DLC-ac4C: A Prediction Model for N4-acetylcytidine Sites in Human mRNA Based on DenseNet and Bidirectional LSTM Methods
CONCLUSION: Our model not only combines DenseNet and Bi-LSTM, but also uses the channel attention mechanism to better capture hidden information features from a sequence perspective, and can identify ac4C sites more effectively.PMID:38178985 | PMC:PMC10761336 | DOI:10.2174/0113892029270191231013111911 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Jianhua Jia Xiaojing Cao Zhangying Wei Source Type: research
Lentiviral Transduction-based CRISPR/Cas9 Editing of < em > Schistosoma mansoni < /em > Acetylcholinesterase
CONCLUSION: Taken together, electroporation is more efficient than lentiviral transduction in the delivery of CRISPR/Cas9 into schistosomes for programmed genome editing. The exploration of tactics for enhancing CRISPR/Cas9 gene editing provides the basis for the future improvement of programmed genome editing in S. mansoni.PMID:38178986 | PMC:PMC10761339 | DOI:10.2174/1389202924666230823094608 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Xiaofeng Du Donald P McManus Juliet D French Haran Sivakumaran Rebecca L Johnston Olga Kondrashova Conor E Fogarty Malcolm K Jones Hong You Source Type: research
Decoding the Link between Periodontitis and Neuroinflammation: The Journey of Bacterial Extracellular Vesicles
Curr Genomics. 2023 Nov 22;24(3):132-135. doi: 10.2174/0113892029258657231010065320.NO ABSTRACTPMID:38178987 | PMC:PMC10761334 | DOI:10.2174/0113892029258657231010065320 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Heon-Jin Lee Youngkyun Lee Su-Hyung Hong Jin-Woo Park Source Type: research
Genome Sequencing and Organization of Three Geographically Different Isolates of Nucleopolyhedrovirus from the Gypsy Moth Reveal Significant Genomic Differences
CONCLUSION: This study provided a more detailed overview of the relationships between different geographic LdMNPV isolates. The results showed remarkable differences between groups at the genome level.PMID:38178988 | PMC:PMC10761337 | DOI:10.2174/0113892029249830231014163829 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Donus Gencer Cihan Inan Zeynep Bayramoglu Remziye Nalcacioglu Feifei Yin Zheng Zhu Jun Wang Zhihong Hu Lillian Pavlik Basil Arif Zihni Demirbag Ismail Demir Source Type: research
Taxonomic Status and Phylogenetic Relationship of the Charadriidae Family Based on Complete Mitogenomes
CONCLUSION: This study highlights the importance of carefully selecting the number of genes used to obtain accurate estimates of the species tree. It also suggests that relying on partial mtDNA genes with fast-evolving rates may lead to misleading results when resolving the Pluvialis sister group. Future research should focus on sequencing more mitogenomes at different taxonomic levels to gain a better understanding of the features and phylogenetic relationships within the Charadriiformes order.PMID:38169623 | PMC:PMC10758130 | DOI:10.2174/0113892029273517231017051819 (Source: Current Genomics)
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Weiya Qian Yizheng Liu Keer Miao Qing Chang Chaochao Hu Source Type: research
Unraveling the Concealed Transcriptomic Landscape of PTEN in Human Malignancies
CONCLUSION: The identification of the described novel PTEN splice variants could have significant implications for understanding PTEN regulation and function, and provide new insights into PTEN biology, opening new avenues for monitoring PTEN-related diseases, including cancer.PMID:38169628 | PMC:PMC10758127 | DOI:10.2174/0113892029265367231013113304 (Source: Current Genomics)
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Michaela A Boti Panagiotis G Adamopoulos Dido Vassilacopoulou Andreas Scorilas Source Type: research
A Study and Analysis of Disease Identification using Genomic Sequence Processing Models: An Empirical Review
Curr Genomics. 2023 Dec 12;24(4):207-235. doi: 10.2174/0113892029269523231101051455.ABSTRACTHuman gene sequences are considered a primary source of comprehensive information about different body conditions. A wide variety of diseases including cancer, heart issues, brain issues, genetic issues, etc. can be pre-empted via efficient analysis of genomic sequences. Researchers have proposed different configurations of machine learning models for processing genomic sequences, and each of these models varies in terms of their performance & applicability characteristics. Models that use bioinspired optimizations are generally...
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Sony K Ahuja Deepti D Shrimankar Aditi R Durge Source Type: research
Complete Chloroplast Genomes of < em > Pterodon emarginatus < /em > Vogel and < em > Pterodon pubescens < /em > Benth: Comparative and Phylogenetic Analyses
CONCLUSION: The genetic information obtained on the chloroplast genomes of P. emarginatus and P. pubescens presented here reinforces the similarity and evolutionary proximity between these species, with a similarity percentage of 99.8%.PMID:38169762 | PMC:PMC10758126 | DOI:10.2174/0113892029244147231016050434 (Source: Current Genomics)
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Juliana Borges Pereira Brito Adriana Maria Antunes Ramilla Dos Santos Braga Ferreira Mariana Pires de Campos Telles Cintia Pelegrineti Targueta Thannya Nascimento Soares Source Type: research
Modulation of Plant MicroRNA Expression: Its Potential Usability in Wheat ( < em > Triticum aestivum L < /em > .) Improvement
Curr Genomics. 2023 Dec 12;24(4):197-206. doi: 10.2174/0113892029264886231016050547.ABSTRACTWheat, a crucial crop for the pursuit of food security, is faced with a plateauing yield projected to fall short of meeting the demands of the exponentially increasing human population. To raise global wheat productivity levels, strong efforts must be made to overcome the problems of (1) climate change-induced heat and drought stress and (2) the genotype-dependent amenability of wheat to tissue culture, which limits the success of recovering genetically engineered plants, especially in elite cultivars. Unfortunately, the mainstream ...
