Advanced imaging modalities to detect cardiotoxicity
Recent advances in cancer treatments have significantly improved survival rates, reemphasizing the focus on reducing the potential complications associated with some therapies. Cardiovascular disease associated with chemotherapies is a major cause of morbidity and mortality in cancer survivors. Early detection of cardiotoxicity improves cardiac outcomes among cancer patients. The review will focus on imaging modalities used to assess cardiotoxicity or the cardiovascular consequences of chemotherapies. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - June 11, 2018 Category: Cancer & Oncology Authors: Magid Awadalla, Malek Z.O. Hassan, Raza M. Alvi, Tomas G. Neilan Source Type: research

Radium-223 (Xofigo ®) with Concurrent Abiraterone or Enzalutamide: Predictive Biomarkers of Improved Overall Survival in a Clinically Advanced Cohort
Prostate cancer remains the second leading cause of cancer death in men with 26,120 deaths annually, accounting for approximately 8% of all male cancer related deaths1. With modern therapies and improved early detection, the 5-year relative survival rate for localized disease has approached 100%, but declines to only 28% for patients diagnosed at distant stages2. Despite promising new therapeutic regimens3 –5, most patients eventually progress to an androgen-insensitive state4,7. Patients with metastatic castrate-resistant prostate cancer (mCRPC) commonly have radiographic evidence of osteoblastic8 bone metastases9&n...
Source: Current Problems in Cancer - May 30, 2018 Category: Cancer & Oncology Authors: John Rathbun Source Type: research

Early access to rapid onset opioids therapy in advanced cancer patients can affect their death place?
The end stage cancer disease is often associated with severe pain1; Break Through cancer Pain (BTcP) is particularly represented in these conditions,2 and the preferred therapy for this type of pain is using the “rapid Onset Opioids” (ROOs).3 (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 24, 2018 Category: Cancer & Oncology Authors: Luca Miceli, Rym Bednarova, Tiziana Bove Tags: Correspondence Source Type: research

Common KRAS and NRAS Gene Mutations in Sporadic Colorectal Cancer in Northeastern Iranian Patients
Mutation analysis of the Epidermal Growth Factor Receptor (EGFR) downstream has been a main part of colorectal carcinoma evaluation. Large prospective clinical trials have shown only colorectal cancer (CRC) with wild-type KRAS and NRAS responds to anti- EGFR treatment. Hence, mutation analysis is necessary prior to treatment. It is essential to conduct studies to learn about the mutation signature of such tumors. The aim of this study was to evaluate the frequency of hotspot mutations in KRAS and NRAS genes in Iranian CRC patients and to explore their correlations with clinicopathological parameters. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 24, 2018 Category: Cancer & Oncology Authors: Leila Hamzehzadeh, Fatemeh Khadangi, Ehsan Ghayoor Karimiani, Alireza Pasdar, Mohammad Amin Kerachian Source Type: research

Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes and poor outcome
Inflammation and caner are linked in a bidirectional manner. CRP is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at the time of diagnosis of breast cancer is associated with metastasis, recurrence and death in breast cancer patients from Malwa region of Punjab where breast cancer is widely feared. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 24, 2018 Category: Cancer & Oncology Authors: Raman Preet Kaur, Rubal, Raja Paramjeet Singh Banipal, Rajesh Vashistha, Monisha Dhiman, Anjana Munshi Source Type: research

Treatment Outcomes and Incidence of Brain Metastases in Pulmonary Large Cell Neuroendocrine Carcinoma
Large cell neuroendocrine carcinoma (LCNEC) is a rare type of high-grade pulmonary neuroendocrine tumor. The study objective is to investigate its survival outcomes, incidence of brain metastases, and patterns of recurrence. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 23, 2018 Category: Cancer & Oncology Authors: Yizhou Zhao, Mathieu Castonguay, Derek Wilke, Zhaolin Xu, Madelaine Plourde, Liam Mulroy, Mary MacNeil, David Bowes Source Type: research

