Acknowledgements to Reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Corrigendum to: Discussion on the paper “Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Wahed Hasona et al.
Discussion on the paper Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Mostafa A. Elogail in “Current Cancer Therapy Reviews”, 2021; 17(2), 93-6. We regret the error and apologize to the readers. The original article can be found online at https://www.eurekaselect.com/189490/article (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

An Analysis of Structure-function Co-relation between GLI Oncoprotein and HLA Immune-gene Transcriptional Regulation through Molecular Docking
Conclusion: This study suggests that HLA class I may not be downregulated by GLI; however, over-expression of GLI1 is may be responsible for HLA class II downregulation. Thus this protein may be responsible for the maintenance of the undifferentiated state of malignant cells. This study also suggests the implicative role of GLI1 in the early definitive stage of hematopoiesis. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Expression of a Disintegrin and Metalloprotease 10 Gene Polymorphisms in a Cohort of Egyptian Patients with Hepatocellular Carcinoma
This study involved 201 cases divided: Group I (67 HCC patients), Group II (67 cirrhotic patients), Group III (67 control). Each group was subjected to laboratory investigations: (CBC, blood sugar, kidney and liver function, viral markers, alpha fetoprotein), imaging: (abdominal ultrasonography, and triphasic C.T) and ADAM 10 gene polymorphism (rs 653765, rs 383902) detection by real – time PCR. Results: There was a statistically significant difference in the frequency and genotyping of ADAM10 SNPs in HCC patients in comparison to cirrhotic and control groups [the frequency of rs 653765 genotypes (p=0.015) and model ...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Emerging Role of Wnt/Beta-Catenin Signalling Pathways in Cancer Progression and Role of Small Molecule Tankyrase Inhibitors in Combating Multistage Cancers
In the present review, an attempt has been made to summarize the development of various Tankyrase inhibitors focussing on Wnt/beta-Catenin pathways along with other cancer targets. The last decade witnessed a plethora of research related to the role of various genetic and epigenetic events that are responsible for the progression of multistage cancers. As a result, the discovery of various signalling pathways responsible for the development of different types of cancers has resulted in the development of molecularly targeted anticancer agents. Out of the many signalling pathways, the Wnt/beta-Catenin pathways have attracte...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Oxidative Stress and Cellular Senescence: The Key Tumor-promoting Factors in Colon Cancer and Beneficial Effects of Polyphenols in Colon Cancer Prevention
Conclusion: This review facilitates a better understanding and might contribute to diagnostic and prognostic systems as well as to find out the novel and targeted therapeutic approaches. Additionally, we focused on the potential role of natural flavonoids in colon cancer therapies and highlighting the flavonoid-based treatments as innovative immunomodulatory strategies to inhibit the growth of colon cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Therapeutic Application of Melatonin in the Treatment of Melanoma: A Review
Melanoma is an aggressive type of skin cancer, which is responsible for more deaths than nonmelanoma skin cancers. Therapeutic strategies include targeted therapy, biochemotherapy, immunotherapy, photodynamic therapy, chemotherapy, and surgical resection. Depending on the clinical stage, single or combination therapy may be used to prevent and treat cancer. Due to resistance development during treatment courses, the efficacy of mentioned therapies can be reduced. In addition to resistance, these treatments have serious side effects for melanoma patients. According to available reports, melatonin, a pineal indolamine with a...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Recent Advancements for the Management of Pancreatic Cancer: Current Insights
One of the most fatal forms of cancer includes cancer of the pancreas And the most rapid malignancy is observed in PDAC (pancreatic ductal adenocarcinoma). The high lethality rate is generally due to very late diagnosis and resistance to traditional chemotherapeutic agents. Desmoplastic stromal barrier results in resistance to immunotherapy. Other reasons for the high lethality rate include the absence of effective treatment and standard screening tests. Hence, there is a need for effective novel carrier systems. “A formulation, method, or device that allows the desired therapeutic substance to reach its site of acti...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Bioinformatics Approach for Data Capturing: The Case of Breast Cancer
Conclusion: Bioinformatics is the evolutionary approach that is used for the capturing of data from the various case studies related to breast cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Efficacy and Safety of PEGPH20 in Pancreatic Cancer: Systematic Review and Meta-analysis
Conclusion: This meta-analysis showed that PEGPH20 did not improve the PFS or OS. Moreover, there was an increased incidence of serious adverse events using PEGPH20 compared to standard therapies. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research

