Incretin Therapy and Insulin Signaling: Therapeutic Targets for Diabetes And Associated Dementia
Curr Diabetes Rev. 2024 Feb 29. doi: 10.2174/0115733998279875240216093902. Online ahead of print.ABSTRACTDementia is the primary cause of disability and dependence among the elderly population worldwide. The population living with dementia is anticipated to double in the next 17 years. Recent studies show the fact that compared to people without diabetes, people with Type 2 Diabetes (T2D) have about a 60% increased chance of developing dementia. In addition to cholinergic function being downregulated, improper insulin signalling also has a negative impact on synaptic plasticity and neuronal survival. Type 2 diabetes and de...
Source: Current Diabetes Reviews - March 1, 2024 Category: Endocrinology Authors: Deepika Joshi Source Type: research
Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source
Curr Diabetes Rev. 2024 Feb 29. doi: 10.2174/0115733998285798240217084632. Online ahead of print.ABSTRACTFlavonoids have been reported to be vital in treating various chronic disorders. Luteolin (3',4',5,7-tetrahydroxyflavone) is a flavonoid present in a variety of plant sources such as celery, green pepper, olive oil, peppermint, thyme, rosemary, oregano, etc. It has been reported to have various pharmacological activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, anti-Alzheimer, antimicrobial, etc. Many scientific studies have been carried out on luteolin for its possible effects on diabetes and i...
Source: Current Diabetes Reviews - March 1, 2024 Category: Endocrinology Authors: Gandhar Pradhan Yogesh A Kulkarni Source Type: research
Incretin Therapy and Insulin Signaling: Therapeutic Targets for Diabetes And Associated Dementia
Curr Diabetes Rev. 2024 Feb 29. doi: 10.2174/0115733998279875240216093902. Online ahead of print.ABSTRACTDementia is the primary cause of disability and dependence among the elderly population worldwide. The population living with dementia is anticipated to double in the next 17 years. Recent studies show the fact that compared to people without diabetes, people with Type 2 Diabetes (T2D) have about a 60% increased chance of developing dementia. In addition to cholinergic function being downregulated, improper insulin signalling also has a negative impact on synaptic plasticity and neuronal survival. Type 2 diabetes and de...
Source: Current Diabetes Reviews - March 1, 2024 Category: Endocrinology Authors: Deepika Joshi Source Type: research
Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source
Curr Diabetes Rev. 2024 Feb 29. doi: 10.2174/0115733998285798240217084632. Online ahead of print.ABSTRACTFlavonoids have been reported to be vital in treating various chronic disorders. Luteolin (3',4',5,7-tetrahydroxyflavone) is a flavonoid present in a variety of plant sources such as celery, green pepper, olive oil, peppermint, thyme, rosemary, oregano, etc. It has been reported to have various pharmacological activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, anti-Alzheimer, antimicrobial, etc. Many scientific studies have been carried out on luteolin for its possible effects on diabetes and i...
Source: Current Diabetes Reviews - March 1, 2024 Category: Endocrinology Authors: Gandhar Pradhan Yogesh A Kulkarni Source Type: research
Promising Phytoconstituents in Diabetes-related Wounds: Mechanistic Insights and Implications
CONCLUSION: However, to fully understand the efficacy and safety of these phytochemicals in managing diabetic wounds, more research and clinical trials are needed.PMID:38424430 | DOI:10.2174/0115733998279112240129074457 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 29, 2024 Category: Endocrinology Authors: Arjina Sultana Ranadeep Borgohain Ashwini Rayaji Dipankar Saha Bhrigu Kumar Das Source Type: research
Qatar's Silent Epidemic: A Comprehensive Meta-analysis on the Prevalence of Metabolic Syndrome
CONCLUSION: The prevalence of metabolic syndrome in the Qatari population is comparable to rates in the Middle East. The study underscores the need for tailored interventions and strategies, especially targeting the older age group. Continuous research and monitoring are essential to track and understand the disease's progression in Qatar.PMID:38424431 | DOI:10.2174/0115733998286706240129074153 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 29, 2024 Category: Endocrinology Authors: Sarah Aqel Jamil Ahmad Sebawe Syaj Majd N Daoud Bashar Araiqat Source Type: research
Exploring the Potential Benefits of Bovine Colostrum Supplementation in the Management of Diabetes and Its Complications: A Comprehensive Review
Curr Diabetes Rev. 2024 Feb 20. doi: 10.2174/0115733998275676240202065952. Online ahead of print.ABSTRACTDiabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream due to the inadequate production or use of insulin in the body. Diabetes can result in a range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are the most important compounds for the treatment of diabetes. Colostrum is a form of lactation produced by mammals in the first days after giving birth to t...