Cutaneous metastases from neuroendocrine carcinoma of the cervix – An unusual metastatic lesion from an uncommon malignancy
Neuroendocrine carcinoma (NEC) is an uncommon and aggressive type of small cell cervical cancer. NECs mostly arise from gastro-entero-pancreatic tract and the lung, but rarely from other organs like cervix. NEC of the cervix is a rare malignancy and constitutes 0.9% to 1.5% of cervical tumors. NEC of cervix are common in peri-menopausal females and presents with abnormal vaginal bleeding and mimics squamous cell cancers, usually with no distinguishing features. On Immuno-histochemistry (IHC), presence of chromogranin, synaptophysin and CD-56 is necessary to make a diagnosis of small cell carcinoma. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 23, 2018 Category: Cancer & Oncology Authors: Dr Bharti Devnani Source Type: research

Factors associated with optimal pain management in advanced cancer patients
To analyze clinical factors that were associated with inadequate pain control in cancer patients with metastatic malignancy and moderate to severe baseline pain. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 23, 2018 Category: Cancer & Oncology Authors: Nanya Wang, Yabing Dong, Lingling Zhao, Hengjun Zhao, Wei Li, Jiuwei Cui Source Type: research

A Case of Primary Squamous Cell Carcinoma of the Breast with Pathologic Complete Response After Neoadjuvant Chemotherapy
Primary squamous cell carcinoma (SCC) of the breast is a metaplastic carcinoma subtype which includes fibromatosis-like and sarcomatoid features.1 Etiology and pathogenesis of primary SCC of breast still remains unclear. This is a very aggressive tumor with poor prognosis and is seen less than 0.1% (0.04% to 0.075%) of all breast malignancies.2 Other sites of primary SCC should be ruled out first to classify these tumors as primary SCC of the breast. Here we present a case of locally advanced primary SCC of the breast. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Ozkan ALAN, Tugba Akin TELLI, Ozlem ERCELEP, Rahib HASANOV, Eda Tanrikulu SIMSEK, Aydan MUTIS, Tunc ONES, Handan KAYA, Perran Fulden YUMUK Source Type: research

Extramedullary relapse and discordant CD19 expression between bone marrow and extramedullary sites in relapsed acute lymphoblastic leukemia after blinatumomab treatment
Blinatumomab, a bispecific T-cell engager antibody construct targeting CD19, has been shown to improve the outcome in patients with relapsed and/or refractory B-cell acute lymphoblastic leukemia. Treatment with blinatumomab demonstrated significant survival benefit over chemotherapy, supporting its use as a bridge therapy to allogeneic hematopoietic stem cell transplantation. Unfortunately, following initial response, approximately 50% of responding patients eventually relapse. At the time of failure, the majority of patients have CD19-positive blasts, yet a concerning number of CD19-negative relapses has been reported. (S...
Source: Current Problems in Cancer - May 7, 2018 Category: Cancer & Oncology Authors: Christos Demosthenous, Chrysavgi Lalayanni, Michalis Iskas, Vassiliki Douka, Nikoleta Pastelli, Achilles Anagnostopoulos Source Type: research

Extramedullary relapse and discordant CD19 expression after blinatumomab treatment
Blinatumomab, a bispecific T-cell engager antibody construct targeting CD19, has been shown to improve the outcome in patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). Treatment with blinatumomab demonstrated significant survival benefit over chemotherapy, supporting its use as a bridge therapy to allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, following initial response, approximately 50% of responding patients eventually relapse. At the time of failure, the majority of patients have CD19-positive blasts, yet a concerning number of CD19-negative relapses has been...
Source: Current Problems in Cancer - May 7, 2018 Category: Cancer & Oncology Authors: Christos Demosthenous, Chrysavgi Lalayanni, Michalis Iskas, Vassiliki Douka, Nikoleta Pastelli, Achilles Anagnostopoulos Source Type: research

Comparison of seventh TNM and eighth TNM staging system in stage III non –small cell lung cancer patients treated with concurrent chemoradiotherapy
Stage classification of a cancer is important as it provides a nomenclature for description and grouping of the patients and helping clinicians for selecting treatment options and predicting the probable outcomes. It enables the comparison and classification of patients with different size and extent of disease. TNM classification is used for staging of lung cancer, according to the definitions regarding primary tumor for T, nodal stations for N, and metastatic lesions for M.1 The eighth edition of TNM lung cancer staging and proposals has been introduced in 2015 and implemented through January 2017 in countries beside Uni...
Source: Current Problems in Cancer - April 28, 2018 Category: Cancer & Oncology Authors: Ufuk Y ılmaz, Özer Özdemir, Ülkü Yılmaz Source Type: research

