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Assessment of clinical response to V937 oncolytic virus after intravenous or intratumoral administration using physiologically-based modelling
Clin Pharmacol Ther. 2023 May 12. doi: 10.1002/cpt.2937. Online ahead of print.ABSTRACTOncolytic viruses (OVs) represent a potential therapeutic strategy in cancer treatment. However, there is currently a lack of comprehensive quantitative models characterizing clinical OV kinetics and distribution to the tumor. In this work, we present a mechanistic modelling framework for V937 OV, after intratumoral (i.t.) or intravascular (i.v.) administration in cancer patients. A minimal physiologically-based pharmacokinetic model was built to characterize biodistribution of OVs in humans. Viral dynamics was incorporated at intra-tumo...
Source: Clinical Pharmacology and Therapeutics - May 12, 2023 Category: Drugs & Pharmacology Authors: Zinnia P Parra-Guill én Aymara Sancho-Araiz Kapil Mayawala Sara Zalba Maria J Garrido Dinesh de Alwis I ñaki F Troconiz Tomoko Freshwater Source Type: research

Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case
Clin Pharmacol Ther. 2023 May 10. doi: 10.1002/cpt.2921. Online ahead of print.NO ABSTRACTPMID:37161547 | DOI:10.1002/cpt.2921 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - May 10, 2023 Category: Drugs & Pharmacology Authors: Guilherme Suarez-Kurtz Vanessa C âmara Fernandes Anna Beatriz Ribeiro Elias Source Type: research

Reply to "Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case"
Clin Pharmacol Ther. 2023 May 10. doi: 10.1002/cpt.2922. Online ahead of print.NO ABSTRACTPMID:37161580 | DOI:10.1002/cpt.2922 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - May 10, 2023 Category: Drugs & Pharmacology Authors: Cassandra White Rodney J Scott Christine Paul Stephen Ackland Source Type: research

Confirmatory DPYD Testing in Patients Receiving Fluoropyrimidines who are Suspected DPYD Variant Carriers Based on a Genetic Data Repository
Clin Pharmacol Ther. 2023 May 10. doi: 10.1002/cpt.2936. Online ahead of print.ABSTRACTUsing pharmacogenetics (PGx) to inform clinical decision making can benefit patients but clinical use of PGx testing has been limited. Existing genetics data obtained in the course of research could be used to identify patients who are suspected, but have not yet been confirmed, to carry clinically actionable genotypes, in whom confirmatory genetic testing could be conducted for highly efficient PGx implementation. Herein we demonstrate that it is regulatorily and technically feasible to implement PGx by identifying suspected carriers of...
Source: Clinical Pharmacology and Therapeutics - May 10, 2023 Category: Drugs & Pharmacology Authors: Amy L Pasternak Robinson Seda Joseph Lipa Rachel L McDevitt Oxana V Crysler Paul L Swiecicki Bryan J Schneider Brett Vanderwerff N Lynn Henry John C Krauss Vaibhav Sahai Daniel L Hertz Source Type: research

Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case
Clin Pharmacol Ther. 2023 May 10. doi: 10.1002/cpt.2921. Online ahead of print.NO ABSTRACTPMID:37161547 | DOI:10.1002/cpt.2921 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - May 10, 2023 Category: Drugs & Pharmacology Authors: Guilherme Suarez-Kurtz Vanessa C âmara Fernandes Anna Beatriz Ribeiro Elias Source Type: research