MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling
CONCLUSIONS: These results suggest that blockade of miR-1225-5p prevents lens fibrosis via targeting Keap1 thereby inhibiting Nrf2 activation. The 'miR-1225-Keap1-Nrf2' signaling axis presumably holds therapeutic promise in the treatment of fibrotic cataracts.PMID:38450708 | DOI:10.1080/02713683.2024.2316712 (Source: Current Eye Research)
Source: Current Eye Research - March 7, 2024 Category: Opthalmology Authors: Peihong Wang Lixiong Gao Tianju Ma Zi Ye Zhaohui Li Source Type: research
Examination of Subbasal Nerve Plexus and Central Corneal Stromal Microstructure in Subjects With Congenital Aniridia, Using < em > in Vivo < /em > Confocal Laser Scanning Microscopy
CONCLUSIONS: Decrease in CNFD, CNFL, and CTBD, as well as increase in CNFW well refer to the congenital aniridia-associated neuropathy. The decreased keratocyte density and the stromal alterations may be related to an increased cell death in congenital aniridia, nevertheless, stromal changes in different stages of AAK have to be further analyzed in detail.PMID:38444179 | DOI:10.1080/02713683.2024.2320779 (Source: Current Eye Research)
Source: Current Eye Research - March 6, 2024 Category: Opthalmology Authors: Anita Csorba Kitti Korm ányos M ária Csidey Annam ária Náray Klaudia Kov ács Orsolya N émeth Krisztina Kn ézy M ária Bausz Andrea Szigeti Dorottya Szab ó Marta Corton K álmán Tory Zolt án Zsolt Nagy Achim Langenbucher Erika Maka N óra Szentmà Source Type: research
Examination of Subbasal Nerve Plexus and Central Corneal Stromal Microstructure in Subjects With Congenital Aniridia, Using < em > in Vivo < /em > Confocal Laser Scanning Microscopy
CONCLUSIONS: Decrease in CNFD, CNFL, and CTBD, as well as increase in CNFW well refer to the congenital aniridia-associated neuropathy. The decreased keratocyte density and the stromal alterations may be related to an increased cell death in congenital aniridia, nevertheless, stromal changes in different stages of AAK have to be further analyzed in detail.PMID:38444179 | DOI:10.1080/02713683.2024.2320779 (Source: Current Eye Research)
Source: Current Eye Research - March 6, 2024 Category: Opthalmology Authors: Anita Csorba Kitti Korm ányos M ária Csidey Annam ária Náray Klaudia Kov ács Orsolya N émeth Krisztina Kn ézy M ária Bausz Andrea Szigeti Dorottya Szab ó Marta Corton K álmán Tory Zolt án Zsolt Nagy Achim Langenbucher Erika Maka N óra Szentmà Source Type: research
Repeatability of Rod-Mediated Dark Adaptation Testing in Normal Aging and Early and Intermediate Age-Related Macular Degeneration
CONCLUSION: We demonstrated that RMDA testing using the RIT metric has excellent repeatability when target location is at 5° in studying older adults from normal aging to intermediate AMD, suggesting the reliable use of this functional measure in trials.PMID:38439539 | DOI:10.1080/02713683.2024.2326077 (Source: Current Eye Research)
Source: Current Eye Research - March 5, 2024 Category: Opthalmology Authors: Cynthia Owsley Thomas A Swain Gerald McGwin Mary Margaret Bernard Mark E Clark Christine A Curcio Source Type: research
Repeatability of Rod-Mediated Dark Adaptation Testing in Normal Aging and Early and Intermediate Age-Related Macular Degeneration
CONCLUSION: We demonstrated that RMDA testing using the RIT metric has excellent repeatability when target location is at 5° in studying older adults from normal aging to intermediate AMD, suggesting the reliable use of this functional measure in trials.PMID:38439539 | DOI:10.1080/02713683.2024.2326077 (Source: Current Eye Research)
Source: Current Eye Research - March 5, 2024 Category: Opthalmology Authors: Cynthia Owsley Thomas A Swain Gerald McGwin Mary Margaret Bernard Mark E Clark Christine A Curcio Source Type: research
Evaluation of Optical Coherence Tomography Angiography Findings in Pars Planitis and Multiple Sclerosis Associated Intermediate Uveitis in Remission
CONCLUSION: OCTA may not be useful in differentiating between PP-IU and MS-IU. Nevertheless, the primary implication in SCP potentially elucidates the pathogenesis of these two subtypes of IU, which are characterized by a shared pathogenesis. The monitoring of the FAZ area in the PP-IU group is valuable in terms of chronicity.PMID:38433455 | DOI:10.1080/02713683.2024.2323520 (Source: Current Eye Research)
Source: Current Eye Research - March 4, 2024 Category: Opthalmology Authors: Berru Yargi-Ozkocak Cigdem Altan Burcu Kemer-Atik Berna Basarir Source Type: research
Deep Learning based Retinal Vessel Caliber Measurement and the Association with Hypertension
CONCLUSION: The proposed deep learning method showed a comparable diagnostic value to Integrative Vessel Analysis software. Compared with semi-automatic software, our deep learning model has significant advantage in efficiency and can be applied to population screening and risk evaluation.PMID:38407139 | DOI:10.1080/02713683.2024.2319755 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Shenshen Yan Jie Zhao Haicheng She Yimeng Jiang Fangfang Fan Guangzhengao Yang Jinqiong Zhou Jia Jia Yan Zhang Li Zhang Source Type: research
Naevi Characterization Using Hyperspectral Imaging: A Pilot Study
