Multi-center dose prediction using attention-aware deep learning algorithm based on transformers for cervical cancer radiotherapy
Accurate dose delivery is crucial for cervical cancer volumetric modulated arc therapy (VMAT). We aimed to develop a robust deep learning (DL) algorithm for fast and accurate dose prediction of cervical cancer VMAT in multi-center datasets and then explore the feasibility of the DL algorithm to endometrial cancer VMAT with different prescriptions. (Source: Clinical Oncology)
Source: Clinical Oncology - March 23, 2024 Category: Radiology Authors: Zhe Wu, Xiaobin Jia, Liming Lu, Cheng Xu, Ya Pang, Shengxian Peng, Mujun Liu, Yi Wu Tags: Original Article Source Type: research
DNA Repair Genetics and the Risk of Radiation Pneumonitis in Patients with Lung Cancer: A Systematic Review and Meta-analysis.
This study aimed to review the effect of 1) these ERCC1/2 SNPs and 2) other SNPs of DNA repair genes on radiation pneumonitis (RP) in patients with lung cancer. (Source: Clinical Oncology)
Source: Clinical Oncology - March 22, 2024 Category: Radiology Authors: Wing San Yiu, Timothy Shun Man Chu, Yinnan Meng, Feng-Ming (Spring) Kong Tags: Original Article Source Type: research
An overview of Real-World Data infrastructure for cancer research
There is increasing interest in the opportunities offered by Real World Data (RWD) to provide evidence where clinical trial data does not exist, but access to appropriate data sources is frequently recognised as a barrier to RWD research. There has, however, been significant progress on facilitating RWD access in the last few years across a range of scales, from local hospital research databases, through regional care records and national repositories, to the impact of federated learning approaches on internationally collaborative studies. (Source: Clinical Oncology)
Source: Clinical Oncology - March 19, 2024 Category: Radiology Authors: Gareth Price, Niels Peek, Iliada Eleftheriou, Katie Spencer, Lizz Paley, Joshi Hogenboom, Johan van Soest, Andre Dekker, Marcel van Herk, Corinne Faivre-Finn Source Type: research
Treatment outcomes of stereotactic ablative body radiotherapy on extra-cranial oligometastatic and oligoprogressive breast cancer: mature results from a single institution experience
This study aims to report the treatment outcomes and to investigate what factors that are prognostic in terms of local control, progression free survival (PFS) and overall survival (OS) in patients receiving SABR for extracranial OM and OP diseases originated from metastatic breast cancer. (Source: Clinical Oncology)
Source: Clinical Oncology - March 19, 2024 Category: Radiology Authors: Shreya Armstrong, Andreas Makris, Katherine Belessiotis-Richards, Mohammed Abdul-Latif, Peter Ostler, Nihal Shah, David Miles, Yat Man Tsang Tags: Original Article Source Type: research
Unveiling Disparities: Exploring Differential Attainment in Postgraduate Training within Clinical Oncology
Differential attainment (DA) in post graduate medical training is a recognised challenge and refers to unexplained variation across groups when split by several protected characteristics. The Royal College of Radiology is committed to fostering diversity, inclusivity, and equality with the goal of narrowing existing gaps and improving training outcomes. (Source: Clinical Oncology)
Source: Clinical Oncology - March 19, 2024 Category: Radiology Authors: Zsuzsanna Iyizoba-Ebozue, Abiola Fatimilehin, Mahaz Kayani, Asadullah Khan, Michael McMahon, Sarah Stewart, Claire Croney, Kobika Sritharan, Madeha Khan, Mariam Obeid, Ogochukwu Igwebike, Rubab Batool, Rubyyat A-Hakim, Tasia Aghadiuno, Vinita Ruparel, Kar Tags: Original Article Source Type: research
A Single-Institution Review of the Use of Radiation in the Adjuvant and Definitive Management of Keloids
Many individuals suffer from keloids that are refractory to standard treatment modalities, including surgical excision alone. Radiation therapy can be used to reduce the risk of recurrent keloids post-operatively, as well as be used as primary treatment for keloids not amenable to surgical resection. The purpose of this study was to review our institutional experience of radiation therapy for keloid management. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: J. Fernandes, D. Liao, A. Dasgupta, M.N. Tsao, E.A. Barnes Tags: Original Article Source Type: research
Neoadjuvant Chemotherapy in Locally Advanced Sinonasal Teratocarcinosarcoma a Rare Malignancy: An Audit From an Academic Tertiary Care Centre in India
Sinonasal teratocarcinosarcomas (SNTCS) are rare sinonasal malignancies, the incidence of which is less than 1% of all tumors. There is limited data available on SNTCS's, often as case reports and small case series. The management of SNTCS is complicated because of its location, locally aggressive biology, difficulty in achieving complete resection, and limited data on chemotherapy in these malignancies. This audit was performed to understand the role of neoadjuvant chemotherapy (NACT) in SNTCS's, its ability to downstage the disease, achieve complete resection, and impact on long-term survival outcomes. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Z. Peelay, S. Saha, V. Patil, N. Menon, A. Singh, M. Shah, A. Sahu, A. Ubharay, O.R. Chowdhury, K. Prabhash, V. Noronha Tags: Original Article Source Type: research
Neoadjuvant chemotherapy in locally advanced Sinonasal Teratocarcinosarcoma a rare malignancy - an audit from an academic Tertiary Care Centre in India
