Development of MatLab Coding for Early Detection of Leukemia through Automated Analysis of RBCs
Background: Bone marrow biopsy has become an integral part of leukemia diagnosis and its treatment. Several advancements are being made towards the analysis of digital images of biopsy samples. Recently, the FDA approved the procedures of digital health. In tune with that, digital image analysis has become propelled. With the advent of high-throughput technologies, the scientific community focuses on the red blood cells (RBCs) for early detection of cancer, including leukemia. The reasons are due to their abundance in peripheral blood and hence, easily accessible compared to the bone marrow biopsy procedure. High magnifica...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts
Conclusion: The particle size of nanoparticles was found to lie in the range of 10 to 50 nm. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Dickkopf-1 and β-catenin as Biomarkers for Early Diagnosis of Hepatocellular Carcinoma
Background & Aims: The clinical value of alpha-fetoprotein (AFP) as a marker to detect early hepatocellular carcinoma (HCC) has been questioned owing to its low sensitivity and specificity. The purpose of this work was to investigate whether serum Wnt/β-catenin and DKK1 levels in chronic hepatitis C patients could be used as early predictors for the risk of HCC development. Methods: The study was conducted on 37 healthy controls, and 150 CHC patients were divided into three groups: CHC, liver cirrhosis (LC), and HCC patients. AFP, AFP-L3, β-catenin, and DKK-1 were assayed by ELISA. Results: Both β-cateni...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Demographic and Clinical Evaluation of Patients with Pancreatic Cancer in Mashhad University of Medical Sciences During 2002-2013
This study includes all data from real charts of patients with a definitive diagnosis of pancreatic cancer, admitted to Ghaem, Imam Reza, and Omid hospitals from 2002 to 2013. All the data which were available in lab results, exams, and patient files, were used accordingly. Results: 348 pancreatic cancer patients entered the study. About 61.5% of the subjects were men. Mean age was 59.67±14.37 years. Main complaints were abdominal pain (42.53%), jaundice (13.79%) or both (37.07%). We found a positive history of cancer in the first-degree relatives of 3.7% of patients, with the most prevalent being gastric cancer (46...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Solanum nigrum Anticancer Effect Through Epigenetic Modulations in Breast Cancer Cell Lines
Background: DNA methylation plays an important role in the regulation of gene expression in mammalian cells and often occurs at CpG islands in the genome. It is more reversible than genetic variations and has therefore attracted much attention for the treatment of many diseases, especially cancer. In the present study, we investigated the effect of Solanum nigrum Extract (SNE) on the methylation status of the VIM and CXCR4 genes in breast cancer cell lines. Methods: The Trypan blue assay was used to study the effect of SNE at various concentrations of 0, 0.1, 1.5, 2.5, 3.5 and 5 mg/ml for 48 h on the survival of three huma...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Brachial Plexopathy as a Complication of Radiotherapy: A Systematic Review
Conclusion: From our findings, we can conclude that the issue of radiation-induced brachial plexus complication in human is of great concern. Common symptoms associated with this complication include paresthesia, numbness, pain and weakness. We recommend the use of individual dose planning and computer-assisted image segmentation techniques that support rapid and reliable contouring of the brachial plexus. Also, the radiation dose to the brachial plexus should be limited as much as possible to reduce the risk of brachial plexopathy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

New Researches about Combinatorial Therapeutic Regimen on Cancer Treatment
Cancer is a refractory disease, which brings physical, mental and economic sufferings on patients and their families. The activation of oncogenes and/or the deletion of tumor repressors result in uncontrolled tumor survival and proliferation. Therapeutic resistance and cancer recurrence are common issues during the course of clinical treatment. Since each single treatment can’t eradicate tumor cells completely, the development of combinatorial therapeutic regimen is in the spotlight for several decades. Combinatorial therapeutic regimen, a treatment modality that combines two or more therapeutic agents, targets key p...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Molecular Pathways, Screening and Follow-up of Colorectal Carcinogenesis: An Overview
Colorectal cancer (CRC) is the development of cancer from the colon or rectum. This kind of cancer presents with a broad spectrum of neoplasms from benign to metastatic forms. The development of the majority of colon cancers appears from adenomatous polyps or adenomas systematically. At least three molecular pathways are involved in CRC pathogenesis including chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Methods such as fecal occult blood tests (FOBTs), colonoscopy, flexible sigmoidoscopy (FOS), computed tomographic colonography (CTC), and fecal DNA are comm...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research