Effect of Conventional Chemotherapies on Natural Killer Cell Activity
Conclusion: Conventional chemotherapy seems to have no effect on NK cell activity levels in cancer patients in both metastatic and adjuvant settings. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Rectal Cancer in Patients Younger than 40: Tumor Characteristics and Comparative Survival Based on a Single Institution
Aim: The aim of this study was to determine tumor characteristics and outcomes of patients with rectal cancer (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Adverse Effects and Safety of Etirinotecan Pegol, a Novel Topoisomerase Inhibitor, in Cancer Treatment: A Systematic Review
Conclusion: Therefore, Etirinotecan Pegol may represent a major contribution to the treatment of various cancers in the future. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Breast Cancer: A Review of Risk Factors and New Insights into Treatment
Today, despite significant advances in cancer treatment have been made, breast cancer remains one of the main health problems and considered a top biomedical investigation urgency. The present study reviewed the common conventional chemotherapy agents and also some alternative and complementary approaches such as oncolytic virotherapy, bacteriotherapy, nanotherapy, immunotherapy, and natural products, which are recommended for breast cancer treatment. In addition to current surgery approaches such as mastectomy, in recent years, a number of novel techniques such as robotic mastectomies, nipple-sparing mastectomy, skin-spar...
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Liver Cancer: New Insights into Surgical and Nonsurgical Treatments
Conclusion: Multidisciplinary and multi-choice treatments and therapies are available for this liver cancer, while there are differences in liver cancer management recommendations among specialties and geographic areas. Current results have shown that treatment strategies have been combined with the advancement of novel treatment modalities. In addition, the use of new approaches with greater efficacy, such as combination therapy, biomaterials, ablation therapy, etc. can be considered the preferred treatment for patients. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Role of Phytochemicals in the Treatment of Breast Cancer: Natural Swords Battling Cancer Cells
Breast cancer is the most common type of malignancy among ladies (around 30% of newly diagnosed patients every year). To date, various modern treatment modalities for breast cancer, such as radiotherapy, surgical method, hormonal therapy, and chemotherapeutic drug utilisation, are available. However, adverse drug reactions, therapeutic resistance, metastasis, or cancer reoccurrence chances remain the primary causes of mortality for breast cancer patients. To overcome all the potential drawbacks, we need to investigate novel techniques and strategies that are not considered previously to treat breast cancer effectively with...
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review
Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechn...
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Meet the Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research

