Diagnostic Error in the Critically Ill
Epidemiologic studies of diagnostic error in the intensive care unit (ICU) consist mostly of descriptive autopsy series. In these studies, rates of diagnostic errors are approximately 5% to 10%. Recently validated methods for retrospectively measuring error have expanded our understanding of the scope of the problem. These alternative measurement strategies have yielded similar estimates for the frequency of diagnostic error in the ICU. Although there is a fair understanding of the frequency of errors, further research is needed to better define the risk factors for diagnostic error in the ICU. (Source: Critical Care Clinics)
Source: Critical Care Clinics - November 16, 2021 Category: Intensive Care Authors: Paul A. Bergl, Yan Zhou Source Type: research
Diagnostic Excellence in the ICU: Thinking Critically and Masterfully
CRITICAL CARE CLINICS (Source: Critical Care Clinics)
Source: Critical Care Clinics - November 16, 2021 Category: Intensive Care Authors: Paul A. Bergl, Rahul S. Nanchal Source Type: research
Copyright
ELSEVIER (Source: Critical Care Clinics)
Source: Critical Care Clinics - November 16, 2021 Category: Intensive Care Source Type: research
Contributors
GREGORY S. MARTIN, MD, MSC (Source: Critical Care Clinics)
Source: Critical Care Clinics - November 16, 2021 Category: Intensive Care Source Type: research
Contents
Paul A. Bergl and Rahul S. Nanchal (Source: Critical Care Clinics)
Source: Critical Care Clinics - November 16, 2021 Category: Intensive Care Source Type: research
Forthcoming Issues
Undiagnosed and Rare Diseases in Critical Care (Source: Critical Care Clinics)
Source: Critical Care Clinics - November 16, 2021 Category: Intensive Care Source Type: research
The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome of high morbidity and mortality with global impact. Current epidemiologic estimates are imprecise given differences in patient populations, risk factors, resources, and practice styles around the world. Despite improvement in supportive care which has improved mortality, effective targeted therapies remain elusive. The Coronavirus Disease 2019 pandemic has resulted in a large number of ARDS cases that, despite less heterogeneity than multietiologic ARDS populations, still exhibit wide variation in physiology and outcomes. Intensive care unit rates of de...
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Kathryn W. Hendrickson, Ithan D. Peltan, Samuel M. Brown Source Type: research
Environmental Factors
The acute respiratory distress syndrome (ARDS) remains a major cause of morbidity and mortality in the intensive care unit. Improving outcomes depends on not only evidence-based care once ARDS has already developed but also preventing ARDS incidence. Several environmental exposures have now been shown to increase the risk of ARDS and related adverse outcomes. How environmental factors impact the risk of developing ARDS is a growing and important field of research that should inform the care of individual patients as well as public health policy. (Source: Critical Care Clinics)
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Katherine D. Wick, Michael A. Matthay Source Type: research
Genetics of Acute Respiratory Distress Syndrome
This article discusses the latest advances in ARDS genomics, provides historical perspective, and highlights some of the ways that the coronavirus disease 2019 (COVID-19) pandemic is accelerating genomic ARDS research. (Source: Critical Care Clinics)
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Heather M. Giannini, Nuala J. Meyer Source Type: research
Pharmacologic Treatments for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome is a heterogenous syndrome with many etiologies for which there are no definitive pharmacologic treatments, despite decades of research. We explore some adjunctive pharmacologic therapies, including neuromuscular blockade, corticosteroids, and inhaled pulmonary vasodilators. Additionally, we explore some investigative therapies, including Vitamin C, beta-agonists, statins, mesenchymal stromal cells, and granulocyte –macrophage colony stimulating factor. We do discuss the potential role of steroids in acute respiratory distress syndrome with severe acute respiratory syndrome coronavirus...
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Nida Qadir, Steven Y. Chang Source Type: research
Toward Optimal Acute Respiratory Distress Syndrome Outcomes
Acute respiratory distress syndrome is a common condition among critically ill patients, but remains under-recognized and undertreated. Under-recognition may result from confusion over the clinical inclusion criteria, as well as a misunderstanding of the complex relationship between the clinical syndrome, the variable histopathologic patterns, and the myriad clinical disorders that cause acute respiratory distress syndrome. The identification of the clinical syndrome and determination of the causal diagnosis are both required to optimize patient outcomes. Here we review the definition, discuss pitfalls in recognizing acute...
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Maya E. Kotas, B. Taylor Thompson Source Type: research
Fluid Therapy and Acute Respiratory Distress Syndrome
The optimal fluid management for acute respiratory distress syndrome (ARDS) remains unknown. Liberal fluid management may improve cardiac function and end-organ perfusion, but may lead to increased pulmonary edema and inhibit gas exchange. Trials suggest that conservative fluid management leads to better clinical outcomes, although prospective randomized, controlled trials have not demonstrated mortality benefit. Recent discoveries suggest there is large heterogeneity in ARDS, and varying phenotypes of ARDS respond differently to fluid treatments. Future advances in management will require real-time assignment of ARDS phen...
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Jisoo Lee, Keith Corl, Mitchell M. Levy Source Type: research
Preface
We are pleased to introduce this issue of Critical Care Clinics, focused on acute respiratory distress syndrome (ARDS). Although planned before the COVID-19 pandemic, this issue is particularly timely given the world events of the past 18 Â months. The articles in this issue address several key topics in the field of ARDS with both a clinical and a research focus, as well as define some of the important questions that need to be answered for our understanding of the pathogenesis and treatment of ARDS to advance. (Source: Critical Care Clinics)
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Michael A. Matthay, Kathleen D. Liu Source Type: research
Acute Respiratory Distress Syndrome
CRITICAL CARE CLINICS (Source: Critical Care Clinics)
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Michael A. Matthay, Kathleen D. Liu Source Type: research
Copyright
ELSEVIER (Source: Critical Care Clinics)
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Source Type: research
