Editorial Board
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Genomics and pharmacogenomics of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukaemia (ALL) is a prevalent form of pediatric cancer that accounts for 70 –80% of all leukemias. Genome-based analysis, exome sequencing, transcriptomics and proteomics have provided insight into genetic classification of ALL and helped identify novel subtypes of the disease. B and T cell-based ALL are two well-characterized genomic subtypes, significantly marked by bon e marrow disorders, along with mutations in trisomy 21 and T53. The other ALLs include Early T-cell precursor ALL, Philadelphia chromosome-like ALL, Down syndrome-associated ALL and Relapsed ALL. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 10, 2018 Category: Cancer & Oncology Authors: Chuan Wu, Wei Li Source Type: research

Genomics and pharmacogenomics of Pediatric Acute Lymphoblastic Leukemia
Acute lymphoblastic leukaemia (ALL) is a prevalent form of pediatric cancer that accounts for 70-80% of all leukemias. Genome-based analysis, exome sequencing, transcriptomics and proteomics have provided insight into genetic classification of ALL and helped identify novel subtypes of the disease. B and T cell-based ALL are two well-characterized genomic subtypes, significantly marked by bone marrow disorders, along with mutations in trisomy 21 and T53. The other ALLs include Early T-cell precursor ALL, Philadelphia chromosome-like ALL, Down syndrome-associated ALL and Relapsed ALL. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 10, 2018 Category: Cancer & Oncology Authors: Chuan Wu, Wei Li Source Type: research

Organization, quality and cost of oncological home-hospitalization: A systematic review
Worldwide, cancer is a major threat to public health. The social as well as economic consequences remain significant for patients and societies (Luengo-Fernandez et al., 2013; Costa et al., 2016; Markman and Luce, 2010). The World Economic Forum estimated direct costs of cancer treatment and attended costs of income losses at US$ 290 billion in 2010 (Bloom et al., 2011). Within the European Union, total cancer costs were estimated at €126 billion in 2009, whereof €51 billion accounted for healthcare (Luengo-Fernandez et al., 2013). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 9, 2018 Category: Cancer & Oncology Authors: Lieselot Cool, Dominique Vandijck, Philip Debruyne, Melissa Desmedt, Tessa Lefebvre, Michelle Lycke, Pieter Jan De Jonghe, Hans Pottel, Veerle Foulon, Koen Van Eygen Tags: Review Source Type: research

The emerging co-regulatory role of long noncoding RNAs in epithelial-mesenchymal transition and the Warburg effect in aggressive tumors
In the last several decades, cancer researchers have reported many distinct hallmarks of tumor cells (Hanahan and Weinberg, 2011). Among the mechanisms that lead to these phenotypes, epithelial-to-mesenchymal transition (EMT) is emerging as a central driver of several malignant behaviors (Kalluri and Weinberg, 2009). EMT is well defined as a series of events in which epithelial cells lose their epithelial characteristics, intercellular contacts and cellular polarity, and acquire various features of mesenchymal cells, such as increased motility, invasiveness, and resistance to apoptosis (Thiery et al., 2009). (Source: Criti...
Source: Critical Reviews in Oncology Hematology - April 9, 2018 Category: Cancer & Oncology Authors: Qian Hua, Baoming Mi, Gang Huang Source Type: research

Organization, Quality and Cost of Oncological Home-Hospitalization: A Systematic Review
Worldwide, cancer is a major threat to public health. The social as well as economic consequences remain significant for patients and societies [1 –3]. The World Economic Forum estimated direct costs of cancer treatment and attended costs of income losses at US$ 290 billion in 2010 [4]. Within the European Union, total cancer costs were estimated at €126 billion in 2009, whereof €51 billion accounted for healthcare [1]. Given the increas ing incidence and prevalence as well as the advanced screening and treatment modalities, there is no doubt cancer costs will only expand [4–7]. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 9, 2018 Category: Cancer & Oncology Authors: Lieselot Cool, Dominique Vandijck, Philip Debruyne, Melissa Desmedt, Tessa Lefebvre, Michelle Lycke, Pieter Jan De Jonghe, Hans Pottel, Veerle Foulon, Koen Van Eygen Source Type: research

The emerging co-regulatory role of long noncoding RNAs in epithelial-mesenchymal transition and the Warburg effect in aggressive tumors
In the last several decades, cancer researchers have reported many distinct hallmarks of tumor cells (Hanahan and Weinberg, 2011). Among the mechanisms that lead to these phenotypes, epithelial-to-mesenchymal transition (EMT) is emerging as a central driver of several malignant behaviors (Kalluri and Weinberg, 2009). EMT is well defined as a series of events in which epithelial cells lose their epithelial characteristics, intercellular contacts and cellular polarity, and acquire various features of mesenchymal cells, such as increased motility, invasiveness, and resistance to apoptosis (Thiery et al., 2009). (Source: Criti...
Source: Critical Reviews in Oncology Hematology - April 9, 2018 Category: Cancer & Oncology Authors: Qian Hua, Baoming Mi, Gang Huang Source Type: research

The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma
Meat a versatile food, is a source of high quality proteins, essential amino acids and many micronutrients including iron, selenium, zinc, vitamin B6, vitamin B12 and omega-3- polyunsaturated fatty acids (Celada et al., 2016). Red meat is defined as flesh from mammals (pork, beef, lamb, veal, etc.), with a higher percentage of red muscle fiber than white (Abid et al., 2014). Meat which is preserved and flavoured using methods such as salting, smoking, fermentation and curing is commonly referred to as processed meat (Bouvard et al., 2015). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 7, 2018 Category: Cancer & Oncology Authors: S.M.K. Gamage, Lakal Dissabandara, Alfred King-Yin Lam, Vinod Gopalan Source Type: research

Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer
Cancer research continues to advance the outcome of patients with cancer as reflected by the higher survival rates and better quality of life. In an effort to enhance outcomes, researchers are focused on evaluating therapies with more effectiveness as well as lesser toxicities. Despite recent discoveries and advances in medicine, pancreatic cancer (PC) has a very poor prognosis that urgently requires novel therapeutic approaches. Currently, the five-year survival rate for PC is 8% (Siegel et al., 2017). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 7, 2018 Category: Cancer & Oncology Authors: Myrna Hurtado, Umesh T. Sankpal, Amalendu Ranjan, Rajasekhar Maram, Jamboor K. Vishwanatha, Ganji Purnachandra Nagaraju, Bassel F. El-Rayes, Riyaz Basha Source Type: research

Radiological evaluation of response to immunotherapy in brain tumors: Where are we now and where are we going?
Brain metastases (BM) are the most common intracranial neoplastic disease in adults, with an incidence of 9 –17% among all brain tumors (Nayak et al., 2012). They are usually caused by lung cancer (either non-small cell (NSCLC) and small cell (SCLC) histologies), breast cancer, melanoma and renal cell carcinoma, with a raising incidence related to the improvements in diagnostic and treatment approaches (Berghoff et al., 2014). However, prognosis remains poor, with a median overall survival (OS) ranging from 3 to 27 months (Brastianos et al., 2013), rendering BM still an unmet medical need. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 7, 2018 Category: Cancer & Oncology Authors: Michele Porcu, Cinzia Solinas, Paolo Garofalo, Evandro de Azambuja, Mario Scartozzi, Karen Willard-Gallo, Matthias Preusser, Luca Saba Source Type: research

The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma
Meat a versatile food, is a source of high quality proteins, essential amino acids and many micronutrients including iron, selenium, zinc, vitamin B6, vitamin B12 and omega-3- polyunsaturated fatty acids (Celada et al., 2016). Red meat is defined as flesh from mammals (pork, beef, lamb, veal, etc.), with a higher percentage of red muscle fiber than white (Abid et al., 2014). Meat which is preserved and flavoured using methods such as salting, smoking, fermentation and curing is commonly referred to as processed meat (Bouvard et al., 2015). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 7, 2018 Category: Cancer & Oncology Authors: S.M.K. Gamage, Lakal Dissabandara, Alfred King-Yin Lam, Vinod Gopalan Source Type: research

Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer
Cancer research continues to advance the outcome of patients with cancer as reflected by the higher survival rates and better quality of life. In an effort to enhance outcomes, researchers are focused on evaluating therapies with more effectiveness as well as lesser toxicities. Despite recent discoveries and advances in medicine, pancreatic cancer (PC) has a very poor prognosis that urgently requires novel therapeutic approaches. Currently, the five-year survival rate for PC is 8% (Siegel et al., 2017). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 7, 2018 Category: Cancer & Oncology Authors: Myrna Hurtado, Umesh T. Sankpal, Amalendu Ranjan, Rajasekhar Maram, Jamboor K. Vishwanatha, Ganji Purnachandra Nagaraju, Bassel F. El-Rayes, Riyaz Basha Source Type: research

Radiological Evaluation of Response to Immunotherapy in Brain Tumors: Where Are We Now and Where Are We Going?
Brain metastases (BM) are the most common intracranial neoplastic disease in adults, with an incidence of 9-17% among all brain tumors (Nayak et al., 2012). They are usually caused by lung cancer (either non-small cell (NSCLC) and small cell (SCLC) histologies), breast cancer, melanoma and renal cell carcinoma, with a raising incidence related to the improvements in diagnostic and treatment approaches (Berghoff et al., 2014). However, prognosis remains poor, with a median overall survival (OS) ranging from 3 to 27 months (Brastianos et al., 2013), rendering BM still an unmet medical need. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 7, 2018 Category: Cancer & Oncology Authors: Michele Porcu, Cinzia Solinas, Paolo Garofalo, Evandro de Azambuja, Mario Scartozzi, Karen Willard-Gallo, Matthias Preusser, Luca Saba Source Type: research

The identification and isolation of CTCs: A biological Rubik ’s cube
Liquid biopsy represents an alternative to conventional biopsies for the evaluation of tumors mainly due to its easy sampling. One of the main applications is the enumeration of Circulating Tumor Cells (CTCs) to evaluate tumor progression or response to treatment. The analysis of the functional characteristics of CTCs could give us much more information about their role in order to establish a more personalized treatment for the patients. The major issue that has to be solved is the isolation of the CTC population. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 6, 2018 Category: Cancer & Oncology Authors: Cristina Mansilla, Elena Soria, Natalia Ram írez Source Type: research

The identification and isolation of CTCs: a Biological Rubik ’s Cube
Liquid biopsy represents an alternative to conventional biopsies for the evaluation of tumors mainly due to its easy sampling. One of the main applications is the enumeration of Circulating Tumor Cells (CTCs) to evaluate tumor progression or response to treatment. The analysis of the functional characteristics of CTCs could give us much more information about their role in order to establish a more personalized treatment for the patients. The major issue that has to be solved is the isolation of the CTC population. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - April 6, 2018 Category: Cancer & Oncology Authors: Cristina Mansilla, Elena Soria, Natalia Ram írez Source Type: research