The Influence of Age on the Relationship Between Allergic Rhinitis and Otitis Media
AbstractPurpose of ReviewTo examine the relationship between otitis media, allergic rhinitis, and age.Recent FindingsOtitis media and allergic rhinitis are prevalent conditions with a controversial relationship. Some data suggest that these entities are significantly associated, either through allergic rhinitis inducing Eustachian tube dysfunction or through allergic pathophysiology simultaneously occurring intranasally and in the ear. Other studies, however, have refuted this relationship. For example, treatment with antihistamines does not reliably improve OME, making causation and association challenging to establish. A...
Source: Current Allergy and Asthma Reports - October 20, 2018 Category: Allergy & Immunology Source Type: research

IgE Test in Secretions of Patients with Respiratory Allergy
AbstractPurpose of ReviewIgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP).Recent FindingsCurrent evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non-atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on tec...
Source: Current Allergy and Asthma Reports - October 13, 2018 Category: Allergy & Immunology Source Type: research

The Multifaceted B Cell Response in Allergen Immunotherapy
AbstractWhile allergen immunotherapy (AIT) for IgE-mediated diseases holds curative potential, the considerable heterogeneity in clinical outcomes may relate to the complex mechanisms of tolerance. The regulation of humoral immunity by AIT contributes to the suppression of allergic responses. Recent findings have revealed novel roles for IgA and IgG antibodies in the induction of tolerance. These mechanisms synergize with their ability to block allergen-IgE binding and mediate inhibitory signaling of effector cells of the allergic response. In addition, the regulatory activity of B cells in AIT extends beyond IL-10 secreti...
Source: Current Allergy and Asthma Reports - October 5, 2018 Category: Allergy & Immunology Source Type: research

Agriculture Occupational Exposures and Factors Affecting Health Effects
Discussions include the impact of farming modernization, education, and personal protective equipment usage among workers, timing and duration in mediating lung health outcomes, and population studies investigating the association between exposure and risk for numerous lung diseases. (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 5, 2018 Category: Allergy & Immunology Source Type: research

Biomarkers in Food Allergy
AbstractPurpose of ReviewTo familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.Recent FindingsMany efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action...
Source: Current Allergy and Asthma Reports - October 3, 2018 Category: Allergy & Immunology Source Type: research

Danger-Associated Molecular Patterns (DAMPs): the Derivatives and Triggers of Inflammation
AbstractPurpose of ReviewAllergen is an umbrella term for irritants of diverse origin. Along with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens can be grouped as inflammatory agents. Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm signals by the innate immune system. Like inflammation, DAMPs play a role in correcting the altered physiological state, but in excess, they can be lethal due to their signal transduction roles. In a vicious loop, inflammatory agents are DAMP generators and DAMPs create a pr...
Source: Current Allergy and Asthma Reports - September 28, 2018 Category: Allergy & Immunology Source Type: research

Emerging Insights into the Occupational Mycobiome
AbstractPurpose of ReviewThe evolution of molecular-based methods over the last two decades has provided new approaches to identify and characterize fungal communities or “mycobiomes” at resolutions previously not possible using traditional hazard identification methods. The recent focus on fungal community assemblages within indoor environments has provided renewed insight into overlooked sources of fungal exposure. In occupational studies, internal transcribed spacer (ITS) region sequencing has recently been utilized in a variety of environments ranging from indoor office buildings to agricultural commodity a...
Source: Current Allergy and Asthma Reports - September 27, 2018 Category: Allergy & Immunology Source Type: research

Telemedicine Technology: a Review of Services, Equipment, and Other Aspects
AbstractPurpose of ReviewTelemedicine uses technology to connect patients with providers at a distance. While the clinical aspects of this have been reviewed extensively, the technical aspects are not as well understood by allergists when they consider adding telemedicine to their practice. This review focuses on the technical aspects of setting up a telemedicine program.Recent FindingsWith the advent of new technologies including high-speed Internet, video conferencing solutions, and digital examination equipment, facilitated virtual visits as replacements for in-person visits are now possible. The technical requirements ...
Source: Current Allergy and Asthma Reports - September 26, 2018 Category: Allergy & Immunology Source Type: research

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment
AbstractPurpose of ReviewAllergy and asthma are growing problems in the developed world. The accelerated increase of these diseases may be related to microbiome modification that leads to aberrant activation of Toll-like receptors (TLRs). Current research supports the concept that changes in microbial communities in early life impact TLR activation, resulting in an altered risk for the development of asthma and allergies.Recent FindingsPrenatal and early childhood events that generate microbiome modification are closely related with TLR activation. Early childhood exposure to a rich array of TLR agonists, particularly lipo...
Source: Current Allergy and Asthma Reports - September 26, 2018 Category: Allergy & Immunology Source Type: research

