Study of a Cold Atmospheric Pressure Plasma jet device for indirect treatment of Squamous Cell Carcinoma
Publication date: Available online 5 September 2018Source: Clinical Plasma MedicineAuthor(s): S. Pereira, E. Pinto, P.A. Ribeiro, S. SérioABSTRACTThe possibility of obtaining plasmas at low temperatures and atmospheric conditions, the Cold Atmospheric Plasmas (CAPs), has triggered several studies on its possible medical applications. The use of CAPs devices applied to oncological treatments is still in a pre-clinical stage, but early investigations have shown promising results, both in vitro and in vivo. In this work, is reported the study of a custom made Cold Atmospheric Pressure Plasma jet device for indirect treatment...
Source: Clinical Plasma Medicine - September 6, 2018 Category: Research Source Type: research
Comparative Study on Manuka and Indonesian Honeys to Support the Application of Plasma Jet during Proliferative Phase on Wound Healing
Publication date: Available online 11 August 2018Source: Clinical Plasma MedicineAuthor(s): Eka Sakti Wahyuningtyas, Arya Iswara, Yunita Sari, Sodiq Kamal, Budi Santosa, Tatsuo Ishijima, Toshio Nakatani, Indri Kartika Putri, N NasruddinAbstractA comparative investigation was conducted to determine the effectiveness of Manuka and Indonesian honeys to support the application of plasma jet treatment during the proliferative phase of cutaneous wound healing in 8-week-old, BALB/c male mice. The effect of honey containing different concentrations to reactive oxygen and nitrogen species (RONS) produced by plasma jet in liquid med...
Source: Clinical Plasma Medicine - August 12, 2018 Category: Research Source Type: research
Side effects in cold plasma treatment of advanced oral cancer—Clinical data and biological interpretation
ConclusionUnderstanding the lack of severe side effects in plasma medicine, the role of radical oxygen species (ROS) and radical nitrogen species (RNS) is discussed, proposing a model in which CAP is not a direct effector of antitumor action but rather triggers a singlet oxygen-mediated switch-on effect on the specific target, leading to reactivation of intercellular ROS/RNS-dependent apoptosis signaling in tumor cells. As these processes are strictly restricted to the specific targets and as normal tissue is devoid of the required target, it is neither harmed nor affected. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research
Targeting malignant melanoma with physical plasmas
Publication date: June 2018Source: Clinical Plasma Medicine, Volume 10Author(s): Gabriella Pasqual-Melo, Rajesh Kumar Gandhirajan, Ingo Stoffels, Sander BekeschusAbstractMelanoma is the deadliest form of cutaneous neoplasia. With a five-year survival rate of only 5–19%, metastatic melanoma presents severe challenges in clinical therapies. In addition, palliation is often problematic due to large numbers of fast growing metastasis. This calls for new therapeutic avenues targeting highly aggressive melanoma in palliative patients. One recently suggested innovative approach for eradication of topical tumor lesions is the ap...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research
Connecting basic cold plasma technology to dermato-oncology
Publication date: June 2018Source: Clinical Plasma Medicine, Volume 10Author(s): Carsten Weishaupt, Steffen EmmertAbstractCold atmospheric plasma was intensively investigated for medical applications in the last decade and a new field of plasma medicine emerged. Basic components of cold plasma and their biomedical effects were deciphered and mainly relate to redox-biologic effects. With regard to wound treatment, cold plasma already reached standard medical care status. In terms of plasma effects in oncology, only preliminary research data are available. This emerging and highly dynamic field of plasma medicine in oncology...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research
A myeloid and lymphoid infiltrate in murine pancreatic tumors exposed to plasma-treated medium
Publication date: Available online 7 July 2018Source: Clinical Plasma MedicineAuthor(s): Kim Rouven Liedtke, Eric Freund, Christine Hackbarth, Claus-Dieter Heidecke, Lars-Ivo Partecke, Sander BekeschusAbstractMetastatic pancreatic cancer often is fatal in patients. Palliation can include disseminating large amounts of chemotherapeutic liquid in the peritoneal cavity to slow tumor growth. We have previously demonstrated that repeated application of plasma-treated medium performed well in decreasing peritoneal tumor burden in mice and prolonging animal survival. We here extend on this study by detailed immune-related analysi...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research
Plasma-treated medium tunes the inflammatory profile in murine bone marrow-derived macrophages
Publication date: September 2018Source: Clinical Plasma Medicine, Volume 11Author(s): Sander Bekeschus, Lukas Scherwietes, Eric Freund, Kim Rouven Liedtke, Christine Hackbarth, Thomas von Woedtke, Lars-Ivo ParteckeAbstractMacrophages are essential drivers of tumor rejection as well as tumor promotion. Especially tumor-associated macrophages (TAM) phenotypically resemble tumor-supporting alternatively activated macrophages (M2). Targeting their phenotype has long been a matter of preclinical research in oncology. Cold physical plasma and plasma-treated medium has recently been recognized as a new possible interventional str...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research
A myeloid and lymphoid infiltrate in murine pancreatic tumors exposed to plasma-treated medium
Publication date: Available online 7 July 2018Source: Clinical Plasma MedicineAuthor(s): Kim Rouven Liedtke, Eric Freund, Christine Hackbarth, Claus-Dieter Heidecke, Lars-Ivo Partecke, Sander BekeschusAbstractMetastatic pancreatic cancer often is fatal in patients. Palliation can include disseminating large amounts of chemotherapeutic liquid in the peritoneal cavity to slow tumor growth. We have previously demonstrated that repeated application of plasma-treated medium performed well in decreasing peritoneal tumor burden in mice and prolonging animal survival. We here extend on this study by detailed immune-related analysi...
