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An attempt to conceptualize the individual onco-functional balance: why a standardized treatment is an illusion for diffuse low-grade glioma patients
In the era of evidence-based medicine, clinicians aim to establish standards of care from randomized studies. Following, personalized medicine has emerged, as new individualized biomarkers could help to predict sensitivity to specific treatment.In this paper, we show that, for diffuse low-grade glioma, some specificities – dual goal of both survival and functional gain, long duration of the disease with multistep treatments, multiparametric evaluation of the onco-functional balance of each treatment modality – call for a change of paradigm. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 13, 2017 Category: Cancer & Oncology Authors: Emmanuel Mandonnet, Hugues Duffau Source Type: research

Publishers Note - Tribute to Matti
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 13, 2017 Category: Cancer & Oncology Source Type: research

The relationship between body mass index and short term postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer: A systematic review and meta-analysis
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 7, 2017 Category: Cancer & Oncology Authors: Arwa S. Almasaudi, Stephen T. McSorley, Christine A. Edwards, Donald C. McMillan Source Type: research

Continuity and diversity
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 7, 2017 Category: Cancer & Oncology Authors: Matti Aapro Tags: Editorial Source Type: research

A question of class: treatment options for patients with relapsed and/or refractory multiple myeloma
Multiple classes of agent with distinct mechanisms of action are now available for the treatment of patients with relapsed and/or refractory multiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies. Additionally, several different drugs may be available within each agent class, each with their own specific efficacy and safety profile. This expansion of the treatment landscape has dramatically improved outcomes for patients. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 2, 2017 Category: Cancer & Oncology Authors: Gordon Cook, Sonja Zweegman, Mar ía-Victoria Mateos, Florence Suzan, Philippe Moreau Source Type: research

Editorial Board
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Long-term toxicity of the treatment for germ cell-cancer. A review
Testicular germ-cell cancer (GCC) is a curable disease. Stage I patients are mostly cured by surgery alone. For those with good prognosis advanced disease, radiotherapy in some patients with stage II Seminoma and chemotherapy for all other patients, are responsible for 95% of long-term survivors. Unfortunately, despite this high level of curability, overall survival has been reported lower for those patients receiving either radiotherapy or chemotherapy versus patients treated by surgery alone. Long-term survivors face a higher incidence of second neoplasms, and a higher risk of cardiovascular disease and metabolic syndrom...
Source: Critical Reviews in Oncology Hematology - November 25, 2017 Category: Cancer & Oncology Authors: P. Maroto Source Type: research

Meta-analyses evaluating surrogate endpoints for overall survival in cancer randomized trials: A critical review
In cancer randomized controlled trials (RCT), alternative endpoints are increasingly being used in place of overall survival (OS) to reduce sample size, duration and cost of trials. It is necessary to ensure that these endpoints are valid surrogates for OS. We aimed at identifying meta-analyses evaluating surrogate endpoints and assessing the strength of evidence for each study. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - November 23, 2017 Category: Cancer & Oncology Authors: Marion Savina, Sophie Gourgou, Antoine Italiano, Derek Dinart, Virginie Rondeau, Nicolas Penel, Simone Mathoulin-Pelissier, Carine Bellera Source Type: research

Epigenetic regulation of the Hedgehog and Wnt pathways in cancer
The Hedgehog (Hh) and wingless-Int1 (Wnt) pathways are important for tissue patterning in the developing embryo. In adult tissue, both pathways are typically dormant but are activated under certain conditions such as tissue damage. Aberrant activation of these pathways by mutations in key pathway regulators contributes to the genesis and progression of several cancer types. In addition, the impact of epigenetic regulation of the Hh and Wnt pathways on cancer is becoming increasingly clear. In this review, current knowledge on the epigenetic control of Hh and Wnt and the impact on tumor formation will be discussed. (Source:...
Source: Critical Reviews in Oncology Hematology - November 23, 2017 Category: Cancer & Oncology Authors: Leon J Wils, Maarten F Bijlsma Source Type: research

The Therapeutic use of human albumin in cancer patients ’ management
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - November 20, 2017 Category: Cancer & Oncology Authors: Moujaess Elissar, Fakhoury May, Assi Tarek, Elias Hanine, El Karak Fadi, Ghosn Marwan, Kattan Joseph Tags: Review Source Type: research

A Review of the Literature on the Relationships Between Genetic Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - November 20, 2017 Category: Cancer & Oncology Authors: Komal P. Singh, Anand A. Dhruva, Elena Flowers, Kord M. Kober, Christine Miaskowski Source Type: research

E-cadherin: Its dysregulation in carcinogenesis and clinical implications
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signalling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT ), E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers. (Source: C...
Source: Critical Reviews in Oncology Hematology - November 20, 2017 Category: Cancer & Oncology Authors: Sonia How Ming Wong, Chee Mun Fang, Lay-Hong Chuah, Chee Onn Leong, Siew Ching Ngai Source Type: research

Mind and Body Practices for Fatigue Reduction in Patients with Cancer and Hematopoietic Stem Cell Transplant Recipients: A Systematic Review and Meta-Analysis
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - November 20, 2017 Category: Cancer & Oncology Authors: Nathan Duong, Hailey Davis, Paula D. Robinson, Sapna Oberoi, Danielle Cataudella, S. Nicole Culos-Reed, Faith Gibson, Miriam G ötte, Pamela Hinds, Sanne L. Nijhof, Deborah Tomlinson, Patrick van der Torre, Elena Ladas, Sandra Cabral, L. Lee Dupuis, Lilli Tags: Review Source Type: research

Systematic review and survival meta-analysis of real world evidence on first-line pazopanib for metastatic renal cell carcinoma
A systematic review was conducted to identify real world studies reporting outcomes after first-line pazopanib in patients with metastatic renal cell carcinoma. Studies had to be observational and report survival data in terms of progression-free survival and overall survival in order to conduct meta-analysis techniques. These real-world data were compared to those obtained in the phase II and III randomized controlled trials of pazopanib. Real world evidence showed that the clinical and safety outcomes were consistent with those observed in the clinical trials despite the inclusion of unselected patients with a wide spect...
Source: Critical Reviews in Oncology Hematology - November 16, 2017 Category: Cancer & Oncology Authors: Miguel A. Climent, Jos é Muñoz Langa, Laura Basterretxea Badiola, Carmen Santander Lobera Tags: Review Source Type: research

Optimization and purification of l-asparaginase from fungi: A systematic review
This study followed the Preferred Reporting Items for Systematic Reviews. The search was conducted on five databases: LILACS, PubMed, Science Direct, Scopus and Web of Science up until July 20th, 2016, with no time or language restrictions. The reference list of the included studies was crosschecked and a partial gray literature search was undertaken. The methodology of the selected studies was evaluated using GRADE. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - November 13, 2017 Category: Cancer & Oncology Authors: Paula Monteiro Souza, Marcela Medeiros de Freitas, Samuel Leite Cardoso, Adalberto Pessoa, Eliete Neves Silva Guerra, P érola Oliveira Magalhães Source Type: research