages (CD14+/CD16+) isolated from inflammatory breast cancer (IBC) patients ′ secrete high levels of IL-10. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Hossam Taha Mohamed, Noura El-Husseiny, Eslam A. El-Ghonaimy, Sherif Abdelaziz Ibrahim, Zainab A. Bazzi, Dora Cavallo-Medved, Michael B. Boffa, Mohamed El-Shinawi, Mona Mostafa Mohamed Source Type: research
A brief report of Plexiform Neurofibroma
Plexiform Neurofibroma (PNF) is a rare variant of Neurofibromatosis type1(NF-1), which histopathologically, is a subtype of benign nerve sheath tumors, Neurofibromas (NF). It develops as a result of proliferation in all parts of peripheral nervous system and can cause the functional damage, deformities, pain, considerable mortality and morbidity and even the increasing risk of malignant transformation in some critical cases. Currently, the surgical intervention is the treatment of choice for PNF patients, which due to the tumor invasion, massive growth and the chance of postoperative regrowth is not possible. (Source: Curr...
Source: Current Problems in Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Mahdi Khajavi, Shahrokh Khoshsirat, Lida Ahangarnazari, Niloofar Majdinasab Source Type: research
High expression of CC chemokine receptor 5 (CCR5) promotes disease progression in patients with B-cell non-Hodgkin lymphomast
Chemokines are small proteins, that regulate cell migration in many physiological and pathological processes in human body. They are also responsible for cancer progression. CC chemokine receptor 5 (CCR5) is responsible for cell recruitment in inflammation and may be involved in antitumor immune response controlling. Aberrant CCR5 can be found in different kind of cancers, not only hematological, but also solid tumors. Non-Hodgkin lymphomas consist of many lymphoma subtypes. They predominantly derive from B cells and can have very heterogenous clinical course. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Aleksandra Butrym, Ilona Kryczek, Dorota Dlubek, Emilia Jaskula, Andrzej Lange, Artur Jurczyszyn, Grzegorz Mazur Source Type: research
Primary hepatic marginal zone lymphoma: A rare coincidence
Primary hepatic lymphoma (PHL) is an extremely rare disease and is often misdiagnosed. The optimal therapy is still unclear and the outcomes are uncertain. Among PHLs, a primary hepatic low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue is still rarer. The present study reports the case of an elderly female diagnosed with PHL (mucosa-associated lymphoid tissue) and treated with single agent rituximab. After 18 months, she had a progressive disease and developed Waldenstorms macroglobulinemia concomitantly. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Soumya Surath Panda, Manas Baisakh, Adyakinkar Panda, Hemlata Das Source Type: research
Adipocytokines and breast cancer
A substantial number of studies have revealed that a growing list of cancers might be influenced by obesity. In this regard, one of the most prominent and well-characterized cancers is breast cancer, the leading cause of cancer death among women. Obesity is associated with an increased risk for the occurrence and development of breast cancer particular in postmenopausal women. Moreover, the relationship between adiposity and breast cancer risk is complex, with associations that differ depending on when body size is assessed (eg, premenopausal vs postmenopausal obesity) and when breast cancer is diagnosed (ie, premenopausal...
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Jiajia Li, Xianghui Han Source Type: research
BRCA1 mutation spectrum, functions, and therapeutic strategies: The story so far
BRCA1 gene mutations account for about 25-28% of hereditary Breast Cancer as BRCA1 is included in the category of high penetrance genes. Except for few commonmutations, there is a heterogenous spectrum of BRCA1 mutations in various ethnic groups. 185AGdel and 5382ins Care the most common BRCA1 alterations (founder mutations) which have been identified in most of the population. This review has been compiled with an aim to consolidate the information on genetic variants reported in BRCA1 found in various ethnic groups, their functional implications if known; involvement of BRCA1 in various cellular pathways/processes and po...