Anti-carcinogenic Effect of Cathepsin K Inhibitor, Odanacatib with a Low Dose of Cisplatin Against Human Breast Carcinoma MCF-7 and MDA-MB231 Cells
Conclusion: This study highlights the potential effects of the combination of ODN with a reduced dose of cisplatin on improving the growth inhibition and apoptosis-inducing effect on breast cancer cells via combined inhibition of NF-κB-induced IL-6 and STAT3 activation. The study result suggests that the further development of this novel inhibitor in combination with a low dose of standard cisplatin-based chemotherapy may contribute to an alternative treatment option for certain cancers. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Current and Future Scenario of Immunotherapy for the Treatment of Hepatocellular Carcinoma
The discovery of the immune checkpoint inhibitors such as programed cell death-1 protein/ Programmed death ligand-1 or 2 and (PD-1/PD-L1 or PD-L2) and Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) paved the way for developing novel cancer treatment. The check point inhibitors are found to be very efficient in treating many hot tumors (with immune environment) such as bladder cancer, melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), etc. Numerous clinical trials have been initiated to evaluate the safety and effectiveness of immune checkpoint inhibitors for patients with different cancer types...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Combination Therapy of Cisplatin and other Agents for Osteosarcoma: A Review
Conclusion: Conclusively, a combination of cisplatin with selected chemotherapeutic drugs has been shown to be effective. However, the unchanged survival rate has posed an urge to search for a new combination regimen. As a collaborative effort to substantiate the therapeutic efficacy, the combination with phytochemical compounds shows a promising response both in vitro as well as in the preclinical study. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Ewing Sarcoma Family Tumors: Past, Present and Future Prospects
Ewing’s sarcoma (ES), also known as mesenchymal primitive neuroectodermal tumor (PNET), is a malignant round blue cell tumor (MRBCT) with a varying degree of neuronal differentiation. PNET arises from the primitive nerve cells of the central nervous system (CNS) but may also occur in the bones of the extremities, pelvis, vertebral column, and chest wall. Extraskeletal ES/PNET may affect the various soft tissues, including those of the pelvis, paraspinal region, and thoracopulmonary region. Histopathological differentiation between ES, PNET, and other related sarcomas is often difficult. On light microscopy, the same ...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Molecular Biomarkers for Lung Adenocarcinoma: A Short Review
Lung cancer is a disease with higher death rates and is responsible for around 2 million deaths per year worldwide. Recently, several breakthroughs have been made in the field of lung cancer that has led to a revolution in the management of lung cancer patients. Identification of molecular markers and the implication of respective targeted therapies has been a great success in the treatment of lung adenocarcinoma patients. Despite the fact that targeted therapy of lung adenocarcinomas represents one of the significant milestones in the treatment of lung cancer that resulted in increased survival rates even in advanced stag...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Discussion on the Paper “Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Wahed Hasona et al.
This report outlines some of these mistakes with suggested corrections to attract the readers' attention through a more in-depth insight into analyzing and exposing these defects. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Glioblastoma Multiforme and its Cell Interruption
Glioblastoma (GBM) is a fatal type of brain cancer or primary glial neoplasm, mostly targeting aged populations. The average survival is only 15 months from the date of occurrence. It is often observed that, the invasive nature of the tumour is the main reason for poor prognosis and strong recurrence of GBM in patients even after prescribed treatments. Despite all types of therapies, it is necessary to understand the various molecular mechanisms and signalling pathways to identify targets for GBM treatment. This compilation is specifically designed to discuss Wnt signalling and Hedgehog-GLI1 pathways, which have positive a...
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2021 Category: Cancer & Oncology Source Type: research

Anti-proliferative and Apoptosis Induction Activity of Rhizome Extracts of Paris polyphylla Smith on Oral Cancer Cell
Conclusion: The present study revealed that P. polyphylla collected from Meghalaya has an anti-proliferative capacity to inhibit the multiplication of the SAS cells. In comparison to PPRMCE extract, PPR-ECE was found to be more effective against SAS proliferation. Though the anticancer property of the herb is well documented, this investigation is the first report on the effects of P. polyphylla extracts against SAS oral cancer cells. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

HLA-DQ Gene Polymorphisms Associated with Hepatitis B Virus in Patients with Hepatocellular Carcinoma Progression
Conclusion: We found that AA and GA haplotype was significantly most frequent in HCC. Our findings suggest that HLA-DQ AA and GG polymorphism might serve as a novel potential predictive marker for HCC and may function in tumorigenesis of HBV. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

A Review on Phytopharmaceuticals having Concomitant Experimental Anti-diabetic and Anti-cancer Effects as Potential Sources for Targeted Therapies Against Insulin-mediated Breast Cancer Cell Invasion and Migration
Diabetes and breast cancer are pathophysiologically similar and clinically established diseases that co-exist with a wider complex similar molecular signalling and having a similar set of risk factors. Insulin plays a pivotal role in the invasion and migration of breast cancer cells. Several ethnopharmacological evidences shed light on the concomitant anti-diabetic and anti-cancer activity of medicinal plant and phytochemicals against breast tumors of patients with diabetes. This present article reviewed the findings on medicinal plants and phytochemicals with concomitant antidiabetic and anti-cancer effects reported in sc...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

