Preparation of multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Ait Mehdi Yamina, Meriem Fizir, Asma Itatahine, Hua He, Pierre Dramou With the intent of enhancing the loading capacity and controlled the release of a low-water soluble drug (quercetin), 6 ar ms (Poly-Ethylene-Glycol)-amine was grafted in the external surface of halloysite nanotubes. The grafted halloysite nanotubes (HNTs-g-PEG) were decorated with carbon quantum dots for additive fluorescents properties. Conjointly, biotin was conjugated to PEG’s free amine groups for precise targeting of tumor tissue and high...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research

Heat-driven size reduction of biodegradable polyelectrolyte multilayer hollow capsules assembled on CaCO3 template
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Daria B. Trushina, Tatiana V. Bukreeva, Tatiana N. Borodina, Daria D. Belova, Sergei Belyakov, Maria N. Antipina Aiming to explore elevated temperatures as a tool for miniaturization of biodegradable polymer multilayer capsules, assembled on spherical vaterite micron- and submicron-sized particles, we subject the shells composed of dextran sulfate (DS) and poly-L-arginine (Parg) to a heat treatment. Changes of the capsule size are studied at various temperatures and ionic strengths of the continuous phase. Unlike some syn...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research

A novel nanocomposite based on fluorescent turn-on gold nanostars for near-infrared photothermal therapy and self-theranostic caspase-3 imaging of glioblastoma tumor cell
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Juang Wang, Zilong Zhou, Fang Zhang, Hui Xu, Wenli Chen, Tingting Jiang We demonstrated a novel nanocomposite based on fluorescent turn-on gold nanostars for simultaneous tumor targeting photothermal therapy (PTT) and feedback apoptosis imaging of the self-therapeutic effect. In this theranostic agent (AuNS@probe), gold nanostars (AuNSs) and fluorescent dye Atto 655, as a fluorophore/quencher pair, were conjugated to form intermolecular fluorescence quenching in virtue of the linkage of a caspase-3 responsive peptide. Fol...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research

Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Xin Ji, Qiao Tang, Peng Pang, Jianping Wu, Thomas Brett Kirk, Jiake Xu, Dong Ma, Wei Xue Antitumor efficacy of ursolic acid (UA) is seriously limited due to its low hydrophilicity and needy bioavailability. To overcome these obstacles, chemosensitive polyspermine (CPSP) conjugated with UA and folic acid (FA) as a novel targeted prodrug was designed and successfully synthesized in this investigation. This prodrug not only showed high aqueous solubility, GSH-triggered degradation and good biocompatibility, but also exhibite...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research

Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Soumya Menon, Shrudhi Devi KS, Santhiya R, Rajeshkumar S, Venkat Kumar S Selenium nanoparticles have at present picked up a vital prospect in the field of medicine, due to their inquisitive properties when compared to other selenium compounds. They are comparatively better as anticancer, non- toxic, and biocompatible operators than selenite (SeO3 −2) and selenate (SeO4 −2) compounds. The mechanism behind the anticancerous property of SeNps is primarily due to the invasion of the apoptotic pathways and cell cyc...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research

Trigonelline hydrochloride: A promising inhibitor for type I collagen fibrillation
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): K. Rasheeda, N. Nishad Fathima Collagen is a major structural protein, with properties such as low toxicity, low immune response and promoting cellular growth. If there is an excess of collagen accumulation, especially in the myocardium it leads to fibrosis, which in turn impairs the normal functioning of the myocardial tissues. In order to overcome collagen fibrillation, trigonelline hydrochloride has been used in this study as a potential agent for inhibiting the spontaneous self-assembly of type I collagen. Trigonellin...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research

Inducement of a spontaneously wrinkled polydimethylsiloxane surface and its potential as a cell culture substrate
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Da Som Kim, Ho Won Lee, Jong Hyun Lee, Hyuck Gi Kwon, Sang Wook Lee, Seung Jin Han, Ok Chan Jeong Spontaneous wrinkling of a polydimethylsiloxane (PDMS) surface was induced by repeated thermal shrinkage of liquid PDMS coated onto a cured PDMS layer. We investigated and evaluated the potential of the resulting surface as a cell culture substrate by monitoring the viability, spreading area, and proliferation rate of MG-63 cells cultured on native, wrinkled, and poly-L-lysine (PLL)-coated PDMS surfaces. Cells seeded on the w...
Source: Colloids and Surfaces B: Biointerfaces - June 21, 2018 Category: Biochemistry Source Type: research

