Editorial Board
(Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - September 30, 2019 Category: Radiology Source Type: research
A religiously-tailored, multilevel intervention in African American churches to increase HIV testing: Rationale and design of the taking it to the pews cluster randomized trial
We describe the rationale and design of a 2-arm cluster randomized trial to test a religiously-tailored HIV testing intervention (Taking It to the Pews [TIPS]) against a standard information arm on HIV testing rates among AA church members and community members they serve. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - September 15, 2019 Category: Radiology Authors: J. Berkley-Patton, C. Bowe Thompson, K. Goggin, D. Catley, M. Berman, A. Ewing-Bradley, K.P. Derose, K. Resnicow, J. Allsworth, S. Simon Source Type: research
Improving communication toward ICU families to facilitate understanding and reduce stress. Protocol for a multicenter randomized and controlled Italian study
Objective: Families of ICU patients have a pressing need for information: they find themselves suddenly in a complex technical environment often because of a life-threatening illness of a loved one. Some evidence suggests that specific communication tools (like websites or brochures) could improve the experience of ICU families.Design: Randomized, multicenter, stepped wedge trial for large-scale assessment of the effectiveness of a multitasking intervention to improve communication with families of critically ill patients. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - September 12, 2019 Category: Radiology Authors: Giovanni Mistraletti, Andrea Mezzetti, Stefania Anania, Alessandra Ionescu Maddalena, Silvia Del Negro, Gian Domenico Giusti, Alessio Gili, Emanuele Iacobone, Silvia Maria Pulitan ò, Giorgio Conti, Maria Grazia Bocci Source Type: research
CHAMP: A cluster randomized-control trial to prevent obesity in child care centers
Foundational elements of lifelong health are formed during the preschool years. Child care attendance has nearly doubled in the past 5 years making child care centers an ideal setting to establish healthy habits that prevent pediatric obesity. Despite the promising evidence of efficacy of child care-based obesity prevention interventions, limited attention has been directed to criteria needed for implementation at scale. There i s potential to improve children's dietary and physical activity behaviors in diverse communities through theory-based, culturally appropriate, manualized interventions, delivered by child care s...
Source: Contemporary Clinical Trials - September 12, 2019 Category: Radiology Authors: Bridget Armstrong, Angela C.B. Trude, Candace Johnson, Romulus J. Castelo, Amy Zemanick, Sophie Haber-Sage, Raquel Arbaiza, Maureen M. Black Source Type: research
Peer mentorship to reduce suicide attempts among high-risk adults (PREVAIL): Rationale and design of a randomized controlled effectiveness-implementation trial
Novel approaches to suicide prevention are needed to address increasing rates of suicide deaths. Research suggests that interventions led by certified Peer Specialists may improve suicide protective factors such as hope and connectedness; however, the effectiveness of a Peer Specialist intervention for reducing suicidal thoughts or behaviors has not previously been tested empirically. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - September 12, 2019 Category: Radiology Authors: Adrienne Lapidos, Kristen M. Abraham, Jennifer Jagusch, James Garlick, Heather Walters, H. Myra Kim, Eduardo Vega, Laura Damschroder, Jane Forman, Brian Ahmedani, Cheryl King, Paul N. Pfeiffer Source Type: research
Interim monitoring in a treatment strategy trial with a composite primary endpoint
When a clinical trial has a composite endpoint and a comparison of treatment strategies with multiple intervention components, interim data reviews by a data safety and monitoring board (DSMB) can be challenging as the data evolve on multiple fronts. We illustrate with a study in the treatment of Kaposi sarcoma (KS), an HIV-associated cancer with a multi-faceted disease presentation. The study, ACTG-A5264/AMC-067, was a 1:1 randomized trial to compare two strategies: immediate initiation of etoposide with antiretroviral therapy (ART), or ART with delayed etoposide upon disease progression. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - September 10, 2019 Category: Radiology Authors: Minhee Kang, Birgit Grund, Sally Hunsberger, David Glidden, Paul Volberding Source Type: research
Communication and coping intervention for mothers of adolescents with type 1 diabetes: Rationale and trial design
Mothers of adolescents with type 1 diabetes (T1D) experience high rates of depressive symptoms and diabetes distress, which are established risk factors for deteriorating glycemic control, problems with adherence, increased depressive symptoms, and poor quality of life in adolescents. Given that adolescents are a high-risk population for suboptimal glycemic control, novel interventions to improve outcomes in adolescents with T1D are needed. Building on effective interventions to treat depression in adults, and our own pilot work in this population, we developed a cognitive behavioral intervention, Communication& Coping, to...