Sinonasal teratocarcinosarcomas (SNTCS) are rare sinonasal malignancies, the incidence of which is less-than 1% of all tumors. There is limited data available on SNTCS ’s, often as case reports and small case series. The management of SNTCS is complicated because of its location, locally aggressive biology, difficulty in achieving complete resection, and limited data on chemotherapy in these malignancies. This audit was performed to understand the role of neoadj uvant chemotherapy (NACT) in SNTCS’s, its ability to downstage the disease, achieve complete resection, and impact on long-term survival outcomes. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Zoya Peelay, Saswata Saha, Vijay Patil, Nandini Menon, Ajaykumar Singh, Minit Shah, Arpita Sahu, Ahmad Ubharay, Oindrila Roy Chowdhury, Kumar Prabhash, Vanita Noronha Tags: Original Article Source Type: research
The Impact of Dose Rate on the Tumor Microenvironment Using Flattening-Filter-Free Beams
Recently, dose delivery technology has rapidly evolved with flattening filter-free beams (FFF), and the biological effects of high dose rates are a matter of interest. We hypothesized that FFF beams at different dose rates obtained with modern linear accelerators have different effects on the TME. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Melek Tugce Yilmaz, Aysenur Gok, Mustafa Emre Gedik, Aydan Caglayan, Fazli Yagiz Yedekci, Sevtap Aydin Dilsiz, Gurcan Gunaydin, Aytekin Akyol, Pervin Hurmuz Tags: Original Article Source Type: research
Reducing Salivary Toxicity with Adaptive Radiotherapy (ReSTART): A Randomized Controlled Trial comparing conventional IMRT to adaptive IMRT in head and neck Squamous Cell Carcinomas
The utility of Adaptive Radiotherapy (ART) in Head and Neck Squamous Cell Carcinoma (HNSCC) remains to be ascertained. While multiple retrospective and single-arm prospective studies have demonstrated its efficacy in decreasing parotid doses and reducing xerostomia, there is a lack of adequate randomized evidence. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Sarbani Ghosh-Laskar, Shwetabh Sinha, Anuj Kumar, Asesh Samanta, Samarpita Mohanty, Srikant Kale, Faizalam Khan, Shirley Lewis Salins, Vedang Murthy Tags: Original Article Source Type: research
Prehabilitation reduces hospital admissions for patients with advanced lung cancer
(Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Iain Phillips, Abi Walton, Colin Barrie, Melanie Mackean Tags: Letter Source Type: research
Systematic review of hypofractionated radiation therapy for the treatment of oesophageal squamous cell carcinoma and oesophageal adenocarcinoma
There has been limited progress made in improving the suboptimal outcomes delivered by conventionally fractionated radiotherapy (RT) for oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC). A greater biological effect may be achieved using hypofractionated RT (HFRT), though the toxicity, tolerability and efficacy of this approach in OAC and OSCC is uncertain. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Chandan Sanghera, Dylan McClurg, Christopher M. Jones Tags: Original Article Source Type: research
A Single Institution Review of the Use of Radiation in the Adjuvant and Definitive Management of Keloids
And purpose: Many individuals suffer from keloids that are refractory to standard treatment modalities, including surgical excision alone. Radiation therapy can be used to reduce the risk of recurrent keloids post-operatively, as well as be used as primary treatment for keloids not amenable to surgical resection. The purpose of this study was to review our institutional experience of radiation therapy for keloid management. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Jason Fernandes, Donna Liao, Archya Dasgupta, May N. Tsao, Elizabeth A. Barnes Tags: Original Article Source Type: research
Radiomics for clinical decision support in radiation oncology
Radiomics is a promising tool for the development of quantitative biomarkers to support clinical decision-making. It has been shown to improve the prediction of response to treatment and outcome in different settings, particularly in the field of radiation oncology by optimising the dose delivery solutions and reducing the rate of radiation-induced side effects, leading to a fully personalised approach.Despite the promising results offered by radiomics at each of these stages, standardised methodologies, reproducibility and interpretability of results are still lacking, limiting the potential clinical impact of these tools...
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Luca Russo, Charles-Davies Diepriye, Silvia Bottazzi, Evis Sala, Luca Boldrini Source Type: research
A Randomised Phase II Trial to Evaluate the Feasibility of Radiotherapy Dose Escalation, Facilitated by Intensity Modulated Arc Radiotherapy Techniques, in High-Risk Neuroblastoma
AND PURPOSE: For high-risk neuroblastoma, planning target volume coverage is often compromised to respect adjacent kidney tolerance. This trial investigated whether intensity modulated arc radiotherapy techniques (IMAT) could facilitate dose escalation better than conventional techniques. (Source: Clinical Oncology)
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Jennifer E. Gains, Amit Patel, Yen-Ch ’ing Chang, Henry C. Mandeville, Gregory Smyth, Christopher Stacey, James Talbot, Keith Wheatley, Mark N. Gaze Tags: Original Article Source Type: research