A novel concept of overcoming the skin barrier using augmented liquid nanocrystals: Box-Behnken optimization, ex vivo and in vivo evaluation
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Mayada Said, Ibrahim Elsayed, Ahmed A. Aboelwafa, Ahmed H. Elshafeey Agomelatine suffers from extensive inactivation through 1st pass effect with a limited oral bioavailability (5%). The aim of this study was to formulate and optimize liquid nanocrystals (LNC) containing agomelatine to enhance the transdermal permeation of the drug. The independent factors of the employed Box-Behnken design were the Pluronic F127, deoxycholic acid sodium salt and propylene glycol percentages. On the other hand, particle size, polydispersi...
Source: Colloids and Surfaces B: Biointerfaces - June 21, 2018 Category: Biochemistry Source Type: research

Mechanism of light-dependent biosynthesis of silver nanoparticles mediated by cell extract of Neochloris oleoabundans
This study investigated the role of chlorophyll and light in the biosynthesis of silver nanoparticles (AgNPs) using disrupted cell aqueous extract of Neochloris oleoabundans. It was found that, while increasing sonication time increased the percentage of disrupted cells and efficiency of aqueous cell extraction, over-sonication reduced AgNPs production. AgNPs biosynthesis required illumination of white, blue, or purple light while AgNPs formation was undetectable under dark condition or illumination of orange or red light, indicating only photons of high energy levels among the photosynthetic active radiations are capable ...
Source: Colloids and Surfaces B: Biointerfaces - June 21, 2018 Category: Biochemistry Source Type: research

The Cu-containing TiO2 coatings with modulatory effects on macrophage polarization and bactericidal capacity prepared by micro-arc oxidation on titanium substrates
In this study, the micro-arc oxidation (MAO) technique was employed to fabricate Cu-containing ceramic coatings on titanium substrates. The macrophages cultured on Cu-containing MAO-fabricated surfaces were polarized to M1 phenotype, evidenced by the high expression levels of inducible nitric oxide synthase (iNOS), low expression levels of arginase1 (Arg1), enhanced pro-inflammatory cytokine interleukin-6 (IL-6) release and inhibited IL-4 and IL-10 (anti-inflammatory cytokines) release. The MAO-treated surface incorporated with larger amounts of Cu (referred as Cu(h)-MAO) could modulate a favorable inflammatory microenviro...
Source: Colloids and Surfaces B: Biointerfaces - June 20, 2018 Category: Biochemistry Source Type: research

Evaluation of biological response induced by molybdenum oxide nanocolloids on in vitro cultured NIH/3T3 fibroblast cells by micro-Raman spectroscopy
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Enza Fazio, Antonio Speciale, Salvatore Spadaro, Martina Bonsignore, Francesco Cimino, Mariateresa Cristani, Domenico Trombetta, Antonella Saija, Fortunato Neri Tailored colloids of uniformly sized and engineered molybdenum oxide nanoparticles were produced, for the first time, by pulsed laser ablation in water. This green technique ensures the formation of contaminant-free nanostructures and the absence of by-products, very useful issues in biological applications. A selective tuning of MoO chemical bonding configuration...
Source: Colloids and Surfaces B: Biointerfaces - June 20, 2018 Category: Biochemistry Source Type: research

Effect of magnetic nanoparticles size on rheumatoid arthritis targeting and photothermal therapy
This study not only offered a novel method for RA therapy but also a guideline for RA targeted drug carrier design. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - June 20, 2018 Category: Biochemistry Source Type: research