Development of MatLab Coding for Early Detection of Leukemia through Automated Analysis of RBCs
Background: Bone marrow biopsy has become an integral part of leukemia diagnosis and its treatment. Several advancements are being made towards the analysis of digital images of biopsy samples. Recently, the FDA approved the procedures of digital health. In tune with that, digital image analysis has become propelled. With the advent of high-throughput technologies, the scientific community focuses on the red blood cells (RBCs) for early detection of cancer, including leukemia. The reasons are due to their abundance in peripheral blood and hence, easily accessible compared to the bone marrow biopsy procedure. High magnifica...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts
Conclusion: The particle size of nanoparticles was found to lie in the range of 10 to 50 nm. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Dickkopf-1 and β-catenin as Biomarkers for Early Diagnosis of Hepatocellular Carcinoma
Background & Aims: The clinical value of alpha-fetoprotein (AFP) as a marker to detect early hepatocellular carcinoma (HCC) has been questioned owing to its low sensitivity and specificity. The purpose of this work was to investigate whether serum Wnt/β-catenin and DKK1 levels in chronic hepatitis C patients could be used as early predictors for the risk of HCC development. Methods: The study was conducted on 37 healthy controls, and 150 CHC patients were divided into three groups: CHC, liver cirrhosis (LC), and HCC patients. AFP, AFP-L3, β-catenin, and DKK-1 were assayed by ELISA. Results: Both β-cateni...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Demographic and Clinical Evaluation of Patients with Pancreatic Cancer in Mashhad University of Medical Sciences During 2002-2013
This study includes all data from real charts of patients with a definitive diagnosis of pancreatic cancer, admitted to Ghaem, Imam Reza, and Omid hospitals from 2002 to 2013. All the data which were available in lab results, exams, and patient files, were used accordingly. Results: 348 pancreatic cancer patients entered the study. About 61.5% of the subjects were men. Mean age was 59.67±14.37 years. Main complaints were abdominal pain (42.53%), jaundice (13.79%) or both (37.07%). We found a positive history of cancer in the first-degree relatives of 3.7% of patients, with the most prevalent being gastric cancer (46...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Solanum nigrum Anticancer Effect Through Epigenetic Modulations in Breast Cancer Cell Lines
Background: DNA methylation plays an important role in the regulation of gene expression in mammalian cells and often occurs at CpG islands in the genome. It is more reversible than genetic variations and has therefore attracted much attention for the treatment of many diseases, especially cancer. In the present study, we investigated the effect of Solanum nigrum Extract (SNE) on the methylation status of the VIM and CXCR4 genes in breast cancer cell lines. Methods: The Trypan blue assay was used to study the effect of SNE at various concentrations of 0, 0.1, 1.5, 2.5, 3.5 and 5 mg/ml for 48 h on the survival of three huma...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Brachial Plexopathy as a Complication of Radiotherapy: A Systematic Review
Conclusion: From our findings, we can conclude that the issue of radiation-induced brachial plexus complication in human is of great concern. Common symptoms associated with this complication include paresthesia, numbness, pain and weakness. We recommend the use of individual dose planning and computer-assisted image segmentation techniques that support rapid and reliable contouring of the brachial plexus. Also, the radiation dose to the brachial plexus should be limited as much as possible to reduce the risk of brachial plexopathy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

