Numerical investigation of unruptured middle cerebral artery bifurcation aneurysms: influence of aspect ratio
Comput Methods Biomech Biomed Engin. 2023 Nov 16:1-16. doi: 10.1080/10255842.2023.2279508. Online ahead of print.ABSTRACTAn aneurysm is a disease condition, which is due to the pathological weakening of an arterial wall. These aneurysms are often found in various branch points and bifurcations of an artery in the cerebral circulation. Most aneurysms come to medical attention, either due to brain hemorrhages caused by rupture or found unruptured. To consider surgically invasive treatment modalities, clinicians need scientific methods such as, hemodynamic analysis to assess rupture risk. The arterial wall loses its structura...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 16, 2023 Category: Biomedical Engineering Authors: Chanikya Valeti Saravanan Gurusamy K Krishnakumar Hariharan Venkat Easwer Santhosh K Kannath B J Sudhir B S V Patnaik Source Type: research

Significance of peripheral layer: the case of mucus flow through a ciliated tube using Rabinowitsch model
Comput Methods Biomech Biomed Engin. 2023 Nov 16:1-12. doi: 10.1080/10255842.2023.2281892. Online ahead of print.ABSTRACTModern medicine has taken energy loss during cilia beating in the human stomach, which under some circumstances causes blood flow to become acidic, very seriously. In current report covering a whole advancement and results for the impact of Rabinowitsch model with cilia-driven flow analysis with the help of ciliary beating in a cylindrical tube. The fluid is incompressible, and layers of fluid do not mix. The fluid flow with heat and mass transfer is firstly modeled in wave and then transformed into fixe...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 16, 2023 Category: Biomedical Engineering Authors: S Shaheen H Huang M B Arain Faisal Z Duraihem Source Type: research

Neural-driven activation of 3D muscle within a finite element framework: exploring applications in healthy and neurodegenerative simulations
Comput Methods Biomech Biomed Engin. 2023 Nov 15:1-11. doi: 10.1080/10255842.2023.2280772. Online ahead of print.ABSTRACTThis paper presents a novel computational framework for neural-driven finite element muscle models, with an application to amyotrophic lateral sclerosis (ALS). The multiscale neuromusculoskeletal (NMS) model incorporates physiologically accurate motor neurons, 3D muscle geometry, and muscle fiber recruitment. It successfully predicts healthy muscle force and tendon elongation and demonstrates a progressive decline in muscle force due to ALS, dropping from 203 N (healthy) to 155 N (120 days after ALS onse...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 15, 2023 Category: Biomedical Engineering Authors: Colton D Babcock Victoria L Volk Wei Zeng Landon D Hamilton Kevin B Shelburne Clare K Fitzpatrick Source Type: research

Neural-driven activation of 3D muscle within a finite element framework: exploring applications in healthy and neurodegenerative simulations
Comput Methods Biomech Biomed Engin. 2023 Nov 15:1-11. doi: 10.1080/10255842.2023.2280772. Online ahead of print.ABSTRACTThis paper presents a novel computational framework for neural-driven finite element muscle models, with an application to amyotrophic lateral sclerosis (ALS). The multiscale neuromusculoskeletal (NMS) model incorporates physiologically accurate motor neurons, 3D muscle geometry, and muscle fiber recruitment. It successfully predicts healthy muscle force and tendon elongation and demonstrates a progressive decline in muscle force due to ALS, dropping from 203 N (healthy) to 155 N (120 days after ALS onse...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 15, 2023 Category: Biomedical Engineering Authors: Colton D Babcock Victoria L Volk Wei Zeng Landon D Hamilton Kevin B Shelburne Clare K Fitzpatrick Source Type: research

The use of finite element models for backface deformation and body armour design: a systematic review
Comput Methods Biomech Biomed Engin. 2023 Nov 14:1-23. doi: 10.1080/10255842.2023.2281275. Online ahead of print.ABSTRACTWhile injuries sustained from body armour backface deformation (BFD) have not been well-documented in military injury trauma registries, data from US law enforcement officers, animal tests and currently available data pertaining to military combatants has shown that BFD can not only cause minor injuries, but also result in serious trauma. However, the nature and severity of injuries sustained depends on a multitude of factors including the projectile type, the impact location and velocity, and the specif...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 14, 2023 Category: Biomedical Engineering Authors: Abd Alhamid R Sarhan Melanie Franklyn Peter V S Lee Source Type: research

Atherosclerosis risk assessment in human carotid artery with variation in sinus length: a numerical approach
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2275546. Online ahead of print.ABSTRACTThe mortality rates due to cardiovascular diseases are on a rise globally. One of the major cardiovascular diseases is stroke which occurs due to atherosclerotic plaques build-up in the carotid artery. The common carotid artery (CCA) bifurcates into the internal carotid artery (ICA) and external carotid artery (ECA). Sinus present at ICA is an ellipsoidal-shaped dilated region acting as a pressure receptor and blood flow regulator. Dimensions of the sinus vary from person to person, affecting the hemodyn...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Jinmay Kalita Subham Show Nirmalendu Biswas Aparesh Datta Source Type: research

Development of reduced volume endosseous cuspid tooth implant using topology optimization by SIMP technique for improved osseointegration
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2279939. Online ahead of print.ABSTRACTThe article aims to design and develop a topology-optimized endosseous cuspid tooth implant of the maxilla region. The manuscript presents a numerical analysis of the resulting von Mises stresses and effective strain resulting in the topology-optimized implant with occlusal loading of 110 N. Solid Isotropic Material with Penalization (SIMP) method is employed for topology optimization and four different models, namely model-1, model-2, model-3, and model-4, are developed based on volume reduction rates o...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Priyanshu Soni Parnika Shrivastava Sanjay Kumar Rai Source Type: research

