Current Neurology and Neuroscience Reports 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Limbic-Predominant Age-Related TDP-43 Encephalopathy: LATE-Breaking Updates in Clinicopathologic Features and Biomarkers
AbstractPurpose of ReviewLimbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined neurodegenerative disease characterized by amnestic phenotype and pathological inclusions of TAR DNA-binding protein 43 (TDP-43). LATE is distinct from rarer forms of TDP-43 diseases such as frontotemporal lobar degeneration with TDP-43 but is also a common copathology with Alzheimer ’s disease (AD) and cerebrovascular disease and accelerates cognitive decline. LATE contributes to clinicopathologic heterogeneity in neurodegenerative diseases, so it is imperative to distinguish LATE from other etiologies.Recent Findi...
Source: Current Neurology and Neuroscience Reports - October 3, 2022 Category: Neuroscience Source Type: research
Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship
AbstractPurpose of ReviewTo elucidate the interconnection between sleep and stroke.Recent FindingsGrowing data support a bidirectional relationship between stroke and sleep. In particular, there is strong evidence that sleep-disordered breathing plays a pivotal role as risk factor and concur to worsening functional outcome. Conversely, for others sleep disorders (e.g., insomnia, restless legs syndrome, periodic limb movements of sleep, REM sleep behavior disorder), the evidence is weak. Moreover, sleep disturbances are highly prevalent also in chronic stroke and concur to worsening quality of life of patients.Promising nov...
Source: Current Neurology and Neuroscience Reports - October 3, 2022 Category: Neuroscience Source Type: research
Cerebrovascular Disease, Cardiovascular Disease, and Chronic Kidney Disease: Interplays and Influences
AbstractPurpose of ReviewWe reviewed reasons for the high cardiovascular risk (CVD) of patients with chronic kidney disease (CKD), and explored alternatives to treatment of traditional risk factors to reduce CVD in CKD.Recent FindingsBesides traditional risk factors, patients with CKD are exposed to uremic toxins of two kinds: systemically derived toxins include asymmetric dimethylarginine (ADMA), total homocysteine (tHcy), thiocyanate, tumor necrosis factor alpha, and interleukin 6. Gut-derived uremic toxins (GDUT), products of the intestinal microbiome, include hippuric acid, indoxyl sulfate, p-cresyl sulfate, p-cresyl g...
Source: Current Neurology and Neuroscience Reports - October 1, 2022 Category: Neuroscience Source Type: research
Promise of Physiological Profiling to Prevent Stroke in People of African Ancestry: Prototyping Ghana
AbstractPurpose of ReviewWorldwide, compared to other racial/ethnic groups, individuals of African ancestry have an excessively higher burden of hypertension-related morbidities, especially stroke. Identifying modifiable biological targets that contribute to these disparities could improve global stroke outcomes. In this scoping review, we discuss how pathological perturbations in the renin –angiotensin–aldosterone pathways could be harnessed via physiological profiling for the purposes of improving blood pressure control for stroke prevention among people of African ancestry.Recent FindingsTranscontinental comparative...
Source: Current Neurology and Neuroscience Reports - October 1, 2022 Category: Neuroscience Source Type: research
Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke
AbstractPurpose of ReviewStroke is a common cause of disability in aging adults. A given individual ’s needs after stroke vary as a function of the stroke extent and location. The purpose of this review was to discuss recent clinical investigations addressing rehabilitation of an array of overlapping functional domains.Recent FindingsResearch is ongoing in the domains of movement, cognition, attention, speech, language, swallowing, and mental health. To best assist patients ’ recovery, innovative research has sought to develop and evaluate behavioral approaches, identify and refine synergistic approaches that augment t...
Source: Current Neurology and Neuroscience Reports - October 1, 2022 Category: Neuroscience Source Type: research
Vestibular Migraine
AbstractPurpose of ReviewTo explore recent developments in vestibular migraine (VM).Recent FindingsThis review discusses the current diagnostic criteria for VM in the adult and pediatric populations, as proposed by the International Headache Society and B árány Society. Recent VM studies confirm the prior findings and reveal new insights, including the wide range of vestibular symptoms, symptoms in the attack-free period, and triggers. Many patients experience persistent vestibular symptoms, even in the absence of acute attacks, which often signifi cantly impact patients’ quality of life. The syndrome of benign recurre...
Source: Current Neurology and Neuroscience Reports - August 31, 2022 Category: Neuroscience Source Type: research
Neurologic Manifestations of Catastrophic Antiphospholipid Syndrome
AbstractPurpose of ReviewUnderstanding of antiphospholipid antibody syndrome (APS), associated neurological manifestations, and disease-directed treatment has grown considerably over the last decade. Herein, we critically review the current and high-yield literature related to the pathophysiology, neurological presentations, and management of APS with particular emphasis on the rare and more fatal subset of APS, catastrophic antiphospholipid syndrome (CAPS).Recent FindingsAPS may manifest with a variety of neurologic syndromes, with cerebrovascular disease representing the most commonly encountered presentation. Diagnostic...
Source: Current Neurology and Neuroscience Reports - August 30, 2022 Category: Neuroscience Source Type: research
Longitudinal Studies of Sleep Disturbances in Parkinson ’s Disease
AbstractPurpose of ReviewSleep disorders are among the most common non-motor symptoms in Parkinson ’s disease (PD). Recent longitudinal studies of sleep in PD have utilized validated sleep questionnaires and video-polysomnography performed over multiple time points. This review summarizes existing longitudinal studies focusing on the prevalence, associations, and changes of sleep disorders in P D over time, as well as the methodologies used in these studies.Recent FindingsFifty-three longitudinal studies of sleep in PD were identified: excessive daytime sleepiness, insomnia, obstructive sleep apnea, rapid eye movement sl...