New Researches about Combinatorial Therapeutic Regimen on Cancer Treatment
Cancer is a refractory disease, which brings physical, mental and economic sufferings on patients and their families. The activation of oncogenes and/or the deletion of tumor repressors result in uncontrolled tumor survival and proliferation. Therapeutic resistance and cancer recurrence are common issues during the course of clinical treatment. Since each single treatment can’t eradicate tumor cells completely, the development of combinatorial therapeutic regimen is in the spotlight for several decades. Combinatorial therapeutic regimen, a treatment modality that combines two or more therapeutic agents, targets key p...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Molecular Pathways, Screening and Follow-up of Colorectal Carcinogenesis: An Overview
Colorectal cancer (CRC) is the development of cancer from the colon or rectum. This kind of cancer presents with a broad spectrum of neoplasms from benign to metastatic forms. The development of the majority of colon cancers appears from adenomatous polyps or adenomas systematically. At least three molecular pathways are involved in CRC pathogenesis including chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Methods such as fecal occult blood tests (FOBTs), colonoscopy, flexible sigmoidoscopy (FOS), computed tomographic colonography (CTC), and fecal DNA are comm...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research

Identifying the Optimal Fractionation Schedules for Improved Response Rates and Survival in Patients with Metastatic Melanoma Treated with Ipilimumab and Radiotherapy
Conclusion: This hypothesis-generating study suggests that patients who cannot receive ablative intent radiotherapy may be more likely to benefit from concurrent radiotherapy with ipilimumab if their fractionation schedule has a BED above 46.5 - 50.9 Gy. Prospective trials evaluating this question should be considered. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Virtual Screening of Novel Hybrid Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Exploring Multiple Targeted Cancer Therapy by an In Silico Approach
Conclusion: The study concluded that compound 2sa, 5sa, 6sa, and 7sa could be further explored for multiple targeted cancer therapy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Cancer Immunotherapy: An Effective Tool in Cancer Control and Treatment
Conclusion: In the review, we described the significance of immunotherapy in the management of various types of cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Possible Biomarkers and Therapeutic Targets for the Management of Cervical Cancer
Conclusion: In this study, we will discuss cervical cancer, its cause, symptoms, pathophysiology and treatments. Early screening and detection can help in reducing the overall burden of cervical cancer in the near future. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Key Signaling Pathways Engaged in Cancer Management: Current Update
Conclusion: A noteworthy challenge for future medication advancement is to detail a synthesis treatment influencing distinctive targets to enhance the treatment of cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Exploring Promises of siRNA in Cancer Therapeutics
Since the discovery of the RNA interference (RNAi) in 2006, several attempts have been made to use it for designing and developing drug treatments for a variety of diseases, including cancer. In this mini-review, we focus on the potential of small interfering RNAs (siRNA) in anticancer treatment. We first describe the significant barriers that exist on the path to clinical application of siRNA drugs. Then the current delivery approaches of siRNAs using lipids, polymers, and, in particular, polymeric carriers that overcome the aforementioned obstacles have been reviewed. Also, few siRNA mediated drugs currently in clinical ...
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Role of the Hsp90-Immunophilin Heterocomplex in Cancer Biology
The identification of new factors that may function as cancer markers and become eventual pharmacologic targets is a challenge that may influence the management of tumor development and management. Recent discoveries connecting Hsp90-binding immunophilins with the regulation of signalling events that can modulate cancer progression transform this family of proteins in potential unconventional factors that may impact on the screening and diagnosis of malignant diseases. Immunophilins are molecular chaperones that group a family of intracellular receptors for immunosuppressive compounds. A subfamily of the immunophilin famil...
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Recent Advances of Novel Therapeutic Agents from Botanicals for Prevention and Therapy of Breast Cancer: An Updated Review
Breast cancer is among the foremost common malignancies and the second leading cause for cancer-related deaths in females. Varied treatment approaches are projected to cause a subject matter reduction in the fatality rate. Carcinoma treatment is highly challenging due to therapeutic resistance and reoccurrence. Several studies have revealed that bioactive compounds isolated from natural products such as plants, vegetables, and marine origins have a therapeutic and preventive role in breast carcinoma. Utilization of these bioactive agents in amelioration of cancer as complementary and alternative therapy increases day by da...
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Targeted Nanomedicines: In the Right Route Towards Improved Therapies
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Preface
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research

