Sex-Based Analysis of Quality Indicators of End-of-Life Care in Gastrointestinal Malignancies
Curr Oncol. 2024 Feb 22;31(3):1170-1182. doi: 10.3390/curroncol31030087.ABSTRACTIndices of aggressive or supportive end-of-life (EOL) care are used to evaluate health services quality. Disparities according to sex were previously described, with studies showing that male sex is associated with aggressive EOL care. This is a secondary analysis of 69,983 patients who died of a GI malignancy in Ontario between 2006 and 2018. Quality indices from the last 14-30 days of life and aggregate measures for aggressive and supportive EOL care were derived from administrative data. Hospitalizations, emergency department use, intensive ...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Caitlin S Lees Hsien Seow Kelvin K W Chan Anastasia Gayowsky Shaila J Merchant Aynharan Sinnarajah Source Type: research
Spatially Resolved Microglia/Macrophages in Recurrent Glioblastomas Overexpress Fatty Acid Metabolism and Phagocytic Genes
CONCLUSION: Tumor-associated microglia/macrophages in recurrent GBM overexpress genes involved in fatty acid/lipid metabolism. Further investigation is needed to fully delineate the role of PLD phospholipases in GBM progression.PMID:38534921 | PMC:PMC10968993 | DOI:10.3390/curroncol31030088 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Akshitkumar M Mistry Jonah Daneshmand SeonYeong Jamie Seo Norman L Lehman Donald M Miller Dylan A Goodin Hermann B Frieboes Joseph Chen Adrianna Masters Brian J Williams Kavitha Yaddanapudi Source Type: research
Unlocking the Potential of Therapy-Induced Cytokine Responses: Illuminating New Pathways in Cancer Precision Medicine
Curr Oncol. 2024 Feb 23;31(3):1195-1206. doi: 10.3390/curroncol31030089.ABSTRACTPrecision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultim...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Dilip R Gunturu Mohammed Hassan Deepa Bedi Pran Datta Upender Manne Temesgen Samuel Source Type: research
The Role of Adjuvant Radiotherapy in the Treatment of Breast Cancer
Curr Oncol. 2024 Feb 24;31(3):1207-1220. doi: 10.3390/curroncol31030090.ABSTRACTThe role of postmastectomy radiotherapy and regional nodal irradiation after radical mastectomy is defined in high-risk patients with locally advanced tumors, positive margins, and unfavorable biology. The benefit of postmastectomy radiotherapy in intermediate-risk patients (T3N0 tumors) remains a matter of controversy. It has been demonstrated that radiotherapy after breast-conserving surgery lowers the locoregional recurrence rate compared with surgery alone and improves the overall survival rate. In patients with four or more positive lymph ...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Iveta Kol ářová Bohuslav Melichar Igor Sir ák Jaroslav Va ňásek Ji ří Petera Kate řina Horáčková Denisa Pohankov á Filip Ďatelinka Zuzana Šinkorová Milan Vo šmik Source Type: research
Modeling 5-FU-Induced Chemotherapy Selection of a Drug-Resistant Cancer Stem Cell Subpopulation
Conclusions: Each individual GA prediction model achieved high accuracy in estimating the expression rate of CSC markers on cancer cells treated with 5-FU. Artificial intelligence can be used as a powerful tool for predicting drug resistance.PMID:38534924 | PMC:PMC10968802 | DOI:10.3390/curroncol31030091 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Amra Ramovi ć Hamzagić Danijela Cvetkovi ć Marina Gazdi ć Janković Nevena Milivojevi ć Dimitrijević Dalibor Nikoli ć Marko Živanović Nikolina Kastratovi ć Ivica Petrovi ć Sandra Nikoli ć Milena Jovanovi ć Dragana Šeklić Nenad Filipovi ć B Source Type: research
Colorectal Cancer Patients' Reported Frequency, Content, and Satisfaction with Advance Care Planning Discussions
