Insights into the Therapeutic Uses of Plant Derive Phytocompounds on Diabetic Nephropathy
Curr Diabetes Rev. 2024 Jan 23. doi: 10.2174/0115733998273395231117114600. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is one of the primary consequences of diabetes mellitus, affecting many people worldwide and is the main cause of death under the age of sixty. Reactive oxygen species (ROS) production rises during hyperglycemia and is crucial to the development of diabetic complications. Advanced glycation end products (AGEs) are produced excessively in a diabetic state and are accumulated in the kidney, where they change renal architecture and impair renal function. Another important targeted pathway for the ...
Source: Current Diabetes Reviews - January 24, 2024 Category: Endocrinology Authors: Palash Mitra Sahadeb Jana Suchismita Roy Source Type: research
Type 2 Diabetes Prevalence, Control and Management within Fiji, Kiribati, Samoa, the Solomon Islands, Tonga, and Vanuatu: A Scoping Review with a Systematic Approach
CONCLUSION: The prevalence, control, and management of T2D varied between Fiji, Kiribati, Samoa, the Solomon Islands, Tonga, and Vanuatu. Significant gaps remain in the data describing these domains; however, there are clearly targetable areas for future research and diabetes management programs.PMID:38258764 | DOI:10.2174/0115733998260306231025151814 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 23, 2024 Category: Endocrinology Authors: Timothy Kuek Source Type: research
Association and Mechanisms of Proton Pump Inhibitors Use with Type-2 Diabetes Mellitus Incidence in Adults: A Systemic Review and Metaanalysis
CONCLUSION: The systematic review concludes that chronic PPI exposure increases the risk of T2DM incidence. The authors recommend the shortest possible duration of PPI use and not prescribing PPIs to high-risk prediabetics and those without a compelling indication for PPI use. Regular education to patients regarding adverse reactions with prolonged use may decrease the risk of adverse effects associated with PPIs. The authors suggest that gut dysbiosis, hypergastrinemia, hypomagnesemia, decreased pancreatic secretions and IGF-1 levels, and PXR activation associated with chronic acid suppression among chronic PPI users and ...
Source: Current Diabetes Reviews - January 20, 2024 Category: Endocrinology Authors: Santenna Chenchula Phulen Sharma Mohan Krishna Ghanta Krishna Chaitanya Amerneni Padmavathi Rajakarunakaran Pavani Saggurthi Madhu Bhargavi Chandra Rupesh Gupta Madhavrao Chavan Source Type: research
Factors Influencing Hypoglycemia in Type 2 Diabetes Mellitus Outpatients with State Health Insurance at Regional General Hospitals in Jakarta, Indonesia
CONCLUSION: The prevalence of hypoglycemia in type 2 diabetes mellitus (DM) outpatients with the state-provided health insurance Jaminan Kesehatan Nasional (JKN) at general hospitals in Jakarta is high. The diabetes self-management education (DSME) services provided by health professionals for these outpatients must be further improved.PMID:38243951 | DOI:10.2174/0115733998280552231228064154 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 20, 2024 Category: Endocrinology Authors: Putu Rika Veryanti Rani Sauriasari Ratu Ayu Dewi Sartika Berna Elya Source Type: research
Impaired Awareness of Hypoglycemia and its Risk Factors among Diabetic Patients in Jazan, Saudi Arabia: A Cross-Sectional Study
CONCLUSION: IAH was prevalent among T1D patients attending Jazan Endocrine and Diabetes Center. The main associated factors included BMI, blood glucose monitoring method, and occupation. Future research should investigate the underlying causes of the observed associations and explore strategies to enhance the awareness of hypoglycemia.PMID:38243952 | DOI:10.2174/0115733998288242240104054438 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 20, 2024 Category: Endocrinology Authors: Omar Oraibi Abdulelah Alameer Mohammed Dalak Sawsan Alsharif Shatha Hakami Mohammed Sumayli Ayman Shami Mostafa Mohrag Mohammed A Madkhali Mohammed Ali Madkhali Luai Alhazmi Majid Darraj Source Type: research
Missed Opportunities in Type 2 Diabetes Mellitus: A Narrative Review
CONCLUSION: Missed opportunities are a concept that is not often considered in diabetes care, which calls upon reflection of real-world activities and consideration of whether patient outcomes could have been improved with changes in decision-making. Future studies that aim to improve patient care should consider this concept.PMID:38243953 | DOI:10.2174/0115733998274651231117101511 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 20, 2024 Category: Endocrinology Authors: Chun Shing Kwok Anne Phillips Supriyo Mukherjee Mahendra G Patel Wasim Hanif Source Type: research
Gut Microbiota and Insulin Resistance: Understanding the Mechanism of Better Treatment of Type 2 Diabetes Mellitus
Curr Diabetes Rev. 2024 Jan 17. doi: 10.2174/0115733998281910231231051814. Online ahead of print.ABSTRACTGut microbiota refers to the population of trillions of microorganisms present in the human intestine. The gut microbiota in the gastrointestinal system is important for an individual's good health and well-being. The possibility of an intrauterine colonization of the placenta further suggests that the fetal environment before birth may also affect early microbiome development. Various factors influence the gut microbiota. Dysbiosis of microbiota may be associated with various diseases. Insulin regulates blood glucose l...