High-throughput label-free microcontact printing graphene-based biosensor for valley fever
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Shih-Ming Tsai, Tyler Goshia, Yen-Chang Chen, Agnes Kagiri, Angelo Sibal, Meng-Hsuen Chiu, Anand Gadre, Vincent Tung, Wei-Chun Chin The highly prevalent and virulent disease in the Western Hemisphere Coccidioidomycosis, also known as Valley Fever, can cause serious illness such as severe pneumonia with respiratory failure. It can also take on a disseminated form where the infection spreads throughout the body. Thus, a serious impetus exists to develop effective detection of the disease that can also operate in a rapid and...
Source: Colloids and Surfaces B: Biointerfaces - June 20, 2018 Category: Biochemistry Source Type: research

Collagen/chitosan/hyaluronic acid – based injectable hydrogels for tissue engineering applications – design, physicochemical and biological characterization
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Adriana Gilarska, Joanna Lewandowska-Łańcucka, Wojciech Horak, Maria Nowakowska Studies on synthesis, physico-chemical and biological properties of novel biomimetic materials, potentially useful as injectable hydrogels are presented. These materials are in situ prepared chemically crosslinked collagen/chitosan/hyaluronic acid-based hydrogels exhibiting potential for tissue regeneration. Optimization of hydrogels involved testing the effect of various concentration of crosslinking agent (genipin) as well as different rat...
Source: Colloids and Surfaces B: Biointerfaces - June 19, 2018 Category: Biochemistry Source Type: research

Anionic and cationic drug sorption on interpolyelectrolyte complexes
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): C.R.M. de Lima, D.N. Gomes, J.R. de Morais Filho, M.R. Pereira, J.L.C. Fonseca Interpolyelectrolyte complexes of chitosan and poly(sodium 4-styrenesulfonate) [NaPSS] were synthesized and obtained in the form of solid particles, with two different sulfonate to aminium molar ratios: 0.7, resulting in particles with positive zeta potential (IPEC+), and 1.4, yielding particles with negative zeta potential (IPEC−). Both particles were characterized as potential drug sorbents using differently charged drugs: sodium cromog...
Source: Colloids and Surfaces B: Biointerfaces - June 18, 2018 Category: Biochemistry Source Type: research

Icariin-loaded electrospun PCL/gelatin nanofiber membrane as potential artificial periosteum
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Min Gong, Cheng Chi, Jingjing Ye, Meihong Liao, Wenqi Xie, Chengai Wu, Rui Shi, Liqun Zhang Due to the significant role of the periosteum in bone regeneration, we hypothesised that using a specially engineered artificial periosteum could lead to an enhancement in osteogenesis in bone grafts. Herein, we describe our work aimed at fabricating an electrospun fibrous membrane as an artificial periosteum that exhibits flexibility, permeability and osteoinduction. This membrane was designed to cover the complex surface of bone ...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Cetuximab-conjugated iodine doped carbon dots as a dual fluorescent/CT probe for targeted imaging of lung cancer cells
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Huifang Su, Ying Liao, Fengshou Wu, Xinzhi Sun, Hongjian Liu, Kai Wang, Xunjin Zhu Iodine doped carbon quantum dots (I-CQDs) have been synthesized by a facile one-pot hydrothermal method using citric acid and iohexol as precursors. The morphology and chemical structures of I-CQDs are investigated by TEM, XRD, XPS, and FTIR spectroscopy. The as-prepared I-CQDs exhibit excitation-dependent PL behavior with the emission quantum yield of 18%. The presence of iodine ions in I-CQDs is confirmed by XPS spectrum, which endows the...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