Clinicopathologic Significance of LAIR-1 Expression in Hepatocellular Carcinoma
Worldwide, hepatocellular carcinoma (HCC) currently represents the fifth most commonly occurring solid tumor mass and the third leading cause of cancer-related deaths [1, 2]. In spite of remarkable progress in the treatment and understanding of HCC, the molecular mechanisms underlying HCC carcinogenesis remain to be elucidated [3, 4]. Most HCC patients are considered incurable as a result of extensive heterogeneity in clinical presentations and tumor biology, which complicates the classification and procedures for therapy [5, 6]. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 28, 2018 Category: Cancer & Oncology Authors: Xiaojie Wu, Leyan Zhang, Jiadi Zhou, Luying Liu, Qiang Fu, Aili Fu, Xiaoying Feng, Rui Xin, Hongrui Liu, Yong Gao, Jiangnan Xue Source Type: research

COMPARISON OF 7th TNM AND 8th TNM STAGING SYSTEM IN STAGE III NON-SMALL CELL LUNG CANCER PATIENTS TREATED WITH CONCURRENT CHEMORADIOTHERAPY
Stage classification of a cancer is important as it provides a nomenclature for description and grouping of the patients and helping clinicians for selecting treatment options and predicting the probable outcomes. It enables the comparison and classification of patients with different size and extent of disease. TNM classification is used for staging of lung cancer, according to the definitions regarding primary tumor for T, nodal stations for N and metastatic lesions for M. [1] The eighth edition of TNM lung cancer staging and proposals has been introduced in 2015 and implemented through January 2017 in countries beside U...
Source: Current Problems in Cancer - April 28, 2018 Category: Cancer & Oncology Authors: Ufuk Y ılmaz, Özer Özdemir, Ülkü Yılmaz Source Type: research

Gearing up T-cell immunotherapy in cervical cancer
The World Health Organization estimates more than 270,000 deaths annually by cervical cancer. Present vaccines are prophylactic in nature which cannot treat huge bulk of cervical cancer patients worldwide. Available therapies like radiotherapy, chemotherapy, or surgery are not effective in high-grade lesion, and hence, there is an unmet medical need for an effective form of therapy. T cells play a significant role in cervical cancer pathogenesis as human papilloma virus uses multiple mechanisms that dodge host T-cell immune-surveillance aiding in persistence of infection and establishment of cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 20, 2018 Category: Cancer & Oncology Authors: Shilpa Raghuvanshi Chauhan, Mausumi Bharadwaj Source Type: research

Gearing up t cell immunotherapy in cervical cancer
The World Health Organization (WHO) estimates more 270000 deaths annually by cervical cancer. Present vaccines are prophylactic in nature which cannot treat huge bulk of cervical cancer patients worldwide. Available therapies like radiotherapy, chemotherapy or surgery are not effective in high grade lesion and hence, there is an unmet medical need for an effective form of therapy. T cells play a significant role in cervical cancer pathogenesis as Human Papilloma Virus (HPV) uses multiple mechanisms that dodge host T cell immune-surveillance aiding in persistence of infection and establishment of cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 20, 2018 Category: Cancer & Oncology Authors: Shilpa Raghuvanshi Chauhan, Mausumi Bharadwaj Source Type: research

Influence of wellness education on first-line icotinib hydrochloride patients with stage IV non –small cell lung cancer and their family caregivers
This study aims to examine the effects of wellness education (WE) intervention on the behavioral change, psychological status, performance status on patients with stage IV non –small cell lung cancer (NSCLC) undergoing icotinib hydrochloride treatment and their relationships with family caregivers. Methods: We conducted an intervention study involving 126 individuals with confirmed activating epidermal growth factor receptor mutation-positive stage IV NSCLC who received icotinib hydrochloride as first-line therapy between January 2014 and January 2016; their caregivers were also included in the study. (Source: Curren...
Source: Current Problems in Cancer - April 10, 2018 Category: Cancer & Oncology Authors: Li Yanwei, Fang Minghui, Quan Manman, Yan Zhuchun, Liu Dongying, Pan Zhanyu Source Type: research