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Babita Sharma, Raman Preet Kaur, Sonali Raut, Anjana Munshi Source Type: research
Drug development and clinical trial design in pancreatico-biliary malignancies
Pancreatico-biliary (P-B) tumors arise from the pancreas, bile duct, and ampulla of Vater. Despite their close anatomical location, they have different etiology and biology. However, they uniformly share a poor prognosis, with no major improvements observed in overall survival over decades, even in the face of progress in diagnostic imaging and surgical techniques, and advances in systemic and loco-regional radiation therapies. To date, cytotoxic treatment has been associated with modest benefits in the advanced disease setting, and survival for patients with stage IV disease has not exceeded a year. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Jennifer Harrington, Louise Carter, Bristi Basu, Natalie Cook Source Type: research
BRCA1 mutation spectrum, functions, and therapeutic strategies: The story so far
BRCA1 gene mutations account for about 25-28% of hereditary Breast Cancer as BRCA1 is included in the category of high penetrance genes. Except for few commonmutations, there is a heterogenous spectrum of BRCA1 mutations in various ethnic groups. 185AGdel and 5382ins Care the most common BRCA1 alterations (founder mutations) which have been identified in most of the population. This review has been compiled with an aim to consolidate the information on genetic variants reported in BRCA1 found in various ethnic groups, their functional implications if known; involvement of BRCA1 in various cellular pathways/processes and po...
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Babita Sharma, Raman Preet Kaur, Sonali Raut, Anjana Munshi Source Type: research
Primary Hepatic Marginal zone Lymphoma: A rare coincidence
Primary hepatic lymphoma (PHL) is an extremely rare disease and is often misdiagnosed. The optimal therapy is still unclear and the outcomes are uncertain. Among PHLs, a primary hepatic low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is still rarer. The present study reports the case of an elderly female diagnosed with primary hepatic lymphoma (MALT lymphoma) and treated with single agent rituximab. After 18 months, she had a progressive disease and developed Waldenstorms Macroglobulinemia concomitantly. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Soumya Surath Panda, Manas Baisakh, Adyakinkar Panda, Hemlata Das Source Type: research
Adipocytokines and Breast Cancer
A substantial number of studies have revealed that a growing list of cancers might be influenced by obesity. In this regard, one of the most prominent and well characterized cancers is breast cancer, the leading cause of cancer death among women. Obesity is associated with an increased risk for the occurrence and development of breast cancer particular in postmenopausal women. Moreover, the relationship between adiposity and breast cancer risk is complex, with associations that differ depending on when body size is assessed (e.g., pre- versus postmenopausal obesity) and when breast cancer is diagnosed (i.e., pre- versus po...
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Jiajia Li, Xianghui Han Source Type: research
BRCA1 mutation spectrum, functions and therapeutic strategies: The story so far
Breast Cancer is not only one of the most commonly diagnosed cancer (23%) but also a leading cause of cancer-related deaths (14%) among women world over.1 In 2015, WHO estimated 231,840 new cases of invasive breast cancer and 60,290 additional in situ cases. The incidence rate varies drastically across the world, ranging from 92 per 100,000 in North America to 27 per 100,000 in Middle Africa and Eastern Asia.1 The Ashkenazi population represents the Jews having ancestors from Eastern and Central Europe, such as Germany, Poland, Lithuania, Ukraine, and Russia. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Babita Sharma, Raman Preet Kaur, Sonali Raut, Anjana Munshi Source Type: research
Drug Development and Clinical Trial Design in Pancreatico-biliary malignancies
Pancreatico-biliary tumours arise from the pancreas, bile duct and Ampulla of Vater. Despite their close anatomical location, they have different aetiology and biology. However, they uniformly share a poor prognosis, with no major improvements observed in overall survival over decades, even in the face of progress in diagnostic imaging, surgical techniques and advances in systemic and loco-regional radiation therapies. To date, cytotoxic treatment has been associated with modest benefits in the advanced disease setting, and survival for patients with stage IV disease has not exceeded a year. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Jennifer Harrington, Louise Carter, Bristi Basu, Natalie Cook Source Type: research
Retroperitoneal follicular dendritic cell sarcoma in a young woman: Diagnosis and treatment challenges
Follicular dendritic cell sarcoma (FDCS) is an uncommon tumor that usually arises in lymph nodes, especially in the cervical, mediastinal, or axillary areas, but rarely in extranodal sites. Few cases have been reported in English literature so far. The scarcity may be partially due to under-recognition of this entity. Through this case report we analyzed the difficulties of clinical and pathological diagnosis of this rare tumor with its unusual location mistaken it with gynecological cancer ’s iliac lymph nodes metastases. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 6, 2018 Category: Cancer & Oncology Authors: Rym Bouriga, Nihed Abdessaied, Makram Hochlef, Najoua Mallat, Mohamed Mahjoub, Badereddine Sriha, Slim Ben Ahmed Source Type: research
