A Connecting Switch Among Aging, Diabetes and Tumor: Avenue Leading to Cancer Therapeutics
In recent, curiosity is at the forefront to understand the complexity of cancer driven by genetic, molecular and epigenetic programming due to life style, environmental pressure and metabolite adaptations. On the other hand, complex and heterogeneous nature of cancer is linked to the metabolic and molecular landscape of diabetic complications. This Letter to editor connects the dots and highlights the need to view cancer beyond the mirror of genetic and epigenetic aberration as metabolic disturbances. In this commentary, the author highlights the major contributions from two elegant papers from Cha et al. (2018) and Wu et ...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Chitosan Nanoparticles as a Carrier for Indigofera intricata Plant Extract: Preparation, Characterization and Anticancer Activity
Conclusion: Our results revealed that traditional medicinal plants could be an excellent source of natural anticancer agents and the chitosan-extract nanoparticles is a promising formulation strategy to enhance their clinical effectiveness. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Serotonin (5HTR2A and 5HTR3A) and GABA (GABAB) Receptor Genes Overexpression are Correlated with Non-small Cell Lung Cancer (NSCLC)
Conclusion: According to our findings, 5-HT and GABA may be involved in the regulation of tumorigenesis via their receptors, thus playing an important role in lung cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Possible Considerations for the Management of Turcot’s Syndrome?
Conclusion: TS is a disease that affects mostly members of families with multiple genetic mutations and types of cancers. And because of the unknown mechanisms of inheritance, it is useful to establish guidelines for the approach of those patients, in order to minimize the high mortality rate. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Statins: A Conceivable Remedial Role for the Regulation of Cancer Progression
The mevalonate pathway (also known as the cholesterol biosynthesis pathway) plays a crucial metabolic role in normal cell function as well as in the pathological environment. It leads to the synthesis of sterol and non-sterol isoprenoid biomolecules which subserve a variety of cellular functions. It is known to be deregulated in many disease processes. Statins and bisphosphonates are prominent inhibitors of the mevalonate pathway. They inhibit cell proliferation and activate apoptotic signalling and suppress tumour growth. Statins subdue metastatic spread of tumours by virtue of their ability to suppress invasion and angio...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy
In this study, we have reviewed the important roles of HATs in different human malignancies. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Beyond PD-1/PD-L1 Axis Blockade: New Combination Strategies in Metastatic Melanoma Treatment
Metastatic melanoma treatment has dramatically changed in the last few years, having a breakthrough with the introduction of targeted agents and immunotherapy. PD-1/PD-L1 pathway is one of the physiologic mechanisms of peripheral immune tolerance, but it also represents a mechanism of tumor immune escape. PD-1/PD-L1 inhibitors represent new immune-checkpoint drugs currently used in metastatic melanoma treatment. Resistance to PD-1/PD-L1 axis blockade, which is the main cause of therapeutic failure during therapeutic use of these drugs, could be linked to several mechanism of immune escape. In fact, other inhibitory recepto...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Implementing Cancer Exercise Rehabilitation: An Update on Recommendations for Clinical Practice
A growing body of research evidence supports the benefit of exercise for cancer survivors both during and after cancer treatment. The purpose of this paper is to provide an update on our previously published review in 2006 on the state of the evidence supporting exercise for survivors of cancer as well as guidelines for integrating exercise programming in the cancer clinical setting. First, we provide a brief overview on the benefits of exercise as well as preliminary evidence supporting the implementation of community-based exercise programs. Second, we summarize the principles and goals of exercise, and the identified ba...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Systemic Therapies for Metastatic Testicular Germ Cell Tumors: Past, Present and Future
Testicular germ cell tumors (TGCTs) are unique to that of most other solid tumors because they are highly curable in the metastatic setting. While the use of cisplatin-based chemotherapy continues to drive cure in this patient population, important improvements in the delivery of therapy, creation of risk-adjusted treatment paradigms, and salvage-therapy options have further enhanced survival as well. The future holds promise for a more multidisciplinary approach to care, through advancements in biochemical markers and a better understanding of how surgical and radiotherapy approaches can integrate into our existing manage...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Meet our Associate Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Review of Patent Series eBook "Topics in Anti-Cancer Research, Volume 6, 2017"
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Purification and Characterization of a Protease Inhibitor with Anticancer Potential from Bacillus endophyticus JUPR15
Conclusion: The isolate exhibited promising anticancer activity on in-vitro Hela and HepG2 cancer cell lines, showing its application potentials. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa
Conclusions: These results underscore the combinatorial treatment using TMZ and L189 to bring desirable cancer cell growth arrest and future molecular study to dissect out the participating pathways. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Prerequisite of a Holistic Blend of Traditional and Modern Approaches of Cancer Management
Conclusion: Both genetic as well as environmental factors have shown their linkage with cancer. Substantial advancements in the field of targeted therapies have opened new horizons for the cancer patients. To fight with this grave situation, a combination of ancient and modern medicinal systems seems to be the need of the hour. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Do we Need Maintenance Chemotherapy in Advanced NSCLC in the Era of Immune and Targeted Therapy?
Conclusion: Maintenance therapy in NSCLC continues to be an important therapeutic line to improve outcome in patients with metastatic and recurrent disease. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Cancer Chemotherapy by Novel Bio-active Natural Products: Looking Towards the Future
Conclusion: Current review has been highlighted on the novel medicinal agents from plant sources have potential effects against many types of cancer, which have been supported by clinical trials. The main findings of these active novel medicinal agents were also summarized and discussed here. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Impact of Probiotics and Prebiotics on Colon Cancer: Mechanistic Insights and Future Approaches
Colon cancer is one of the most common and most diagnosed types of cancer. It is a major cause of increased rate of morbidity and mortality across the globe. Currently, the focus has been shifted towards natural remedies for the treatment of colon cancer. These new methods of treatment include prebiotics and probiotics, as they offer great potential for alleviating symptoms of cancer. These are more promising and have lesser side effects than existing medications. Probiotics are living organisms which confer health benefits when ingested into adequate amounts. Prebiotics are non-digestible ingredients which promote the gro...
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Comparative Analysis of DNA Motif Discovery Algorithms: A Systemic Review
Conclusion: Nature-inspired algorithms and many of combinatorial algorithms are recently proposed to overcome the problems of consensus and probabilistic approaches. This paper presents a general classification of motif discovery algorithms with new sub-categories. It also presents a summary comparison between them. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

