Diagnosis of Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is a rare genetic disease leading to bronchiectasis in most patients. In addition to the lungs, PCD might affect multiple organ systems, and patients frequently have multiple clinical problems, which require multidisciplinary management. Diagnosis of PCD needs a combination of tests, many of which require expertise and expensive equipment. Measurement of nasal nitric oxide is the first test to consider when PCD is suspected. Detailed clinical history using available predictive scores in combination with information on functional and structural aspects of lung disease is important to identif...
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: Myrofora Goutaki, Amelia Shoemark Source Type: research
Antibiotic Management in Bronchiectasis
This article reviews the role of antibiotics in the treatment of exacerbations, for maintenance therapy to reduce exacerbation frequency, and for eradicating potentially harmful organisms such as Pseudomonas aeruginosa. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: Charles S. Haworth, Roderigo Andres Floto Source Type: research
Bronchiectasis from 2012 to 2022
The previous issue of Clinics in Chest Medicine was published in 2012 and described the state of the art in the disease at that time. In the intervening years, bronchiectasis has experienced something of a renaissance, leaving behind the label of an “orphan disease.” Major developments in the past 10 years including a deeper understanding of epidemiology include the development of international registries. An exponential increase in randomized clinical trials in bronchiectasis has strengthened the evidence base for treatments but much work remains to translate the increasing global interest in the disease into a better...
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: James D. Chalmers Source Type: research
Allergic Bronchopulmonary Aspergillosis
Allergic bronchopulmonary aspergillosis (ABPA) is a complex allergic disorder caused by immune reactions against Aspergillus fumigatus. ABPA most commonly complicates the course of patients with poorly controlled asthma. Patients commonly present with uncontrolled asthma, fleeting pulmonary opacities, and bronchiectasis. Pathogenetically, ABPA is characterized by the persistence of A. fumigatus in the airways and an exaggerated type-2 immune response. The interest in ABPA stems from the fact that bronchiectasis in ABPA can be prevented if the disorder is diagnosed timely and treated appropriately. Herein, we summarize the ...
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: Ritesh Agarwal, Valliappan Muthu, Inderpaul S. Sehgal, Sahajal Dhooria, Kuruswamy T. Prasad, Ashutosh N. Aggarwal Source Type: research
The Spectrum of Airway Involvement in Inflammatory Bowel Disease
Inflammatory bowel disease is associated with a wide spectrum of central, large, and small airway abnormalities, including bronchiectasis. The bronchiectasis associated with inflammatory bowel disease has a distinct phenotype, with marked inflammation and at times severe sterile bronchorrhea that can be responsive to inhaled corticosteroids. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: Philippe Camus, Thomas V. Colby Source Type: research
Airway Clearance and Mucoactive Therapies in Bronchiectasis
In this article, we review airway clearance techniques, mucoactive agents, and the role of pulmonary rehabilitation in the treatment of patients with bronchiectasis. Topics include the physiology of airway clearance, specific techniques and therapies, and practical considerations for ensuring adherence to the therapies and education for the patient. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: Anne E. O ’Donnell Source Type: research
Future Directions in Bronchiectasis Research
Bronchiectasis treatment is challenging, and many recent randomized controlled trials have failed to prove any clinical improvement. The most reasonable explanation for that problem is the high heterogeneity of patients ’ groups. For that reason, there is an urgent need to find new biomarkers to better stratify patients. The present chapter addresses the future directions in biomarkers, omics technologies, endotypes, and new treatments toward a personalized medicine in the field of bronchiectasis. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: Rosanel Amaro, L ídia Perea, Oriol Sibila Source Type: research
Bronchiectasis: Advances in Diagnosis and Management
Bronchiectasis remains a major clinical challenge. It is increasing in prevalence globally, and as our understanding of the disease increases, we gain a deeper understanding of its complexity. The word most commonly used in discussions about bronchiectasis is “heterogeneity,” defined as “being diverse in character and content.” It is a fitting description for a condition that has many possible causes, diverse clinical presentations, overlapping conditions, and complex treatment. This heterogeneity makes bronchiectasis challenging but also a fasci nating topic to study and clinical conundrum to solve. (Source: Clini...
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: James D. Chalmers Tags: Preface Source Type: research
Bronchiectasis
CLINICS IN CHEST MEDICINE (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Authors: James D. Chalmers Source Type: research
Copyright
ELSEVIER (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Source Type: research
Contributors
JAMES D. CHALMERS, MBChB, PhD, FRCPE, FERS (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Source Type: research
Contents
James D. Chalmers (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Source Type: research
Forthcoming Issues
Sleep Deficiency and Health (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 28, 2022 Category: Respiratory Medicine Source Type: research
Updates in Pleural Imaging
Pleural disease affects more than 300 people per 100,000 population each year and leads to more than 150 admissions per 100,000 population/y (costing >$10 billion in the United States alone). Radiological investigation is key in establishing a diagnosis for patients presenting with pleural effusion, thickening, masses, and pneumothorax. Radiological findings also often determine the initial management options and monitoring for ongoing management. Chest radiography remains the initial modality of choice for the investigation of pleural disease. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 11, 2021 Category: Respiratory Medicine Authors: Maria Tsakok, Rob Hallifax Source Type: research
Ultrasound-Guided Pleural Investigations
Pleural diseases are frequently encountered across multiple inpatient and outpatient settings, making pleural drainage and sampling one of the most common medical procedures. With the widespread adoption of bedside ultrasound examination, ultrasound machines are now readily available in many clinical settings, providing both diagnostic and procedural guidance. The modern management of pleural disease is dominated by ultrasound assessment with strong evidence supporting its use to guide pleural interventions. Here, we review the current landscape of ultrasound use to guide pleural drainage, pneumothorax management, and pleu...
Source: Clinics in Chest Medicine - November 11, 2021 Category: Respiratory Medicine Authors: Jeffrey Thiboutot, Kyle T. Bramley Source Type: research