Source: Current Diabetes Reviews - January 20, 2024 Category: Endocrinology Authors: Alsalt Al-Busaidi Omer Alabri Jaifar Alomairi Ahmed ElSharaawy Abdullah Al Lawati Hanan Al Lawati Srijit Das Source Type: research
The Value of Microbiome-targeted Therapy on Lipid Indices of Patients with Type 2 Diabetes Mellitus: An Umbrella Meta-analysis of Randomized Controlled Trials
CONCLUSION: This research has provided promising insights into the potential impact of MTT on lipid levels in patients diagnosed with T2DM. Notably, MTT had the greatest impact on HDL levels, followed by TG, TC, and LDL. As a result of our study, MTT is recommended as an adjunctive therapeutic option for T2DM treatment due to its capability to regulate lipid profiles.</p.PMID:38243955 | DOI:10.2174/0115733998284844240102110559 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 20, 2024 Category: Endocrinology Authors: Mohammad-Hossein Keivanlou Ehsan Amini-Salehi Soheil Hassanipour Reza Zare Erfan Mohammadi-Vajari Mohammad Hashemi Arsalan Salari Parham Porteghali Source Type: research
Number of People with Type 2 Diabetes Mellitus in 2035 and 2050: A Modelling Study in 188 Countries
CONCLUSIONS: There will be a massive growth in the number of people living with T2DM, and low-income countries and countries in Sub-Saharan Africa will be the most affected. Health systems must be strengthened to ensure optimal care for the future population with T2DM.PMID:38231048 | DOI:10.2174/0115733998274323231230131843 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 17, 2024 Category: Endocrinology Authors: Wilmer Cristobal Guzman-Vilca Rodrigo M Carrillo-Larco Source Type: research
Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells
CONCLUSION: In summary, different in vitro models using inflammatory, oxidative stress, and high insulin conditions under hypoxic conditions can capture various aspects of in vivo adipose tissue insulin resistance (IR). Among these models, acute TNFα treatment may offer the most robust approach for inducing IR in 3T3-L1 cells.PMID:38204253 | DOI:10.2174/0115733998263359231211044539 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 11, 2024 Category: Endocrinology Authors: Hend Al-Jaber Shamma Al-Muraikhy Aldana Jabr Jabr Aisha Yousuf Najeha Anwardeen Mohamed Elrayess Layla Al-Mansoori Source Type: research
Impact of Ramadan Fasting on Cardiometabolic and Inflammatory Biomarkers among Saudi Adults with Diabetes
CONCLUSIONS: Ramadan fasting was associated with increased HDL-C levels and decreased anthropometric measurements and inflammatory cytokine levels. These results support the beneficial role of Ramadan fasting in reducing cardiometabolic abnormalities and inflammation in adults with diabetes.PMID:38192134 | DOI:10.2174/0115733998274064231114075657 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 9, 2024 Category: Endocrinology Authors: Abeer Aljahdalia Reham Al-Maiman Saada Al-Orf Nahla Bawazeer Source Type: research
Brain-derived Neurotrophic Factor Level and Gene Polymorphism as Risk Factors for Depression in Patients with type 2 Diabetes Mellitus- A Case-Controlled Study
Conclusion: In this pilot, Low levels of BDNF were associated with depression in patients with type 2 diabetes. Carriers of the Met/ Met allele have the lowest serum BDNF levels. Multicenter studies with more participants are required.PMID:38192135 | DOI:10.2174/0115733998274778231218145449 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 9, 2024 Category: Endocrinology Authors: Hany Hammad Inass Shaltout Mai M Fawzy Laila A Rashed Noha A Mahfouz Tarek S Abdelaziz Source Type: research
Impact of Ramadan Fasting on Cardiometabolic and Inflammatory Biomarkers among Saudi Adults with Diabetes
CONCLUSIONS: Ramadan fasting was associated with increased HDL-C levels and decreased anthropometric measurements and inflammatory cytokine levels. These results support the beneficial role of Ramadan fasting in reducing cardiometabolic abnormalities and inflammation in adults with diabetes.PMID:38192134 | DOI:10.2174/0115733998274064231114075657 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 9, 2024 Category: Endocrinology Authors: Abeer Aljahdalia Reham Al-Maiman Saada Al-Orf Nahla Bawazeer Source Type: research
Brain-derived Neurotrophic Factor Level and Gene Polymorphism as Risk Factors for Depression in Patients with type 2 Diabetes Mellitus- A Case-Controlled Study
Conclusion: In this pilot, Low levels of BDNF were associated with depression in patients with type 2 diabetes. Carriers of the Met/ Met allele have the lowest serum BDNF levels. Multicenter studies with more participants are required.PMID:38192135 | DOI:10.2174/0115733998274778231218145449 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 9, 2024 Category: Endocrinology Authors: Hany Hammad Inass Shaltout Mai M Fawzy Laila A Rashed Noha A Mahfouz Tarek S Abdelaziz Source Type: research
Comprehensive Factors for Predicting the Complications of Diabetes Mellitus: A Systematic Review
CONCLUSION: This study is a thorough literature review to provide a clear state of the art for academicians, clinicians, and other stakeholders regarding the risk factors and their importance.PMID:38178670 | DOI:10.2174/0115733998271863231116062601 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - January 5, 2024 Category: Endocrinology Authors: Madurapperumage Anuradha Erandathi William Yu Chung Wang Michael Mayo Ching-Chi Lee Source Type: research