The Pure Guy – The Scientist
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research

Acknowledgements to Reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

End of Life Issues – Hong Kong, France and Canada
Conclusion: Different Canadian hospitals developed practical guidelines and procedures by 2017 already. Ramifications of MAID will be discussed in this review. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Palliative Care for Chest Tumors – Hong Kong, France and Canada
In Asia, North America and Europe, lung cancer remains one of the top contributors to cancer-related death. Oncology training programs span 4-5 years and palliative care fellowship is around 2 years. However, the multi-disciplinary conference is increasingly viewed as preferable to assist with decision making in most modern centers. Palliative care for lung cancer likewise differs between regions. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Palliative Radiation of Chest Tumors
Palliation may be the goal of care for some patients with intra-thoracic lung cancer. Factors such as the extent of disease, comorbidities, performance status, or symptom burden, may indicate that patients are unsuitable for more aggressive approaches with a curative intent. A palliative treatment plan implies a focus on the effective relief and control of symptoms, while preserving both the quality and quantity of life. Therapeutic measures may include palliative radiotherapy, palliative chemotherapy, or other forms of systemic treatment. In addition, certain interventional procedures may be used to achieve symptom pallia...
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Lung Cancer Brachytherapy
Conclusion: In spite of the rapid development of external beam radiation therapy brachytherapy continues to remain an important mode of therapy and is often a default treatment when external beam radiation option is limited. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Systemic Treatment of Chest Tumors: Highlighting Some Differences Between Eastern and Western Countries
Conclusion: The approaches of this review are to highlight the recent management advances and contrast the differences of treatment practice between Western and Asian countries. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Current Overview of Lung Cancer from Pathology, Screening to Treatment
Conclusion: This article provides a brief current overview of literature pertaining to the role of radiation therapy in the management of lung cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Updates for Chest Tumors
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 12, 2018 Category: Cancer & Oncology Source Type: research

Papain Loaded Solid Lipid Nanoparticles for Colorectal Cancer Therapy
Conclusion: In this research, we successfully formulated the P-SLN for the treatment of colorectal cancer therapy. We investigate the various formulation parameters, drug release profile and cytotoxic efficacy of P-SLN. Upon successful completion of this work, P-SLNs delivery system is predictable to produce enhanced cytotoxic efficacy against HT-29 colorectal cancer cells. The papain loaded SLNs can potentially be utilized as a drug delivery system for the treatment of colorectal cancer. In future, we will explore further to investigate the mechanism of anticancer activity and clinical investigation of P-SLN. (Source: Cur...
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Stereotactic Body Radiation Therapy in Head and Neck Squamous Cell Carcinoma: Science or Art?
Conclusion: The use of stereotactic body radiotherapy is still evolving and multiple studies are needed to optimize the dose fractionation of SBRT and its integration with systemic therapy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Role of Stereotactic Radiosurgery in the Management of Brain and Spine Metastases
Conclusion: While the data support its use, there needs to be continued research with improved technology, on the use of radiosurgery for larger brain metastases, and on the toxicities of radiosurgery and its management. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