Influence of wellness-education on first-line icotinib hydrochloride patients with stage IV non-small cell lung cancer and their family caregivers
This study aims to examine the effects of wellness-education (WE) intervention on the behavioral change, psychological status, performance status on patients with stage IV non-small cell lung cancer (NSCLC) undergoing icotinib hydrochloride treatment and their relationships with family caregivers. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 10, 2018 Category: Cancer & Oncology Authors: Li Yanwei, Fang minghui, Quan manman, Yan zhuchun, Liu dongying, Pan zhanyu Source Type: research

HPV: Molecular pathways and targets
Infection of high-risk human papillomaviruses (HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that high-risk HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation ...
Source: Current Problems in Cancer - April 5, 2018 Category: Cancer & Oncology Authors: Shilpi Gupta, Prabhat Kumar, Bhudev C. Das Source Type: research

HPV: Molecular Pathways and Targets
Infection of high-risk human papillomaviruses (HR-HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous and/or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that HR-HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation ...
Source: Current Problems in Cancer - April 5, 2018 Category: Cancer & Oncology Authors: Shilpi Gupta, Prabhat Kumar, Bhudev C. Das Source Type: research

Combined chemoradiation vs radiation therapy alone in stage-II nasopharyngeal carcinoma: A meta-analysis of the published literature
The aim of this meta-analysis was to evaluate the efficacy and toxicity of adding chemotherapy to radiotherapy (RT) in the treatment of stage-II nasopharyngeal carcinoma (NPC). We searched Pubmed, Cochrane Library, Embase, China National Knowledge Internet, China Biology Medicine, VIP, and Wanfang database for studies of the RT with or without chemotherapy in patients with stage-II NPC that were published in any language. Analyses were carried out using RevMan 5.3 software. The relative risk was used to evaluate the data, the I2 test was used to compare heterogeneity, sensitivity analysis was used to evaluate the stability...
Source: Current Problems in Cancer - April 2, 2018 Category: Cancer & Oncology Authors: Sufang Wang, Shan Li, Liangfang Shen Source Type: research

Combined Chemoradiation Versus Radiation Therapy Alone in stage-II Nasopharyngeal Carcinoma: A Meta-analysis of the published literature
The aim of this meta-analysis was to evaluate the efficacy and toxicity of adding chemotherapy to radiotherapy (RT) in the treatment of stage-II nasopharyngeal carcinoma (NPC). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 2, 2018 Category: Cancer & Oncology Authors: Sufang Wang, Shan Li, Liangfang Shen Source Type: research

Encapsulated papillary carcinoma of the breast: A clinicopathological study of 49 cases
Background: Encapsulated papillary carcinoma (EPC) has been considered as a variant of ductal carcinoma in situ. Recent studies suggest that EPC could be invasive, as it often lacks myoepithelial cells (MECs) at their periphery. The current study was performed to investigate the biological features of EPC. Methods: Forty-nine EPC patients admitted to the Tai'an Central Hospital and Qilu Hospital of Shandong University from January 2004-December 2014 were included in this study. We retrospectively analyzed the clinicopathological findings, the presence and distribution of MECs, as well as the outcomes. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 30, 2018 Category: Cancer & Oncology Authors: Xiaomei Li, Yanmei Xu, Hong Ye, Shuming Qin, Feng Hou, Wenlou Liu Source Type: research

Encapsulated papillary carcinoma of the breast: A clinicopathological study of 49 cases
Encapsulated papillary carcinoma (EPC) has been considered as a variant of ductal carcinoma in situ (DCIS). Recent studies suggest that EPC could be invasive, as it often lacks myoepithelial cells (MECs) at their periphery. The current study was performed to investigate the biological features of EPC. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 30, 2018 Category: Cancer & Oncology Authors: Xiaomei Li, Yanmei Xu, Hong Ye, Shuming Qin, Feng Hou, Wenlou Liu Source Type: research