Source: Current Neurology and Neuroscience Reports - August 26, 2022 Category: Neuroscience Source Type: research
Outpatient Approach to Resistant and Refractory Migraine in Children and Adolescents: a Narrative Review
We describe the level of evidence for interventional procedures (onabotulinumtoxinA injections, greater occipital and other nerve blocks), neuromodulation (single-pulse transcranial magnetic stimulation, external trigeminal nerve stimulation, remote electrical neuromodulation, and non-invasive vagal nerve stimulation), calcitonin gene-related peptide (CGRP) pathway antagonists (anti-CGRP monoclonal antibodies and gepants), psychological therapies, and manual therapies (acupuncture, craniosacral therapy, massage and physical therapy, and spinal manipulation). (Source: Current Neurology and Neuroscience Reports)
Source: Current Neurology and Neuroscience Reports - August 26, 2022 Category: Neuroscience Source Type: research
Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson ’s Disease
AbstractPurpose of ReviewSleep disturbances are an important nonmotor feature of Parkinson ’s disease (PD) that can cause polysomnographic (PSG) alterations. These alterations are already present in early PD and may be associated with a specific disease course. This systematic review describes the role of PSG variables as predictors of sleep dysfunction, motor and cognitive dysfunction progression in PD.Recent FindingsNineteen longitudinal cohort studies were included. Their main findings were that (1) REM sleep behavioral events, REM sleep without atonia (RSWA), and electroencephalography (EEG) changes (mainly microslee...
Source: Current Neurology and Neuroscience Reports - August 22, 2022 Category: Neuroscience Source Type: research
Headache and Autonomic Dysfunction: a Review
AbstractPurpose of ReviewWe explore the anatomy of the central and peripheral autonomic pathways involved in primary headache as well as the mechanisms for secondary headache associated with disorders of the autonomic nervous system. The prevalence and clinical presentation of cranial and systemic autonomic symptoms in these conditions will be discussed, with a focus on recent studies.Recent FindingsSeveral small studies have utilized the relationship between headache and the autonomic nervous system to identify potential biomarkers to aid in diagnosis of migraine and cluster headache. Headache in postural orthostatic tach...
Source: Current Neurology and Neuroscience Reports - August 22, 2022 Category: Neuroscience Source Type: research
Sleep Dysfunction in Movement Disorders: a Window to the Disease Biology
AbstractPurpose of ReviewTo comprehensively summarize the sleep pathologies associated with movement disorders, focusing on neurodegenerative diseases.Recent FindingsMounting evidence has further implicated both sleep and circadian disruption in the pathophysiology of many movement disorders. In particular, recent data illuminate the mechanisms by which poor sleep quality and circadian dysfunction can exacerbate neurodegeneration. In addition, anti-IgLON5 disease is a recently described autoimmune disease with various symptoms that can feature prominent sleep disruption and parasomnia.SummaryMany movement disorders are ass...
Source: Current Neurology and Neuroscience Reports - July 22, 2022 Category: Neuroscience Source Type: research
Advances in DBS Technology and Novel Applications: Focus on Movement Disorders
AbstractPurpose of ReviewDeep brain stimulation (DBS) is an established treatment in several movement disorders, including Parkinson ’s disease, dystonia, tremor, and Tourette syndrome. In this review, we will review and discuss the most recent findings including but not limited to clinical evidence.Recent FindingsNew DBS technologies include novel hardware design (electrodes, cables, implanted pulse generators) enabling new stimulation patterns and adaptive DBS which delivers potential stimulation tailored to moment-to-moment changes in the patient ’s condition.Better understanding of movement disorders pathophysiolog...
Source: Current Neurology and Neuroscience Reports - July 15, 2022 Category: Neuroscience Source Type: research
The Interaction Between Sleep and Epilepsy
AbstractPurpose of ReviewTo review the mutual interactions between sleep and epilepsy, including mechanisms of epileptogenesis, the relationship between sleep apnea and epilepsy, and potential strategies to treat seizures.Recent FindingsRecent studies have highlighted the role of functional network systems underlying epileptiform activation in sleep in several epilepsy syndromes, including absence epilepsy, benign focal childhood epilepsy, and epileptic encephalopathy with spike-wave activation in sleep. Sleep disorders are common in epilepsy, and early recognition and treatment can improve seizure frequency and potentiall...
Source: Current Neurology and Neuroscience Reports - July 8, 2022 Category: Neuroscience Source Type: research
Neurological Manifestations of Paragangliomas of the Head and Neck
AbstractPurpose of ReviewThis paper will outline the clinical neurologic presentation and diagnostic evaluation of patients with paragangliomas of the head and neck. Contemporary management options will be outlined for these rare and complex tumors.Recent FindingsThe majority of recent publications and research on these tumors are dedicated to traditional and robotic image-guided radiosurgery in the treatment of head and neck paragangliomas.SummaryParagangliomas are rare, slow-growing tumors of the head and neck which usually cause silent cranial nerve deficits or compensated mild speech or swallowing symptoms. While radio...
Source: Current Neurology and Neuroscience Reports - June 29, 2022 Category: Neuroscience Source Type: research