The Role of Stereotactic Body Radiation Therapy in Pancreatic Cancer
Conclusion: SBRT represents an emerging treatment option for patients to improve local control through delivery of ablative, high-dose radiation while reducing radiation treatment time as compared to conventionally fractionated chemoradiation. Further studies are needed to explore the full potential and toxicities of SBRT in pancreatic cancer. The importance of technical considerations in this modality cannot be overstated. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Stereotactic Body Radiotherapy (SBRT) in the Management of Clinically Localized Prostate Cancer: Where are We Now?
Background: Stereotactic body radiotherapy (SBRT) is a recent addition to the armamentarium for treating clinically localized prostate cancer. SBRT is a special form of image-guided radiotherapy (IGRT) that involves the delivery of a small number of very high-dose fractions (e.g. 35 to 40 Gy, in 4 to 5 fractions). The slow-growing nature of prostate adenocarcinoma is thought to be associated to a low α[alpha]/β[beta] ratio of ~1.5, that is believed to confer a preferential sensitivity to ultra-hypofractionation. Literature documenting excellent long-term outcomes and relatively low toxicity with high dose-rate (...
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

SBRT for Liver Cancer
Conclusion: Stereotactic body radiation therapy is a non-invasive, effective and welltolerated treatment modality for patients with liver cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Editorial: The Role of Stereotactic Body Radiotherapy: A Review
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Preface
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 28, 2018 Category: Cancer & Oncology Source Type: research

Acknowledgements to Reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

In Silico Study and Cytotoxicity of the Synthesized Open-chain Analogues of Antimycin A3 Against HEP-2 Laryngeal Cancer Cells
Conclusion: Open-chain analogues of antimycin A3 were successfully synthesized in a good yield from Boc-L-Threonine by esterification, amidation, and Sharpless asymmetric dihydroxylation. Consistent with in silico study, the analogues exhibited a greater anticancer activity against laryngeal HEP-2 cells than the original antimycin A3 with IC50 ranging of 31.6 µM to 46.3 µM. Our results clearly demonstrate that the open-chain analogues of antimycin A3 as a promising candidates of new anti-laryngeal cancer agents. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

Emerging Family of Protein-protein Interaction Inhibitors Targeting PD-1 Checkpoint Pathway
Conclusion: The potential use of PD-1 checkpoint inhibitor alone or in combination with other agents is substantial, and will further reveal the important role of PD-1 pathway in immunomodulation and disease control. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

PDE5 Inhibitors Offer Novel Mechanisms in Combination and Solo Cancer Therapy
Conclusion: This review offers insights into the various mechanisms by which PDE5 inhibitors exert their antineoplastic actions. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy
Conclusion: This review discusses emerging issues and potential avenues related to the scope and limitations of peptide mimetics in cancer treatment. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target
Conclusion: This review highlights the areas of most promise in treating MPM, these include immune checkpoint blockade, passive immunization, and based on our recently published data, targeting of CD26 with its specific mAb. Finally we describe how the anti-CD26 mAb YS110 was recently evaluated in the first-in-human phase I clinical trial, showing prolonged disease stabilization and a favorable side effect profile. Through better understanding of CD26, new pathways to treating and potentially curing malignant mesothelioma may be discovered. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research

Targeted Nanosystems for Cancer Therapy
Conclusion: Here we provide an update on the recent clinical trials in nanocarrier based therapy of colon rectal cancer, food and drug administration (FDA) approved nanomedicines for cancer and those in nanoplatforms which have reached an advanced stage of clinical development. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research

Inhibition of Angiogenesis as a Treatment Strategy for Neuroblastoma
Background: Angiogenesis stands as a symbol for the development of tumor as well as its metastasis. In this review, we discuss the various components that induce and enhance angiogenesis along with its several inhibitors in neuroblastoma. Angiogenesis is vital for tumor development and migration and it is dependent on the creation of angiogenic elements by tumor cell lines. Methodology: Neuroblastoma (NB) is a general pediatric tumor which originates from neural crest that is biologically and physiologically diverse. As tumor vascular index increases, it leads to the unfavorable consequence of NB. Tumor vascularity is very...
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research

Phenothiazines and Related Drugs as Multi Drug Resistance Reversal Agents in Cancer Chemotherapy Mediated by p-glycoprotein
Conclusion: This review will discuss the work done on the SAR and QSAR of phenothiazines as anti-MDR agents along with their putative mechanism of action as MDR reversal agents. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research

Cancer and Treatment Modalities
Conclusion: Over recent years, radiotherapy techniques have been greatly developed which create various suitable conditions for the treatment of different cancers while sparing normal tissues. As the radiotherapy techniques developed, tumor covering and precision on dose delivery increased. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research

Erlotinib: A Targeted Anticancer Drug
Conclusion: In nonclinical toxicology studies, the drug has not shown any results of fertility impairment, carcinogenesis or mutagenesis. Though the EGFR-TKIs have shown great clinical significance, the development of drug resistance has also been reported by the patients. The resistance for EGFR-TKIs can occur through any of the several mechanisms involved like secondary mutation (T790M), ATP binding cassette transporter effusion, alteration of the downstream pathways, etc. This article reviews the safety and efficacy of erlotinib along with chemistry, mechanism, pharmacokinetics, drug interactions and resistance to the d...
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research