Acknowledgements to reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

The Cancer Hygiene Hypothesis: From Theory to Therapeutic Helminths
Conclusion: Here we discuss the major implications of these findings for the association between microorganisms and cancer, and also between some immune pathologies, like autoimmune diseases, and cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

In Silico Analysis and Molecular Docking Studies of Novel 6,7-dihydropyrano [2,3-d] pyrimidin-5-one Derivatives as Human Epidermal Growth Factor Receptor 2 (HER2) and Epidermal Growth Factor Receptor (EGFR) Inhibitors
Conclusion: The bioactivity prediction shows that all compounds are active to moderately active. These positive results show that it could be further investigated and explored. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Crocins: The Active Constituents of Crocus Sativus L. Stigmas, Exert Significant Cytotoxicity on Tumor Cells In Vitro
Conclusion: Our data demonstrate that crocins could be a novel promising agent for the improvement of tumor treatment. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

A Model for Heterogeneous Brain Tumor Cells that Cause Dizziness
Conclusion: The positive and negative points of the image-based cell models and computergenerated cell models some scientific advices are presented in this work. Generally, the imagebased cell models could offer analytical facts for each state, but they are expensive and timeconsuming; besides, their performance is heavily influenced by deformation techniques. The computer-generated cell model, on the other hand, provides a higher cost of production and simplicity, but its main contribution is the overall performance and accuracy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Main Nutritional and Environmental Risk Factors in Children with Leukemia from a Public Hospital of the State of Guanajuato, Mexico
Conclusion: The main nutritional and environmental risk factors found were early complementary feeding, cow’s milk prior to 1 year of age, a duration of breastfeeding of fewer than 6 months, birth weight of>3,500 g, a positive smoking habit in the children’s parents, as well as exposure to arsenic in drinking water. Identification of these risk factors could constitute an input for integrating novel prevention alternatives and the nutritional management of leukemia. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Efficacy and Safety of Targeting Androgen Receptor in Advanced Breast Cancer: A Systematic Review
Conclusion: Androgen receptor pathway targeting in advanced breast cancer remains a valid option with reasonable clinical benefit in non-selected patients. Future studies are needed to define an AR addicted cohort with better responses and outcome. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Crocetin as an Active Secondary Metabolite of Saffron Stigma and Anticancer Effects
This study aimed to review previous invitro and invivo investigations on anticancer effects of this carotenoid and also proposed molecular mechanisms of its action. Literature reviewing between 1990 and 2017 was performed using pubmed and scopus databases. Anti-proliferative and pro-apoptotic effects of crocetin have been observed in several cancers cell lines and also model organisms that might be due to the alternation in the expression of cancer-related genes and epigenetic changes. Moreover, several studies indicated synergistic effects of crocetin with common chemotherapy agents and mentioned it as a potential novel a...
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Anti-angiogenic Treatment in Metastatic Colorectal Cancer: Current Issues and Future Aims
We describe the principal mechanisms of resistance to anti-VEGF therapy and discuss potential biomarkers to be investigated in the near future. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Immunology Behind Tumors: A Mini Review
Conclusion: This review is focused not only on the mechanism by which the immune system protects us but also on the ways in which it can inflict the body and how to modulate it with therapy. Thus, understanding the interaction of a tumor with the immune system provides insights into mechanisms that can be utilized to elicit anti-tumor immune responses. Here, we have recapitulated the function of the tumor microenvironment and immune checkpoints. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research