Telemedicine Technology: a Review of Services, Equipment, and Other Aspects
AbstractPurpose of ReviewTelemedicine uses technology to connect patients with providers at a distance. While the clinical aspects of this have been reviewed extensively, the technical aspects are not as well understood by allergists when they consider adding telemedicine to their practice. This review focuses on the technical aspects of setting up a telemedicine program.Recent FindingsWith the advent of new technologies including high-speed Internet, video conferencing solutions, and digital examination equipment, facilitated virtual visits as replacements for in-person visits are now possible. The technical requirements ...
Source: Current Allergy and Asthma Reports - September 26, 2018 Category: Allergy & Immunology Source Type: research

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment
AbstractPurpose of ReviewAllergy and asthma are growing problems in the developed world. The accelerated increase of these diseases may be related to microbiome modification that leads to aberrant activation of Toll-like receptors (TLRs). Current research supports the concept that changes in microbial communities in early life impact TLR activation, resulting in an altered risk for the development of asthma and allergies.Recent FindingsPrenatal and early childhood events that generate microbiome modification are closely related with TLR activation. Early childhood exposure to a rich array of TLR agonists, particularly lipo...
Source: Current Allergy and Asthma Reports - September 26, 2018 Category: Allergy & Immunology Source Type: research

Impact of Climate Change on Pollen and Respiratory Disease
AbstractPurpose of ReviewA warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. This review is intended to discuss significant factors related to individuals with allergic and respiratory disease.Recent FindingsRecent findings include the increased growth of allergenic plants in response to higher carbon dioxide levels and warmer temperatures. This also contributes to the increased production of pollen as well as the appearance of allergenic species in new climactic areas. Stinging insects will extend thei...
Source: Current Allergy and Asthma Reports - September 20, 2018 Category: Allergy & Immunology Source Type: research

Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought
AbstractPurpose of ReviewThe development of allergic disease is shaped by genetics and the environment, including diet. Many studies suggest a role for maternal diet during pregnancy. In this article, we discuss potential mechanisms by which specific nutrients, particular foods, and dietary patterns may influence allergic disease development and review studies examining the relationship between prenatal diet and the risk of childhood allergy.Recent FindingsThe combination ofin utero exposures and genetic predisposition may contribute to the development of allergic disease by altering immune and organ development. Inflammat...
Source: Current Allergy and Asthma Reports - September 18, 2018 Category: Allergy & Immunology Source Type: research

Administering a Telemedicine Program
AbstractPurpose of ReviewThe purpose of this review is to describe the process of administering a telemedicine program including reviewing telemedicine guidelines; discussing licensing, credentialing, and privileging of providers; outlining scheduling and recruitment of patients; and measuring outcomes of a telemedicine program.Recent FindingsRecent literature findings suggest that telemedicine in specialty clinics continues to grow at a rapid pace. Medical specialty programs should prepare to adopt a practice that includes telemedicine to better serve their patients and families who have expressed significant satisfaction...
Source: Current Allergy and Asthma Reports - September 15, 2018 Category: Allergy & Immunology Source Type: research

Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is behind the Geographic Restriction?
AbstractPurpose of ReviewTo critically examine evidence suggesting that food allergy induced by lipid transfer proteins (LTPs) follows a geographic pattern.Recent FindingsLTP syndrome remains most common in the Mediterranean basin, with a clear gradient seen in prevalence of LTP sensitization between northern and southern Europe. We hypothesize that high levels of birch pollen seem to protect against LTP allergy, as these higher levels correlate with a lower prevalence of LTP hypersensitivity. Nevertheless, LTP food allergy cases still appear in areas having a high environmental level of birch pollen.SummaryFood allergy ca...
Source: Current Allergy and Asthma Reports - September 11, 2018 Category: Allergy & Immunology Source Type: research

Biologics and Small Molecule Agents in Allergic and Immunologic Skin Diseases
This article reviews recent literature on small molecules and biologics for the treatment of atopic dermatitis and psoriasis. (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - August 31, 2018 Category: Allergy & Immunology Source Type: research