High dispersed phyto-phospholipid complex/TPGS 1000 with mesoporous silica to enhance oral bioavailability of tanshinol
In this study, a high dispersed phyto- phospholipid complex with mesoporous silica containing TPGS 1000 (TPC-SD) was fabricated using Tanshinol (Tan) as model drug. Phospholipid complex (PC) was employed to improve the n-octanol/water partition coefficient (log P) and apparent permeability coefficients (P app) of Tan. Mesoporous silica was used to compensate for the negative effects of phospholipid on drug’s dispersion and dissolution owing to its viscosity and poor water-solubility. TPGS 1000, a P-gp inhibitor, was used to block the efflux of Tan. Log P tests showed that the lipophilicity of Tan was significantly en...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Real-time imaging tracking of a dual-fluorescent drug delivery system based on doxorubicin-loaded globin- polyethylenimine nanoparticles for visible tumor therapy
In this study, the Doxorubicin loaded genipin-crosslinked globin and PEI nanoparticles (Gb-G-PEI/Dox NPs) were designed as a dual fluorescent drug delivery system to track the drug release and carrier degradation process. Both confocal laser scanning microscopy and flow cytometric results showed that Gb-G-PEI/Dox NPs had a higher cellular uptake efficiency than Doxorubicin in the Bel-7402 cell line due to its small size and positively charged surface. The in vivo metabolism experiments tracked by the multispectral fluorescence imaging system elucidated the sustained drug release and carrier degradation process of the Gb-G-...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Fatty acid and quaternary ammonium modified chitosan nanoparticles for insulin delivery
This study demonstrates that the nanoparticles fabricated from fatty acid modified polymer are an effective liver-targeted delivery system of insulin. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Effect of ion partitioning on electrostatics of soft particles with volumetrically charged inner core coated with pH-regulated polyelectrolyte layer
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Ardalan Ganjizade, Arman Sadeghi, Seyed Nezameddin Ashrafizadeh The effect of ion partitioning on the electrostatics of a soft particle with a volumetrically charged core and a pH-dependent polyelectrolyte layer (PEL) is numerically investigated. It is observed that, whenever the ion partitioning is noticeable, the soft layer can be fully charged in a broader range of pH. Besides, a higher number density of the PEL functional groups and a lower charge density of the core result in a sharper dependence of the electric pote...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Synthesis and antidiabetic properties of chitosan-stabilized selenium nanoparticles
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Siqi Zeng, Yu Ke, Yixi Liu, Yingbin Shen, Lan Zhang, Cheng Li, Aiping Liu, Li Shen, Xinjie Hu, Hejun Wu, Wenjuan Wu, Yuntao Liu Chitosan-stabilized selenium nanoparticles (CTS-SeNPs) were prepared through the reduction of selenite acid with ascorbic acid. The optimal synthesis conditions of CTS-SeNPs were obtained by orthogonal experiments. Besides, the size, morphology and stability of CTS-SeNPs were characterized by transmission electron microscopy (TEM), scanning electron microscope (SEM) and dynamic light scattering (...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

In vitro assessment of antimicrobial and genotoxic effect of metallosurfactant based nickel hydroxide nanoparticles against Escherichia coli and its genomic DNA
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Varsha Dogra, Gurpreet Kaur, Amanpuneet Kaur, Rajeev Kumar, Sandeep Kumar In the present study, we have synthesized nickel hydroxide nanosuspensions (Ns) using microemulsion technique. This approach is eco-friendly and makes use of Tween 80 (a non-ionic biocompatible surfactant) and newly synthesized metallosurfactants for the formation of uniform nanoparticles in the form of nanosuspensions (Ns). The nickel hydroxide Ns’s were derived from three different metallosurfactants i.e. NiCTAC (Bishexadecyltrimethylammoniu...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Simultaneous two drugs release form Janus particles prepared via polymerization-induced phase separation approach
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Elham Dehghani, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani Seeded emulsion polymerization of 2-dimethylaminoethylamino methacrylate (DMAEMA) was carried out using monodispersed poly(2-hydroxyehtyl methacrylate) (PHEMA) seeds to produce Janus particles. Three feeding approaches were used comprising one together, rest and continuous feeding methods to investigate different morphologies. However, FE-SEM results showed that all feeding approaches yielded dumbbell-like Janus particles. Furthermore, snowman-like Janus part...
Source: Colloids and Surfaces B: Biointerfaces - June 16, 2018 Category: Biochemistry Source Type: research

Modulation of serum albumin protein corona for exploring cellular behaviors of fattigation-platform nanoparticles
In this study, the effect of bovine serum albumin (BSA) on gelatin-oleic nanoparticles’ (GONs) physicochemical properties and cellular uptake were evaluated. Coumarin-6 was used as indicator to track the cellular uptake of GONs. The binding of BSA onto the GON surface increased the size, slightly reduced the negative net charge of the GON, and improved GON stability. The presence of BSA in cell culture media reduced the cellular uptake of BSA-uncoated GONs on human embryonic kidney cells 293 (HEK 293) and human adenocarcinoma alveolar basal epithelial cells (A549) in the media without FBS addition. Pre-coated BSA cor...
Source: Colloids and Surfaces B: Biointerfaces - June 13, 2018 Category: Biochemistry Source Type: research