Source: Contemporary Clinical Trials - September 5, 2019 Category: Radiology Authors: Sarah S. Jaser, Emily R. Hamburger, Sherry Pagoto, Rodayne Williams, Alison Meyn, Abigail C. Jones, Jill H. Simmons Source Type: research
Health coaching to improve self-care of informal caregivers of adults with chronic heart failure – iCare4Me: Study protocol for a randomized controlled trial
Persons with chronic heart failure are living longer. These patients typically live in the community and are cared for at home by informal caregivers. These caregivers are an understudied and stressed group. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - September 5, 2019 Category: Radiology Authors: Barbara Riegel, Alexandra Hanlon, Norma B. Coe, Karen B. Hirschman, Gladys Thomas, Michael Stawnychy, Joyce W. Wald, Kathryn H. Bowles Source Type: research
Editorial Board
(Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - August 31, 2019 Category: Radiology Source Type: research
A randomized controlled trial of a smoking cessation self-help intervention for Spanish-speaking Hispanic/Latinx smokers: Study design and baseline characteristics
Although the current smoking prevalence among Hispanics/Latinxs (10%) is lower than in non-Hispanic whites (15%), higher prevalence is observed among certain subgroups (e.g., Puerto Rican males, 19%). Hispanic/Latinx smokers face unique challenges such as lower awareness and acceptability of nicotine replacement aids, lower prevalence of using counseling or medication, and receiving less advice to quit by their health care providers. Despite these barriers to smoking cessation, few interventions specifically targeted to Hispanic/Latinx smokers have been developed and evaluated. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - August 28, 2019 Category: Radiology Authors: Patricia Medina-Ram írez, Steven K. Sutton, Úrsula Martínez, Cathy D. Meade, Margaret M. Byrne, Karen O. Brandon, Lauren R. Meltzer, Fiorella M. Gonzales, Thomas H. Brandon, Vani N. Simmons Source Type: research
A gate-keeping test for selecting adaptive interventions under general designs of sequential multiple assignment randomized trials
This article proposes a method to overcome limitations in current methods that address multiple comparisons of adaptive interventions embedded in sequential multiple assignment randomized trial (SMART) designs. Because a SMART typically consists of numerous adaptive interventions, inferential procedures based on pairwise comparisons of all may suffer a substantial loss in power after accounting for multiplicity. Meanwhile, traditional methods for multiplicity adjustments in comparing non-adaptive interventions require prior knowledge of correlation structures, which can be difficult to postulate when analyzing SMART data o...
Source: Contemporary Clinical Trials - August 26, 2019 Category: Radiology Authors: Xiaobo Zhong, Bin Cheng, Min Qian, Ying Kuen Cheung Tags: Full Length Article Source Type: research
Investigating gains in neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol
Despite the ubiquity of normal age-related cognitive decline there is an absence of effective approaches for improving neurocognitive health. Fortunately, moderate intensity exercise is a promising method for improving brain and cognitive health in late life, but its effectiveness remains a matter of skepticism and debate because of the absence of large, comprehensive, Phase III clinical trials. Here we describe the protocol for such a randomized clinical trial called IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), a study capable of more definitively addressing whether exercise influen...
Source: Contemporary Clinical Trials - August 25, 2019 Category: Radiology Authors: Kirk I. Erickson, George A. Grove, Jeffrey M. Burns, Charles H. Hillman, Arthur F. Kramer, Edward McAuley, Eric D. Vidoni, James T. Becker, Meryl A. Butters, Katerina Gray, Haiqing Huang, John M. Jakicic, M. Ilyas Kamboh, Chaeryon Kang, William E. Klunk, Source Type: research
Design and participant characteristics of TX sprouts: A school-based cluster randomized gardening, nutrition, and cooking intervention
To outline the study design, outcome measures, protocol and baseline characteristics of enrolled participants of Texas (TX) Sprouts, a one-year school-based gardening, nutrition, and cooking cluster randomized trial. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - August 22, 2019 Category: Radiology Authors: JaimieN. Davis, Katie Nikah, Fiona M. Asigbee, Matthew J. Landry, Sarvenaz Vandyousefi, Reem Ghaddar, Amy Hoover, Matthew Jeans, Stephen J. Pont, Daphne Richards, Deanna M. Hoelscher, Alexandra E. Van Den Berg, Meagan Bluestein, Adriana P érez Source Type: research
Publisher ’s Note
(Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - August 21, 2019 Category: Radiology Source Type: research
Implementing electronic substance use disorder and depression and anxiety screening and behavioral interventions in primary care clinics serving people with HIV: Protocol for the promoting access to care engagement (PACE) trial
Substance use disorders (SUDs) and psychiatric disorders are common among people with HIV (PWH) and lead to poor outcomes. Yet these conditions often go unrecognized and untreated in primary care. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - August 21, 2019 Category: Radiology Authors: Derek D. Satre, Alexandra N. Anderson, Amy S. Leibowitz, Tory Levine-Hall, Sally Slome, Jason Flamm, C. Bradley Hare, Jennifer McNeely, Constance M. Weisner, Michael Horberg, Paul Volberding, Michael J. Silverberg Source Type: research