An Overview of High-grade Glioma: Current and Emerging Treatment Approaches
High grade glioma is one of the severe form of tumour that progresses in the glial cells of the brain and spinal cord. Age, gender, exposure to infections, race, ethnicity, viruses and allergens, environmental carcinogens, diet, head injury or trauma and ionizing radiation may report with increased glioma risk. Headache, seizure mainly generalized tonic-clonic seizure, memory loss and altered sensorium are considered as common symptoms of glioma. Magnetic Resonance Imaging (MRI), CT scans, neurological examinations and biopsy are considered as the diagnostic option for glioma. Treatment for glioma mainly depended upon the ...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

The Role of Bacterial Superantigens in the Immune Response: From Biology to Cancer Treatment
Conclusion: Superantigens induce the proliferation of T lymphocytes and antigen-presenting cells by binding to MHCII molecules and V beta regions in T cell receptors. Therefore, the presentation of tumor cell antigens is increased. Additionally, the production of important cytokines by T cells and APCs contributes to the stimulation of immune response against tumor cells. The manipulation of bacterial vector systems through incorporating genesrelated to SAgs and other immune response factors is a good strategy for the immune system stimulating and eradicating tumor cells along with other immunotherapy agents. (Source: Curr...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

Carbohydrate-functionalized Liposomes in Cancer Therapy
Existing cancer treatments are often accompanied by adverse side effects that can greatly reduce the quality of life of cancer patients; this sets the platform for the development and application of nanocarrier-based platforms for the delivery of anticancer drugs. Among these nanocarriers, liposomes have demonstrated excellent potential in drug delivery applications. Furthermore, the overexpression of certain receptors on cancer cells has led to the development of active targeting approaches where liposome surfaces are decorated with ligands against these receptors. Given the central role that sugars play in cancer biology...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

Preface
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research

Acknowledgements to Reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Titanium Oxide Nanoparticles Improve the Chemotherapeutic Action of Erlotinib in Liver Cancer Cells
Conclusion: Our data showed that loading ERL on TiO2NPs was more efficient than AuNPs. However, both nanocarriers were efficient compared with control. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Association of CA 15-3 and CEA with Liver Metastases in Patients with Breast Cancer
Conclusion: The increase in the levels of CEA and ALP can be diagnostic markers for liver metastases from breast cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Drug Delivery Approaches for Doxorubicin in the Management of Cancers
Conclusion: In the review, we described the significance of DOX in the form of different delivery approaches in the management of cancers with a reduction in the associated toxicity. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Immunoliposomes: Synthesis, Structure, and their Potential as Drug Delivery Carriers
Immunoliposomes have emerged as attractive drug targeting vehicles for cancer treatment. This review presents the recent advances in the design of immunoliposomes encapsulating a variety of chemotherapeutic agents. We provided an overview of different routes that can be used to conjugate antibodies to the surfaces of liposomes, as well as several examples of stimuliresponsive immunoliposome systems and their therapeutic potential for cancer treatment. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

The Important Role of Oncolytic Viruses in Common Cancer Treatments
Oncolytic viruses (OV) are considered as promising tools in cancer treatment. In addition to direct cytolysis, the stimulation of both innate and adaptive immune responses is the most important mechanism in oncolytic virotherapy that finally leads to the long-standing tumor retardations in the advanced melanoma clinical trials. The OVs have become a worthy method in cancer treatment, due to their several biological advantages including (1) the selective replication in cancer cells without affecting normal cells; (2) the lack of resistance to the treatment; (3) cancer stem cell targeting; (4) the ability to be spread; and (...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Hepatoblastoma: Review of Pathology, Diagnosis and Modern Treatment Strategies
Hepatoblastoma (HB) is the most common primary malignant hepatic tumor of childhood and, occurring predominantly in the first two years of life. Approximately 100 cases are diagnosed every year in the United States of America. The management of HB has changed markedly over the last three decades. Alfa feto protein (AFP) and beta human chorionic gonadotrophin (beta HCG) are the main tumor markers and are markers for diagnosis and follow up. International collaborative efforts have led to the implementation of the Pre - Treatment Extent of the Disease PRETEXT staging system consensus classification to assess upfront resectab...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

