Current Neurology and Neuroscience Reports 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Sporadic Late-Onset Nemaline Myopathy: Current Landscape
AbstractPurpose of ReviewSporadic late-onset nemaline myopathy (SLONM) is a rare adult-onset, acquired, muscle disease that can be associated with monoclonal gammopathy or HIV infection. The pathological hallmark of SLONM is the accumulation of nemaline rods in muscle fibers. We review here current knowledge about its presentation, pathophysiology, and management.Recent FindingsSLONM usually manifests with subacutely progressive proximal and axial weakness, but it can also present with chronic progressive weakness mimicking muscular dystrophy. The pathophysiology of the disease remains poorly understood, with evidence poin...
Source: Current Neurology and Neuroscience Reports - October 19, 2023 Category: Neuroscience Source Type: research
The Association Between Cognitive Domains and Postural Balance among Healthy Older Adults: A Systematic Review of Literature and Meta-Analysis
AbstractPurpose of ReviewThis review aims to explore which cognitive domain is more closely associated with which type of balance (static or dynamic).Resent FindingBased on recent reviews, inhibitory control, a part of cognition, plays a crucial role in balance performance. Previous reviews report significant links between cognition, mobility, and physical function in older adults. However, evidence regarding the relationship between cognition and balance scores remains inconclusive.SummaryThe strength of association between cognition and balance appears to be domain-specific and task-specific. Executive function exhibits ...
Source: Current Neurology and Neuroscience Reports - October 19, 2023 Category: Neuroscience Source Type: research
Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities
AbstractPurpose of ReviewDysautonomia refers to the dysfunction of the autonomic nervous system and encompasses a wide variety of autonomic symptoms and disorders. The most common autonomic disorders are postural orthostatic tachycardia syndrome (POTS), neurocardiogenic syncope (NCS), and orthostatic hypotension (OH), which may be encountered in clinical practice as part of a triad of dysautonomia, hypermobility spectrum disorders (HSD), and mast cell activation syndrome (MCAS). Migraine is one of the most common comorbidities of POTS, HSD, and MCAS; conversely, these conditions are also prevalent in patients with migraine...
Source: Current Neurology and Neuroscience Reports - October 17, 2023 Category: Neuroscience Source Type: research
Post-stroke Everything
ConclusionsAn integrative approach to stroke complications and collaborations between providers across specialties are more likely to improve stroke outcomes. (Source: Current Neurology and Neuroscience Reports)
Source: Current Neurology and Neuroscience Reports - October 14, 2023 Category: Neuroscience Source Type: research
REM Behavior Disorder: Implications for PD Therapeutics
This article reviews RBD, its treatments, and implications for PD therapeutics.Recent FindingsRecent research recognizes RBD as a prodromal marker of PD, resulting in expansion of basic science and clinical investigations of RBD. Current basic science research investigates the pathophysiology of RBD and explores animal models to allow therapeutic development. Clinical research has focused on natural history observation, as well as potential RBD treatments and their impact on sleep and phenoconversion to neurodegenerative disease.SummaryRBD serves as a fresh access point to develop both neuroprotective and symptomatic thera...
Source: Current Neurology and Neuroscience Reports - October 13, 2023 Category: Neuroscience Source Type: research
Molecular Profiling and Targeted Therapies in Gliomas
AbstractPurpose of ReviewMolecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection of appropriate therapies. This review summarizes the current role of molecular profiling and targeted therapies for gliomas.Recent FindingsMolecular profiling is an integral part of the 2021 WHO classification of gliomas. Progress in the development of targeted therapies remains limited due to many factors including the presence of the blood –brain barrier and issues of tumor heterogeneity. Nonetheless, advances have been made with the IDH1/2 inhibitor vorasidenib fo...
Source: Current Neurology and Neuroscience Reports - October 9, 2023 Category: Neuroscience Source Type: research
Exercise Made Accessible: the Merits of Community-Based Programs for Persons with Parkinson ’s Disease
AbstractPurpose of ReviewMany studies have identified positive effects of physiotherapy and exercise for persons with Parkinson ’s disease (PD). Most work has thus far focused on the therapeutic modality of exercise as used within physiotherapy programs. Stimulated by these positive findings, there is now a strong move to take exercise out of the clinical setting and to deliver the interventions in the community. Although the goals and effects of many such community-based exercise programs overlap with those of physiotherapy, it has also become more clear that both exercise modalities also differ in various ways. Here, w...
Source: Current Neurology and Neuroscience Reports - October 4, 2023 Category: Neuroscience Source Type: research
Pediatric Multiple Sclerosis: Changing the Trajectory of Progression
AbstractPurpose of ReviewMultiple sclerosis is a chronic inflammatory disease of the central nervous system. When seen in children and adolescents, crucial stages of brain development and maturation may be affected. Prompt recognition of multiple sclerosis in this population is essential, as early intervention with disease-modifying therapies may change developmental trajectories associated with the disease. In this paper, we will review diagnostic criteria for pediatric multiple sclerosis, outcomes, differential diagnosis, and current therapeutic approaches.Recent FindingsRecent studies have demonstrated the utility of ne...