Bifocal hepatocellular carcinoma: Magnetic resonance imaging features after transarterial embolization
The aim of this article is to show the typical appearance of a bifocal hepatocellular carcinoma on contrast enhanced magnetic resonance imaging before and after locoregional treatment consisting of transarterial embolization (TAE). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 28, 2018 Category: Cancer & Oncology Authors: Picchia Simona, Bali Maria Antonietta Source Type: research

Bifocal hepatocellular carcinoma (HCC): Magnetic resonance imaging features after trans-arterial embolization (TAE)
Typical imaging findings of HCC are demonstrated in this case. The spontaneous high signal intensity on unenhanced T1-weighted fat saturation (Fig. 1a; arrow) is likely related to the presence of glycogen.1 On post-contrast T1-weighted (Gadoterate meglumine. Dotarem, Guerbet, France) the tumour appears hypervascular at the arterial phase (wash-in) followed by hypovascular appearance at the portal venous phase (wash-out) when compared to the surrounding non-tumoral hepatic parenchyma (Fig. 1b-c). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 28, 2018 Category: Cancer & Oncology Authors: Picchia Simona, Bali Maria Antonietta Source Type: research

The role of epigenetic therapies in colorectal cancer
Although developments in the diagnosis and therapy of colorectal cancer (CRC) have been made in the last decade, much work remains to be done as it remains the second leading cause of cancer death. It is now well established that epigenetic events, together with genetic alterations, are key events in initiation and progression of CRC. Epigenetics refers to heritable alterations in gene expression that do not involve changes in the DNA sequence. These alterations include DNA methylation, histone alterations, chromatin remodelers, and noncoding RNAs. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 12, 2018 Category: Cancer & Oncology Authors: Marina Baretti, Nilofer Saba Azad Source Type: research

The Role of Epigenetic Therapies in Colorectal Cancer
Although developments in the diagnosis and therapy of colorectal cancer (CRC) have been made in the last decade, much work remains to be done as it remains the second leading cause of cancer death. It is now well established that epigenetic events, together with genetic alterations, are key events in initiation and progression of CRC. Epigenetics refers to heritable alterations in gene expression that do not involve changes in the DNA sequence. These alterations include DNA methylation, histone alterations, chromatin remodelers and noncoding RNAs. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 12, 2018 Category: Cancer & Oncology Authors: Marina Baretti, Nilofer Saba Azad Source Type: research

Title Page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research

Information for Readers
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research

Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research

A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma
In this study, we aimed to explore a novel signature of microRNA expression for predicting the overall survival (OS) of patients with UCEC. The genome-wide miRNA expression profiles and relevant clinical characteristics of 348 patients with UCEC were downloaded from the Cancer Genome Atlas (TCGA) data portal and analyzed comprehensively. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Yue Wang, Mu Xu, Qing Yang Source Type: research

A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma
In this study, we aimed to explore a novel signature of microRNA expression for predicting the overall survival (OS) of UCEC patients. The genome-wide miRNA expression profiles and relevant clinical characteristics of 348 patients with UCEC were downloaded from the Cancer Genome Atlas (TCGA) data portal and analyzed comprehensively. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Yue Wang, Mu Xu, Qing Yang Source Type: research

Primary squamous cell carcinoma arising from endometriosis of the ovary: A case report and literature review
We present a SCC case arising from endometriosis, and analyzed the clinical, therapeutic, and pathologic features through a comprehensive literature review. A 43-year premenopausal woman (gravida 2, para 1) presented to our hospital due to sudden pain in lower abdomen. Exploratory laparotomy indicated rupture of left ovarian cyst and intra-abdominal hemorrhage were observed. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Yalan Xu, Lei Li Source Type: research

Primary squamous cell carcinoma arising from endometriosis of the ovary: A case report and literature review
Cases of squamous cell carcinoma (SCC) arising from ovarian endometriosis have been rarely reported. Most of the patients show a poor prognosis and present with a diminished survival time. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Yalan Xu, Lei Li Source Type: research

The importance of quality-of-life management in patients with advanced pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, and as such, a focus on quality of life is vital. This review will discuss various aspects of quality of life in patients with PDAC and their treatment. Pancreatic exocrine and endocrine insufficiency may result in issues related to nutrition, and pain and fatigue are other common symptoms, and may be managed with pharmaceutical or nonpharmaceutical methods. It has also been reported that low mood is a particular problem for patients with PDAC compared to patients with other cancers; however, the data supporting this is inconsistent. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 3, 2018 Category: Cancer & Oncology Authors: Alexandra R. Lewis, Rille Pihlak, Mair éad G. McNamara Source Type: research

