Management of Colovesical Fistulae: The Updated Evidence
AbstractPurpose of ReviewThe aim of this review is to summarize the latest literature available about the management of patients affected by colovesical fistulae (CVFs).Recent FindingsRecent systematic reviews have shed light on optimal approaches for managing colovesical fistulae, offering a comprehensive understanding of the disease in a systematic manner. These recent findings contribute significantly to refining diagnostic protocols and treatment strategies.SummaryThe management of colovesical fistulae has evolved in recent years. Emphasizing the significance of a thorough diagnostic evaluation and advocating minimally...
Source: Current Bladder Dysfunction Reports - February 14, 2024 Category: Urology & Nephrology Source Type: research

In the Era of Holmium Laser Enucleation of the Prostate Is Preoperative Urodynamics Required for Men in Urinary Retention?
AbstractPurpose of ReviewThe goal of this review is to challenge the dogma that urodynamics is required to identify detrusor underactivity and bladder outlet obstruction for men in urinary retention prior to offering any bladder outlet surgery in the era of holmium laser enucleation of the prostate (HoLEP). Classically, bladder outlet surgery was not recommended for patients with detrusor underactivity as men with detrusor underactivity who underwent transurethral resection of the prostate (TURP) had worse outcomes than those who underwent TURP for bladder outlet obstruction without detrusor underactivity. We review the ev...
Source: Current Bladder Dysfunction Reports - February 8, 2024 Category: Urology & Nephrology Source Type: research

Use and Outcomes of Botulinum Toxin A for Both Neurogenic and Non-neurogenic Voiding Dysfunction in the Pediatric Patient
AbstractPurpose of ReviewIn this review, we seek to present the most recent data that is available and not perform an exhaustive review of the whole literature. Many recent publications have provided us with randomized prospective studies which confirmed much of the prior groundbreaking work done by the authors who published some of the original work in the field. In some cases, we may intersperse data from an adult study when there is a lack of data from a pediatric study.Recent FindingsIn a 48-week prospective, multicenter, randomized, double-blind study in children (aged 5 –17 years) with neurogenic detrusor overact...
Source: Current Bladder Dysfunction Reports - February 6, 2024 Category: Urology & Nephrology Source Type: research

Chronic Eosinophilic Cystitis: Up to Date Evidence Review
AbstractPurpose of ReviewEosinophilic cystitis is a rare condition of unknown etiology. However, many factors can trigger such pathology, its symptoms may mimic many other clinical situations. In this article, the author is aiming to illustrate and summarize the up-to-date evidence about this disorder.Recent FindingsThe latest published evidence about eosinophilic cystitis was reviewed and data about different triggers was collected. Different treatment modalities ranging from medications such as steroids to surgical interventions were mentioned in this review.SummaryThere are different recommended treatments owing to diff...
Source: Current Bladder Dysfunction Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research

Urinary Biomarkers of Detrusor Underactivity
AbstractPurpose of ReviewDetrusor underactivity (DU) is a urodynamic diagnosis, often related with the multifactorial symptom complex designated as underactive bladder (UAB), resulting in prolonged and/or incomplete bladder emptying, and many times with a high postvoid residual. DU is a largely under-researched topic and constitutes a multifactorial condition, with several underlying pathophysiological mechanisms, which can be categorized as idiopathic, neurogenic, myogenic, or functional. The main etiological factors of DU are aging, diabetes mellitus, neurogenic disorders, and bladder outlet obstruction (BOO). Biomarkers...
Source: Current Bladder Dysfunction Reports - January 29, 2024 Category: Urology & Nephrology Source Type: research

Using Pictures Instead of Words: Visual-Validated Questionnaires for LUTS and Neurogenic Bladder
AbstractPurpose of ReviewIn this review, we evaluate the potential of visual questionnaires for lower urinary tract symptoms (LUTS) as a clinically viable alternative to written questionnaires, aiming for improved accuracy and user-friendliness.Recent FindingsSeveral visual questionnaires, including VPSS, modified VPSS, SVPI, VASUS, LUTS-V, and DRIPSS, have been developed and validated for the assessment of male LUTS through predominantly quantitative studies, with a limited number of qualitative studies.SummaryVisual questionnaires demonstrate comparable efficacy to the written questionnaires, particularly proving their s...
Source: Current Bladder Dysfunction Reports - January 27, 2024 Category: Urology & Nephrology Source Type: research

Unresolved Pyuria
AbstractPurpose of ReviewIn this review, the most recent literature regarding causes of sterile pyuria and the conditions that can co-occur or present with sterile pyuria will be addressed. Specifically, we examine sterile pyuria in the context of genitourinary tuberculosis, sexually transmitted infections, interstitial cystitis, and genitourinary malignancy.Recent FindingsNewer diagnostic technologies such as next-generation sequencing (NGS) have shown that urine may not truly be sterile. Unresolved pyuria (i.e., pyuria without identifiable cause) may therefore be caused by sub-clinical infections or the result of underly...
Source: Current Bladder Dysfunction Reports - January 25, 2024 Category: Urology & Nephrology Source Type: research