CONCLUSION: Choroidal naevi are better visible in longer wavelengths compared to shorter wavelengths. This finding can be used to contour and follow choroidal naevi. Choroidal naevi expose different optical density spectra that can be grouped into three different clusters. One of these clusters has an optical density spectra resembling the absorption spectra of lipofuscin, which may indicate the content of this pigment.PMID:38407145 | DOI:10.1080/02713683.2024.2314602 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Madeleine Selvander Jan Alexander Diego Guenot Source Type: research
Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects With Diabetes Without Diabetic Retinopathy
CONCLUSIONS: CS is the most sensitive CPG index for detecting alterations in the cone mosaic. The DCP and the cone photoreceptors are significantly correlated, indicating that alterations in the DCP can affect the cones. Future work elucidating the vascular alterations and neurodegeneration present in diabetic eyes should focus on the DCP and multiple CPG indices, not solely CD. Moreover, such alterations are highly localized, hence using larger regions e.g. parafovea versus smaller areas, such as the PTQ, will potentially mask significant correlations.PMID:38407181 | DOI:10.1080/02713683.2024.2320787 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Danae A Johnson Nathan Doble Stacey S Choi Source Type: research
Deep Learning based Retinal Vessel Caliber Measurement and the Association with Hypertension
CONCLUSION: The proposed deep learning method showed a comparable diagnostic value to Integrative Vessel Analysis software. Compared with semi-automatic software, our deep learning model has significant advantage in efficiency and can be applied to population screening and risk evaluation.PMID:38407139 | DOI:10.1080/02713683.2024.2319755 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Shenshen Yan Jie Zhao Haicheng She Yimeng Jiang Fangfang Fan Guangzhengao Yang Jinqiong Zhou Jia Jia Yan Zhang Li Zhang Source Type: research
Naevi Characterization Using Hyperspectral Imaging: A Pilot Study
CONCLUSION: Choroidal naevi are better visible in longer wavelengths compared to shorter wavelengths. This finding can be used to contour and follow choroidal naevi. Choroidal naevi expose different optical density spectra that can be grouped into three different clusters. One of these clusters has an optical density spectra resembling the absorption spectra of lipofuscin, which may indicate the content of this pigment.PMID:38407145 | DOI:10.1080/02713683.2024.2314602 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Madeleine Selvander Jan Alexander Diego Guenot Source Type: research
Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects With Diabetes Without Diabetic Retinopathy
CONCLUSIONS: CS is the most sensitive CPG index for detecting alterations in the cone mosaic. The DCP and the cone photoreceptors are significantly correlated, indicating that alterations in the DCP can affect the cones. Future work elucidating the vascular alterations and neurodegeneration present in diabetic eyes should focus on the DCP and multiple CPG indices, not solely CD. Moreover, such alterations are highly localized, hence using larger regions e.g. parafovea versus smaller areas, such as the PTQ, will potentially mask significant correlations.PMID:38407181 | DOI:10.1080/02713683.2024.2320787 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Danae A Johnson Nathan Doble Stacey S Choi Source Type: research
Deep Learning based Retinal Vessel Caliber Measurement and the Association with Hypertension
CONCLUSION: The proposed deep learning method showed a comparable diagnostic value to Integrative Vessel Analysis software. Compared with semi-automatic software, our deep learning model has significant advantage in efficiency and can be applied to population screening and risk evaluation.PMID:38407139 | DOI:10.1080/02713683.2024.2319755 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Shenshen Yan Jie Zhao Haicheng She Yimeng Jiang Fangfang Fan Guangzhengao Yang Jinqiong Zhou Jia Jia Yan Zhang Li Zhang Source Type: research
Naevi Characterization Using Hyperspectral Imaging: A Pilot Study
CONCLUSION: Choroidal naevi are better visible in longer wavelengths compared to shorter wavelengths. This finding can be used to contour and follow choroidal naevi. Choroidal naevi expose different optical density spectra that can be grouped into three different clusters. One of these clusters has an optical density spectra resembling the absorption spectra of lipofuscin, which may indicate the content of this pigment.PMID:38407145 | DOI:10.1080/02713683.2024.2314602 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Madeleine Selvander Jan Alexander Diego Guenot Source Type: research
Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects With Diabetes Without Diabetic Retinopathy
CONCLUSIONS: CS is the most sensitive CPG index for detecting alterations in the cone mosaic. The DCP and the cone photoreceptors are significantly correlated, indicating that alterations in the DCP can affect the cones. Future work elucidating the vascular alterations and neurodegeneration present in diabetic eyes should focus on the DCP and multiple CPG indices, not solely CD. Moreover, such alterations are highly localized, hence using larger regions e.g. parafovea versus smaller areas, such as the PTQ, will potentially mask significant correlations.PMID:38407181 | DOI:10.1080/02713683.2024.2320787 (Source: Current Eye Research)
Source: Current Eye Research - February 26, 2024 Category: Opthalmology Authors: Danae A Johnson Nathan Doble Stacey S Choi Source Type: research
