Biosimilars in IBD: What Every Clinician Needs to Know
AbstractPurpose of ReviewBiosimilars were introduced to decrease biologic-related expenditures, but their uptake in inflammatory bowel disease (IBD) remains suboptimal. Herein, we review biosimilar concepts, current products available for IBD treatment, and resources to support biosimilar utilization.Recent FindingsAlthough a cornerstone of IBD treatment, biologics are costly due to their development. Biosimilars, which are biologic products highly similar to a reference product, aim to decrease these expenditures. Infliximab, adalimumab, and ustekinumab biosimilars are approved for IBD, but uptake remains low due to biosi...
Source: Current Gastroenterology Reports - January 20, 2024 Category: Gastroenterology Source Type: research
Advanced Therapies for Inflammatory Bowel Disease: Navigating Payor and Financial Challenges
AbstractPurpose of ReviewIn the United Sates the cost of managing Crohn ’s disease and ulcerative colitis, the two most common inflammatory bowel diseases, is a major factor that can alter the course of treatment. The increasing use of advanced therapies such as biologics and oral small molecules is a driver of these costs. Many IBD providers find navigating the payor and non-insurance cost assistance processes to be a significant challenge in care management. We aim to clarify these processes and provide an outline for success.Recent FindingsInsurance companies use various processes to manage medication costs and while ...
Source: Current Gastroenterology Reports - January 20, 2024 Category: Gastroenterology Source Type: research
Clinical Application of Intestinal Ultrasound in Inflammatory Bowel Disease
AbstractPurpose of ReviewIntestinal ultrasound (IUS) is a non-invasive, accurate, and well-tolerated tool that provides real-time assessment of inflammatory bowel disease (IBD) activity and is therefore an ideal monitoring tool. This review describes the evolving role of IUS in each phase of clinical management of IBD.Recent FindingsAccumulating evidence has demonstrated that IUS is an excellent tool for the assessment of suspected IBD, with a very high negative predictive value. It accurately assesses disease activity, disease complications, and in the pre-treatment phase, provides a benchmark for subsequent follow-up. IU...
Source: Current Gastroenterology Reports - January 20, 2024 Category: Gastroenterology Source Type: research
Biosimilars in IBD: What Every Clinician Needs to Know
AbstractPurpose of ReviewBiosimilars were introduced to decrease biologic-related expenditures, but their uptake in inflammatory bowel disease (IBD) remains suboptimal. Herein, we review biosimilar concepts, current products available for IBD treatment, and resources to support biosimilar utilization.Recent FindingsAlthough a cornerstone of IBD treatment, biologics are costly due to their development. Biosimilars, which are biologic products highly similar to a reference product, aim to decrease these expenditures. Infliximab, adalimumab, and ustekinumab biosimilars are approved for IBD, but uptake remains low due to biosi...
Source: Current Gastroenterology Reports - January 20, 2024 Category: Gastroenterology Source Type: research
Advanced Therapies for Inflammatory Bowel Disease: Navigating Payor and Financial Challenges
AbstractPurpose of ReviewIn the United Sates the cost of managing Crohn ’s disease and ulcerative colitis, the two most common inflammatory bowel diseases, is a major factor that can alter the course of treatment. The increasing use of advanced therapies such as biologics and oral small molecules is a driver of these costs. Many IBD providers find navigating the payor and non-insurance cost assistance processes to be a significant challenge in care management. We aim to clarify these processes and provide an outline for success.Recent FindingsInsurance companies use various processes to manage medication costs and while ...
Source: Current Gastroenterology Reports - January 20, 2024 Category: Gastroenterology Source Type: research
Clinical Update on the Prevention and Management of Postoperative Crohn ’s Disease Recurrence
AbstractPurpose of ReviewDespite advances in therapeutics, a significant portion of patients with Crohn ’s disease still require surgical management. In this article, we present updates to the natural history, prognostication and postoperative monitoring, and novel therapeutics in the prevention and treatment of postoperative Crohn’s disease recurrence.Recent FindingsClinical risk factors have been associated with higher rates of postoperative recurrence (POR), and in recent studies demonstrate an increased cumulative risk with presence of additional risk factors. Additional novel clinical, histologic, and “-omic” ...
