Acknowledgements to Reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Corrigendum to: Discussion on the paper “Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Wahed Hasona et al.
Discussion on the paper Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Mostafa A. Elogail in “Current Cancer Therapy Reviews”, 2021; 17(2), 93-6. We regret the error and apologize to the readers. The original article can be found online at https://www.eurekaselect.com/189490/article (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
An Analysis of Structure-function Co-relation between GLI Oncoprotein and HLA Immune-gene Transcriptional Regulation through Molecular Docking
Conclusion: This study suggests that HLA class I may not be downregulated by GLI; however, over-expression of GLI1 is may be responsible for HLA class II downregulation. Thus this protein may be responsible for the maintenance of the undifferentiated state of malignant cells. This study also suggests the implicative role of GLI1 in the early definitive stage of hematopoiesis. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Expression of a Disintegrin and Metalloprotease 10 Gene Polymorphisms in a Cohort of Egyptian Patients with Hepatocellular Carcinoma
This study involved 201 cases divided: Group I (67 HCC patients), Group II (67 cirrhotic patients), Group III (67 control). Each group was subjected to laboratory investigations: (CBC, blood sugar, kidney and liver function, viral markers, alpha fetoprotein), imaging: (abdominal ultrasonography, and triphasic C.T) and ADAM 10 gene polymorphism (rs 653765, rs 383902) detection by real – time PCR. Results: There was a statistically significant difference in the frequency and genotyping of ADAM10 SNPs in HCC patients in comparison to cirrhotic and control groups [the frequency of rs 653765 genotypes (p=0.015) and model (p=0...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Emerging Role of Wnt/Beta-Catenin Signalling Pathways in Cancer Progression and Role of Small Molecule Tankyrase Inhibitors in Combating Multistage Cancers
In the present review, an attempt has been made to summarize the development of various Tankyrase inhibitors focussing on Wnt/beta-Catenin pathways along with other cancer targets. The last decade witnessed a plethora of research related to the role of various genetic and epigenetic events that are responsible for the progression of multistage cancers. As a result, the discovery of various signalling pathways responsible for the development of different types of cancers has resulted in the development of molecularly targeted anticancer agents. Out of the many signalling pathways, the Wnt/beta-Catenin pathways have attracte...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Oxidative Stress and Cellular Senescence: The Key Tumor-promoting Factors in Colon Cancer and Beneficial Effects of Polyphenols in Colon Cancer Prevention
Conclusion: This review facilitates a better understanding and might contribute to diagnostic and prognostic systems as well as to find out the novel and targeted therapeutic approaches. Additionally, we focused on the potential role of natural flavonoids in colon cancer therapies and highlighting the flavonoid-based treatments as innovative immunomodulatory strategies to inhibit the growth of colon cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Therapeutic Application of Melatonin in the Treatment of Melanoma: A Review
Melanoma is an aggressive type of skin cancer, which is responsible for more deaths than nonmelanoma skin cancers. Therapeutic strategies include targeted therapy, biochemotherapy, immunotherapy, photodynamic therapy, chemotherapy, and surgical resection. Depending on the clinical stage, single or combination therapy may be used to prevent and treat cancer. Due to resistance development during treatment courses, the efficacy of mentioned therapies can be reduced. In addition to resistance, these treatments have serious side effects for melanoma patients. According to available reports, melatonin, a pineal indolamine with a...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Recent Advancements for the Management of Pancreatic Cancer: Current Insights
One of the most fatal forms of cancer includes cancer of the pancreas And the most rapid malignancy is observed in PDAC (pancreatic ductal adenocarcinoma). The high lethality rate is generally due to very late diagnosis and resistance to traditional chemotherapeutic agents. Desmoplastic stromal barrier results in resistance to immunotherapy. Other reasons for the high lethality rate include the absence of effective treatment and standard screening tests. Hence, there is a need for effective novel carrier systems. “A formulation, method, or device that allows the desired therapeutic substance to reach its site of action i...
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Bioinformatics Approach for Data Capturing: The Case of Breast Cancer
Conclusion: Bioinformatics is the evolutionary approach that is used for the capturing of data from the various case studies related to breast cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Efficacy and Safety of PEGPH20 in Pancreatic Cancer: Systematic Review and Meta-analysis
Conclusion: This meta-analysis showed that PEGPH20 did not improve the PFS or OS. Moreover, there was an increased incidence of serious adverse events using PEGPH20 compared to standard therapies. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 29, 2021 Category: Cancer & Oncology Source Type: research
Effect of Conventional Chemotherapies on Natural Killer Cell Activity
Conclusion: Conventional chemotherapy seems to have no effect on NK cell activity levels in cancer patients in both metastatic and adjuvant settings. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Rectal Cancer in Patients Younger than 40: Tumor Characteristics and Comparative Survival Based on a Single Institution
Aim: The aim of this study was to determine tumor characteristics and outcomes of patients with rectal cancer (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Adverse Effects and Safety of Etirinotecan Pegol, a Novel Topoisomerase Inhibitor, in Cancer Treatment: A Systematic Review
Conclusion: Therefore, Etirinotecan Pegol may represent a major contribution to the treatment of various cancers in the future. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Breast Cancer: A Review of Risk Factors and New Insights into Treatment
Today, despite significant advances in cancer treatment have been made, breast cancer remains one of the main health problems and considered a top biomedical investigation urgency. The present study reviewed the common conventional chemotherapy agents and also some alternative and complementary approaches such as oncolytic virotherapy, bacteriotherapy, nanotherapy, immunotherapy, and natural products, which are recommended for breast cancer treatment. In addition to current surgery approaches such as mastectomy, in recent years, a number of novel techniques such as robotic mastectomies, nipple-sparing mastectomy, skin-spar...
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
Liver Cancer: New Insights into Surgical and Nonsurgical Treatments
Conclusion: Multidisciplinary and multi-choice treatments and therapies are available for this liver cancer, while there are differences in liver cancer management recommendations among specialties and geographic areas. Current results have shown that treatment strategies have been combined with the advancement of novel treatment modalities. In addition, the use of new approaches with greater efficacy, such as combination therapy, biomaterials, ablation therapy, etc. can be considered the preferred treatment for patients. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 24, 2021 Category: Cancer & Oncology Source Type: research