Source: Current Neurology and Neuroscience Reports - October 4, 2023 Category: Neuroscience Source Type: research
Palliative Care in Neuro-oncology: an Update
AbstractPurpose of ReviewWhile the benefits of palliative care for patients with cancer are well established, palliative care in neuro-oncology is still in its early stages. However, in recent years, there has been increasing attention drawn to the need for better palliative care for patients with brain tumors.Recent FindingsThere is a growing body of literature demonstrating the high symptom burden and significant supportive care and information needs of these patients and their caregivers. In the area of caregiver needs, the last 3 years has seen a more rapid growth in recognizing and characterizing these needs. Howeve...
Source: Current Neurology and Neuroscience Reports - September 26, 2023 Category: Neuroscience Source Type: research
The Auditory Agnosias: a Short Review of Neurofunctional Evidence
AbstractPurpose of ReviewTo investigate the neurofunctional correlates of pure auditory agnosia and its varieties (global, verbal, and nonverbal), based on 116 anatomoclinical reports published between 1893 and 2022, with emphasis on hemispheric lateralization, intrahemispheric lesion site, underlying cognitive impairments.Recent FindingsPure auditory agnosia is rare, and observations accumulate slowly. Recent patient reports and neuroimaging studies on neurotypical subjects offer insights into the putative mechanisms underlying auditory agnosia, while challenging traditional accounts.SummaryGlobal auditory agnosia frequen...
Source: Current Neurology and Neuroscience Reports - September 25, 2023 Category: Neuroscience Source Type: research
The Financial Burden of Functional Neurological Disorders
This article reports the findings of recent research investigating the economic costs of FND diagnosis and management. We define what the costs are, why they exist, and suggest actionable steps to reduce them.Recent FindingsThe financial burden of FND exists across the globe characterized by high healthcare utilization resulting in exorbitant direct and indirect costs for the patient, healthcare system, and society. Inadequate medical education and stigmatization of the disorder prolong the time to diagnosis, during which cyclical utilization of inpatient and emergency department services drive up costs. Despite being cost...
Source: Current Neurology and Neuroscience Reports - September 11, 2023 Category: Neuroscience Source Type: research
Brain Sagging Dementia
AbstractPurpose of ReviewBrain sagging dementia (BSD) is a rare but devastating form of early-onset dementia characterized by intracranial hypotension and behavioral changes resembling behavioral variant frontotemporal dementia. This review aims to provide a comprehensive overview of BSD, highlighting its pathomechanism, diagnostic tools, and available treatment options.Recent FindingsBSD exhibits a complex clinical manifestation with insidious onset and gradual progression of behavioral disinhibition, apathy, inertia, and speech alterations. Additionally, patients may exhibit brainstem and cerebellar signs such as hyperso...
Source: Current Neurology and Neuroscience Reports - September 7, 2023 Category: Neuroscience Source Type: research
Sleep Disturbances in Autoimmune Neurological Diseases
AbstractPurpose of ReviewTo summarize the current evidence on the associations between autoimmune neurological diseases (e.g., multiple sclerosis, myasthenia gravis) and sleep disturbances (e.g., insomnia, parasomnias), as well as to review the main characteristics of sleep disorders with an immune-related pathophysiology (e.g., narcolepsy, anti-IgLON5 disease).Recent FindingsAn immune-mediated damage of the areas in the central nervous system that control sleep and wake functions (e.g., hypothalamus, brainstem) can lead to sleep disorders and sleep symptoms. Sleep disturbances are the reason to seek for medical attention ...
Source: Current Neurology and Neuroscience Reports - September 6, 2023 Category: Neuroscience Source Type: research
Headache in COVID-19 and Long COVID: to Know Facts for Clinical Practice
AbstractPurpose of ReviewHeadache is one of the most frequent symptoms of the acute and post-acute phase of COVID-19. Specific epidemiology, clinical features, risk factors, pathophysiology, and treatment have been reported in these two scenarios. With this narrative review of the literature, we aim to provide updated knowledge on headache in the COVID-19 setting and give clinicians a practical approach on this topic to guide them in their clinical practice.Recent FindingsHeadache mechanisms in COVID-19 are still poorly understood. Strong evidence is also lacking on how to best treat and manage these patients, especially t...
Source: Current Neurology and Neuroscience Reports - September 4, 2023 Category: Neuroscience Source Type: research
The Kinetics of Transtentorial Brain Herniation: Kernohan-Woltman Notch Phenomenon Revisited
AbstractPurpose of ReviewTo critically review recent literature in understanding the pathological consequences of transtentorial brain herniation resulting from unilateral expanding supratentorial mass lesions.Recent FindingsModern neuroimaging assists in understanding the consequences of transtentorial brain herniation with the development of the Kernohan-Woltman notch phenomenon. MRI studies in post-operative patients undergoing craniotomy and removal of expanding unilateral hemispheric mass lesions (usually an extradural or subdural hematoma) have shown striking findings in the contralateral crus cerebri suggestive of d...
Source: Current Neurology and Neuroscience Reports - August 23, 2023 Category: Neuroscience Source Type: research