Source: Clinical Plasma Medicine - July 8, 2018 Category: Research Source Type: research
Clinical experience with cold plasma in the treatment of locally advanced head and neck cancer
ConclusionThe trial demonstrates the clinical relevance of CAP in cancer treatment. There are three approaches for discussion of tumor remission: (i) the role of myeloid cells, (ii) the ROS/RNS model of cellular impact and (iii) the immunogenic cell death model of cancer treatment, and there is a reflection on non-sustainable tumor response due to adapted tumor microenvironment. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
Cold atmospheric pressure plasma jet for the treatment of Aspergillus keratitis
ConclusionBoth in vitro and in vivo results demonstrated that CAPPJ treatment was effective in inactivating fungal pathogens and therefore it may be considered as a new treatment modality for fungal keratitis. However, further studies are required to investigate its long-term safety. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
The effect of polymeric denture modified in low-temperature glow discharge on human oral mucosa: Clinical case
Publication date: March 2018Source: Clinical Plasma Medicine, Volume 9Author(s): T. Vasilieva, Aung Myat Hein, A. Vargin, E. Kudasova, E. Kochurova, M. NekludovaAbstractThe modification hot curing poly(methyl methacrylate) (PMMA) denture base “Villacryl H Plus” in RF-discharge plasma is described The plasma chemical modification of PMMA plates in the oxygen RF-discharge (13.56 MHz) decreased the water contact angles by 1.5–2.5 times with respect to unmodified samples while their surface free energy increased up to 1.5 times due to the formation of additional oxygen containing polar chemical groups at the plasma-...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
Alternative method for healing the diabetic foot by means of a plasma needle
This report presents the results of the case of an 83-year-old woman who was healed of a neuropathic ulcer after being exposed to a helium cold plasma using a plasma needle-type reactor. Along with this antecedent, we propose an alternative method consisting of the application of the helium cold plasma as an adequate option for the treatment and healing of this type of wounds. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
Comparing two different plasma devices kINPen and Adtec SteriPlas regarding their molecular and cellular effects on wound healing
ConclusionsThis comparative study showed that cold atmospheric plasma has several positive effects on wound healing and that kINPen and MicroPlaSter are two devices with substantial, comparable basic research. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge
Publication date: March 2018Source: Clinical Plasma Medicine, Volume 9Author(s): Monika Gelker, Christel C. Müller-Goymann, Wolfgang ViölAbstractA direct ex vivo treatment of human skin with cold atmospheric plasma, specifically a dielectric barrier discharge (DBD) using skin as the ground electrode, is able to permeabilize the stratum corneum (SC) throughout a treated area of 0.5 cm2. Silver sheet oxidation subsequent to a plasma treatment of isolated human SC revealed a regular pattern of local permeabilized regions greater in number than the expected number of skin appendages. The transepithelial electrical resistan...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
Side effects in cold plasma treatment of advanced oral cancer—Clinical data and biological interpretation
ConclusionUnderstanding the lack of severe side effects in plasma medicine, the role of radical oxygen species (ROS) and radical nitrogen species (RNS) is discussed, proposing a model in which CAP is not a direct effector of antitumor action but rather triggers a singlet oxygen-mediated switch-on effect on the specific target, leading to reactivation of intercellular ROS/RNS-dependent apoptosis signaling in tumor cells. As these processes are strictly restricted to the specific targets and as normal tissue is devoid of the required target, it is neither harmed nor affected. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research