A Review of Portable Electronic Spirometers: Implications for Asthma Self-Management
AbstractPurpose of ReviewAlthough portable electronic spirometers allow for at-home lung function monitoring, a comprehensive review of these devices has not yet been conducted. We conducted a systematic search and review of commercially available portable electronic spirometers designed for asthma patient use.Recent FindingsAll devices (N = 16) allowed for monitoring of basic lung function parameters, but only 31% provided in-app videos on how to perform breathing maneuvers. Most devices (63%) provided graphical representations of lung function results, but only 44% gave immediate feedback on the quality of ...
Source: Current Allergy and Asthma Reports - August 25, 2018 Category: Allergy & Immunology Source Type: research

Telemedicine: a Primer
AbstractPurpose of ReviewDue to rapid advancements in quality of real-time, interactive, audio-visual, and digital technologies as well as impressive gains in internet speed and capacity, medicine delivered over distance is happening faster than many healthcare providers and leaders can grasp.Recent FindingsDepending on which market report you ascribe to, industry projections for the global compounded annual growth rate of telemedicine are between 13 and 27%, with valuation growing to over 20 billion US dollars in the next several years. The Mayo Clinic has reworked its entire telemedicine interest to a model with centrali...
Source: Current Allergy and Asthma Reports - August 25, 2018 Category: Allergy & Immunology Source Type: research

A Review of Portable Electronic Spirometers: Implications for Asthma Self-Management
AbstractPurpose of ReviewAlthough portable electronic spirometers allow for at-home lung function monitoring, a comprehensive review of these devices has not yet been conducted. We conducted a systematic search and review of commercially available portable electronic spirometers designed for asthma patient use.Recent FindingsAll devices (N = 16) allowed for monitoring of basic lung function parameters, but only 31% provided in-app videos on how to perform breathing maneuvers. Most devices (63%) provided graphical representations of lung function results, but only 44% gave immediate feedback on the quality of ...
Source: Current Allergy and Asthma Reports - August 25, 2018 Category: Allergy & Immunology Source Type: research

Telemedicine: a Primer
AbstractPurpose of ReviewDue to rapid advancements in quality of real-time, interactive, audio-visual, and digital technologies as well as impressive gains in internet speed and capacity, medicine delivered over distance is happening faster than many healthcare providers and leaders can grasp.Recent FindingsDepending on which market report you ascribe to, industry projections for the global compounded annual growth rate of telemedicine are between 13 and 27%, with valuation growing to over 20 billion US dollars in the next several years. The Mayo Clinic has reworked its entire telemedicine interest to a model with centrali...
Source: Current Allergy and Asthma Reports - August 25, 2018 Category: Allergy & Immunology Source Type: research

Bedroom Allergen Exposure Beyond House Dust Mites
AbstractPurpose of ReviewThe review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest, and fungal exposures.Recent FindingsLarge-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, have extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation o...
Source: Current Allergy and Asthma Reports - August 20, 2018 Category: Allergy & Immunology Source Type: research

Tips for Seeing Patients via Telemedicine
AbstractPurpose of ReviewTelemedicine is a technology that permits patients to be seen at a distance. This review describes different types of telemedicine, why they might be useful for a practice, what equipment is needed, and how to select and schedule patients.Recent FindingsThe use of synchronous telemedicine is increasing rapidly and has surpassed 50% of ambulatory encounters in some instances. Management of patients is particularly germane for an allergy practice since it is an outpatient specialty with patients who live in widely distributed locations with limited access to allergists. With utilization of digital ex...
Source: Current Allergy and Asthma Reports - August 15, 2018 Category: Allergy & Immunology Source Type: research

Clinical Manifestation of Hyper IgE Syndrome Including Otitis Media
AbstractPurpose of ReviewThe hyper IgE syndromes (HIES) comprise a group of rare primary immunodeficiency disorders (PIDDs), which are characterized by extremely high serum IgE levels, eczema, recurrent skin and pulmonary infections. Both autosomal dominant (AD) HIES due to STAT3 mutations and autosomal recessive (AR) HIES due to PGM3, SPINK5, DOCK8 and TKY2 mutations have been reported. Here, we aim to summarize and compare the major clinical manifestations of different subtypes of HIES. We will also discuss otitis media, which usually do not get enough attention in HIES. Update and familiarity with these clinical feature...
Source: Current Allergy and Asthma Reports - August 15, 2018 Category: Allergy & Immunology Source Type: research

