Iris Melanoma: Review of Clinical Features, Risks, Management and Outcomes
Primary uveal melanoma is rare and affects approximately 8,000 persons per year worldwide. This malignancy can involve the iris, ciliary body, and choroid. Of these three structures, the iris is the least commonly affected site, representing only 4% of all uveal melanomas. Iris melanoma can arise from iris melanocytic nevus, iris melanocytosis, or de novo. In a longitudinal study of 1,611 patients followed with iris nevus, transformation into melanoma, using Kaplan-Meier estimates, was found in 2.6% by 5 years and 4.1% by 10 years. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 19, 2023 Category: Dermatology Authors: Elliot Cherkas, Nicholas E. Kalafatis, Molly R. Marous, Carol L. Shields Source Type: research
Covid-19 and the Eye
There is growing literature describing the ocular manifestations of Covid-19. Herein we assess published reviews, cross-sectional analyses, and clinical reports to summarize the ocular manifestations of the disease and available vaccines, identify the potential role of ocular transmission, and offer basic clinical guidance to healthcare providers. Ultimately, self-limiting conjunctivitis and conjunctival hyperemia are the most frequently reported ocular findings; several rarer entities may warrant targeted topical therapies. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 18, 2023 Category: Dermatology Authors: Christian Gronbeck, Andrzej Grzybowski, Jane M. Grant-Kels Source Type: research
Ocular and eyelid involvement in collagen vascular diseases. Part I. Sj ögren syndrome and systemic lupus erythematosus
Collagen vascular disease is a heterogeneous group of autoimmune diseases that affect multiple organ systems. Sj ögren syndrome, dermatomyositis, scleroderma, systemic lupus erythematosus, and sarcoidosis are collagen vascular diseases that often present with characteristic cutaneous manifestations. Although less known, various ocular manifestations that affect both external and internal structures of the eye can be seen in these conditions. Multidisciplinary management between dermatologists and ophthalmologists is essential in the early diagnosis and management of collagen vascular diseases affecting both the skin and e...
Source: Clinics in Dermatology - October 17, 2023 Category: Dermatology Authors: Ndidi Enwereji, Sueheidi Santiago, Christina Jiang, Khayyam Durrani, Sona Chaudhry, Jun Lu Source Type: research
DUPLICATE: Sexually Transmitted Infections and HIV in Ophthalmology
The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.clindermatol.2023.08.011. The duplicate article has therefore been withdrawn.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 17, 2023 Category: Dermatology Authors: Lorin A Bibb, Kyaw Zin Htet, Corey W Waldman, Steven Brett Sloan Source Type: research
Conjunctival Melanoma: Insights into Classification, Outcomes, and Biomarkers
Conjunctival melanoma is quite rare, estimated at approximately 0.5/1 million persons/year. This malignancy arises from a pre-existing nevus (7%), primary acquired melanosis (74%), or de novo without pre-existing condition (19%) and develops most often in patients with Fitzpatrick skin types I (23%) and II (62%). At initial presentation, the tumor size is approximately 13 mm in cross-sectional diameter and 3 mm thickness, involving the bulbar (97%), forniceal (30%), tarsal (28%), or caruncular (11%) regions, often with corneal (54%) and rarely with orbital (4%) involvement. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 17, 2023 Category: Dermatology Authors: Carol L. Shields, Ana Maria Velasco Silva, Andrea Laiton, Nicholas E. Kalafatis, Emily Schiller, Sara E. Lally, Jane M. Grant-Kels, Jerry A. Shields Source Type: research
Sexually Transmitted Infections and HIV in Ophthalmology
The ocular and periocular manifestations of sexually transmitted infections (STIs) are heterogeneous in etiology, manifestations, and complications. Etiologic agents include bacteria, viruses, parasites, and protozoa, which are most frequently transmitted via direct ocular contact with an active lesion or infected bodily fluid, autoinoculation, or dissemination from a distant site. Vertical transmission most commonly occurs perinatally during vaginal delivery. The complications of ophthalmia neonatorum can be severe with the potential for permanent blindness or life-threatening systemic involvement if untreated. (Source: C...
Source: Clinics in Dermatology - October 17, 2023 Category: Dermatology Authors: Lorin A Bibb, Kyaw Zin Htet, Corey W Waldman, Steven Brett Sloan Source Type: research
Ocular and eyelid involvement in collagen vascular diseases. Part I. Sj ögren's Syndrome and Systemic Lupus Erythematosus
Collagen vascular disease is a heterogeneous group of autoimmune diseases that affect multiple organ systems. Sjogren's syndrome, dermatomyositis, scleroderma, systemic lupus erythematosus, and sarcoidosis are collagen vascular diseases that often present with characteristic cutaneous manifestations. Although less known, various ocular manifestations that affect both external and internal structures of the eye can be seen in these conditions. Multidisciplinary management between dermatologists and ophthalmologists is essential in the early diagnosis and management of collagen vascular diseases affecting both the skin and e...
