Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors
Curr Genomics. 2023 Nov 22;24(3):136-145. doi: 10.2174/0113892029265046231011100327.ABSTRACTEpigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: post-translational modifications of histone proteins, control by non-coding RNA and DNA methylation. Since histone modifications can directly affect chromatin structure and accessibility, they can regulate gene expression levels. Abnormal expression and ...
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Ezgi Man Serap Evran Source Type: research
Using Chaos-Game-Representation for Analysing the SARS-CoV-2 Lineages, Newly Emerging Strains and Recombinants
CONCLUSION: Our findings demonstrate the efficacy of the CGR method for accurate classification and tracking of rapidly evolving viruses, offering valuable insights into the evolution and emergence of new SARS-CoV-2 strains and recombinants.PMID:38178984 | PMC:PMC10761335 | DOI:10.2174/0113892029264990231013112156 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Amarinder Singh Thind Somdatta Sinha Source Type: research
DLC-ac4C: A Prediction Model for N4-acetylcytidine Sites in Human mRNA Based on DenseNet and Bidirectional LSTM Methods
CONCLUSION: Our model not only combines DenseNet and Bi-LSTM, but also uses the channel attention mechanism to better capture hidden information features from a sequence perspective, and can identify ac4C sites more effectively.PMID:38178985 | PMC:PMC10761336 | DOI:10.2174/0113892029270191231013111911 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Jianhua Jia Xiaojing Cao Zhangying Wei Source Type: research
Lentiviral Transduction-based CRISPR/Cas9 Editing of < em > Schistosoma mansoni < /em > Acetylcholinesterase
CONCLUSION: Taken together, electroporation is more efficient than lentiviral transduction in the delivery of CRISPR/Cas9 into schistosomes for programmed genome editing. The exploration of tactics for enhancing CRISPR/Cas9 gene editing provides the basis for the future improvement of programmed genome editing in S. mansoni.PMID:38178986 | PMC:PMC10761339 | DOI:10.2174/1389202924666230823094608 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Xiaofeng Du Donald P McManus Juliet D French Haran Sivakumaran Rebecca L Johnston Olga Kondrashova Conor E Fogarty Malcolm K Jones Hong You Source Type: research
Decoding the Link between Periodontitis and Neuroinflammation: The Journey of Bacterial Extracellular Vesicles
Curr Genomics. 2023 Nov 22;24(3):132-135. doi: 10.2174/0113892029258657231010065320.NO ABSTRACTPMID:38178987 | PMC:PMC10761334 | DOI:10.2174/0113892029258657231010065320 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Heon-Jin Lee Youngkyun Lee Su-Hyung Hong Jin-Woo Park Source Type: research
Genome Sequencing and Organization of Three Geographically Different Isolates of Nucleopolyhedrovirus from the Gypsy Moth Reveal Significant Genomic Differences
CONCLUSION: This study provided a more detailed overview of the relationships between different geographic LdMNPV isolates. The results showed remarkable differences between groups at the genome level.PMID:38178988 | PMC:PMC10761337 | DOI:10.2174/0113892029249830231014163829 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Donus Gencer Cihan Inan Zeynep Bayramoglu Remziye Nalcacioglu Feifei Yin Zheng Zhu Jun Wang Zhihong Hu Lillian Pavlik Basil Arif Zihni Demirbag Ismail Demir Source Type: research
Trop-2 as an Actionable Biomarker in Breast Cancer
Curr Genomics. 2023 Nov 22;24(3):129-131. doi: 10.2174/1389202924666230726112233.NO ABSTRACTPMID:38178982 | PMC:PMC10761338 | DOI:10.2174/1389202924666230726112233 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Giulia Cursano Emanuele Frigo Elham Sajjadi Mariia Ivanova Konstantinos Venetis Elena Guerini-Rocco Carmen Criscitiello Giuseppe Curigliano Nicola Fusco Source Type: research
Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors
Curr Genomics. 2023 Nov 22;24(3):136-145. doi: 10.2174/0113892029265046231011100327.ABSTRACTEpigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: post-translational modifications of histone proteins, control by non-coding RNA and DNA methylation. Since histone modifications can directly affect chromatin structure and accessibility, they can regulate gene expression levels. Abnormal expression and ...
