A Comparison of Ultrasound and Fluoroscopy-guided Celiac Plexus Neurolysis in Patients with Pancreatic Cancer
Conclusion: The study revealed that ultrasound-guided celiac plexus neurolysis is more durable, tolerable, effective and safe compared to fluoroscopy-guided neurolysis of patient suffering from pancreatic cancer pain. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Modern Treatments for Gliomas Improve Outcome
Glioma is the most common type of tumor in the central nervous system (CNS). Diagnosis is through history, physical examination, radiology, histology and molecular profiles. Magnetic resonance imaging is a standard workup for all CNS tumors. Multidisciplinary team management is strongly recommended. The management of low-grade gliomas is still controversial with regards to early surgery, radiotherapy, chemotherapy, or watchful waiting watchful waiting. Patients with suspected high-grade gliomas should undergo an assessment by neurosurgeons for the consideration of maximum safe resection to achieve optimal tumor debulking, ...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Overview of Modern Surgical Management of Central Nervous System Tumors: North American Experience
A wide variety of neoplasms can affect the central nervous system. Surgical management is impacted by tumor biology and anatomic location. In this review, an overview is presented of common and clinically significant CNS tumor types based on anatomic location. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Central Nervous System Neoplasms in Hong Kong: An Inscription of Local Studies
A registry of brain and central nervous system (CNS) tumor patients in Hong Kong comprising of data from both public and private neurosurgical practices (with approximately 98% patients of Chinese origin), suggested geographical or racial variations in disease incidence. The data confers the finding of a comparatively lower incidence rate of meningioma and malignant gliomas as in other parts of Southeast Asia. With data suggesting epidemiological difference, the treatment response, particularly in highgrade glioma, was studied. Patients suffering from glioblastoma (GBM) in Hong Kong received the standard of care, which inv...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Radiotherapy for Brain Tumors: Current Practice and Future Directions
Radiotherapy is an important component of the treatment for primary and metastatic brain tumors. Due to the close proximity of critical structures and normal brain parenchyma, Central Nervous System (CNS) radiotherapy is associated with adverse effects such as neurocognitive deficits, which must be weighed against the benefit of improved tumor control. Advanced radiotherapy technology may help to mitigate toxicity risks, although there is a paucity of high-level evidence to support its use. Recent advances have been made in the treatment for gliomas, meningiomas, benign tumors, and metastases, although outcomes remain poor...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Metastatic Brain Tumors: To Treat or Not to Treat, and with What?
A long time ago, metastatic brain tumors were often not treated and patients were only given palliative care. In the past decade, researchers selected those with single or 1-3 metastases for more aggressive treatments like surgical resection, and/or stereotactic radiosurgery (SRS), since the addition of whole brain radiotherapy (WBRT) did not increase overall survival for the vast majority of patients. Different studies demonstrated significantly less cognitive deterioration in 0-52% patients after SRS versus 85-94% after WBRT at 6 months. WBRT is the treatment of choice for leptomeningeal metastases. WBRT can lower the ri...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
The Ever Changing Treatments for Tumors of the Central Nervous System
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
Development of MatLab Coding for Early Detection of Leukemia through Automated Analysis of RBCs
Background: Bone marrow biopsy has become an integral part of leukemia diagnosis and its treatment. Several advancements are being made towards the analysis of digital images of biopsy samples. Recently, the FDA approved the procedures of digital health. In tune with that, digital image analysis has become propelled. With the advent of high-throughput technologies, the scientific community focuses on the red blood cells (RBCs) for early detection of cancer, including leukemia. The reasons are due to their abundance in peripheral blood and hence, easily accessible compared to the bone marrow biopsy procedure. High magnifica...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts
Conclusion: The particle size of nanoparticles was found to lie in the range of 10 to 50 nm. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Dickkopf-1 and β-catenin as Biomarkers for Early Diagnosis of Hepatocellular Carcinoma
Background & Aims: The clinical value of alpha-fetoprotein (AFP) as a marker to detect early hepatocellular carcinoma (HCC) has been questioned owing to its low sensitivity and specificity. The purpose of this work was to investigate whether serum Wnt/β-catenin and DKK1 levels in chronic hepatitis C patients could be used as early predictors for the risk of HCC development. Methods: The study was conducted on 37 healthy controls, and 150 CHC patients were divided into three groups: CHC, liver cirrhosis (LC), and HCC patients. AFP, AFP-L3, β-catenin, and DKK-1 were assayed by ELISA. Results: Both β-catenin an...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Demographic and Clinical Evaluation of Patients with Pancreatic Cancer in Mashhad University of Medical Sciences During 2002-2013
This study includes all data from real charts of patients with a definitive diagnosis of pancreatic cancer, admitted to Ghaem, Imam Reza, and Omid hospitals from 2002 to 2013. All the data which were available in lab results, exams, and patient files, were used accordingly. Results: 348 pancreatic cancer patients entered the study. About 61.5% of the subjects were men. Mean age was 59.67±14.37 years. Main complaints were abdominal pain (42.53%), jaundice (13.79%) or both (37.07%). We found a positive history of cancer in the first-degree relatives of 3.7% of patients, with the most prevalent being gastric cancer (46.1%). ...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Solanum nigrum Anticancer Effect Through Epigenetic Modulations in Breast Cancer Cell Lines
Background: DNA methylation plays an important role in the regulation of gene expression in mammalian cells and often occurs at CpG islands in the genome. It is more reversible than genetic variations and has therefore attracted much attention for the treatment of many diseases, especially cancer. In the present study, we investigated the effect of Solanum nigrum Extract (SNE) on the methylation status of the VIM and CXCR4 genes in breast cancer cell lines. Methods: The Trypan blue assay was used to study the effect of SNE at various concentrations of 0, 0.1, 1.5, 2.5, 3.5 and 5 mg/ml for 48 h on the survival of three huma...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Brachial Plexopathy as a Complication of Radiotherapy: A Systematic Review
Conclusion: From our findings, we can conclude that the issue of radiation-induced brachial plexus complication in human is of great concern. Common symptoms associated with this complication include paresthesia, numbness, pain and weakness. We recommend the use of individual dose planning and computer-assisted image segmentation techniques that support rapid and reliable contouring of the brachial plexus. Also, the radiation dose to the brachial plexus should be limited as much as possible to reduce the risk of brachial plexopathy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
New Researches about Combinatorial Therapeutic Regimen on Cancer Treatment
Cancer is a refractory disease, which brings physical, mental and economic sufferings on patients and their families. The activation of oncogenes and/or the deletion of tumor repressors result in uncontrolled tumor survival and proliferation. Therapeutic resistance and cancer recurrence are common issues during the course of clinical treatment. Since each single treatment can’t eradicate tumor cells completely, the development of combinatorial therapeutic regimen is in the spotlight for several decades. Combinatorial therapeutic regimen, a treatment modality that combines two or more therapeutic agents, targets key pathw...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
