The role of epigenetic therapies in colorectal cancer
Although developments in the diagnosis and therapy of colorectal cancer (CRC) have been made in the last decade, much work remains to be done as it remains the second leading cause of cancer death. It is now well established that epigenetic events, together with genetic alterations, are key events in initiation and progression of CRC. Epigenetics refers to heritable alterations in gene expression that do not involve changes in the DNA sequence. These alterations include DNA methylation, histone alterations, chromatin remodelers, and noncoding RNAs. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 12, 2018 Category: Cancer & Oncology Authors: Marina Baretti, Nilofer Saba Azad Source Type: research
The Role of Epigenetic Therapies in Colorectal Cancer
Although developments in the diagnosis and therapy of colorectal cancer (CRC) have been made in the last decade, much work remains to be done as it remains the second leading cause of cancer death. It is now well established that epigenetic events, together with genetic alterations, are key events in initiation and progression of CRC. Epigenetics refers to heritable alterations in gene expression that do not involve changes in the DNA sequence. These alterations include DNA methylation, histone alterations, chromatin remodelers and noncoding RNAs. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 12, 2018 Category: Cancer & Oncology Authors: Marina Baretti, Nilofer Saba Azad Source Type: research
Title Page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research
Information for Readers
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research
A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma
In this study, we aimed to explore a novel signature of microRNA expression for predicting the overall survival (OS) of patients with UCEC. The genome-wide miRNA expression profiles and relevant clinical characteristics of 348 patients with UCEC were downloaded from the Cancer Genome Atlas (TCGA) data portal and analyzed comprehensively. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Yue Wang, Mu Xu, Qing Yang Source Type: research
A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma
In this study, we aimed to explore a novel signature of microRNA expression for predicting the overall survival (OS) of UCEC patients. The genome-wide miRNA expression profiles and relevant clinical characteristics of 348 patients with UCEC were downloaded from the Cancer Genome Atlas (TCGA) data portal and analyzed comprehensively. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Yue Wang, Mu Xu, Qing Yang Source Type: research
Primary squamous cell carcinoma arising from endometriosis of the ovary: A case report and literature review
We present a SCC case arising from endometriosis, and analyzed the clinical, therapeutic, and pathologic features through a comprehensive literature review. A 43-year premenopausal woman (gravida 2, para 1) presented to our hospital due to sudden pain in lower abdomen. Exploratory laparotomy indicated rupture of left ovarian cyst and intra-abdominal hemorrhage were observed. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Yalan Xu, Lei Li Source Type: research
Primary squamous cell carcinoma arising from endometriosis of the ovary: A case report and literature review
Cases of squamous cell carcinoma (SCC) arising from ovarian endometriosis have been rarely reported. Most of the patients show a poor prognosis and present with a diminished survival time. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Yalan Xu, Lei Li Source Type: research
The importance of quality-of-life management in patients with advanced pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, and as such, a focus on quality of life is vital. This review will discuss various aspects of quality of life in patients with PDAC and their treatment. Pancreatic exocrine and endocrine insufficiency may result in issues related to nutrition, and pain and fatigue are other common symptoms, and may be managed with pharmaceutical or nonpharmaceutical methods. It has also been reported that low mood is a particular problem for patients with PDAC compared to patients with other cancers; however, the data supporting this is inconsistent. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 3, 2018 Category: Cancer & Oncology Authors: Alexandra R. Lewis, Rille Pihlak, Mair éad G. McNamara Source Type: research
The importance of quality of life management in patients with advanced pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, and as such, a focus on quality of life is vital. This review will discuss various aspects of quality of life in patients with PDAC and their treatment. Pancreatic exocrine and endocrine insufficiency may result in issues related to nutrition, and pain and fatigue are other common symptoms, and may be managed with pharmaceutical or non-pharmaceutical methods. It has also been reported that low mood is a particular problem for patients with PDAC compared to patients with other cancers; however the data supporting this is inconsistent. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 3, 2018 Category: Cancer & Oncology Authors: Alexandra R. Lewis, Rille Pihlak, Mair éad G. McNamara Source Type: research
Chemotherapy and targeted therapy in the management of cervical cancer
Management of cervical cancer has undergone refinement in the past two decades; concurrent chemo-radiation (CCRT) (with cisplatin alone or in combination) is currently the standard treatment approach for patients with locally advanced disease (FIGO stage IIB-IVA). About 30%-40% of such patients fail to achieve complete response; alternative approaches are needed to improve outcome for them. Treatment with bevacizumab (an inhibitor of vascular endothelial growth factor) along with chemotherapy is associated with improved survival in patients with recurrent or metastatic cervical cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 2, 2018 Category: Cancer & Oncology Authors: Lalit Kumar, P. Harish, Prabhat S. Malik, S. Khurana Source Type: research
Chemotherapy and Targeted Therapy in the Management of Cervical Cancer
Management of cervical cancer has undergone refinement in the past two decades; concurrent chemo-radiation (CCRT) (with cisplatin alone or in combination) is currently the standard treatment approach for patients with locally advanced disease (FIGO stage IIB-IVA). About 30% to 40% of such patients fail to achieve complete response ; alternative approaches are needed to improve outcome for them. Treatment with bevacizumab- (an inhibitor of vascular endothelial growth factor) along with chemotherapy is associated with improved survival in patients with recurrent/metastatic cervical cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 2, 2018 Category: Cancer & Oncology Authors: Lalit Kumar, P. Harish, Prabhat S. Malik, S. Khurana Source Type: research
The challenge of treating older patients with pancreaticobiliary malignancies
Pancreatic and biliary tract cancers are aggressive malignancies. They commonly present with metastatic or unresectable disease. Those that do present with resectable cancer have high rates of recurrence. Despite recent advances in surgical technique, chemotherapy, and radiotherapy regimens, they are associated with poor survival outcomes. These cancers represent an exception to the trend of improved overall survival evident in most malignancies in recent decades. Depending on the goal of treatment, active management of pancreatic and biliary cancers involves surgery, chemotherapy, and radiation therapy, either alone or in...
Source: Current Problems in Cancer - January 19, 2018 Category: Cancer & Oncology Authors: Lynda R. Corrigan, Dara M. Bracken-Clarke, Anne M. Horgan Source Type: research