Tips for Seeing Patients via Telemedicine
AbstractPurpose of ReviewTelemedicine is a technology that permits patients to be seen at a distance. This review describes different types of telemedicine, why they might be useful for a practice, what equipment is needed, and how to select and schedule patients.Recent FindingsThe use of synchronous telemedicine is increasing rapidly and has surpassed 50% of ambulatory encounters in some instances. Management of patients is particularly germane for an allergy practice since it is an outpatient specialty with patients who live in widely distributed locations with limited access to allergists. With utilization of digital ex...
Source: Current Allergy and Asthma Reports - August 15, 2018 Category: Allergy & Immunology Source Type: research

Clinical Manifestation of Hyper IgE Syndrome Including Otitis Media
AbstractPurpose of ReviewThe hyper IgE syndromes (HIES) comprise a group of rare primary immunodeficiency disorders (PIDDs), which are characterized by extremely high serum IgE levels, eczema, recurrent skin and pulmonary infections. Both autosomal dominant (AD) HIES due to STAT3 mutations and autosomal recessive (AR) HIES due to PGM3, SPINK5, DOCK8 and TKY2 mutations have been reported. Here, we aim to summarize and compare the major clinical manifestations of different subtypes of HIES. We will also discuss otitis media, which usually do not get enough attention in HIES. Update and familiarity with these clinical feature...
Source: Current Allergy and Asthma Reports - August 15, 2018 Category: Allergy & Immunology Source Type: research

Allergic Contact Dermatitis Evaluation: Strategies for the Preschooler
AbstractPurpose of ReviewThe environment for the developing children is complex as they are exposed to a variety of activities and settings where potential environmental allergens may be encountered. Recent evidence supports the clinical benefit of patch testing young children suffering from recalcitrant dermatitis. While patch testing has been recently approved by the Food and Drug Administration in children ages 6 –18 years old, patch testing strategies for young children of preschool age (between 2 and 6 years old) have yet to be defined.Recent FindingsAllergic contact dermatitis is underdiagnosed among ...
Source: Current Allergy and Asthma Reports - August 1, 2018 Category: Allergy & Immunology Source Type: research

Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions
AbstractPurpose of ReviewImpaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma). How motile ciliary disorders (impaired ciliogenesis, ciliary beating and ultrastructural defects) are implicated in chronic airway inflammatory diseases is not fully understood. Elaboration of the role of motile ciliary disorders may serve as therapeutic targets for improving mucociliary clearance, thereby complementing contemporary disease management.Recent FindingsWe have summarized th...
Source: Current Allergy and Asthma Reports - July 26, 2018 Category: Allergy & Immunology Source Type: research

Is Allergen Immunotherapy in Children Disease Modifying? A Review of the Evidence
AbstractPurpose of ReviewAlthough evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural history of these conditions.Recent FindingsIn aeroallergen immunotherapy, studies suggest that prevention of asthma can be attained. Less evident is the ability of immunotherapy to prevent new allergen sensitizations and more studies are needed to test whether immunotherapy can continue suppressing airway symptoms after treatment discontinuation. In food allergen immunotherapy, there is evidence that unr...
Source: Current Allergy and Asthma Reports - July 11, 2018 Category: Allergy & Immunology Source Type: research

Endotypes of Chronic Rhinosinusitis Across Ancestry and Geographic Regions
AbstractPurpose of ReviewPreliminary studies have suggested differences in endotypes of chronic rhinosinusitis (CRS) across ancestry/ethnic groups. Eosinophilic CRS (ECRS) is the predominant subtype for Western/European ancestry CRS patients and non-eosinophilic CRS (nECRS) for Asian patients. This review aims to re-analyze CRS endotypes across ancestry populations using one consistent criteria to existing data.Recent FindingsAlthough tissue eosinophilia is the most commonly used criterion for ECRS, various cut-off points are suggested. Surrogate markers have been extensively studied. Sixty-six cohorts with study criteria ...
Source: Current Allergy and Asthma Reports - July 11, 2018 Category: Allergy & Immunology Source Type: research

Is Allergen Immunotherapy in Children Disease Modifying? A Review of the Evidence
AbstractPurpose of ReviewAlthough evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural history of these conditions.Recent FindingsIn aeroallergen immunotherapy, studies suggest that prevention of asthma can be attained. Less evident is the ability of immunotherapy to prevent new allergen sensitizations and more studies are needed to test whether immunotherapy can continue suppressing airway symptoms after treatment discontinuation. In food allergen immunotherapy, there is evidence that unr...
Source: Current Allergy and Asthma Reports - July 11, 2018 Category: Allergy & Immunology Source Type: research

