Challenges and Solutions to STI Control in the Era of HIV and STI Prophylaxis
This article reviews current efforts to control bacterial sexually transmitted infections (STIs) among HIV pre-exposure prophylaxis (PrEP) users and outlines the opportunities and challenges to controlling STIs within HIV PrEP programs.Recent FindingsThe incidence of STIs continues to rise globally especially among HIV PrEP users, with an estimated 1 in 4 PrEP users having a curable bacterial STI. STIs and HIV comprise a syndemic needing dual interventions. The majority of STIs are asymptomatic, and when testing is available, many STIs occur in extragenital sites that are missed when relying on urine testing or genital swa...
Source: Current HIV/AIDS Reports - September 26, 2023 Category: Infectious Diseases Source Type: research
The New Era of Long-Acting Antiretroviral Therapy: When and Why to Make the Switch
AbstractPurpose of ReviewDespite the availability of safe and effective oral combination antiretroviral therapy, barriers to maintaining viral suppression remain a challenge to ending the HIV epidemic. Long-acting injectable antiretroviral therapy was developed as an alternative to daily oral therapy. This review summarizes the current literature on the efficacy of long-acting cabotegravir plus rilpivirine for the treatment of HIV-1, reasons to switch to injectable therapy, and barriers to switching.Recent FindingsLong-acting cabotegravir plus rilpivirine is safe and effective in maintaining HIV-1 virologic suppression. Id...
Source: Current HIV/AIDS Reports - September 21, 2023 Category: Infectious Diseases Source Type: research
Integrated Care Models: HIV and Substance Use
AbstractPurpose of ReviewBehaviors and practices associated with substance use contribute to lack of HIV virologic suppression and onward transmission. In the USA, many recent HIV outbreaks have been connected with substance use. Evidence-based strategies for integrating care of those at risk for and living with HIV and who use substances continue to evolve. This review, based on scientific and medical literature through March 2023, provides an overview and evaluation of initiatives for integrated care aimed to serve patients at risk for and with HIV and a substance use disorder.Recent FindingsIntegrated care services can ...
Source: Current HIV/AIDS Reports - September 12, 2023 Category: Infectious Diseases Source Type: research
Spiraling Risk: Visualizing the multilevel factors that socially pattern HIV risk among gay, bisexual & amp; other men who have sex with men using Complex Systems Theory
AbstractPurpose of reviewGlobal disparities in HIV infection, particularly among gay, bisexual, and other men who have sex with men (GBMSM), indicate the importance of exploring the multi-level processes that shape HIV ’s spread. We used Complex Systems Theory and the PRISMA guidelines to conduct a systematic review of 63 global reviews to understand how HIV is socially patterned among GBMSM. The purpose was to conduct a thematic analysis of the reviews to (1) synthesize the multi-level risk factors of HIV risk, (2) categorize risk across the socioecological model, and (3) develop a conceptual model that visualizes the i...
Source: Current HIV/AIDS Reports - August 1, 2023 Category: Infectious Diseases Source Type: research
Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections
AbstractPurpose of ReviewThe long-acting reversible intramuscularly-injected contraceptive depot medroxyprogesterone acetate (DMPA-IM) is widely used by cisgender women in Africa. Although DMPA-IM provides reliable contraception, potential effects on the female genital tract (FGT) mucosa have raised concern, including risk of HIV infection. This review summarises and compares evidence from observational cohort studies and the randomised Evidence for Contraceptive Options in HIV Outcomes (ECHO) Trial.Recent FindingsAlthough previous observational studies found women using DMPA-IM had higher abundance of bacterial vaginosis ...
Source: Current HIV/AIDS Reports - June 21, 2023 Category: Infectious Diseases Source Type: research
Interventions to Improve Adolescent HIV Care Outcomes
AbstractPurpose of ReviewThis review of recent studies evaluating interventions to improve HIV care outcomes among adolescents with HIV (AHIV) was conducted to provide a comprehensive overview of the recent evidence, highlight promising approaches, and suggest directions for future research.Recent FindingsOur scoping review revealed 65 studies evaluating a variety of interventions and using a range of study designs at various stages of research. Effective approaches included community-based, integrated service delivery models with case management, trained community adolescent treatment supporters, and consideration of soci...
Source: Current HIV/AIDS Reports - June 10, 2023 Category: Infectious Diseases Source Type: research
Interventions to Reduce Alcohol Use and HIV Risk among Sexual and Gender Minority Populations: a Systematic Review
AbstractPurpose of ReviewSexual and gender minority (SGM) individuals are diagnosed with HIV at disproportionate rates, and hazardous alcohol use can increase their HIV risk. This review assessed the state of the literature examining interventions for addressing alcohol use and sexual HIV risk behaviors among SGM individuals.Recent FindingsFourteen manuscripts from 2012 to 2022 tested interventions that address both alcohol use and HIV risk behaviors among SGM populations, with only 7 randomized controlled trials (RCTs). Virtually all the interventions targeted men who have sex with men, with none focused on transgender po...
Source: Current HIV/AIDS Reports - May 25, 2023 Category: Infectious Diseases Source Type: research
A Review of Serious Gaming as an Intervention for HIV Prevention
AbstractPurposeof ReviewYoung people face the highest number of new HIV infections globally. With today ’s increasing access to smartphones, serious games have been viewed as an effective means of improving knowledge and behavioral outcomes. This systematic review describes current HIV prevention serious games and their relationship with HIV-related knowledge and behavioral outcomes.Recent FindingsA search of HIV prevention serious games was conducted using PubMed, CINAL, IEEE, Web of Science, and Google Scholar. A total of 31 papers were identified, which consist of 20 studies and 11 protocols. Results for knowledge, at...
Source: Current HIV/AIDS Reports - May 22, 2023 Category: Infectious Diseases Source Type: research
Mpox and HIV: a Narrative Review
AbstractPurpose of ReviewWe reviewed the available literature on mpox in People with HIV (PWH). We highlight special considerations of mpox infection related to epidemiology, clinical presentation, diagnostic and treatment considerations, prevention, and public health messaging in PWH.Recent FindingsDuring the 2022 mpox outbreak, PWH were disproportionally impacted worldwide. Recent reports suggest that the disease presentation, management, and prognosis of these patients, especially those with advanced HIV disease, can widely differ from those without HIV-associated immunodeficiency.SummaryMpox can often be mild and resol...
Source: Current HIV/AIDS Reports - May 13, 2023 Category: Infectious Diseases Source Type: research