Source: Clinics in Dermatology - October 17, 2023 Category: Dermatology Authors: Ndidi Enwereji, Sueheidi Santiago, Christina Jisang, Khayyam Durrani, Sona Chaudhry, Jun Lu Source Type: research
Popularity of Infrared Saunas and Potential Dermatologic Risks: A Google Trends Analysis
To the Editor, (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 11, 2023 Category: Dermatology Authors: Sharon Pan, Benjamin Gallo Marin, Sara D. Ragi, Rachel K. Lim, Katie A. O'Connell, Tiffany J. Libby Tags: Correspondence Source Type: research
Scraping method: a new treatment strategy for longitudinal melanonychia with minimal nail deformity
The etiology of longitudinal melanonychia (LM) ranges from more common benign causes to less known invasive melanomas. While approximately 5% of LM in adults is attributed to melanoma1, it is usually benign in childhood. Although rare, a few cases of pediatric subungual melanoma in situ have been reported 2. For some patients and their families, melanonychia is very worrisome, and they prefer removal if only for peace of mind. Unfortunately, a surgical procedure may leave a nail deformity due to the injury to the nail matrix. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 11, 2023 Category: Dermatology Authors: Hyun Jee Kim, Hae Eun Park, Chul Hwan Bang, Ji Hyun Lee, Young Min Park, Yeong Ho Kim Tags: Correspondence Source Type: research
Targeting dysbiosis in psoriasis, atopic dermatitis, and hidradenitis suppurativa: the gut-skin axis and microbiome-directed therapy
Emerging evidence highlights the gut-skin microbiota as a potential therapeutic target for the management of inflammatory-driven cutaneous diseases as well as the interconnection of the gut-skin microbiota in disease pathogenesis and progression. Although not fully understood, recent research has indicated that commensal microbiota and the interaction of the gut-skin axis play an important role in maintaining skin homeostasis. Dysbiosis and disruption of the skin-gut microbiome may lead to impaired skin barrier function, thus triggering downstream inflammatory responses involved in the development of inflammatory skin diso...
Source: Clinics in Dermatology - October 8, 2023 Category: Dermatology Authors: Chibuzo Aguwa, Ndidi Enwereji, Sueheidi Santiago, Ashley Hine, George G. Kels, Jean McGee, Jun Lu Tags: Comment and Controversy Source Type: research
Targeting Dysbiosis in Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa: An Updated Review of the Gut-Skin Axis and Microbiome-Directed Therapy
Emerging evidence highlights the interconnection of the gut-skin microbiota in disease pathogenesis, progression, and as a potential therapeutic target for the management of inflammatory-driven cutaneous diseases. Although not fully understood, recent research has indicated that commensal microbiota and the interaction of the gut-skin axis play an important role in maintaining the skin homeostasis. Dysbiosis and disruption of skin-gut microbiome may lead to impaired skin barrier function thus triggering downstream inflammatory responses involved in the development of inflammatory skin disorders, especially in atopic dermat...
Source: Clinics in Dermatology - October 8, 2023 Category: Dermatology Authors: Chibuzo Aguwa, Ndidi Enwereji, Sueheidi Santiago, Ashley Hine, George G. Kels, Jean McGee, Jun Lu Tags: Comment and Controversy Source Type: research
Mpox and herpes simplex virus type 2 coinfection in a patient with HIV
The emergence of mpox (MPX) on a global scale has become a major source of concern for patients and clinicians. Infection by this double-stranded DNA virus is characterized by a viral prodrome of flulike symptoms before the development of numerous firm, well-circumscribed papules, many of which become umbilicated and develop central erosions, ulcerations, or crust. Typical sites of involvement include the hands, feet, face, mouth, and anogenital region. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 6, 2023 Category: Dermatology Authors: Han Li, Navid Farahbakhsh, Mahtab Forouzandeh, Naveen Baskaran, Kiran Motaparthi Tags: Correspondence Source Type: research
Mpox and herpes simplex virus type 2 coinfection in a patient with human immunodeficiency virus
Consent for the publication of all patient photographs and medical information was provided by the authors at the time of article submission to the journal stating that all patients gave consent for their photographs and medical information to be published in print and online and with the understanding that this information may be publicly available. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 6, 2023 Category: Dermatology Authors: Han Li, Navid Farahbakhsh, Mahtab Forouzandeh, Naveen Baskaran, Kiran Motaparthi Source Type: research
The top 100 most cited contributions on prurigo nodularis: A bibliometric analysis
Prurigo nodularis (PN) is a chronic dermatologic condition characterized by intense pruritus and round, hard, keratotic1 nodules ranging from a few to several hundreds.1,2 Of unknown etiology, PN is a relatively rare condition found mostly in middle-aged women, although pediatric cases have also been observed.1 (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 3, 2023 Category: Dermatology Authors: Nicolas Andre, Amir Horev Tags: Correspondence Source Type: research
The top 100 most cited publications on Prurigo Nodularis: a bibliometric analysis
Prurigo Nodularis (PN) is a chronic dermatologic condition characterized by intense pruritus and round, hard, keratotic1 nodules ranging from a few to several hundreds1,2. Of unknown etiology, PN is a relatively rare condition mostly found in middle-aged women, though pediatric cases have also been observed1. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - October 3, 2023 Category: Dermatology Authors: Nicolas Andre, Amir Horev Tags: Correspondence Source Type: research