Source: Current Gastroenterology Reports - January 16, 2024 Category: Gastroenterology Source Type: research
Persistent Ostomy Following Percutaneous Endoscopic Gastrostomy Removal: Treatment Strategies
AbstractPurpose of ReviewThe purpose of this article is to review available literature on management of persistent ostomy following PEG tube removal. We will discuss the incidence of persistent gastrocutaneous fistula (GCF) following PEG tube removal, risk factors for their development, and management strategies that have been proposed and their efficacy.Recent FindingsThe use of over the scope clips (OTSC) have evolved recently in the management of gastrointestinal bleeding, perforation, and fistula closures. OTSC has become more readily available and proven to be effective and safe. Suturing devices have shown promising ...
Source: Current Gastroenterology Reports - January 9, 2024 Category: Gastroenterology Source Type: research
Persistent Ostomy Following Percutaneous Endosecopic Gastrostomy Removal: Treatment Strategies
AbstractPurpose of ReviewThe purpose of this article is to review available literature on management of persistent ostomy following PEG tube removal. We will discuss the incidence of persistent gastrocutaneous fistula (GCF) following PEG tube removal, risk factors for their development, and management strategies that have been proposed and their efficacy.Recent FindingsThe use of over the scope clips (OTSC) have evolved recently in the management of gastrointestinal bleeding, perforation, and fistula closures. OTSC has become more readily available and proven to be effective and safe. Suturing devices have shown promising ...
Source: Current Gastroenterology Reports - January 9, 2024 Category: Gastroenterology Source Type: research
Managing IBD Patients with Concomitant HIV Infection - a Systematic Review
AbstractPurpose of ReviewInflammatory Bowel Disease (IBD) is a chronic GI inflammatory condition induced by a dysregulated immune system activation, whereas HIV infection causes depletion of the immune system, inducing immunosuppression. Given the increasing incidence of IBD across the globe, including in developing countries, the co-prevalence of both conditions is expected to increase. Herein, we systematically review the data describing disease course when both pathologies co-exist.Recent FindingsOverall, the co-prevalence of IBD and HIV is around 0.1 to 2%. While IBD does not seem to affect HIV course, the opposite is ...
Source: Current Gastroenterology Reports - January 5, 2024 Category: Gastroenterology Source Type: research
Getting the BS out of Irritable Bowel Syndrome with Diarrhea (IBS-D): Let ’s Make a Diagnosis
AbstractPurpose of reviewIrritable bowel syndrome with diarrhea (IBS-D) is diagnosed when chronic symptoms of abdominal pain accompany loose stools, and alarm features, such as fever, anemia, rectal bleeding, and weight loss are absent. This combination of symptoms makes structural disorders, such as inflammatory bowel disease or cancer, unlikely, but does not exclude other conditions that cause these symptoms. The question is whether making a “positive diagnosis” of IBS-D based on symptoms alone and instituting therapy based on that diagnosis still makes sense.Recent findingsClinical observations suggest that at least...
Source: Current Gastroenterology Reports - January 1, 2024 Category: Gastroenterology Source Type: research
Neurogastroenterology and Motility Disorders of the Gastrointestinal Tract in Cystic Fibrosis
AbstractPurpose of ReviewTo discuss all the various motility disorders impacting people with Cystic Fibrosis (PwCF) and provide diagnostic and management approaches from a group of pediatric and adult CF and motility experts and physiologists with experience in the management of this disease.Recent FindingsGastrointestinal (GI) symptoms coexist with pulmonary symptoms in PwCF regardless of age and sex. The GI manifestations include gastroesophageal reflux disease, esophageal dysmotility gastroparesis, small bowel dysmotility, small intestinal bacterial overgrowth syndrome, distal idiopathic obstruction syndrome, constipati...
Source: Current Gastroenterology Reports - December 7, 2023 Category: Gastroenterology Source Type: research
