Role of Phytochemicals in the Treatment of Breast Cancer: Natural Swords Battling Cancer Cells
Breast cancer is the most common type of malignancy among ladies (around 30% of newly diagnosed patients every year). To date, various modern treatment modalities for breast cancer, such as radiotherapy, surgical method, hormonal therapy, and chemotherapeutic drug utilisation, are available. However, adverse drug reactions, therapeutic resistance, metastasis, or cancer reoccurrence chances remain the primary causes of mortality for breast cancer patients. To overcome all the potential drawbacks, we need to investigate novel techniques and strategies that are not considered previously to treat breast cancer effectively with...
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review
Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechn...
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Meet the Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Anti-carcinogenic Effect of Cathepsin K Inhibitor, Odanacatib with a Low Dose of Cisplatin Against Human Breast Carcinoma MCF-7 and MDA-MB231 Cells
Conclusion: This study highlights the potential effects of the combination of ODN with a reduced dose of cisplatin on improving the growth inhibition and apoptosis-inducing effect on breast cancer cells via combined inhibition of NF-κB-induced IL-6 and STAT3 activation. The study result suggests that the further development of this novel inhibitor in combination with a low dose of standard cisplatin-based chemotherapy may contribute to an alternative treatment option for certain cancers. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Current and Future Scenario of Immunotherapy for the Treatment of Hepatocellular Carcinoma
The discovery of the immune checkpoint inhibitors such as programed cell death-1 protein/ Programmed death ligand-1 or 2 and (PD-1/PD-L1 or PD-L2) and Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) paved the way for developing novel cancer treatment. The check point inhibitors are found to be very efficient in treating many hot tumors (with immune environment) such as bladder cancer, melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), etc. Numerous clinical trials have been initiated to evaluate the safety and effectiveness of immune checkpoint inhibitors for patients with different cancer types...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Combination Therapy of Cisplatin and other Agents for Osteosarcoma: A Review
Conclusion: Conclusively, a combination of cisplatin with selected chemotherapeutic drugs has been shown to be effective. However, the unchanged survival rate has posed an urge to search for a new combination regimen. As a collaborative effort to substantiate the therapeutic efficacy, the combination with phytochemical compounds shows a promising response both in vitro as well as in the preclinical study. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Ewing Sarcoma Family Tumors: Past, Present and Future Prospects
Ewing’s sarcoma (ES), also known as mesenchymal primitive neuroectodermal tumor (PNET), is a malignant round blue cell tumor (MRBCT) with a varying degree of neuronal differentiation. PNET arises from the primitive nerve cells of the central nervous system (CNS) but may also occur in the bones of the extremities, pelvis, vertebral column, and chest wall. Extraskeletal ES/PNET may affect the various soft tissues, including those of the pelvis, paraspinal region, and thoracopulmonary region. Histopathological differentiation between ES, PNET, and other related sarcomas is often difficult. On light microscopy, the same hist...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Molecular Biomarkers for Lung Adenocarcinoma: A Short Review
Lung cancer is a disease with higher death rates and is responsible for around 2 million deaths per year worldwide. Recently, several breakthroughs have been made in the field of lung cancer that has led to a revolution in the management of lung cancer patients. Identification of molecular markers and the implication of respective targeted therapies has been a great success in the treatment of lung adenocarcinoma patients. Despite the fact that targeted therapy of lung adenocarcinomas represents one of the significant milestones in the treatment of lung cancer that resulted in increased survival rates even in advanced stag...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Discussion on the Paper “Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Wahed Hasona et al.
This report outlines some of these mistakes with suggested corrections to attract the readers' attention through a more in-depth insight into analyzing and exposing these defects. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Glioblastoma Multiforme and its Cell Interruption
Glioblastoma (GBM) is a fatal type of brain cancer or primary glial neoplasm, mostly targeting aged populations. The average survival is only 15 months from the date of occurrence. It is often observed that, the invasive nature of the tumour is the main reason for poor prognosis and strong recurrence of GBM in patients even after prescribed treatments. Despite all types of therapies, it is necessary to understand the various molecular mechanisms and signalling pathways to identify targets for GBM treatment. This compilation is specifically designed to discuss Wnt signalling and Hedgehog-GLI1 pathways, which have positive a...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research
Anti-proliferative and Apoptosis Induction Activity of Rhizome Extracts of Paris polyphylla Smith on Oral Cancer Cell
Conclusion: The present study revealed that P. polyphylla collected from Meghalaya has an anti-proliferative capacity to inhibit the multiplication of the SAS cells. In comparison to PPRMCE extract, PPR-ECE was found to be more effective against SAS proliferation. Though the anticancer property of the herb is well documented, this investigation is the first report on the effects of P. polyphylla extracts against SAS oral cancer cells. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
HLA-DQ Gene Polymorphisms Associated with Hepatitis B Virus in Patients with Hepatocellular Carcinoma Progression
Conclusion: We found that AA and GA haplotype was significantly most frequent in HCC. Our findings suggest that HLA-DQ AA and GG polymorphism might serve as a novel potential predictive marker for HCC and may function in tumorigenesis of HBV. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
A Review on Phytopharmaceuticals having Concomitant Experimental Anti-diabetic and Anti-cancer Effects as Potential Sources for Targeted Therapies Against Insulin-mediated Breast Cancer Cell Invasion and Migration
Diabetes and breast cancer are pathophysiologically similar and clinically established diseases that co-exist with a wider complex similar molecular signalling and having a similar set of risk factors. Insulin plays a pivotal role in the invasion and migration of breast cancer cells. Several ethnopharmacological evidences shed light on the concomitant anti-diabetic and anti-cancer activity of medicinal plant and phytochemicals against breast tumors of patients with diabetes. This present article reviewed the findings on medicinal plants and phytochemicals with concomitant antidiabetic and anti-cancer effects reported in sc...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
An Overview of High-grade Glioma: Current and Emerging Treatment Approaches
High grade glioma is one of the severe form of tumour that progresses in the glial cells of the brain and spinal cord. Age, gender, exposure to infections, race, ethnicity, viruses and allergens, environmental carcinogens, diet, head injury or trauma and ionizing radiation may report with increased glioma risk. Headache, seizure mainly generalized tonic-clonic seizure, memory loss and altered sensorium are considered as common symptoms of glioma. Magnetic Resonance Imaging (MRI), CT scans, neurological examinations and biopsy are considered as the diagnostic option for glioma. Treatment for glioma mainly depended upon the ...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
