Update on Lung Transplantation for Cystic Fibrosis
Lung transplantation provides a treatment option for many individuals with advanced lung disease due to cystic fibrosis (CF). Since the first transplants for CF in the 1980s, survival has improved and the opportunity for transplant has expanded to include individuals who previously were not considered candidates for transplant. Criteria to be a transplant candidate vary significantly among transplant programs, highlighting that the engagement in more than one transplant program may be necessary. Individuals with highly resistant CF pathogens, malnutrition, osteoporosis, CF liver disease, and other comorbidities may be suit...
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Authors: Joseph M. Pilewski Source Type: research
Cystic Fibrosis in the Era of Highly Effective CFTR Modulators
Cystic fibrosis (CF) was described as a clinical entity more than eighty years ago.1 –3 With the development of comprehensive care centers and therapies directed at the signs and symptoms of the disease, survival improved.4 What once was a disease only of children has become a chronic disease of adults for whom the median predicted survival is fifty years of age.5,6 As the natural history of CF has evolved, so has the recognition of previously underdiagnosed populations of people with CF, contributing to its rising prevalence around the world. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Authors: Clemente J. Britto, Jennifer L. Taylor-Cousar Tags: Preface Source Type: research
Cystic Fibrosis in the Era of Highly Effective CFTR Modulator Therapy
CLINICS IN CHEST MEDICINE (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Authors: Clemente J. Britto, Jennifer L. Taylor-Cousar Source Type: research
Copyright
ELSEVIER (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Source Type: research
Contributors
CLEMENTE J. BRITTO, MD, ATSF (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Source Type: research
Contents
Clemente J. Britto and Jennifer L. Taylor-Cousar (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Source Type: research
Forthcoming Issues
Lung Transplantation (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 5, 2022 Category: Respiratory Medicine Source Type: research
Lung Transplantation for Coronavirus Disease-2019 Patients and Coronavirus Disease-2019 in Lung Transplant Recipients
Lung transplant is a life-saving treatment for carefully selected patients with respiratory failure related to the infection with coronavirus disease-2019. Despite a complex pretransplant medical course, the posttransplant outcomes are excellent when performed by experienced centers. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 3, 2022 Category: Respiratory Medicine Authors: Diego Avella, Henry Neumann, Ankit Bharat Source Type: research
Lung Transplantation for COVID-19 patients and COVID-19 in Lung Transplant Recipients
Lung transplant is a life-saving treatment for carefully selected patients with respiratory failure related to the infection with COVID-19. Despite a complex pre-transplant medical course, the post-transplant outcomes are excellent when performed by experienced centers. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - November 3, 2022 Category: Respiratory Medicine Authors: Diego Avella, Ankit Bharat Source Type: research
Point-of-Care Ultrasound in the Intensive Care Unit
The use of point-of-care ultrasonography in the intensive care unit has been rapidly advancing over the past 20 years. This review will provide a broad overview of the discipline spanning lung ultrasonography to advanced critical care echocardiography. It will highlight new research that questions the utility of the inferior vena cava for determining volume responsiveness and will introduce the reader to cutting-edge technology including artificial intelligence, which is likely to revolutionize ultrasound teaching and image interpretation, increasing the reach of this modality for the frontline clinician. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - September 1, 2022 Category: Respiratory Medicine Authors: Yonatan Y. Greenstein, Keith Guevarra Source Type: research
Capnography for Monitoring of the Critically Ill Patient
Capnography has been widely adopted in multiple clinical areas. The capnogram and end-tidal carbon dioxide offer a wealth of information, in the right clinical setting, and when properly interpreted. In this article, the authors aim to review the most common clinical scenarios during which capnography has been shown to be of benefit. This includes the areas of fluid responsiveness, cardiopulmonary resuscitation, and conscious sedation. They review the published literature, highlighting its pitfalls and identifying its limitations. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - September 1, 2022 Category: Respiratory Medicine Authors: Boulos S. Nassar, Gregory A. Schmidt Source Type: research
Novel and Rapid Diagnostics for Common Infections in the Critically Ill Patient
There are several novel platforms that enhance detection of pathogens that cause common infections in the intensive care unit. These platforms have a sample to answer time of a few hours, are often higher yield than culture, and have the potential to improve antibiotic stewardship. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - September 1, 2022 Category: Respiratory Medicine Authors: Chiagozie I. Pickens, Richard G. Wunderink Source Type: research
Pharmacologic Management of Delirium in the Intensive Care Unit
Delirium, often underdiagnosed in the intensive care unit, is a common complication of critical illness that contributes to significant morbidity and mortality. Clinicians should be aware of common risk factors and triggers and should work to mitigate these as much as possible to reduce the occurrence of delirium. This review first provides an overview of the epidemiology, pathophysiology, evaluation, and consequences of delirium in critically ill patients. Presented next is the current evidence for the pharmacologic management of delirium, focusing on prevention and treatment of delirium in the intensive care unit. It con...
Source: Clinics in Chest Medicine - September 1, 2022 Category: Respiratory Medicine Authors: Perry J. Tiberio, Niall T. Prendergast, Timothy D. Girard Source Type: research
Management of the Critically Ill Patient with Pulmonary Arterial Hypertension and Right Heart Failure
Right ventricular (RV) failure is a recognized complication of pulmonary hypertension (PH). Pregnancy and surgery represent unique challenges to the patient with PH and require input from an interprofessional team. Approach to treatment must embrace sound physiologic principles that are based on optimization of RV preload, contractility, and afterload to improve cardiac function and tissue perfusion before the onset of multiorgan dysfunction. Failure of medical therapy needs to be recognized before the onset of irreversible shock. When appropriate, eligible patients should be considered for mechanical circulatory support a...
Source: Clinics in Chest Medicine - September 1, 2022 Category: Respiratory Medicine Authors: John Granton, Ricardo Teijeiro-Paradis Source Type: research
Critical Care of the Lung Transplant Patient
Lung transplantation is a therapeutic option for end-stage lung disease that improves survival and quality of life. Prelung transplant admission to the intensive care unit (ICU) for bridge to transplant with mechanical ventilation and extracorporeal membrane oxygenation (ECMO) is common. Primary graft dysfunction is an important immediate complication of lung transplantation with short- and long-term morbidity and mortality. Later transplant-related causes of respiratory failure necessitating ICU admission include acute cellular rejection, atypical infections, and chronic lung allograft dysfunction. Lung transplantation fo...
Source: Clinics in Chest Medicine - September 1, 2022 Category: Respiratory Medicine Authors: Alyssa A. Perez, Rupal J. Shah Source Type: research
