Contents
Lauren R. Sorce and Joy D. Howell (Source: Critical Care Clinics)
Source: Critical Care Clinics - March 9, 2023 Category: Intensive Care Source Type: research

Forthcoming Issues
History of Critical Care Medicine (Source: Critical Care Clinics)
Source: Critical Care Clinics - March 9, 2023 Category: Intensive Care Source Type: research

Preface
Critical care has its roots in many different areas of medicine: infectious disease, surgery and anesthesia, neurology, cardiology, and nursing. However, one disease, polio, was an outsized driver of many of the key developments that led to this new field. (Source: Critical Care Clinics)
Source: Critical Care Clinics - February 26, 2023 Category: Intensive Care Authors: Hannah Wunsch Source Type: research

From Strict Bedrest to Early Mobilization
Critically ill patients are at risk of post-intensive care syndrome, including physical, cognitive, and psychological sequelae. Physiotherapists are rehabilitation experts who focus on restoring strength, physical function, and exercise capacity. Critical care has evolved from a culture of deep sedation and bed rest to one of awakening and early mobility; physiotherapeutic interventions have developed to address patients ’ rehabilitation needs. Physiotherapists are assuming more prominent roles in clinical and research leadership, with opportunities for wider interdisciplinary collaboration. This paper reviews the evolut...
Source: Critical Care Clinics - February 26, 2023 Category: Intensive Care Authors: Michelle E. Kho, Bronwen Connolly Source Type: research

Evolution of Visiting the Intensive Care Unit
This article gives a historical perspective of visitation in the intensive care unit (ICU) since the establishment of critical care units. Initially, visitors were not allowed because it was thought to be harmful to the patient. Despite the evidence, ICUs with open visitation have consistently been in the minority and the COVID-19 pandemic halted progress in this area. Virtual visitation was introduced during the pandemic to maintain family presence, but limited evidence suggests that this is not equivalent to in-person visitation. Going forward ICUs and health systems must consider family presence policies that allow for ...
Source: Critical Care Clinics - February 26, 2023 Category: Intensive Care Authors: Kerry A. Milner Source Type: research

Challenges of ICU Care in the Early Days
This article will focus pa rticularly on some of the significant issues that arose in the initial years between the opening of the unit in 1958 and the arrival of clinically available blood gas measurement in the early 1960s. (Source: Critical Care Clinics)
Source: Critical Care Clinics - February 20, 2023 Category: Intensive Care Authors: H. Barrie Fairley Source Type: research

Airway Management During the Last 100 Years
This article reviews the main developments in this period, starting with modern day laryngoscopy in the 1940s, fiberoptic laryngoscopy in the 1960s, supraglottic airway devices in the 1980s, algorithms for dif ficult airway in the 1990s, and finally modern video-laryngoscopy in the 2000s. (Source: Critical Care Clinics)
Source: Critical Care Clinics - February 20, 2023 Category: Intensive Care Authors: Sonia Vaida, Luis Gaitini, Mostafa Somri, Ibrahim Matter, Jansie Prozesky Source Type: research

Designing and Implementing “Living and Breathing” Clinical Trials
This article provides an overview of “living, breathing” trials, including current state, anticipated developments, and areas of controversy. (Source: Critical Care Clinics)
Source: Critical Care Clinics - February 16, 2023 Category: Intensive Care Authors: Christopher M. Horvat, Andrew J. King, David T. Huang Source Type: research

Designing and Implementing ‘Living and Breathing’ Clinical Trials – An Overview and Lessons Learned from the COVID-19 Pandemic
This article provides an overview of ‘living, breathing’ trials, including current state, anticipated developments, and areas of controversy. (Source: Critical Care Clinics)
Source: Critical Care Clinics - February 16, 2023 Category: Intensive Care Authors: Christopher M. Horvat, Andrew J. King, David T. Huang Source Type: research

Beyond Conventional Hemodynamic Monitoring —Monitoring to Improve Our Understanding of Disease Process and Interventions
Monitoring the hemodynamic state of patients is a hallmark of any intensive care environment. However, no single monitoring strategy can provide all the necessary data to paint the entire picture of the state of a patient; each monitor has strengths and weaknesses, advantages, and limitations. We review the currently available hemodynamic monitors used in pediatric critical care units using a clinical scenario. This provides the reader with a construct to understand the progression from basic to more advanced monitoring modalities and how they serve to inform the practitioner at the bedside. (Source: Critical Care Clinics)
Source: Critical Care Clinics - December 22, 2022 Category: Intensive Care Authors: Michelle Ram írez, Mjaye L. Mazwi, Ronald A. Bronicki, Paul A. Checchia, Jacqueline S.M. Ong Source Type: research