The importance of quality of life management in patients with advanced pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, and as such, a focus on quality of life is vital. This review will discuss various aspects of quality of life in patients with PDAC and their treatment. Pancreatic exocrine and endocrine insufficiency may result in issues related to nutrition, and pain and fatigue are other common symptoms, and may be managed with pharmaceutical or non-pharmaceutical methods. It has also been reported that low mood is a particular problem for patients with PDAC compared to patients with other cancers; however the data supporting this is inconsistent. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 3, 2018 Category: Cancer & Oncology Authors: Alexandra R. Lewis, Rille Pihlak, Mair éad G. McNamara Source Type: research

Chemotherapy and targeted therapy in the management of cervical cancer
Management of cervical cancer has undergone refinement in the past two decades; concurrent chemo-radiation (CCRT) (with cisplatin alone or in combination) is currently the standard treatment approach for patients with locally advanced disease (FIGO stage IIB-IVA). About 30%-40% of such patients fail to achieve complete response; alternative approaches are needed to improve outcome for them. Treatment with bevacizumab (an inhibitor of vascular endothelial growth factor) along with chemotherapy is associated with improved survival in patients with recurrent or metastatic cervical cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 2, 2018 Category: Cancer & Oncology Authors: Lalit Kumar, P. Harish, Prabhat S. Malik, S. Khurana Source Type: research

Chemotherapy and Targeted Therapy in the Management of Cervical Cancer
Management of cervical cancer has undergone refinement in the past two decades; concurrent chemo-radiation (CCRT) (with cisplatin alone or in combination) is currently the standard treatment approach for patients with locally advanced disease (FIGO stage IIB-IVA). About 30% to 40% of such patients fail to achieve complete response ; alternative approaches are needed to improve outcome for them. Treatment with bevacizumab- (an inhibitor of vascular endothelial growth factor) along with chemotherapy is associated with improved survival in patients with recurrent/metastatic cervical cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 2, 2018 Category: Cancer & Oncology Authors: Lalit Kumar, P. Harish, Prabhat S. Malik, S. Khurana Source Type: research

The challenge of treating older patients with pancreaticobiliary malignancies
Pancreatic and biliary tract cancers are aggressive malignancies. They commonly present with metastatic or unresectable disease. Those that do present with resectable cancer have high rates of recurrence. Despite recent advances in surgical technique, chemotherapy, and radiotherapy regimens, they are associated with poor survival outcomes. These cancers represent an exception to the trend of improved overall survival evident in most malignancies in recent decades. Depending on the goal of treatment, active management of pancreatic and biliary cancers involves surgery, chemotherapy, and radiation therapy, either alone or in...
Source: Current Problems in Cancer - January 19, 2018 Category: Cancer & Oncology Authors: Lynda R. Corrigan, Dara M. Bracken-Clarke, Anne M. Horgan Source Type: research

The challenge of treating older patients with pancreaticobiliary malignancies
Pancreatic and biliary tract cancers are aggressive malignancies. They commonly present with metastatic or unresectable disease. Those that do present with resectable cancer have high rates of recurrence. Despite recent advances in surgical technique, chemotherapy and radiotherapy regimens, they are associated with poor survival outcomes. These cancers represent an exception to the trend of improved overall survival evident in most malignancies in recent decades. Depending on the goal of treatment, active management of pancreatic and biliary cancers involves surgery, chemotherapy and radiation therapy, either alone or in c...
Source: Current Problems in Cancer - January 19, 2018 Category: Cancer & Oncology Authors: Lynda R. Corrigan, Dara M. Bracken-Clarke, Anne M. Horgan Source Type: research