A Connecting Switch Among Aging, Diabetes and Tumor: Avenue Leading to Cancer Therapeutics
In recent, curiosity is at the forefront to understand the complexity of cancer driven by genetic, molecular and epigenetic programming due to life style, environmental pressure and metabolite adaptations. On the other hand, complex and heterogeneous nature of cancer is linked to the metabolic and molecular landscape of diabetic complications. This Letter to editor connects the dots and highlights the need to view cancer beyond the mirror of genetic and epigenetic aberration as metabolic disturbances. In this commentary, the author highlights the major contributions from two elegant papers from Cha et al. (2018) and Wu et ...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Chitosan Nanoparticles as a Carrier for Indigofera intricata Plant Extract: Preparation, Characterization and Anticancer Activity
Conclusion: Our results revealed that traditional medicinal plants could be an excellent source of natural anticancer agents and the chitosan-extract nanoparticles is a promising formulation strategy to enhance their clinical effectiveness. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Serotonin (5HTR2A and 5HTR3A) and GABA (GABAB) Receptor Genes Overexpression are Correlated with Non-small Cell Lung Cancer (NSCLC)
Conclusion: According to our findings, 5-HT and GABA may be involved in the regulation of tumorigenesis via their receptors, thus playing an important role in lung cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Possible Considerations for the Management of Turcot’s Syndrome?
Conclusion: TS is a disease that affects mostly members of families with multiple genetic mutations and types of cancers. And because of the unknown mechanisms of inheritance, it is useful to establish guidelines for the approach of those patients, in order to minimize the high mortality rate. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Statins: A Conceivable Remedial Role for the Regulation of Cancer Progression
The mevalonate pathway (also known as the cholesterol biosynthesis pathway) plays a crucial metabolic role in normal cell function as well as in the pathological environment. It leads to the synthesis of sterol and non-sterol isoprenoid biomolecules which subserve a variety of cellular functions. It is known to be deregulated in many disease processes. Statins and bisphosphonates are prominent inhibitors of the mevalonate pathway. They inhibit cell proliferation and activate apoptotic signalling and suppress tumour growth. Statins subdue metastatic spread of tumours by virtue of their ability to suppress invasion and angio...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy
In this study, we have reviewed the important roles of HATs in different human malignancies. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Beyond PD-1/PD-L1 Axis Blockade: New Combination Strategies in Metastatic Melanoma Treatment
Metastatic melanoma treatment has dramatically changed in the last few years, having a breakthrough with the introduction of targeted agents and immunotherapy. PD-1/PD-L1 pathway is one of the physiologic mechanisms of peripheral immune tolerance, but it also represents a mechanism of tumor immune escape. PD-1/PD-L1 inhibitors represent new immune-checkpoint drugs currently used in metastatic melanoma treatment. Resistance to PD-1/PD-L1 axis blockade, which is the main cause of therapeutic failure during therapeutic use of these drugs, could be linked to several mechanism of immune escape. In fact, other inhibitory recepto...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Implementing Cancer Exercise Rehabilitation: An Update on Recommendations for Clinical Practice
A growing body of research evidence supports the benefit of exercise for cancer survivors both during and after cancer treatment. The purpose of this paper is to provide an update on our previously published review in 2006 on the state of the evidence supporting exercise for survivors of cancer as well as guidelines for integrating exercise programming in the cancer clinical setting. First, we provide a brief overview on the benefits of exercise as well as preliminary evidence supporting the implementation of community-based exercise programs. Second, we summarize the principles and goals of exercise, and the identified ba...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Systemic Therapies for Metastatic Testicular Germ Cell Tumors: Past, Present and Future
Testicular germ cell tumors (TGCTs) are unique to that of most other solid tumors because they are highly curable in the metastatic setting. While the use of cisplatin-based chemotherapy continues to drive cure in this patient population, important improvements in the delivery of therapy, creation of risk-adjusted treatment paradigms, and salvage-therapy options have further enhanced survival as well. The future holds promise for a more multidisciplinary approach to care, through advancements in biochemical markers and a better understanding of how surgical and radiotherapy approaches can integrate into our existing manage...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research

Meet our Associate Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research