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Louie Cris Lopos Urbashi Panthi Igor Kovalchuk Andriy Bilichak Source Type: research
Taxonomic Status and Phylogenetic Relationship of the Charadriidae Family Based on Complete Mitogenomes
CONCLUSION: This study highlights the importance of carefully selecting the number of genes used to obtain accurate estimates of the species tree. It also suggests that relying on partial mtDNA genes with fast-evolving rates may lead to misleading results when resolving the Pluvialis sister group. Future research should focus on sequencing more mitogenomes at different taxonomic levels to gain a better understanding of the features and phylogenetic relationships within the Charadriiformes order.PMID:38169623 | PMC:PMC10758130 | DOI:10.2174/0113892029273517231017051819 (Source: Current Genomics)
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Weiya Qian Yizheng Liu Keer Miao Qing Chang Chaochao Hu Source Type: research
Unraveling the Concealed Transcriptomic Landscape of PTEN in Human Malignancies
CONCLUSION: The identification of the described novel PTEN splice variants could have significant implications for understanding PTEN regulation and function, and provide new insights into PTEN biology, opening new avenues for monitoring PTEN-related diseases, including cancer.PMID:38169628 | PMC:PMC10758127 | DOI:10.2174/0113892029265367231013113304 (Source: Current Genomics)
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Michaela A Boti Panagiotis G Adamopoulos Dido Vassilacopoulou Andreas Scorilas Source Type: research
A Study and Analysis of Disease Identification using Genomic Sequence Processing Models: An Empirical Review
Curr Genomics. 2023 Dec 12;24(4):207-235. doi: 10.2174/0113892029269523231101051455.ABSTRACTHuman gene sequences are considered a primary source of comprehensive information about different body conditions. A wide variety of diseases including cancer, heart issues, brain issues, genetic issues, etc. can be pre-empted via efficient analysis of genomic sequences. Researchers have proposed different configurations of machine learning models for processing genomic sequences, and each of these models varies in terms of their performance & applicability characteristics. Models that use bioinspired optimizations are generally...
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Sony K Ahuja Deepti D Shrimankar Aditi R Durge Source Type: research
Complete Chloroplast Genomes of < em > Pterodon emarginatus < /em > Vogel and < em > Pterodon pubescens < /em > Benth: Comparative and Phylogenetic Analyses
CONCLUSION: The genetic information obtained on the chloroplast genomes of P. emarginatus and P. pubescens presented here reinforces the similarity and evolutionary proximity between these species, with a similarity percentage of 99.8%.PMID:38169762 | PMC:PMC10758126 | DOI:10.2174/0113892029244147231016050434 (Source: Current Genomics)
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Juliana Borges Pereira Brito Adriana Maria Antunes Ramilla Dos Santos Braga Ferreira Mariana Pires de Campos Telles Cintia Pelegrineti Targueta Thannya Nascimento Soares Source Type: research
Modulation of Plant MicroRNA Expression: Its Potential Usability in Wheat ( < em > Triticum aestivum L < /em > .) Improvement
Curr Genomics. 2023 Dec 12;24(4):197-206. doi: 10.2174/0113892029264886231016050547.ABSTRACTWheat, a crucial crop for the pursuit of food security, is faced with a plateauing yield projected to fall short of meeting the demands of the exponentially increasing human population. To raise global wheat productivity levels, strong efforts must be made to overcome the problems of (1) climate change-induced heat and drought stress and (2) the genotype-dependent amenability of wheat to tissue culture, which limits the success of recovering genetically engineered plants, especially in elite cultivars. Unfortunately, the mainstream ...
Source: Current Genomics - January 3, 2024 Category: Genetics & Stem Cells Authors: Louie Cris Lopos Urbashi Panthi Igor Kovalchuk Andriy Bilichak Source Type: research
Mitochondrial Lipid Metabolism Genes as Diagnostic and Prognostic Indicators in Hepatocellular Carcinoma
CONCLUSION: MTLT-related genes may serve as diagnostic and prognostic biomarkers for HCC as well as novel therapeutic targets, which may be beneficial for facilitating further understanding the molecular pathogenesis and providing potential therapeutic strategies for HCC.PMID:37994323 | PMC:PMC10662382 | DOI:10.2174/1389202924666230914110649 (Source: Current Genomics)
Source: Current Genomics - November 23, 2023 Category: Genetics & Stem Cells Authors: Xuejing Li Ying Tan Bihan Liu Houtian Guo Yongjian Zhou Jianhui Yuan Feng Wang Source Type: research
