Anticarcinogenic Effects of Capsaicin-Loaded Nanoparticles on In vitro Hepatocellular Carcinoma
Conclusions: TMCs nanoparticles investigated in this study may be a good drug delivery vehicle for capsaicin. Application of capsaicin-loaded NPs in HCC management as an adjunct therapeutic approach may be a novel strategy to improve the treatment efficacy and resistance of the conventionally used chemotherapy. (Source: Current Chemical Biology)
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
Wi-Fi Radiation Negatively Influences Plant Growth and Biochemical Responses of Capsicum annuum L var. Pusa Jwala
Conclusions: The electromagnetic radiations emitted by the Wi-Fi router have a negative influence on the growth and biochemical responses in Chilli plants. (Source: Current Chemical Biology)
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
An Insight to the Toxic Effect of Sulfamerazine on Porcine Pancreatic Amylase and Lactate Dehydrogenase Activity: An In Vitro Study
Conclusion: Detailed study is to be conducted to confirm whether the molecular scaffold of Sulfamerazine might serve as an effective repurposed drug acting as a lead molecule to design antidiabetic drugs of future use. Alternatively, it should be prescribed with caution under specific medical situations like diabetes, cancer and hepatic disorders manifesting lactic acidosis to avoid the crisis. (Source: Current Chemical Biology)
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
Synthesis and Antibacterial Activity of New Chalcones Bearing an Imidazo[ 1,2-a]pyridine Moiety
Conclusion: The synthesized antibacterial compounds were obtained with appealing advantages such as high purity, simple pathway, good to excellent yields, inexpensive and easy availability of materials as well as good activities against bacteria. So in this work, a new class of antibacterial chalcones based on imidazo[1,2-a]pyridine has been reported. (Source: Current Chemical Biology)
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
Cyclin-Dependent Kinase as a Novel Therapeutic Target: An Endless Story
Cyclin-Dependent Kinases (CDKs) are a family of enzymes that, along with their Cyclin partners, play a crucial role in cell cycle regulation at many biological functions such as proliferation, differentiation, DNA repair, and apoptosis. Thus, they are tightly regulated by a number of inhibitory and activating enzymes. Deregulation of these kinases’ activity either by amplification, overexpression or mutation of CDKs or Cyclins leads to uncontrolled proliferation of cancer cells. Hyperactivity of these kinases has been reported in a wide variety of human cancers. Hence, CDKs have been established as one of the most attrac...
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
Serum Biomarkers for Noninvasive Diagnosis of Liver Diseases: How Laudable are These Tools?
Innumerable reasons have been reported that affect and infect the liver and cause liver diseases. The evaluation and follow-up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, it has become evident that this once defined as “gold-standard” is now not the best method as it involves many limitations. Attempts to reveal non-invasive diagnostic tools have generated serum biomarkers, multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and are less expensive than a liver biopsy. Biomarkers have various advantages like m...
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
Meet the Editorial Board Member
(Source: Current Chemical Biology)
Source: Current Chemical Biology - August 9, 2021 Category: Biochemistry Source Type: research
Prostaglandin E2 Receptor 4 (EP4): A Promising Therapeutic Target for the Treatment of Cancer and Inflammatory Diseases
Prostaglandin E2 (PGE2) is involved in several biological processes, including inflammation, pain, fever, renal function, mucosal integrity, angiogenesis and tumor growth. PGE2 receptor subtypes (EP1-4) play pivotal roles in PGE2-mediated biological events. Recent studies revealed the fact that EP4 is commonly upregulated in cancer to stimulate cell proliferation, migration, invasion, and metastasis. Additionally, the EP4 receptor has a role in several anti-inflammatory processes, bone formation and hemostasis. EP4 receptor modulators can be used as drugs of specific interest. A number of EP4 receptor agonists and antagoni...
Source: Current Chemical Biology - April 27, 2021 Category: Biochemistry Source Type: research
Ovarian Cancer Biomarkers: Headway Towards Early Diagnosis
The advancements in cancer treatment have no significant effect on ovarian cancer [OC]. The lethality of the OC remains on the top list of gynecological cancers. The long term survival rate of the OC patients with the advanced stage is less than 30%. The only effective measure to increase the survivability of the patient is the detection of disease in stage I. The earlier the diagnosis, the more will be the chances of survival of the patient. But due to the absence of symptoms and effective diagnosis, only a few % of OC are detected in stage I. A valid, reliable having a high acceptance test is imperative to detect OC in i...
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Molecular Processes Involved in Pancreatic Cancer and Therapeutics
Despite advances in the development of cytotoxic and targeted therapies, pancreatic adenocarcinoma (PAC) remains a significant cause of cancer mortality worldwide. It is also difficult to detect it at an early stage due to a number of factors. Most of the patients are present with locally advanced or metastatic disease, which precludes curative resection. In the absence of effective screening methods, considerable efforts have been made to identify better systemic treatments during the past decade. This review describes the recent advances in molecular mechanisms involved in pancreatic cancer initiation, progression, and m...
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Understanding Molecular Process and Chemotherapeutics for the Management of Breast Cancer
Breast cancer is the most common and highly heterogeneous neoplastic disease comprised of several subtypes with distinct molecular etiology and clinical behaviours. The mortality observed over the past few decades and the failure in eradicating the disease is due to the lack of specific etiology, molecular mechanisms involved in the initiation and progression of breast cancer. Understanding of the molecular classes of breast cancer may also lead to new biological insights and eventually to better therapies. The promising therapeutic targets and novel anti-cancer approaches emerging from these molecular targets that could b...
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Prostaglandin E2 Receptor 4 (EP4): A Promising Therapeutic Target for the Treatment of Cancer and Inflammatory Diseases
Prostaglandin E2 (PGE2) is involved in several biological processes, including inflammation, pain, fever, renal function, mucosal integrity, angiogenesis and tumor growth. PGE2 receptor subtypes (EP1-4) play pivotal roles in PGE2-mediated biological events. Recent studies revealed the fact that EP4 is commonly upregulated in cancer to stimulate cell proliferation, migration, invasion, and metastasis. Additionally, the EP4 receptor has a role in several anti-inflammatory processes, bone formation and hemostasis. EP4 receptor modulators can be used as drugs of specific interest. A number of EP4 receptor agonists and antagoni...
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Therapies of Hematological Malignancies: An Overview of the Potential Targets and Their Inhibitors
Conclusion: The correlation of physiological proteins with cancerous hematological conditions has been discussed here. These can be crucial for the development of potent inhibitors as chemotherapeutic agents to contest such malignancies. This review will also be useful in the chemotherapeutic agent development by providing crucial information about such hematological malignancy-related proteins and their inhibitors. The repurposed drugs with potential for anticancer applications are also discussed. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Targeting Protein Degradation in Cancer Treatment
The ubiquitin proteasome system (UPS) is a crucial protein degradation pathway that involves several enzymes to maintain cellular protein homeostasis. This system has emerged as a major drug target against certain types of cancer as a disruption at the cellular level of UPS enzyme components forces the transformation of normal cell into cancerous cell. Although enormous advancements have been achieved in the understanding of tumorigenesis, efficient cancer therapy remains a goal towards alleviating this serious health issue. Since UPS has become a promising target for anticancer therapies, herein, we provide comprehensive ...
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Molecular Processes in Cancers and Cancer Chemotherapy
(Source: Current Chemical Biology)
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