Conclusions: Patients reported more frequent conversations compared to the literature and clinical documentation. While the satisfaction with these conversations is high, there is room for quality improvement, particularly in eliciting patients' personal goals for their treatment.PMID:38534925 | PMC:PMC10969091 | DOI:10.3390/curroncol31030092 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Said Hussein Chloe Ahryung Lim Thulasie Manokaran Shireen Kassam Madalene Earp Patricia A Tang Safiya Karim Patricia Biondo Sharon M Watanabe Aynharan Sinnarajah Amy Tan Jessica Simon Source Type: research
Haploidentical Hematopoietic Stem Cell Transplantation for Patients with Severe Aplastic Anemia-Single-Centre Experience
Curr Oncol. 2024 Feb 26;31(3):1246-1252. doi: 10.3390/curroncol31030093.ABSTRACTSevere aplastic anemia (SAA) is a life-threatening type of aplastic anemia for which allogeneic stem cell transplantation or immunosuppressive therapy are the principal treatment modalities. Only about 25-30% of patients have a matched sibling donor, and finding an unrelated donor in ethnic minorities is a challenge. The use of related haploidentical donor transplants in severe aplastic anemia is uncommon. We would like to report our experience with the first four patients who underwent haploidentical transplants for severe aplastic anemia. Thi...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Vered Stavi Niranjan Khaire Jeffrey H Lipton Rajat Kumar Source Type: research
High Symptom Burden in Patients Receiving Radiotherapy and Factors Associated with Being Offered an Intervention
Curr Oncol. 2024 Feb 27;31(3):1253-1265. doi: 10.3390/curroncol31030094.ABSTRACTPatient report outcomes are commonly collected during oncology visits to elicit symptom burden and guide management. We aimed to determine the frequency of intervention for patients undergoing radiotherapy with high symptom complexity scores and identify which factors are associated with being offered an intervention. A retrospective chart audit was completed of adult patients with cancer who had at least one radiotherapy appointment and were assigned a high symptom complexity. A total of 200 patients were included; 150 (75.0%) patients were of...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Allison Rau Demetra Yannitsos Petra Grendarova Siwei Qi Linda Watson Lisa Barbera Source Type: research
Adapting an Adolescent and Young Adult Program Housed in a Quaternary Cancer Centre to a Regional Cancer Centre: Creating Equitable Access to Developmentally Tailored Support
Curr Oncol. 2024 Feb 27;31(3):1266-1277. doi: 10.3390/curroncol31030095.ABSTRACTAdolescents and young adults (AYAs) with cancer, representing those between 15 and 39 years of age, face distinctive challenges balancing their life stage with the physical, emotional, and social impacts of a cancer diagnosis. These challenges include fertility concerns, disruptions to educational and occupational pursuits, issues related to body image and sexual health, and the need for age-appropriate psychosocial support within their communities. The Princess Margaret Cancer Centre (PM), a quaternary care center, established a specialized AY...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Marlie Smith Simone Kurup Kaviya Devaraja Shaayini Shanawaz Lorrie Reynolds Jill Ross Andrea Bezjak Abha A Gupta Alisha Kassam Source Type: research
Does Pre-Emptive Availability of PREDICT 2.1 Results Change Ordering Practices for Oncotype DX? A Multi-Center Prospective Cohort Study
Curr Oncol. 2024 Feb 27;31(3):1278-1290. doi: 10.3390/curroncol31030096.ABSTRACTFor early-stage hormone receptor (HR)-positive and HER2-negative breast cancer, tools to estimate treatment benefit include free and publicly available algorithms (e.g., PREDICT 2.1) and expensive molecular assays (e.g., Oncotype DX). There remains a need to identify patients who de-rive the most benefit from molecular assays and where this test may be of poor value. In this multicenter prospective cohort study, we evaluated whether use of PREDICT 2.1 would impact physician decision making. For the first 6 months of the study, data on physician...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Arif Ali Awan Deanna Saunders Gregory Pond Caroline Hamm Nadia Califaretti Mihaela Mates Vikaash Kumar Mohammed F K Ibrahim Ana-Alicia Beltran-Bless Lisa Vandermeer John Hilton Mark Clemons Source Type: research