Ultrasonic fabrication of flexible antibacterial ZnO nanopillar array film
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Kwang Se Lee, Chi Hyun Kim, Soon Woo Jeong, Younseong Song, Nam Ho Bae, Seok Jae Lee, Kyoung G. Lee Antibacterial activity is essential and highly demanded in worldwide to prevent potential bacterial infection. Here in this work, we report a new approch for the fabrication of flexible zinc oxide nanopillar arrays (ZG-NPA) film with an efficient antibacterial activity. A flexible NPA film served as a substrate for the rapid formation of ZnO by using ultrasound-assisted method. The enhancement of antibacterial activity were...
Source: Colloids and Surfaces B: Biointerfaces - June 13, 2018 Category: Biochemistry Source Type: research

An electrochemical Bisphenol F sensor based on ZnO/G nano composite and CTAB surface modified carbon paste electrode architecture
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): G. Manasa, Ronald J. Mascarenhas, Ashis K. Satpati, Basavanakote M. Basavaraja, Sriram Kumar Due to the enforcement of regulatory restrictions to prevent risk to human health from Bisphenol A (BPA), its structural analogue Bisphenol F (BPF) has been introduced into the market as an alternative. But however recent studies describe BPF as an effectual endocrine disruptor. Hence, there is an indispensible need for research concerning BPF human and environmental exposure level. In this work, we have elicited the development o...
Source: Colloids and Surfaces B: Biointerfaces - June 10, 2018 Category: Biochemistry Source Type: research

Amine functional magnetic nanoparticles via waterborne thiol –ene suspension photopolymerization for antibody immobilization
In this study, for the very first time waterborne TESP was performed in the presence of MNPs. Neat MNPs were coated and in situ functionalized with amine groups by using thiol-ene chemistry. Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription. Anti-EN2 antibodies were immobilized onto these MNPs by physical adsorption and covalent bonding methods, respectively. The amount of the physically immobilized antibodies (0.54 mg/g) were foun...
Source: Colloids and Surfaces B: Biointerfaces - June 10, 2018 Category: Biochemistry Source Type: research

An electrochemical sensor for homocysteine detection using gold nanoparticle incorporated reduced graphene oxide
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Rajendran Rajaram, Jayaraman Mathiyarasu In this work, we report a methodology for the quantification of Homocysteine (HcySH) at neutral pH (pH-7.0) using Au nanoparticles incorporated reduced graphene oxide (AuNP/rGO/GCE) modified glassy carbon electrode. The modified electrode was characterized using SEM and XRD techniques. The electrode exhibited a typical behavior against the standard redox probe [Fe(CN)6]3−/4− and resulted in 0.06 V peak to peak potential value. The modified electrode exhibited electroc...
Source: Colloids and Surfaces B: Biointerfaces - June 9, 2018 Category: Biochemistry Source Type: research

Bacterial adhesion and inactivation on Ag decorated TiO2-nanotubes under visible light: Effect of the nanotubes geometry on the photocatalytic activity
This study investigates the effect of the diameter of TiO2 nanotubes and silver decorated nanotubes on optical properties and photocatalytic inactivation of Escherichia coli under visible light. The TiO2 nanotubes (TiO2-NTs) were prepared using the electrochemical method varying the anodization potential starting from 20 V until 70 V. The Ag nanoparticles were carried out using the photoreduction process under the same experimental conditions. The diameter size was determined using the scanning electronic microscopy (SEM). TiO2-NTs diameter reached ∼100 nm at 70 V. Transmission electronic microscopy (TEM) imagi...
Source: Colloids and Surfaces B: Biointerfaces - June 9, 2018 Category: Biochemistry Source Type: research

Solvent-free and one pot synthesis of silver and zinc nanoparticles: Activity toward cell membrane component and insulin signaling pathway in experimental diabetes
Conclusion AgNPs and ZnONPs represent promising materials in attenuating diabetic complications and insulin resistance in experimental diabetes; no Impressive differences were observed between the effect of ZnONPs and AgNPs in this current research. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - June 6, 2018 Category: Biochemistry Source Type: research