How to Diagnose Dysfunctional Voiding
AbstractPurposeThis review aims to discuss the diagnosis and assessment of dysfunctional voiding in both children and adults.Recent FindingsAlthough the pillars of diagnosing dysfunctional voiding are a history, physical exam, and uroflowmetry with electromyography or urodynamics, new technology may aid in this evaluation. The use of urinary biomarkers may be a helpful, non-invasive adjunct in diagnosis. In addition, novel devices and smartphone apps may make diagnosis more accessible to patients and providers.SummaryDysfunctional voiding refers to the condition where there is a lack of coordination between the sphincter a...
Source: Current Bladder Dysfunction Reports - January 19, 2024 Category: Urology & Nephrology Source Type: research

Gene Therapy and Overactive Bladder
AbstractPurpose of ReviewWithin the last decade, a number of gene therapies have been developed as a treatment option for monogenic diseases. Overactive bladder is a multifactorial syndrome with likely many underlying causes and regulatory components. The goal of this paper is to review current gene therapy in and outside of the genitourinary system, review the pathophysiology and genetics of OAB, and discuss recent advances in application of this technology for OAB treatment.Recent FindingsVarious genes have been found to be upregulated in OAB patients including receptors involved in purinergic signaling, gap junctions be...
Source: Current Bladder Dysfunction Reports - January 15, 2024 Category: Urology & Nephrology Source Type: research

Urodynamics in the Transplant Population
AbstractPurpose of ReviewUrodynamic testing (UDS) is a valuable tool for understanding the safety of the lower urinary tract (LUT). The goal of this review is to provide evidence-based indications for use of UDS in both the pre- and post-kidney transplant (KT) settings.Recent FindingsPre-transplant bladder cycling with UDS for anuric or oliguric patients is no longer recommended. Instead, UDS aids in identifying LUT anomalies that may require optimization prior to transplant, especially in patients with known urologic etiologies of end-stage renal disease (ERSD). In pre-KT patients with recurrent urinary tract infections (...
Source: Current Bladder Dysfunction Reports - January 15, 2024 Category: Urology & Nephrology Source Type: research

Machine Learning and Artificial Intelligence to Improve Interpretation of Urodynamics
This study is not a clinical trial and thus does not warrant registration as such. (Source: Current Bladder Dysfunction Reports)
Source: Current Bladder Dysfunction Reports - January 13, 2024 Category: Urology & Nephrology Source Type: research

Overactive Bladder: the Patient Perspective
We present a narrative review of literature published in the last 5  years surrounding the patient perspective of OAB.Recent FindingsOAB has a negative effect on health-related quality of life (HRQoL). Management of OAB generates significant cost to the patient, including physician visits, incontinence pads, treatment of urinary tract infections, and management of skin infections and irritation. Patients with OAB suffer in terms of work productivity, food insecurity, and financial strain, and these effects are more profound in patients of lower socioeconomic status and education level. Recent literature investigating the ...
Source: Current Bladder Dysfunction Reports - January 8, 2024 Category: Urology & Nephrology Source Type: research

The Current State of Implantable Tibial Nerve Stimulation Therapy
AbstractPurpose of ReviewOveractive bladder (OAB) is a prevalent condition affecting 23% of the population in the USA. There are several options for third-line therapies (intradetrusoronabotulinumtoxinA injections, sacral (S3) nerve stimulation, and posterior tibial nerve stimulation (PTNS)), each with its own strengths and weaknesses.Recent FindingsImplantable tibial nerve stimulators (ITNS) are a new type of device based on PTNSprinciples; however, ITNS may carry several advantages over previous therapeutic modalities. Typically, ITNS is an office-based procedure obviating the need for general anesthesia or sedation. The...
Source: Current Bladder Dysfunction Reports - December 1, 2023 Category: Urology & Nephrology Source Type: research

Our Knowledge of the Relationship of the Urinary Microbiome and Overactive Bladder: Past, Present, Future
AbstractPurpose of ReviewThis review covers the latest research on the urinary microbiome and its relationship to overactive bladder. We sought to understand what urinary microbiome characteristics may be associated with overactive bladder and what research has been done to come to these conclusions.Recent FindingsThe latest research has gone beyond simply characterizing the microbial environment of urine and has transcended deeper into relationships between microbes and lower urinary tract disorders, specifically overactive bladder. Advances in next-generation sequencing technologies have largely made this possible. Multi...
Source: Current Bladder Dysfunction Reports - November 30, 2023 Category: Urology & Nephrology Source Type: research

Management of the Devastated Female Urethra
AbstractPurpose of ReviewCritical evaluation of literature published in last 5 years pertaining to management of the devastated urethra in female patients.Recent FindingsThe devastated female urethra is a debilitating heterogenous disease that can be extremely difficult to manage. The recent published literature has largely been retrospective in nature but has shown good long-term outcomes for multiple operative approaches.SummaryFemale patients with incontinence due to devastation of the urethra pose a challenge due to limited surgical options. To achieve dryness, all patients will require closure of the bladder outlet, w...
Source: Current Bladder Dysfunction Reports - November 16, 2023 Category: Urology & Nephrology Source Type: research