Extracorporeal Membrane Oxygenation Then and Now; Broadening Indications and Availability
Extracorporeal membrane oxygenation (ECMO) is a life support technology provided to children to support respiratory failure, cardiac failure, or cardiopulmonary resuscitation after failure of conventional management. Over the decades, ECMO has expanded in use, advanced in technology, shifted from experimental to a standard of care, and evidence supporting its use has increased. The expanded ECMO indications and medical complexity of children have also necessitated focused studies in the ethical domain such as decisional authority, resource allocation, and equitable access. (Source: Critical Care Clinics)
Source: Critical Care Clinics - December 22, 2022 Category: Intensive Care Authors: Blythe E. Pollack, Roxanne Kirsch, Rachel Chapman, Robert Hyslop, Graeme MacLaren, Ryan P. Barbaro Source Type: research

Cytokine Release Syndrome in the Pediatric Population and Implications for Intensive Care Management
Cytokine release syndrome represents a spectrum of disease varying from fever alone to multiorgan system failure. Most commonly seen following treatment with chimeric antigen receptor T  cell therapy, it is increasingly being described with other immunotherapies as well as following hematopoietic stem cell transplant. As its symptoms are nonspecific, awareness is key to timely diagnosis and initiation of treatment. Given the high risk of cardiopulmonary involvement, critical care providers must be familiar with the cause, symptoms, and therapeutic options. Current treatment modalities focus on immunosuppression and target...
Source: Critical Care Clinics - November 17, 2022 Category: Intensive Care Authors: Juliana Romano, Eric Wilsterman, Megan Toal, Christine Joyce Source Type: research

Screening for Social Determinants of Health in the Pediatric Intensive Care Unit
Social determinants of health (SDoH) play a significant role in the health and well-being of children in the United States. Disparities in the risk and outcomes of critical illness have been extensively documented but are yet to be fully explored through the lens of SDoH. In this review, we provide justification for routine SDoH screening as a critical first step toward understanding the causes of, and effectively addressing health disparities affecting critically ill children. Second, we summarize important aspects of SDoH screening that need to be considered before implementing this practice in the pediatric critical car...
Source: Critical Care Clinics - November 17, 2022 Category: Intensive Care Authors: Manzilat Akande, Erin T. Paquette, Paula Magee, Mallory A. Perry-Eaddy, Ericka L. Fink, Katherine N. Slain Source Type: research

Youth Firearm Injury
Firearms are now the leading cause of death among youth in the United States, with rates of homicide and suicide rising even more steeply during the SARS-CoV-2 pandemic. These injuries and deaths have wide-ranging consequences for the physical and emotional health of youth and families. While pediatric critical care clinicians must treat the injured survivors, they can also play a role in prevention by understanding the risks and consequences of firearm injuries; taking a trauma-informed approach to the care of injured youth; counseling patients and families on firearm access; and advocating for youth safety policy and pro...
Source: Critical Care Clinics - November 14, 2022 Category: Intensive Care Authors: Elinore J. Kaufman, Therese S. Richmond, Katelin Hoskins Source Type: research

Pediatric Critical Care in the Twenty-first Century and Beyond
Pediatric critical care addresses prevention, diagnosis, and treatment of organ dysfunction in the setting of increasingly complex patients, therapies, and environments. Soon burgeoning data science will enable all aspects of intensive care: driving facilitated diagnostics, empowering a learning health-care environment, promoting continuous advancement of care, and informing the continuum of critical care outside the intensive care unit preceding and following critical illness/injury. Although novel technology will progressively objectify personalized critical care, humanism, practiced at the bedside, defines the essence o...
Source: Critical Care Clinics - November 14, 2022 Category: Intensive Care Authors: Mary Dahmer, Aimee Jennings, Margaret Parker, Lazaro N. Sanchez-Pinto, Ann Thompson, Chani Traube, Jerry J. Zimmerman Source Type: research