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Ezgi Man Serap Evran Source Type: research
Using Chaos-Game-Representation for Analysing the SARS-CoV-2 Lineages, Newly Emerging Strains and Recombinants
CONCLUSION: Our findings demonstrate the efficacy of the CGR method for accurate classification and tracking of rapidly evolving viruses, offering valuable insights into the evolution and emergence of new SARS-CoV-2 strains and recombinants.PMID:38178984 | PMC:PMC10761335 | DOI:10.2174/0113892029264990231013112156 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Amarinder Singh Thind Somdatta Sinha Source Type: research
DLC-ac4C: A Prediction Model for N4-acetylcytidine Sites in Human mRNA Based on DenseNet and Bidirectional LSTM Methods
CONCLUSION: Our model not only combines DenseNet and Bi-LSTM, but also uses the channel attention mechanism to better capture hidden information features from a sequence perspective, and can identify ac4C sites more effectively.PMID:38178985 | PMC:PMC10761336 | DOI:10.2174/0113892029270191231013111911 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Jianhua Jia Xiaojing Cao Zhangying Wei Source Type: research
Lentiviral Transduction-based CRISPR/Cas9 Editing of < em > Schistosoma mansoni < /em > Acetylcholinesterase
CONCLUSION: Taken together, electroporation is more efficient than lentiviral transduction in the delivery of CRISPR/Cas9 into schistosomes for programmed genome editing. The exploration of tactics for enhancing CRISPR/Cas9 gene editing provides the basis for the future improvement of programmed genome editing in S. mansoni.PMID:38178986 | PMC:PMC10761339 | DOI:10.2174/1389202924666230823094608 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Xiaofeng Du Donald P McManus Juliet D French Haran Sivakumaran Rebecca L Johnston Olga Kondrashova Conor E Fogarty Malcolm K Jones Hong You Source Type: research
Decoding the Link between Periodontitis and Neuroinflammation: The Journey of Bacterial Extracellular Vesicles
Curr Genomics. 2023 Nov 22;24(3):132-135. doi: 10.2174/0113892029258657231010065320.NO ABSTRACTPMID:38178987 | PMC:PMC10761334 | DOI:10.2174/0113892029258657231010065320 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Heon-Jin Lee Youngkyun Lee Su-Hyung Hong Jin-Woo Park Source Type: research
Genome Sequencing and Organization of Three Geographically Different Isolates of Nucleopolyhedrovirus from the Gypsy Moth Reveal Significant Genomic Differences
CONCLUSION: This study provided a more detailed overview of the relationships between different geographic LdMNPV isolates. The results showed remarkable differences between groups at the genome level.PMID:38178988 | PMC:PMC10761337 | DOI:10.2174/0113892029249830231014163829 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Donus Gencer Cihan Inan Zeynep Bayramoglu Remziye Nalcacioglu Feifei Yin Zheng Zhu Jun Wang Zhihong Hu Lillian Pavlik Basil Arif Zihni Demirbag Ismail Demir Source Type: research
Trop-2 as an Actionable Biomarker in Breast Cancer
Curr Genomics. 2023 Nov 22;24(3):129-131. doi: 10.2174/1389202924666230726112233.NO ABSTRACTPMID:38178982 | PMC:PMC10761338 | DOI:10.2174/1389202924666230726112233 (Source: Current Genomics)
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Giulia Cursano Emanuele Frigo Elham Sajjadi Mariia Ivanova Konstantinos Venetis Elena Guerini-Rocco Carmen Criscitiello Giuseppe Curigliano Nicola Fusco Source Type: research
Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors
Curr Genomics. 2023 Nov 22;24(3):136-145. doi: 10.2174/0113892029265046231011100327.ABSTRACTEpigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: post-translational modifications of histone proteins, control by non-coding RNA and DNA methylation. Since histone modifications can directly affect chromatin structure and accessibility, they can regulate gene expression levels. Abnormal expression and ...
Source: Current Genomics - January 5, 2024 Category: Genetics & Stem Cells Authors: Ezgi Man Serap Evran Source Type: research