Timing of Surgery and Social Determinants of Health Related to Pathologic Complete Response after Total Neoadjuvant Therapy for Rectal Adenocarcinoma: Retrospective Study of National Cancer Database
This study utilized the National Cancer Database (NCDB) to retrospectively analyze 5997 stage-appropriate RAC cases treated with TNT from 2016 to 2020. The overall pCR rate was 18.6%, with most patients undergoing induction chemotherapy followed by long-course chemoradiation (81.5%). Multivariable logistic regression models revealed a significant non-linear relationship between the rest period and pCR (p = 0.033), with optimal odds at 14.7-15.9 weeks post radiation (odds ratio: 1.49, 95% confidence interval: 1.13-1.98) when compared to 4.0 weeks. Medicaid, distance to the treatment facility, and community education were as...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Megan Mai Jodi Goldman Duke Appiah Ramzi Abdulrahman John Kidwell Zheng Shi Source Type: research
Real-World Analysis of the Clinical and Economic Impact of the 21-Gene Recurrence Score (RS) in Invasive Lobular Early-Stage Breast Carcinoma in Ireland
Conclusions: The use of this test resulted in a 75% reduction in chemotherapy and a significant cost savings in our publicly funded health system.PMID:38534931 | PMC:PMC10969553 | DOI:10.3390/curroncol31030098 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Lynda M McSorley Mehala Tharmabala Fathiya Al Rahbi Fergus Keane Denis Evoy James G Geraghty Jane Rothwell Damian P McCartan Megan Greally Miriam O'Connor Deirdre O'Mahony Maccon Keane Michael John Kennedy Seamus O'Reilly Steve J Millen John P Crown Cathe Source Type: research
ITGAV Promotes the Progression of Head and Neck Squamous Cell Carcinoma
In conclusion, our studies suggest that ITGAV promotes the progression of HNSCC cells and may be regulated by SOX11 in HNSCC cells.PMID:38534932 | PMC:PMC10969037 | DOI:10.3390/curroncol31030099 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Lingyi Xu Jeremy G Barrett Jiayi Peng Suk Li Diana Messadi Shen Hu Source Type: research
A Survival Analysis of Patients with Recurrent Epithelial Ovarian Cancer Based on Relapse Type: A Multi-Institutional Retrospective Study in Armenia
CONCLUSIONS: Overall, despite new therapeutic approaches, ovarian cancer continues to be one of the deadly malignant diseases affecting women, especially in developing countries with a lack of resources, where chemotherapy remains the primary available systemic treatment for the majority of patients. Low survival rates demonstrate the urgent need for more research focused on this group of patients with poor outcomes.PMID:38534933 | PMC:PMC10968888 | DOI:10.3390/curroncol31030100 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Lilit Harutyunyan Evelina Manvelyan Nune Karapetyan Samvel Bardakhchyan Aram Jilavyan Gevorg Tamamyan Armen Avagyan Liana Safaryan Davit Zohrabyan Narine Movsisyan Anna Avinyan Arevik Galoyan Mariam Sargsyan Martin Harutyunyan Hasmik Nersoyan Arevik Stepa Source Type: research
Scheduled and Breakthrough Opioid Use for Cancer Pain in an Inpatient Setting at a Tertiary Cancer Hospital
Conclusions: BTO/SCH ratios are frequently prescribed higher than the recommended dose. Daily pain scores, BTO MEDDs, scheduled opioid MEDDs, and total MEDDs were higher among the SCC group than the pre-SCC group, but the number of BTO doses/day was lower.PMID:38534934 | PMC:PMC10969060 | DOI:10.3390/curroncol31030101 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Aline Rozman de Moraes Elif Erdogan Ahsan Azhar Suresh K Reddy Zhanni Lu Joshua A Geller David Mill Graves Michal J Kubiak Janet L Williams Jimin Wu Eduardo Bruera Sriram Yennurajalingam Source Type: research