MiR-492 as an Important Biomarker for Early Diagnosis and Targeted Treatment in Different Cancers
Recent studies have led to a more detailed understanding of the roles played by microRNAs in health and disease, and their potential use as biomarkers in physiological and pathophysiological processes involving cancer initiation and progression. MiR-492 is encoded by a pseudogene, has a key role in some human cancer cells and its overexpression in tissues, and it has been proposed that it can be used as a good biomarker for management and early diagnosis of some cancers including breast cancer, colorectal and ovarian cancer, hepatocellular cancer, retinoblastoma and pancreatic cancer. The aim of this review was to summariz...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Exploring Nanoemulsion for Liver Cancer Therapy
Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. Among these, at least 0.78 million people died of liver cancer alone. The recognized risk factors for liver cancer include chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, exposure to dietary aflatoxin, fatty liver disease, alcohol-induced cirrhosis, obesity, smoking, diabetes, and iron overload. The treatment plan for early diagnosed patients includes radiation therapy, tumour ablation, surgery, immunotherapy, and chemotherapy. Some sort of drug delivery vehicles has to be used when the treatment plan is targ...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research

Vagaries of the Host Response in the Development of Hepatitis B-related Hepatocellular Carcinoma: A Case Series
The hepatitis B virus (HBV) is one of the leading causes of hepatocellular carcinoma (HCC) worldwide. In the endemic region, the infection is commonly spread through vertical transmission in which mother and child possess genetically identical viral genotypes in the setting of similar host genomes. Despite these genetic similarities, clinical outcomes from chronic hepatitis B (CHB) can vary widely, ranging from lifelong asymptomatic infection to terminal HCC. Presented here are the longitudinal observations over multiple decades of three family clusters, including monozygotic twins with non-discordant HCC, that demonstrate...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research

A Comparison of Ultrasound and Fluoroscopy-guided Celiac Plexus Neurolysis in Patients with Pancreatic Cancer
Conclusion: The study revealed that ultrasound-guided celiac plexus neurolysis is more durable, tolerable, effective and safe compared to fluoroscopy-guided neurolysis of patient suffering from pancreatic cancer pain. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research

Modern Treatments for Gliomas Improve Outcome
Glioma is the most common type of tumor in the central nervous system (CNS). Diagnosis is through history, physical examination, radiology, histology and molecular profiles. Magnetic resonance imaging is a standard workup for all CNS tumors. Multidisciplinary team management is strongly recommended. The management of low-grade gliomas is still controversial with regards to early surgery, radiotherapy, chemotherapy, or watchful waiting watchful waiting. Patients with suspected high-grade gliomas should undergo an assessment by neurosurgeons for the consideration of maximum safe resection to achieve optimal tumor debulking, ...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research

Overview of Modern Surgical Management of Central Nervous System Tumors: North American Experience
A wide variety of neoplasms can affect the central nervous system. Surgical management is impacted by tumor biology and anatomic location. In this review, an overview is presented of common and clinically significant CNS tumor types based on anatomic location. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research

Central Nervous System Neoplasms in Hong Kong: An Inscription of Local Studies
A registry of brain and central nervous system (CNS) tumor patients in Hong Kong comprising of data from both public and private neurosurgical practices (with approximately 98% patients of Chinese origin), suggested geographical or racial variations in disease incidence. The data confers the finding of a comparatively lower incidence rate of meningioma and malignant gliomas as in other parts of Southeast Asia. With data suggesting epidemiological difference, the treatment response, particularly in highgrade glioma, was studied. Patients suffering from glioblastoma (GBM) in Hong Kong received the standard of care, which inv...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research

Radiotherapy for Brain Tumors: Current Practice and Future Directions
Radiotherapy is an important component of the treatment for primary and metastatic brain tumors. Due to the close proximity of critical structures and normal brain parenchyma, Central Nervous System (CNS) radiotherapy is associated with adverse effects such as neurocognitive deficits, which must be weighed against the benefit of improved tumor control. Advanced radiotherapy technology may help to mitigate toxicity risks, although there is a paucity of high-level evidence to support its use. Recent advances have been made in the treatment for gliomas, meningiomas, benign tumors, and metastases, although outcomes remain poor...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research