Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes
CONCLUSION: Our work provides insights into the various alterations that might possibly lead to colorectal cancer and suggests the possibility of utilizing the most important genes identified for wet-lab experimentation.PMID:38544823 | PMC:PMC10964087 | DOI:10.2174/0113892029285310231227105503 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Chandrashekar Karunakaran Vidya Niranjan Anagha S Setlur Dhanya Pradeep Jitendra Kumar Source Type: research
Preface 25 Years of Current Genomics
Curr Genomics. 2024 Feb 23;25(1):1. doi: 10.2174/138920292501240205235837.NO ABSTRACTPMID:38544824 | PMC:PMC10964086 | DOI:10.2174/138920292501240205235837 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Fabio Copped è Source Type: research
Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients
CONCLUSION: The findings of this study provide important insights into the COVID-19 disease and susceptibility risk. The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), IL-10 (-1082 G>A), rs1800896 and CXCR2 +785 C>T (rs2230054) are associated with the risk of susceptibility to COVID-19 and with mortality in COVID-19 patients. Further studies with larger sample sizes are necessary to confirm our findings.PMID:38544825 | PMC:PMC10964085 | DOI:10.2174/0113892029272497240103052359 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Badr A Alsayed Rashid Mir Mohammad M Mir Tarig M S Alnour Shereen Fawzy Mesaik M Ahmed Dnyanesh Amle Source Type: research
Analysis of the Expression of < em > PRDX6 < /em > in Patients with Hepatocellular Carcinoma and its Effect on the Phenotype of Hepatocellular Carcinoma Cells
CONCLUSION: The expression of PRDX6 may be closely related to the prognosis of HCC. Lentivirus-mediated PRDX6 knockdown can inhibit the proliferation, migration and invasion of HCC cells, which may be related to its regulating the PI3K/Akt/mTOR and Notch1 signaling pathways. PRDX6 is expected to be a new target for the diagnosis and treatment of liver cancer.PMID:38544826 | PMC:PMC10964084 | DOI:10.2174/0113892029273682240111052317 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Runhong Mu Mingzhu Chang Chuanbo Feng Yunhe Cui Tingyu Li Chang Liu Yilin Wang Xiao Guo Source Type: research
A Novel Methylation-based Model for Prognostic Prediction in Lung Adenocarcinoma
CONCLUSION: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.PMID:38544827 | PMC:PMC10964088 | DOI:10.2174/0113892029277397231228062412 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Manyuan Li Xufeng Deng Dong Zhou Xiaoqing Liu Jigang Dai Quanxing Liu Source Type: research
Epigenetic Diversity Underlying Seasonal and Annual Variations in Brown Planthopper (BPH) Populations as Revealed by Methylation- sensitive Restriction Assay
CONCLUSION: Screening field-collected BPH populations revealed the presence of previously unreported epigenetic polymorphisms and provided a platform for future studies aimed at investigating their significance for BPH. Furthermore, these findings can form the basis for understanding the contribution(s) of DNA methylation in providing phenotypic plasticity to BPH.PMID:38327650 | PMC:PMC10845068 | DOI:10.2174/0113892029276542231205065843 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Ayushi Gupta Suresh Nair Source Type: research
Aberrant Expressions of < em > PSMD14 < /em > in Tumor Tissue are the Potential Prognostic Biomarkers for Hepatocellular Carcinoma after Curative Resection
CONCLUSION: In conclusion, our research showed that PSMD14 might be related to recurrence in HCC patients, and the expression of PSMD14 in tumor tissue might be a potential prognostic biomarker after tumor resection in HCC patients.PMID:38327651 | PMC:PMC10845065 | DOI:10.2174/0113892029277262231108105441 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Yi-Mei Xiong Fang Zhou Jia-Wen Zhou Fei Liu Si-Qi Zhou Bo Li Zhong-Jian Liu Yang Qin Source Type: research
Identification of Two Novel Pathogenic Variants of the < em > ATM < /em > Gene in the Iranian-Azeri Turkish Ethnic Group by Applying Whole Exome Sequencing
CONCLUSION: Genetic analysis of three unrelated families with ATM-related disorders discovered two novel pathogenic variants. A homozygous missense pathogenic variant was identified in a woman with bi-lateral breast cancer, and a synonymous but pathogenic variant was found in a family with a history of different cancers.PMID:38327652 | PMC:PMC10845066 | DOI:10.2174/0113892029268949231104165301 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Amir-Reza Dalal Amandi Neda Jabbarpour Shadi Shiva Mortaza Bonyadi Source Type: research
Oxford Nanopore Technology and its Application in Liquid Biopsies
Curr Genomics. 2023 Dec 28;24(6):337-344. doi: 10.2174/0113892029286632231127055733.ABSTRACTAdvanced medical technologies are transforming the future of healthcare, in particular, the screening and detection of molecular-genetic changes in patients suspected of having a neoplasm. They are based on the assumption that neoplasms release small amounts of various neoplasm-specific molecules, such as tumor DNA, called circulating DNA (cirDNA), into the extracellular space and subsequently into the blood. The detection of tumor-specific molecules and specific molecular changes in body fluids in a noninvasive or minimally invasiv...
