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Total Body Irradiation in Allogeneic Bone Marrow Transplantation Conditioning Regimens: A Review
Hematologic malignancies may require, at one point during their treatment, allogeneic bone marrow transplantation. Total body irradiation combined with chemotherapy or radiomimetic used in allogeneic bone marrow transplantation is known to be very toxic. Total body irradiation (TBI) induces immunosuppression to prevent the rejection of donor marrow. TBI is also used to eradicate malignant cells and is in sanctuary organs that are not reached by chemotherapy drugs. TBI has evolved since its introduction in the late fifties, but acute and late toxicities remain. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - February 2, 2018 Category: Cancer & Oncology Authors: Adrien Paix, Delphine Antoni, Waisse Waissi, Marie-Pierre Ledoux, Karin Bilger, Luc Fornecker, Georges Noel Source Type: research

Editorial Board
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Diet and supplements in cancer prevention and treatment: Clinical evidences and future perspectives
In recent years, calorie-restricted dietary regimens and compounds such as vitamins, curcumin, green tea extracts and omega-3 fatty acids have attracted attention for their potential anticancer effects. While definitive conclusions cannot be drawn in this field, many patients adopt complementary antitumor therapies aiming to improve efficacy or reduce toxicity of chemotherapy, with uncertain benefits and the risk of additional toxicities or antagonistic interactions with standard therapies.In this manuscript, we review the different levels of available evidence to suggest or discourage specific dietary changes or supplemen...
Source: Critical Reviews in Oncology Hematology - January 21, 2018 Category: Cancer & Oncology Authors: Claudio Vernieri, Federico Nichetti, Alessandra Raimondi, Sara Pusceddu, Marco Platania, Franco Berrino, Filippo de Braud Source Type: research

The stem cell division theory of cancer
All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and lung cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote....
Source: Critical Reviews in Oncology Hematology - January 21, 2018 Category: Cancer & Oncology Authors: Miguel L ópez-Lázaro Source Type: research

Treatment of squamous cell carcinoma of the anal canal: A new strategies with anti-EGFR therapy and immunotherapy
The incidence of squamous cell carcinoma of the anal canal (SCAC) is increasing in both sexes but the standard treatment remains that of 20 years ago. However, interesting data have recently emerged on the use of anti-epidermal growth factor receptor (EGFR) agents and immunotherapy in advanced disease. Thus, new avenues of research are opening up that will hopefully lead to more effective therapeutic strategies. We provide an overview of the latest studies published on this tumor and discuss the possible future therapeutic options for combination therapy, anti-EGFR treatment and radiotherapy. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 19, 2018 Category: Cancer & Oncology Authors: A. Casadei Gardini, A. Passardi, L. Fornaro, Rosetti, M. Valgiusti, S. Ruscelli, M. Monti, C. Casadei, F. Pagan, G.L. Frassineti Source Type: research

Regulation of Epithelial to Mesenchymal Transition by BRCA1 in breast cancer
Reports till its discovery has proven multiple facets of Breast Cancer type 1 susceptibility gene (BRCA1) from nucleus to cytoplasm; from DNA repair to drug resistance; from Homologous Recombination (HR) to Ubiquitination; from breast to brain; from cancer to HIV and many of the roles are still unexplored. One of the recent attractions of BRCA1 is its role in regulating breast cancer metastasis though the exact mechanism is poorly understood. In this review, we will discuss the molecular interactions between BRCA1 and the key molecules of Epithelial and Mesenchymal Transition (EMT) associated with metastasis, its associate...
Source: Critical Reviews in Oncology Hematology - January 19, 2018 Category: Cancer & Oncology Authors: Satheesh Kumar Sengodan, Sreelatha K.H., Revathy Nadhan, Priya Srinivas Source Type: research

Reappraisal of primary hepatic lymphoma: Is surgical resection underestimated?
Primary hepatic lymphoma (PHL) is defined as a lympho-proliferative disorder limited to the liver without any involvement of the spleen, lymph nodes, bone marrow or blood. Diffuse large B-cell lymphoma (DLBCL) is the most common histological type counting more than 60 –80% of all PHL. Usually, it occurs in middle-aged men with aspecific symptoms and diagnosis is confirmed by histopathology. In order to expand current knowledge and to investigate an optimal therapeutic strategy, a systematic review of literature was conducted in February 2016. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 18, 2018 Category: Cancer & Oncology Authors: Manuela Cesaretti, Marine Loustau, Chiara Robba, Lorenzo Senescende, Alban Zarzavadjian Le Bian Source Type: research