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Isha Chawla Meenakshi Dhanawat Manu Sharma Sumeet Gupta Source Type: research
The Natural Products as Novel Anti-obesity Agents: Mechanisms Based on Adipose Tissue
In conclusion, we have determined that natural compounds are significant candidates for the treatment of obesity, and adipose tissue represents a crucial target in the therapeutic process. We hope that our research will contribute novel perspectives for the development of future pharmaceuticals and dietary supplements, as well as provide innovative directions for clinical trials in the field.PMID:38415495 | DOI:10.2174/0115733998278959240216044936 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Lei Cao Chunwei Wu Miao Liu Wenlong Zhang Hailong Chen Ruolin Wang Ze He Source Type: research
Recent Patterns and Assessment of Long-term Complications following SARS-CoV-2 Infection and Vaccination in the Context of Diabetes Prevalence among Blood Donors
CONCLUSION: Increase in HbA1c in 50% of donors, irrespective of gender, is an alarming figure for health authorities, with altered LFT, KFT and LDH tests and, in the near future, may increase the incidence of T2D. Large-scale population-based studies are required to prevent future incidences of T2D in young children who will be vaccinated.PMID:38415496 | DOI:10.2174/0115733998274390231110050809 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Turki Mohammed M Alqahtani Mohammed Abdullah Ali Alghamdi Mirza Rafi Baig Fahad A Al-Abbasi Rizwan Shiek Sultan Alhayyani Turky Omar Asar Firoz Anwar Vikas Kumar Source Type: research
Exploring the Potential Benefits of Bovine Colostrum Supplementation in the Management of Diabetes and Its Complications: A Comprehensive Review
Curr Diabetes Rev. 2024 Feb 20. doi: 10.2174/0115733998275676240202065952. Online ahead of print.ABSTRACTDiabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream due to the inadequate production or use of insulin in the body. Diabetes can result in a range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are the most important compounds for the treatment of diabetes. Colostrum is a form of lactation produced by mammals in the first days after giving birth to t...
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Isha Chawla Meenakshi Dhanawat Manu Sharma Sumeet Gupta Source Type: research
The Natural Products as Novel Anti-obesity Agents: Mechanisms Based on Adipose Tissue
In conclusion, we have determined that natural compounds are significant candidates for the treatment of obesity, and adipose tissue represents a crucial target in the therapeutic process. We hope that our research will contribute novel perspectives for the development of future pharmaceuticals and dietary supplements, as well as provide innovative directions for clinical trials in the field.PMID:38415495 | DOI:10.2174/0115733998278959240216044936 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Lei Cao Chunwei Wu Miao Liu Wenlong Zhang Hailong Chen Ruolin Wang Ze He Source Type: research
Recent Patterns and Assessment of Long-term Complications following SARS-CoV-2 Infection and Vaccination in the Context of Diabetes Prevalence among Blood Donors
CONCLUSION: Increase in HbA1c in 50% of donors, irrespective of gender, is an alarming figure for health authorities, with altered LFT, KFT and LDH tests and, in the near future, may increase the incidence of T2D. Large-scale population-based studies are required to prevent future incidences of T2D in young children who will be vaccinated.PMID:38415496 | DOI:10.2174/0115733998274390231110050809 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Turki Mohammed M Alqahtani Mohammed Abdullah Ali Alghamdi Mirza Rafi Baig Fahad A Al-Abbasi Rizwan Shiek Sultan Alhayyani Turky Omar Asar Firoz Anwar Vikas Kumar Source Type: research
Exploring the Potential Benefits of Bovine Colostrum Supplementation in the Management of Diabetes and Its Complications: A Comprehensive Review
Curr Diabetes Rev. 2024 Feb 20. doi: 10.2174/0115733998275676240202065952. Online ahead of print.ABSTRACTDiabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream due to the inadequate production or use of insulin in the body. Diabetes can result in a range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are the most important compounds for the treatment of diabetes. Colostrum is a form of lactation produced by mammals in the first days after giving birth to t...
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Isha Chawla Meenakshi Dhanawat Manu Sharma Sumeet Gupta Source Type: research
The Natural Products as Novel Anti-obesity Agents: Mechanisms Based on Adipose Tissue
In conclusion, we have determined that natural compounds are significant candidates for the treatment of obesity, and adipose tissue represents a crucial target in the therapeutic process. We hope that our research will contribute novel perspectives for the development of future pharmaceuticals and dietary supplements, as well as provide innovative directions for clinical trials in the field.PMID:38415495 | DOI:10.2174/0115733998278959240216044936 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Lei Cao Chunwei Wu Miao Liu Wenlong Zhang Hailong Chen Ruolin Wang Ze He Source Type: research
Recent Patterns and Assessment of Long-term Complications following SARS-CoV-2 Infection and Vaccination in the Context of Diabetes Prevalence among Blood Donors
CONCLUSION: Increase in HbA1c in 50% of donors, irrespective of gender, is an alarming figure for health authorities, with altered LFT, KFT and LDH tests and, in the near future, may increase the incidence of T2D. Large-scale population-based studies are required to prevent future incidences of T2D in young children who will be vaccinated.PMID:38415496 | DOI:10.2174/0115733998274390231110050809 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - February 28, 2024 Category: Endocrinology Authors: Turki Mohammed M Alqahtani Mohammed Abdullah Ali Alghamdi Mirza Rafi Baig Fahad A Al-Abbasi Rizwan Shiek Sultan Alhayyani Turky Omar Asar Firoz Anwar Vikas Kumar Source Type: research