Assessing turbulent effects in ascending aorta in presence of bicuspid aortic valve
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-13. doi: 10.1080/10255842.2023.2279938. Online ahead of print.ABSTRACTAortic valves with bicuspids have two rather than three leaflets, which is a congenital heart condition. About 0.5-2% of people have a bicuspid aortic valve. Blood flow through the aorta is commonly believed to be laminar, although aortic valve disorders can cause turbulent transitions. Understanding the impact of turbulence is crucial for foreseeing how the disease will progress. The study's objective was use large eddy simulation to provide a thorough analysis of the turbulence in bicuspid aortic valve...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Rukiye Kara Christian Vergara Source Type: research

Atherosclerosis risk assessment in human carotid artery with variation in sinus length: a numerical approach
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2275546. Online ahead of print.ABSTRACTThe mortality rates due to cardiovascular diseases are on a rise globally. One of the major cardiovascular diseases is stroke which occurs due to atherosclerotic plaques build-up in the carotid artery. The common carotid artery (CCA) bifurcates into the internal carotid artery (ICA) and external carotid artery (ECA). Sinus present at ICA is an ellipsoidal-shaped dilated region acting as a pressure receptor and blood flow regulator. Dimensions of the sinus vary from person to person, affecting the hemodyn...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Jinmay Kalita Subham Show Nirmalendu Biswas Aparesh Datta Source Type: research

Development of reduced volume endosseous cuspid tooth implant using topology optimization by SIMP technique for improved osseointegration
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2279939. Online ahead of print.ABSTRACTThe article aims to design and develop a topology-optimized endosseous cuspid tooth implant of the maxilla region. The manuscript presents a numerical analysis of the resulting von Mises stresses and effective strain resulting in the topology-optimized implant with occlusal loading of 110 N. Solid Isotropic Material with Penalization (SIMP) method is employed for topology optimization and four different models, namely model-1, model-2, model-3, and model-4, are developed based on volume reduction rates o...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Priyanshu Soni Parnika Shrivastava Sanjay Kumar Rai Source Type: research

Assessing turbulent effects in ascending aorta in presence of bicuspid aortic valve
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-13. doi: 10.1080/10255842.2023.2279938. Online ahead of print.ABSTRACTAortic valves with bicuspids have two rather than three leaflets, which is a congenital heart condition. About 0.5-2% of people have a bicuspid aortic valve. Blood flow through the aorta is commonly believed to be laminar, although aortic valve disorders can cause turbulent transitions. Understanding the impact of turbulence is crucial for foreseeing how the disease will progress. The study's objective was use large eddy simulation to provide a thorough analysis of the turbulence in bicuspid aortic valve...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Rukiye Kara Christian Vergara Source Type: research

Atherosclerosis risk assessment in human carotid artery with variation in sinus length: a numerical approach
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2275546. Online ahead of print.ABSTRACTThe mortality rates due to cardiovascular diseases are on a rise globally. One of the major cardiovascular diseases is stroke which occurs due to atherosclerotic plaques build-up in the carotid artery. The common carotid artery (CCA) bifurcates into the internal carotid artery (ICA) and external carotid artery (ECA). Sinus present at ICA is an ellipsoidal-shaped dilated region acting as a pressure receptor and blood flow regulator. Dimensions of the sinus vary from person to person, affecting the hemodyn...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Jinmay Kalita Subham Show Nirmalendu Biswas Aparesh Datta Source Type: research

Development of reduced volume endosseous cuspid tooth implant using topology optimization by SIMP technique for improved osseointegration
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2279939. Online ahead of print.ABSTRACTThe article aims to design and develop a topology-optimized endosseous cuspid tooth implant of the maxilla region. The manuscript presents a numerical analysis of the resulting von Mises stresses and effective strain resulting in the topology-optimized implant with occlusal loading of 110 N. Solid Isotropic Material with Penalization (SIMP) method is employed for topology optimization and four different models, namely model-1, model-2, model-3, and model-4, are developed based on volume reduction rates o...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Priyanshu Soni Parnika Shrivastava Sanjay Kumar Rai Source Type: research

Assessing turbulent effects in ascending aorta in presence of bicuspid aortic valve
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-13. doi: 10.1080/10255842.2023.2279938. Online ahead of print.ABSTRACTAortic valves with bicuspids have two rather than three leaflets, which is a congenital heart condition. About 0.5-2% of people have a bicuspid aortic valve. Blood flow through the aorta is commonly believed to be laminar, although aortic valve disorders can cause turbulent transitions. Understanding the impact of turbulence is crucial for foreseeing how the disease will progress. The study's objective was use large eddy simulation to provide a thorough analysis of the turbulence in bicuspid aortic valve...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Rukiye Kara Christian Vergara Source Type: research

Atherosclerosis risk assessment in human carotid artery with variation in sinus length: a numerical approach
Comput Methods Biomech Biomed Engin. 2023 Nov 10:1-15. doi: 10.1080/10255842.2023.2275546. Online ahead of print.ABSTRACTThe mortality rates due to cardiovascular diseases are on a rise globally. One of the major cardiovascular diseases is stroke which occurs due to atherosclerotic plaques build-up in the carotid artery. The common carotid artery (CCA) bifurcates into the internal carotid artery (ICA) and external carotid artery (ECA). Sinus present at ICA is an ellipsoidal-shaped dilated region acting as a pressure receptor and blood flow regulator. Dimensions of the sinus vary from person to person, affecting the hemodyn...
Source: Computer Methods in Biomechanics and Biomedical Engineering - November 11, 2023 Category: Biomedical Engineering Authors: Jinmay Kalita Subham Show Nirmalendu Biswas Aparesh Datta Source Type: research