A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 16, 2018 Category: Cancer & Oncology Authors: Bhanu Prasad Venkatesulu, Supriya Mallick, Steven H. Lin, Sunil Krishnan Source Type: research

Immunotherapy, an evolving approach for the management of triple negative breast cancer: converting non-responders to responders
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 12, 2018 Category: Cancer & Oncology Authors: Mai F. Tolba, Hany A. Omar Source Type: research

Global comparison of targeted alpha vs targeted beta therapy for cancer: in vitro, in vivo and clinical trials
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 10, 2018 Category: Cancer & Oncology Authors: Loredana Marcu, Eva Bezak, Barry J. Allen Source Type: research

Immune dysregulation in myelodysplastic syndrome: Clinical features, pathogenesis and therapeutic strategies
Myelodysplastic syndrome (MDS) is a heterogeneous hematological malignancy, characterized by cytopenia and accompanied by a risk of transformation into acute myeloid leukemia (AML). Epidemiological studies for decades have shown association between autoimmune diseases (AIDs) and MDS. Specifically, patients with antecedent AIDs tends to have an increased risk of developing MDS, and these patients display different clinical characteristics and outcomes. Importantly, immune dysregulation has been the common driving force between MDS and AIDs pathogenesis. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 3, 2018 Category: Cancer & Oncology Authors: Cong Wang, Yan Yang, Sujun Gao, Jingcheng Chen, Jinyuan Yu, Han Zhang, Mingxi Li, Xingying Zhan, Wei Li Source Type: research

ECCO Essential Requirements for Quality Cancer Care: Oesophageal and Gastric Cancer
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 2, 2018 Category: Cancer & Oncology Authors: William Allum, Florian Lordick, Maria Alsina, Elisabeth Andritsch, Ahmed Ba-Ssalamah, Marc Beishon, Marco Braga, Carmela Caballero, Fatima Carneiro, Fernando Cassinello, Jan Willem Dekker, Roberto Delgado-Bolton, Karin Haustermans, Geoffrey Henning, Betti Source Type: research

ECCO Essential Requirements for Quality Cancer Care: Melanoma
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - January 2, 2018 Category: Cancer & Oncology Authors: Michel W. Wouters, Olivier Michielin, Ether Bastiaannet, Marc Beishon, Orlando Catalano, Veronique del Marmol, Roberto Delgado-Bolton, R émi Dendale, Maria Die Trill, Andrea Ferrari, Ana-Marie Forsea, Hannelore Kreckel, József Lövey, Gre Luyten, Daniel Source Type: research

Loco-regional treatment for castration-resistant prostate cancer: Is there any rationale? A critical review from the AFU-GETUG
Prostate cancer (PCa) is a major health concern, being the second most common diagnosed cancer worldwide, and the fifth leading cause of cancer death in men (American Cancer Society, 2015). Most patients are diagnosed with localized disease. Some of these patients will eventually present with disease progression, and develop metastatic disease, for which the mainstay of treatment is androgen deprivation therapy (ADT) (Mottet et al., 2017). Despite initial responses, almost all men with metastatic disease will progress to metastatic castration-resistant prostate cancer (mCRPC). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 30, 2017 Category: Cancer & Oncology Authors: Jean-Baptiste Beauval, Yohann Loriot, Christophe Hennequin, Fran çois Rozet, Philippe Barthelemy, Delphine Borchiellini, Friederike Schlürmann Constans, Emmanuel Gross, Denis Maillet, Gilles Pasticier, Géraldine Pignot, Marc-Olivier Timsit, Sébastien Source Type: research

Loco-regional treatment for castration-resistant prostate cancer: is there any rationale?A critical review from the AFU-GETUG
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 30, 2017 Category: Cancer & Oncology Authors: Jean-Baptiste Beauval, Yohann Loriot, Christophe Hennequin, Fran çois Rozet, Philippe Barthelemy, Delphine Borchiellini, Friederike Schlürmann Constans, Emmanuel Gross, Denis Maillet, Gilles Pasticier, Géraldine Pignot, Marc-Olivier Timsit, Sébastien Source Type: research