Therapeutic effects of finasteride: inhibition of disease progression and serum prostate-specific antigen reduction in patients with prostatic intraepithelial neoplasia
The objective of this study was to evaluate the impact of finasteride on the progression of prostate intraepithelial neoplasia and levels of prostate-specific antigen (PSA) in patients. A total of 120 patients with high-grade prostatic intraepithelial neoplasia were included in this study from January 2013 to January 2018. All patients underwent prostate biopsies. Among them, 60 patients were assigned to the observation group and received a daily dosage of 5 mg finasteride for 60 months, while the remaining 60 patients were assigned to the control group and did not receive finasteride. PSA levels were measured every six mo...
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Jia Wei He Zi-Xuan Huang Jian-Liang Wu Yan-Feng Su Xiao-Long Xu Source Type: research
Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents
CONCLUSIONS: In conclusion, a three-month course of a combination of Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica seems to be an interesting tool to avoid unnecessary prostate biopsies among men with higher-than-normal PSA levels.PMID:38391402 | PMC:PMC10888467 | DOI:10.3390/clinpract14010016 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Tommaso Cai Irene Tamanini Marco Puglisi Leonardo Bizzotto Michele Rizzo Giovanni Liguori Luca Gallelli Alessandro Palmieri Truls E Bjerklund Johansen Source Type: research
Magnetic resonance guided adaptive post prostatectomy radiotherapy: Accumulated dose comparison of different workflows
CONCLUSIONS: Daily MRgART treatment consistently met planning criteria. Target volume variability in prostate bed treatment can be mitigated by using MRgART and deliver satisfactory coverage of CTV whilst minimizing dose to adjacent OARs and reducing toxicity.PMID:38394627 | DOI:10.1002/acm2.14253 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Sean P Hassan Jeremiah de Leon Vikneswary Batumalai Zoe Moutrie Louise Hogan Yuanyuan Ge Phillip Stricker Michael G Jameson Source Type: research
Stroma-specific gene expression signature identifies prostate cancer subtype with high recurrence risk
This study demonstrates the potential of stromal signatures in identification of clinically relevant PC subtypes, and further indicated that stromal characterization may enhance risk stratification in LPC and may be particularly promising in cases with high prognostic ambiguity based on clinical parameters.PMID:38395986 | DOI:10.1038/s41698-024-00540-x (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Martin Rasmussen Jacob Freds øe Paul Vinu Salachan Marcus Pii Lunau Blanke Stine Hesselby Larsen Benedicte Parm Ulh øi J ørgen Bjerggaard Jensen Michael Borre Karina Dalsgaard S ørensen Source Type: research
Prostate-Specific Membrane Antigen PET/CT Detection of Prostate Cancer Metastasis to Thyroid and Cricoid Cartilages
Clin Nucl Med. 2024 Feb 23. doi: 10.1097/RLU.0000000000005111. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) PET/CT has revolutionized the imaging of prostate cancer. Historically, prostate cancer metastasis to thyroid and cricoid cartilages was thought to be exceedingly rare, with only a few reported cases in the literature. Prostate cancer metastasis to the laryngeal cartilages was detected in 4 of 221 patients who underwent imaging with 18F-PSMA (Pylarify) or 68Ga-PSMA (Illuccix) PET/CT for initial staging of high-risk prostate cancer or restaging evaluation in the setting of biochemical recurr...
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Joshua Eichhorn Nadia Nelson Surbhi Raichandani Aaron Sesler Fathima Fijula Palot Manzil Source Type: research
Monitoring Dual-Cancer Treatment in a Patient With Prostate and Hepatocellular Carcinoma Using Prostate-Specific Membrane Antigen-Directed PET/CT
We report on a 70-year-old man affected with prostate carcinoma (PC) scheduled for prostate-specific membrane antigen (PSMA) PET/CT using 18F-PSMA1007. Because of uptake in the liver and corresponding findings on magnetic resonance, diagnosis of hepatocellular carcinoma (HCC, G1) was established. The patient was then scheduled for antihormonal treatment for PC and locoregional therapy due to HCC. On follow-up PSMA-targeted PET/CT, we observed durable response to PC-associated therapy, whereas hepatic lesions showed progressive disease. As such, we herein report on a dual-cancer targeting molecular imaging strategy to deter...
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Florian Reiter Alexander Weich Takahiro Higuchi Sebastian E Serfling Ralph Kickuth Rudolf A Werner Source Type: research
Pluvicto-Induced 18F-PSMA PET Bone Flare
Clin Nucl Med. 2024 Feb 23. doi: 10.1097/RLU.0000000000005104. Online ahead of print.ABSTRACTA 79-year-old man with a history of metastatic prostate cancer was initially treated with Eligard and switched to relugolix in 2021. The 2022 bone scan presented superscan and extensive osseous metastatic lesions; some had intense PSMA uptake on the initial PSMA PET scan without nodal or visceral metastatic lesions. We treated him with Pluvicto and relugolix. The intermediate PSMA scan demonstrated prominent bone marrow PSMA uptake. However, PSA decreased 58.5%. We hypothesized that the patient might have a bone flare. The final PS...
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Xiaofei Wang Daniel Martin Thomas Hogan Kenneth Veselicky Source Type: research
A Hangover Under 177Lu-PSMA-617 Therapy: A Red Flag for Brain 68Ga-PSMA-11 PET/MRI?