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Mariya Levkova Trifon Chervenkov Lyudmila Angelova Deyan Dzenkov Source Type: research
Epigenetic Diversity Underlying Seasonal and Annual Variations in Brown Planthopper (BPH) Populations as Revealed by Methylation- sensitive Restriction Assay
CONCLUSION: Screening field-collected BPH populations revealed the presence of previously unreported epigenetic polymorphisms and provided a platform for future studies aimed at investigating their significance for BPH. Furthermore, these findings can form the basis for understanding the contribution(s) of DNA methylation in providing phenotypic plasticity to BPH.PMID:38327650 | PMC:PMC10845068 | DOI:10.2174/0113892029276542231205065843 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Ayushi Gupta Suresh Nair Source Type: research
Aberrant Expressions of < em > PSMD14 < /em > in Tumor Tissue are the Potential Prognostic Biomarkers for Hepatocellular Carcinoma after Curative Resection
CONCLUSION: In conclusion, our research showed that PSMD14 might be related to recurrence in HCC patients, and the expression of PSMD14 in tumor tissue might be a potential prognostic biomarker after tumor resection in HCC patients.PMID:38327651 | PMC:PMC10845065 | DOI:10.2174/0113892029277262231108105441 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Yi-Mei Xiong Fang Zhou Jia-Wen Zhou Fei Liu Si-Qi Zhou Bo Li Zhong-Jian Liu Yang Qin Source Type: research
Identification of Two Novel Pathogenic Variants of the < em > ATM < /em > Gene in the Iranian-Azeri Turkish Ethnic Group by Applying Whole Exome Sequencing
CONCLUSION: Genetic analysis of three unrelated families with ATM-related disorders discovered two novel pathogenic variants. A homozygous missense pathogenic variant was identified in a woman with bi-lateral breast cancer, and a synonymous but pathogenic variant was found in a family with a history of different cancers.PMID:38327652 | PMC:PMC10845066 | DOI:10.2174/0113892029268949231104165301 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Amir-Reza Dalal Amandi Neda Jabbarpour Shadi Shiva Mortaza Bonyadi Source Type: research
Oxford Nanopore Technology and its Application in Liquid Biopsies
Curr Genomics. 2023 Dec 28;24(6):337-344. doi: 10.2174/0113892029286632231127055733.ABSTRACTAdvanced medical technologies are transforming the future of healthcare, in particular, the screening and detection of molecular-genetic changes in patients suspected of having a neoplasm. They are based on the assumption that neoplasms release small amounts of various neoplasm-specific molecules, such as tumor DNA, called circulating DNA (cirDNA), into the extracellular space and subsequently into the blood. The detection of tumor-specific molecules and specific molecular changes in body fluids in a noninvasive or minimally invasiv...
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Mariya Levkova Trifon Chervenkov Lyudmila Angelova Deyan Dzenkov Source Type: research
Epigenetic Diversity Underlying Seasonal and Annual Variations in Brown Planthopper (BPH) Populations as Revealed by Methylation- sensitive Restriction Assay
CONCLUSION: Screening field-collected BPH populations revealed the presence of previously unreported epigenetic polymorphisms and provided a platform for future studies aimed at investigating their significance for BPH. Furthermore, these findings can form the basis for understanding the contribution(s) of DNA methylation in providing phenotypic plasticity to BPH.PMID:38327650 | PMC:PMC10845068 | DOI:10.2174/0113892029276542231205065843 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Ayushi Gupta Suresh Nair Source Type: research
Aberrant Expressions of < em > PSMD14 < /em > in Tumor Tissue are the Potential Prognostic Biomarkers for Hepatocellular Carcinoma after Curative Resection
CONCLUSION: In conclusion, our research showed that PSMD14 might be related to recurrence in HCC patients, and the expression of PSMD14 in tumor tissue might be a potential prognostic biomarker after tumor resection in HCC patients.PMID:38327651 | PMC:PMC10845065 | DOI:10.2174/0113892029277262231108105441 (Source: Current Genomics)
Source: Current Genomics - February 8, 2024 Category: Genetics & Stem Cells Authors: Yi-Mei Xiong Fang Zhou Jia-Wen Zhou Fei Liu Si-Qi Zhou Bo Li Zhong-Jian Liu Yang Qin Source Type: research