Characterizations of hyaluronate-based terpolymeric hydrogel synthesized via free radical polymerization mechanism for biomedical applications
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Dipankar Das, Thi Thu Hien Pham, Insup Noh In the present study, a novel terpolymeric hydrogel was developed using sodium hyaluronate (HA), 2-hydroxyethyl acrylate (2-HEA), and poly(ethylene glycol) diacrylate (PEGDA) via free radical polymerization for biomedical applications. To achieve elasticity, swelling ability, porous architecture and sufficient gel strength, hyaluronate was chemically modified by grafting and crosslinking methods using 2-HEA and PEGDA, respectively. The structure and compositions of the fabricated...
Source: Colloids and Surfaces B: Biointerfaces - June 6, 2018 Category: Biochemistry Source Type: research

The fabrication and in vitro properties of antibacterial polydopamine-LL-37-POPC coatings on micro-arc oxidized titanium
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Ye He, Yangyang Zhang, Xinkun Shen, Bailong Tao, Ju Liu, Zhang Yuan, Kaiyong Cai Bacterial infection commonly occurs in clinical settings when the procedure involves a medical implant. Thus, the fabrication of antimicrobial medical materials has attracted much attention in recent years. To improve the antibacterial properties of titanium (Ti)-based biomedical materials, surface microporous structures, with antimicrobial peptide coatings, were employed in this study. Native Ti substrates were endowed with a certain level o...
Source: Colloids and Surfaces B: Biointerfaces - June 3, 2018 Category: Biochemistry Source Type: research

Interfacial reinforcement in a poly-l-lactic acid/mesoporous bioactive glass scaffold via polydopamine
This study suggested that the PLLA/p-MBG scaffold may have a potential application in tissue engineering. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - June 3, 2018 Category: Biochemistry Source Type: research

Association and sequestered dissociation of an anticancer drug from liposome membrane: Role of hydrophobic hydration
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Bijan K. Paul, Narayani Ghosh, Saptarshi Mukherjee Herein, the interaction of a potent anticancer drug (Sanguinarine, SG) with dimyristoyl-l-α-phosphatidylglycerol (DMPG) liposome membrane has been investigated at physiological pH. The spectroscopic fluorescence decay results demonstrate a modification of the photophysics of SG within DMPG-encapsulated state leading to preferential stabilization of the iminium ion over the alkanolamine form. This suggests a key role of electrostatic force underlying the interaction....
Source: Colloids and Surfaces B: Biointerfaces - June 2, 2018 Category: Biochemistry Source Type: research

A comprehensive review on green nanomaterials using biological systems: Recent perception and their future applications
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Rijuta Ganesh Saratale, Indira Karuppusamy, Ganesh Dattatraya Saratale, Arivalagan Pugazhendhi, Gopalakrishanan Kumar, Yooheon Park, Gajanan S. Ghodake, Ram Naresh Bharagava, J. Rajesh Banu, Han Seung Shin Over the last few years, nanotechnology is increasingly developing in scientific sector, which has attracted a great deal of interest because of its abundant applications in almost all the areas. In recent times, green nanotechnology is a relative and multidisciplinary field that has emerged as a rapidly developing rese...
Source: Colloids and Surfaces B: Biointerfaces - June 1, 2018 Category: Biochemistry Source Type: research

Protection of dopamine towards autoxidation reaction by encapsulation into non-coated- or chitosan- or thiolated chitosan-coated-liposomes
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): A. Trapani, D. Mandracchia, G. Tripodo, S. Cometa, S. Cellamare, E. De Giglio, P. Klepetsanis, S.G. Antimisiaris The aim of this work is to evaluate the potential of non-coated-, chitosan-(CS)- or chitosan-glutathione conjugate- (CS-GSH)-coated liposomes to protect the neurotransmitter Dopamine (DA) from the autoxidation reaction in neutral/alkaline conditions. This may be of interest in the development of nanotechnology-based approaches to improve Parkinson’s disease treatment because decreased ROS production and r...
Source: Colloids and Surfaces B: Biointerfaces - May 31, 2018 Category: Biochemistry Source Type: research

Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Yonglin Yu, Xinkun Shen, Junjie Liu, Yan Hu, Qichun Ran, Caiyun Mu, Kaiyong Cai Titanium substrates with micro/nano hierarchical features could positively mediate the osteogenesis of a titanium implant; nevertheless, the underlying molecular mechanism needs to be further revealed. In this work, we fabricated a micro/nano hierarchically structured Ti (MNT) sample and attempted to evaluate its topography-mediated biological effects and potential molecular mechanisms in vitro. The results proved that MNT could not only affec...
Source: Colloids and Surfaces B: Biointerfaces - May 30, 2018 Category: Biochemistry Source Type: research

A widened emission window of the peroxydisulfate-oxygen system for the detection of L-alanine
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Peiyao Ran, Shu Zhu, Jinyi Song, Jingling Wu, Fangjing Mo, Yingzi Fu Peroxydisulfate-oxygen (S2O8 2−-O2) system has become one of the most used systems in electrogenerated chemiluminscence (ECL) field. Due to S2O8 2− can be used as Fenton Reagent, this work designed an ECL biosensor based on the S2O8 2−-O2 system for the detection of L-alanine in a widened emission window and using hemin/G-quadruplex and platinum and palladium nanowires (Pt-Pd NWs) to in situ generate O2 to amplify the ECL intensity. T...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