Clin Nucl Med. 2024 Feb 23. doi: 10.1097/RLU.0000000000005126. Online ahead of print.ABSTRACTLeptomeningeal carcinomatosis in prostate cancer is extremely rare. Because of the low overall penetration of drugs into the brain and the prolonged survival of castration-resistant prostate cancer (CRPC) patients, a special attention should be paid to the appearance of neurological symptoms in long-term CRPC survivors. A patient suffering from a CRPC with bone metastases underwent 4 cycles of 177Lu-PSMA (prostate-specific membrane antigen)-617. Starting from the third cycle, he reported an increasing feeling of a permanent hangove...
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Nathan Poterszman Laura Somme Caroline Bund Emilie Hutt Fran çois Somme Source Type: research
Therapeutic effects of finasteride: inhibition of disease progression and serum prostate-specific antigen reduction in patients with prostatic intraepithelial neoplasia
The objective of this study was to evaluate the impact of finasteride on the progression of prostate intraepithelial neoplasia and levels of prostate-specific antigen (PSA) in patients. A total of 120 patients with high-grade prostatic intraepithelial neoplasia were included in this study from January 2013 to January 2018. All patients underwent prostate biopsies. Among them, 60 patients were assigned to the observation group and received a daily dosage of 5 mg finasteride for 60 months, while the remaining 60 patients were assigned to the control group and did not receive finasteride. PSA levels were measured every six mo...
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Jia Wei He Zi-Xuan Huang Jian-Liang Wu Yan-Feng Su Xiao-Long Xu Source Type: research
Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents
CONCLUSIONS: In conclusion, a three-month course of a combination of Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica seems to be an interesting tool to avoid unnecessary prostate biopsies among men with higher-than-normal PSA levels.PMID:38391402 | DOI:10.3390/clinpract14010016 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Tommaso Cai Irene Tamanini Marco Puglisi Leonardo Bizzotto Michele Rizzo Giovanni Liguori Luca Gallelli Alessandro Palmieri Truls E Bjerklund Johansen Source Type: research
Magnetic resonance guided adaptive post prostatectomy radiotherapy: Accumulated dose comparison of different workflows
CONCLUSIONS: Daily MRgART treatment consistently met planning criteria. Target volume variability in prostate bed treatment can be mitigated by using MRgART and deliver satisfactory coverage of CTV whilst minimizing dose to adjacent OARs and reducing toxicity.PMID:38394627 | DOI:10.1002/acm2.14253 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 23, 2024 Category: Cancer & Oncology Authors: Sean P Hassan Jeremiah de Leon Vikneswary Batumalai Zoe Moutrie Louise Hogan Yuanyuan Ge Phillip Stricker Michael G Jameson Source Type: research
Investigating the Current Harmonization Status of Tumor Markers Using Global External Quality Assessment Programs: A Feasibility Study
CONCLUSIONS: This study provides relevant information about the current harmonization status of 6 tumor markers. A pilot harmonization investigation for CEA, CA125, CA15-3, and CA19-9 would be desirable.PMID:38385453 | DOI:10.1093/clinchem/hvae005 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 22, 2024 Category: Cancer & Oncology Authors: Huub H van Rossum Stefan Holdenrieder Bart E P B Ballieux Tony C Badrick Yeo-Min Yun Chuanbao Zhang Dina Patel Marc Thelen Junghan Song Nathalie Wojtalewicz Nick Unsworth Hubert W Vesper Wei Cui Lakshmi V Ramanathan Catharine Sturgeon Qing H Meng Source Type: research
A longitudinal mixed-methods study of pathology explanation clinics in patients with newly diagnosed localized prostate cancer
CONCLUSIONS: In this small pilot, PECs positively affected patients with prostate cancer, their clinicians, and the overall care system. Additional studies in larger populations and diverse settings will be useful.PMID:38387034 | DOI:10.1093/ajcp/aqae008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 22, 2024 Category: Cancer & Oncology Authors: Sarah E Bergholtz Sophia R Kurnot Esha Elahi Melissa DeJonckheere Sarah T Hawley Scott R Owens Simpa Salami Todd M Morgan Cathryn J Lapedis Source Type: research
Investigating the Current Harmonization Status of Tumor Markers Using Global External Quality Assessment Programs: A Feasibility Study
CONCLUSIONS: This study provides relevant information about the current harmonization status of 6 tumor markers. A pilot harmonization investigation for CEA, CA125, CA15-3, and CA19-9 would be desirable.PMID:38385453 | DOI:10.1093/clinchem/hvae005 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 22, 2024 Category: Cancer & Oncology Authors: Huub H van Rossum Stefan Holdenrieder Bart E P B Ballieux Tony C Badrick Yeo-Min Yun Chuanbao Zhang Dina Patel Marc Thelen Junghan Song Nathalie Wojtalewicz Nick Unsworth Hubert W Vesper Wei Cui Lakshmi V Ramanathan Catharine Sturgeon Qing H Meng Source Type: research
Artificial intelligence-based algorithms for the diagnosis of prostate cancer: A systematic review
CONCLUSIONS: The published evidence suggests that AI can be reliably used for prostate cancer detection and grading, assisting pathologists in the time-consuming screening of slides. Further technologic improvement would help widening AI's adoption in prostate pathology, as well as expanding its prognostic predictive potential.PMID:38381582 | DOI:10.1093/ajcp/aqad182 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 21, 2024 Category: Cancer & Oncology Authors: Stefano Marletta Albino Eccher Filippo Maria Martelli Nicola Santonicco Ilaria Girolami Aldo Scarpa Fabio Pagni Vincenzo L'Imperio Liron Pantanowitz Stefano Gobbo Davide Seminati Angelo Paolo Dei Tos Anil Parwani Source Type: research
