Selective Progesterone Receptor Modulators (SPRMs) and Androgen Receptor Modulators (SARMs) as Treatment for Benign Gynecologic Diseases
In this report we review current evidence for selective progesterone receptor modulators and selective androgen receptor modulators as treatment options for benign gynecologic conditions. (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Selective Estrogen Receptor Modulators in Gynecology Practice
Selective estrogen receptor (ER) modulators have variable tissue specific estrogen agonist and antagonist activities. Tamoxifen is approved for treatment and prevention of breast cancer; acts as an endometrial estrogen agonist. Raloxifene is approved for prevention and treatment of osteoporosis and prevention of breast cancer. The selective ER modulators bazedoxifene paired with conjugated estrogens relieves vasomotor symptoms and prevents bone loss with neutral effects on breast and amenorrhea similar to placebo. Ospemifene is approved to treat dyspareunia. Lasofoxifene is in development for resistant ER positive breast c...
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Compounded Bioidentical Hormones: Myths and Realities
The spectacular success of compounded bioidentical hormone therapy is a product of the unanticipated negative-to-neutral findings of the Women’s Health Initiative hormone trial and the peculiarities of their regulatory status. By not having to provide scientific evidence of safety and efficacy, a requirement for all Food and Drug Administration (FDA)-approved hormone therapy products, the industry’s relatively unfettered marketing now accounts for about one third of menopausal hormone therapy prescriptions. Clinicians are often caught in the middle between patient beliefs and a desire to practice evidence-based medicin...
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Do Women Need Androgens Like a Fish Needs a Bicycle? A Review of the Literature and Clinical Guidelines
Biopotent androgens such as testosterone circulate in low levels in women. However, androgen precursors, such as dehyroepiandrosterone, are among the most abundant hormones produced in both men and women. While testosterone exerts obvious phenotypic effects in men and is essential for male sexual function, considerable debate and controversy abounds over the role of androgens in women and whether androgens exert an analogous role in women as they do in men. This piece reviews androgen economy in women and the clinical case for and against androgen treatment for women for specific indications. (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
The Role of Progestogens in Menopausal Hormone Therapy
Progestogens are steroid compounds that have the ability to induce secretory transformation in the endometrium and are utilized in menopausal hormone therapy to prevent endometrial hyperplasia and endometrial cancer. Progestogens can be derived from 21-carbon or 19-carbon steroid cytoskeletons and thus have different properties and metabolic effects beyond the progestational effects on the endometrium. This limited review will focus on the available progestogens utilized in combination hormone therapy including progesterone, medroxyprogesterone acetate, norethindrone, norethindrone acetate, levonorgestrel, and drospirenone...
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Menopausal Hormone Therapy and the Role of Estrogen
Menopause is a universal experience for midlife women. The physiological decline in endogenous estrogen can be associated with vasomotor symptoms or hot flashes, sleep disruption, and mood disorders. Long-term concerns arise with sequelae of estrogen loss such as genitourinary syndrome of menopause and osteoporosis. Although the pendulum has swung widely since the 1942 approval of conjugated equine estrogens, estrogen therapy, now available in an ever-expanding menu of preparations, routes of administration, and dosing, remains the most effective means to collectively address these, and potentially, additional concerns. Re...
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Transgender Medicine and Hormone Therapy: What the Gynecologist Needs to Know
The transgender community comprises individuals with diverse identities in both gender and sexual orientation. Unfortunately, many face discrimination and harassment within our society—including within the medical system. There is an overall lack of provider training in transgender specific health which has led to health disparities and inequities within this population. This chapter aims to elucidate the medical needs unique to transgender and gender nonconforming individuals and thus enable medical providers to meet those needs with competency and compassion. (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Hormonal Contraception: Systemic Estrogen and Progestin Preparations
Combined hormonal contraception (CHC) are short-acting, reversible methods containing both estrogen and progestin. Available CHC methods include combined oral contraceptives, transdermal patches, and vaginal rings. The combined oral contraceptive remains the most commonly used contraceptive method in the United States. The general principles of CHC will be reviewed, including mechanism of action and effectiveness. Unless otherwise stated, these principles apply to all CHCs. When discussing clinical studies and specific considerations related only to pills, patches, or rings, the method(s) will be specified. Words that spec...
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Foreword: Hormone Use in Gynecology
No abstract available (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research
Contributors: Hormone Use in Gynecology
No abstract available (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - October 21, 2021 Category: OBGYN Tags: Contributors: Hormone Use in Gynecology Source Type: research
Index
No abstract available (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - July 29, 2021 Category: OBGYN Tags: Index Source Type: research
Spirituality in Pregnancy
This article discusses the role of spirituality in pregnancy, childbirth, and postpartum. It highlights the importance of more fully integrating this concept into births traditionally attended by physicians and midwives in the hospital setting. This discussion covers birthing practices ingrained with culture and spirituality. The article concludes with strategies to elicit and integrate spirituality into routine practice to provide improved health care to patients and to find more fulfillment in the role as birth attendant. (Source: Clinical Obstetrics and Gynecology)
Source: Clinical Obstetrics and Gynecology - July 29, 2021 Category: OBGYN Tags: Complementary/Alternative Medicine (Cam) In Obstetrics Source Type: research
Mind-Body Techniques in Pregnancy and Postpartum
Maternal stress can perturb physiology and psychiatric health leading to adverse outcomes. This review investigates the effectiveness of several mind-body therapies—namely biofeedback, progressive muscle relaxation, guided imagery, tai chi, and yoga—as interventions in reducing maternal stress and other pregnancy-related conditions. Through randomized trials, these techniques have shown promising benefits for reducing pain, high blood pressure, stress, anxiety, depressive symptoms, labor pain and outcomes, and postpartum mood disturbances. As these interventions are easy to implement, low cost, and safe to perform in p...
Source: Clinical Obstetrics and Gynecology - July 29, 2021 Category: OBGYN Tags: Complementary/Alternative Medicine (Cam) In Obstetrics Source Type: research
Meditation and Mindfulness in Pregnancy and Postpartum: A Review of the Evidence
Given their growing popularity, mindfulness practices including meditation are actively being studied in clinical trials to assess their efficacy at improving health outcomes during pregnancy and the postpartum period. We conducted a literature review to compile these studies and assessed their findings. There is sufficient evidence to support the practice of mindfulness practices in pregnancy to reduce anxiety, depression, and stress during pregnancy, which may continue to have beneficial effects through the postpartum period. There is limited evidence on the benefits of mindfulness and meditation for other aspects of pre...
Source: Clinical Obstetrics and Gynecology - July 29, 2021 Category: OBGYN Tags: Complementary/Alternative Medicine (Cam) In Obstetrics Source Type: research
Massage During Pregnancy and Postpartum
Massage is systematic touch and manipulation of the soft tissues of the body that is increasingly being used as an adjunctive therapy for stress relief and to promote relaxation and wellbeing during pregnancy and as an alternative to pharmacologic or invasive forms of analgesia during labor. Literature to support the use of massage in pregnancy and labor is limited; however, evidence to support its use has been increasing over the past 30 years. Massage has been shown to be valuable to pregnant women with anxiety, depression, leg, and back pain, and has shown significant benefit in perception of pain during labor. (Source:...
Source: Clinical Obstetrics and Gynecology - July 29, 2021 Category: OBGYN Tags: Complementary/Alternative Medicine (Cam) In Obstetrics Source Type: research