In vitro evaluation of lysophosphatidic acid delivery via reverse perfluorocarbon emulsions to enhance alveolar epithelial repair
Conclusions The availability and thus the biological effect of LPA is significantly blunted during emulsified delivery in vitro, and this attenuation depends on the specific cellular function examined. Thus, the cellular level effects of drug delivery to the lungs via PFC emulsion are likely to vary based on the drug and the effect it is intended to create. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Two-stage controlled release system possesses excellent initial and long-term efficacy
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Jian Luo, Tong-fang Jing, Da-xia Zhang, Xian-peng Zhang, Beixing Li, Feng Liu In this work, a series of polyurea-based lambda-cyhalothrin-loaded microcapsules (MCs) with three different size distributions (average diameters of 1.35 μm, MC-S; 5.13 μm, MC-M; and 21.48 μm, MC-L) were prepared and characterized. The results indicated that MCs with a smaller particle size distribution had a faster release rate and excellent initial efficacy against pests. MC-L had a remarkably slow incipient release rate, outs...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Cytotoxic consequences of Halloysite nanotube/iron oxide nanocomposite and iron oxide nanoparticles upon interaction with bacterial, non-cancerous and cancerous cells
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): R. Abhinayaa, G. Jeevitha, D. Mangalaraj, N. Ponpandian, Kalieswaran Vidhya, Jayaraman Angayarkanni Cytotoxic effects of iron oxide (Fe3O4) nanoparticles and Halloysite nanotube/iron oxide (HNT/Fe3O4) nanocomposite are compared based on their interaction with Gram-negative bacteria Escherichia coli and Gram-positive bacteria Bacillus subtilis. Similarly, the action of these two nanomaterials on non-cancerous Vero cell lines and human lung cancerous (A-549) cell lines are compared. The cytotoxicity studies on Fe3O4 nanop...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Potential of rhBMP-2 and dexamethasone-loaded Zein/PLLA scaffolds for enhanced in vitro osteogenesis of mesenchymal stem cells
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Rongjun Li, Yali Ma, Yan Zhang, Mei Zhang, Dahui Sun Nanofibers fabricated by electrospinning simulate the extracellular matrix of bone cells and so researchers have taken a keen interest in them for regenerating bone tissue. The aim of this study was to fabricate ideal Zein/PLLA nanofibers by coaxial electrospinning and to load them with bone morphogenetic protein 2 (BMP-2) and dexamethasone (DEX) for dual controlled-release for bone tissue engineering applications. Morphology, surface hydrophilicity and core-shell con...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Catarina Pereira-Leite, Cláudia Nunes, José C. Bozelli, Shirley Schreier, Christina S. Kamma-Lorger, Iolanda M. Cuccovia, Salette Reis Nitric oxide (NO)-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) have been developed to overcome the gastrointestinal and cardiovascular toxicity of NSAIDs, by chemically associating a NO-releasing moiety with commercial NSAIDs. Since increasing evidence supports that NSAIDs toxicity is related to their topical actions in membrane lipids, this work aims to evaluate...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Effect of vanadium released from micro-arc oxidized porous Ti6Al4V on biocompatibility in orthopedic applications
In this study, the surface features and chemical compositions were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDS) and X-ray photoelectron spectroscopy (XPS). The ion release of Ti, Al and V was quantitatively measured by inductively-coupled plasma mass spectroscopy (ICP-MS) after immersion in Hanks’ solution. To probe the mechanism of V release, the corrosion resistance of porous Ti6Al4V before and after the MAO process was evaluated by electrochemical tests. Thereafter, the effects on the biocompatibility were tested in vitro by cell culture assays and then in vivo by...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Engineering PCL/lignin nanofibers as an antioxidant scaffold for the growth of neuron and Schwann cell
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Jing Wang, Lingling Tian, Baiwen Luo, Seeram Ramakrishna, Dan Kai, Xian Jun Loh, In Hong Yang, G. Roshan Deen, Xiumei Mo Antioxidant is critical for the successful of nerve tissue regeneration, and biomaterials with antioxidant activity might be favorable for peripheral nerve repair. Lignin, a biopolymer from wood with excellent antioxidant properties, is still “unexplored” as biomaterials. To design an antioxidative bioscaffold for nerve regeneration, here we synthesized lignin-polycaprolactone (PCL) copoly...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Identifying three routes of the sensing mechanism for casein-directed gold nanoclusters
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Shanshan Wang, Yingyi Wang, Xiaoming Yang Although there have existed kinds of gold nanoclusters (AuNCs) employed for various sensing purposes, scarce studies were proposed for systematically exploring their multiple routes of the sensing mechanism since that plays the critical role for broadening their analysis applications. Herein, casein-directed gold nanoclusters (AuNCs@casein) have been successfully raised for identifying their multiple routes towards the sensing mechanism. Initially, the current nanoclusters were ...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Bacterial response to spatially organized microtopographic surface patterns with nanometer scale roughness
In this study, the influence of nanometer scale roughness on bacterial adhesion and subsequent biofilm formation has been evaluated using spatially organized microtopographic surface patterns for four major opportunistic pathogens of the genus Staphylococcus (S. epidermidis and S. aureus) responsible for associated-biofilm infections on biomedical devices. The results presented demonstrated that regardless of the strain employed the initial adhesion events to these surfaces are directed by cell-surface contact points maximisation and thus, bacterial cells actively choose their position to settle based on that principle. Ac...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Catechin-conjugated mesoporous hydroxyapatite nanoparticle: A novel nano-antioxidant with enhanced osteogenic property
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Elnaz Sistanipour, Azadeh Meshkini, Hamid Oveisi Hydroxyapatite is the main component of mineral phase of bone which is widely employed for coating metal implants and scaffold materials in synthetic bone grafts owing to its osteoinductive property. In order to improve the bioactivity of hydroxyapatite, mesoporous hydroxyapatite nanoparticles (MHAP) were synthesized and chemically functionalized with 3-aminopropyltriethoxysilane. The amine-functionalized nanoparticles were conjugated with a natural antioxidant, catechin ...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research

Graphene oxide-assisted Au nanoparticle strip biosensor based on GR-5 DNAzyme for rapid lead ion detection
This study has reported that a GR-5 DNAzyme based lead ion strip biosensor could exhibit an enhanced specificity with the assistance of graphene oxide (GO). This enhancement results from the specific π-stacking interaction between the ribose rings of the nucleobases and the carbon hexagons in GO which can reduce the false positive interference by removing unhybridized ssDNA during the annealing of GR-5 DNAzyme. Meanwhile, conjugate pad was sprayed with two kinds of AuNP-DNA probes, and nitrocellulose membrane test zone and control zone were immobilized with two kinds of biotin-DNA probes, respectively. The limit of dete...
Source: Colloids and Surfaces B: Biointerfaces - May 26, 2018 Category: Biochemistry Source Type: research