Risk factors for prostate cancer: A multifactorial case-control study
Prostate cancer is the third most commonly diagnosed cancer among Pakistani men. It is a multifactorial disease involving genetics together with environmental factors. Countries where men have greater dietary fat intake showed increased prostate cancer mortality rates. A population based case-control study was conducted to evaluate various prostate cancer risk factors. Study subjects were 896 prostate cancer cases (2010-2015) and 900 age matched controls. Odds ratio (OR) and 95% CI were used to estimate the association between different risk factors and prostate cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Saima Shakil Malik, Rakshanda Batool, Nosheen Masood, Azra Yasmin Source Type: research

Evaluation for therapeutic measures to small gastric stromal tumor: A retrospective study of 90 cases
In this study, we reviewed the clinical and pathological features of patients with sGST receiving surgery and discussed the value of surgical intervention. In all, 90 patients who were diagnosed as sGST(less than 2cm) and accepted surgical treatment were enrolled, correspondently, another 104 patients with GSTs between 2 –5cm and 74 patients with GSTs>5cm were collected as Control groups 1 and 2, respectively, and all of them received surgical treatment. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Qun Zhao, Yong Li, Peigang Yang, Yanqiu Zang, Liqiao Fan, Bibo Tan, Yuan Tian Source Type: research

Ifosfamide and doxorubicin in the treatment of advanced leiomyosarcoma
Leiomyosarcomas (LMS) are rare tumors with poor prognosis owing to the high rate of recurrent and metastatic disease. The combination of doxorubicin (Adriamycin) plus ifosfamide and mesna (AIM) results in moderate response rates of 10%-30%. The aim of this study was to assess the efficacy of the AIM regimen along with multimodality treatment including surgery and radiotherapy in patients with LMS. The clinicopathologic characteristics and outcomes of 51 patients with recurrent or metastatic LMS diagnosed between 2000 and 2014 who received the AIM regimen were analyzed retrospectively. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Serkan Akin, Omer Dizdar, Yusuf Karakas, Alev Turker, Ayse Kars Source Type: research

Risk factors for prostate cancer: A multifactorial case-control study
Prostate cancer is the third most commonly diagnosed cancer among Pakistani men. It is a multifactorial disease involving genetics together with environmental factors. Countries where men have greater dietary fat intake showed increased prostate cancer mortality rates. A population based case-control study was conducted to evaluate various prostate cancer risk factors. Study subjects were 896 prostate cancer cases (2010-2015) and 900 age matched controls. Odds ratio (OR) and 95% CI were used to estimate the association between different risk factors and prostate cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Saima Shakil Malik, Rakshanda Batool, Nosheen Masood, Azra Yasmin Source Type: research

Risk factors for prostate cancer: A multi-factorial case control study
Prostate cancer is the third most commonly diagnosed cancer among Pakistani men. It is a multi-factorial disease involving genetics together with environmental factors. Countries where men have greater dietary fat intake showed increased prostate cancer mortality rates. A population based case control study was conducted to evaluate various prostate cancer risk factors. Study subjects were 896 prostate cancer cases (2010 –2015) and 900 age matched controls. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association between different risk factors and prostate cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Saima Shakil Malik, Rakshanda Batool, Nosheen Masood, Azra Yasmin Source Type: research

Evaluation for therapeutic measures to small gastric stromal tumor: A retrospective study of 90 cases
In this study, we reviewed the clinical and pathological features of patients with sGST receiving surgery and discussed the value of surgical intervention. 90 patients who were diagnosed as sGST(less than 2cm) and accepted surgical treatment were enrolled, correspondently, another 104 patients with GSTs between 2 –5cm and 74 patients with GSTs> 5cm were collected as Control group 1 and 2 respectively and all of them received surgical treatment. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Qun Zhao, Yong Li, Peigang Yang, Yanqiu Zang, Liqiao Fan, Bibo Tan, Yuan Tian Source Type: research

Ifosfamide and Doxorubicin in the Treatment of Advanced Leiomyosarcoma
Leiomyosarcomas (LMS) are rare tumors with poor prognosis due to the high rate of recurrent and metastatic disease. The combination of doxorubicin (Adriamycin) and ifosfamide (AIM) results in moderate response rates of 10 to 30%. The aim of this study was to assess the efficacy of the AIM regimen along with multimodality treatment including surgery and radiotherapy in patients with LMS. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Serkan Akin, Omer Dizdar, Yusuf Karakas, Alev Turker, Ayse Kars Source Type: research