Endotypes of Chronic Rhinosinusitis Across Ancestry and Geographic Regions
AbstractPurpose of ReviewPreliminary studies have suggested differences in endotypes of chronic rhinosinusitis (CRS) across ancestry/ethnic groups. Eosinophilic CRS (ECRS) is the predominant subtype for Western/European ancestry CRS patients and non-eosinophilic CRS (nECRS) for Asian patients. This review aims to re-analyze CRS endotypes across ancestry populations using one consistent criteria to existing data.Recent FindingsAlthough tissue eosinophilia is the most commonly used criterion for ECRS, various cut-off points are suggested. Surrogate markers have been extensively studied. Sixty-six cohorts with study criteria ...
Source: Current Allergy and Asthma Reports - July 11, 2018 Category: Allergy & Immunology Source Type: research

Prospects for Monoclonal Antibody Therapy in Pediatric Asthma
AbstractPurpose of ReviewThe profile of biologic therapies for asthma is growing rapidly. We discuss how to match the proper pediatric patient with the most effective therapy.Recent FindingsCurrently available biologic therapies are most effective in patients with T2 high asthma. Newer drugs are currently being studied which target TSLP and interleukin 33. These newer drugs may provide options for asthmatics who do not respond to the current anti-IgE, anti-IL5, and anti-IL4/13 therapies.SummaryAsthma is a heterogeneous disease which can be driven by different inflammatory mediators in different patients. To select the most...
Source: Current Allergy and Asthma Reports - July 10, 2018 Category: Allergy & Immunology Source Type: research

The Child with Recurrent Mycobacterial Disease
AbstractPurpose of ReviewMany genetic conditions predispose affected individuals to opportunistic infections. A number of immunodeficiency diseases, including genetic defects termed Mendelian susceptibility to mycobacterial disease (MSMD), permit infection from many different strains of mycobacteria that would otherwise not cause disease. These include tuberculous and nontuberculous mycobacteria, and bacille Calmette-Gu érin vaccine (BCG). Patients may present with infections from other organisms that depend on macrophage function for containment. Defects in multiple genes in the IL-12 and NFKB signaling pathways ca...
Source: Current Allergy and Asthma Reports - June 23, 2018 Category: Allergy & Immunology Source Type: research

What Is the Relationship Between Eosinophilic Esophagitis (EoE) and Aeroallergens? Implications for Allergen Immunotherapy
AbstractPurpose of ReviewObservations suggesting that aeroallergens trigger eosinophilic esophagitis (EoE) in a subset of patients raise questions about the implications this finding has on the evaluation and management of patients with EoE, including a potential role for allergen immunotherapy.Recent FindingsThe majority of studies evaluating the potential role of aeroallergens as provocateurs of EoE have addressed this issue by assessing the seasonal variation in EoE diagnosis and/or symptom onset or worsening, with mixed results. For various reasons, reaching accurate conclusions based on this methodology is potentially...
Source: Current Allergy and Asthma Reports - June 16, 2018 Category: Allergy & Immunology Source Type: research

Olfactory Dysfunction in Neurodegenerative Diseases
AbstractPurpose of ReviewThe sense of smell is today one of the focuses of interest in aging and neurodegenerative disease research. In several neurodegenerative diseases, such as Parkinson ’s disease and Alzheimer’s disease, the olfactory dysfunction is one of the initial symptoms appearing years before motor symptoms and cognitive decline, being considered a clinical marker of these diseases’ early stages and a marker of disease progression and cognitive decline. Overall and un der the umbrella of precision medicine, attention to olfactory function may help to improve chances of success for neuroprotect...
Source: Current Allergy and Asthma Reports - June 15, 2018 Category: Allergy & Immunology Source Type: research

Food-Induced Anaphylaxis: an Update
AbstractPurpose of ReviewThis review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA).Recent FindingsFood allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Oral, sublingual, and epicutaneous immunotherapy can desensitize a significant portion of subjects. Epinephrine use for FIA remains sub-optimal.SummaryAs the burden of food allergy continues to increase, it appears that the corresponding increase i...
Source: Current Allergy and Asthma Reports - June 14, 2018 Category: Allergy & Immunology Source Type: research

Atypical Cutaneous Presentations of Sarcoidosis: Two Case Reports and Review of the Literature
AbstractPurpose of ReviewThe goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.Recent FindingsWhile the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised distri...
Source: Current Allergy and Asthma Reports - June 14, 2018 Category: Allergy & Immunology Source Type: research

Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches
AbstractPurpose of ReviewThe aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy.Recent FindingsAIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the...
Source: Current Allergy and Asthma Reports - June 9, 2018 Category: Allergy & Immunology Source Type: research