Sustained weight loss with semaglutide once weekly in patients without type 2 diabetes and post ‐bariatric treatment failure
SummaryAbout 20% –25% of patients experience weight regain (WR) or insufficient weight loss (IWL) following bariatric surgery (BS). Therefore, we aimed to retrospectively assess the effectiveness of adjunct treatment with semaglutide in patients without type 2 diabetes (T2D) with post-bariatric treatment failure o ver a 12 months period. Post-bariatric patients without T2D with WR or IWL (n = 29) were included in the analysis. The primary endpoint was weight loss 12 months after initiation of adjunct treatment. Secondary endpoints included change in body mass index, HbA1c, lipid profile, high sensitive C-reactive p...
Source: Clinical Obesity - June 27, 2023 Category: Eating Disorders & Weight Management Authors: Anne Lautenbach,
Tobias Kantowski,
Jonas Wagner,
Oliver Mann,
Fabian Stoll,
Jens Aberle Tags: ORIGINAL RESEARCH Source Type: research
Poor dental service utilization in those with clinically severe obesity: A neglected issue with solutions needed
This study highlighted the frequency of medical complications, lack of wellbeing, and poor mental health, which were evident in this cohort and may complicate dental mana gement. (Source: Clinical Obesity)
Source: Clinical Obesity - June 23, 2023 Category: Eating Disorders & Weight Management Authors: Zanab Malik,
Woosung Sohn,
Shanika Nanayakkara,
Kathryn Williams Tags: ORIGINAL RESEARCH Source Type: research
Expression analysis of MMP14: Key enzyme action in modulating visceral adipose tissue plasticity in patients with obesity
SummaryCompromised adipose tissue plasticity is a hallmark finding of obesity orchestrated by the intricate interplay between various extracellular matrix components. Collagen6 (COL6) is well characterized in obese visceral adipose tissue (VAT), not much is known about MMP14 which is hypothesized to be the key player in matrix reorganization. Subjects with obesity (BMI ≥40;n = 50) aged 18–60 years undergoing bariatric surgery and their age-matched controls (BMI < 25;n = 30) were included. MMP14, Col6A3 and Tissue inhibitor of metalloproteinase 2 (TIMP2) mRNA expression was assessed in VAT and their se...
Source: Clinical Obesity - June 22, 2023 Category: Eating Disorders & Weight Management Authors: Astha Sachan,
Sandeep Aggarwal,
Manjunath Maruti Pol,
Archna Singh,
Rakhee Yadav Tags: ORIGINAL RESEARCH Source Type: research
Attrition from paediatric weight management impacts anthropometric outcomes at 2 years, but not health‐related quality of life
SummaryThe study objective is to evaluate the influence of attrition from a paediatric weight management program (PWM) on health indicators over a 2-year period. In this observational study, children and youth with obesity were recruited at entry into a family-based behaviour modification PWM and had four research study visits, independent of clinic visits, over 2 years. Participants were divided into attrition groups based on length of clinic enrolment. Body composition, cardiometabolic health and health-related quality of life (HRQoL) were assessed. Among 269 children enrolled, 19% had no clinic treatment visit, 16% h...
Source: Clinical Obesity - June 15, 2023 Category: Eating Disorders & Weight Management Authors: Katherine M. Morrison,
Elizabeth Gunn,
Stephanie Schwindt,
Linda Hu,
Mark Tarnopolsky Tags: ORIGINAL RESEARCH Source Type: research
Support needs of people undertaking bariatric surgery: A narrative review
(Source: Clinical Obesity)
Source: Clinical Obesity - June 8, 2023 Category: Eating Disorders & Weight Management Authors: Sally Badorrek,
Janet Franklin,
Michael Devadas,
Kathryn Williams Tags: REVIEW Source Type: research
Predictors of early weight loss in post ‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating
This study examined baseline patient characteristics as predictors of early weight loss, defined as any weight loss within the first month of treatment, among patients receiving adjunctive behavioural treatments for loss-of-control (LOC) eating about 6 months after bariatric surgery. Participants were 126 patients in a treatment trial for LOC-eating (roughly 6 months postoperatively) categorized by early weight change following 1 month of treatment. Early weight-loss, defined as any weight loss following 1 month of treatment, and weight-gain, defined as any weight gain, groups were compared on sociodemographic and clinical...
Source: Clinical Obesity - June 1, 2023 Category: Eating Disorders & Weight Management Authors: Caitlin E. Smith,
Abhaya Dilip,
Valentina Ivezaj,
Andrew J. Duffy,
Carlos M. Grilo Tags: ORIGINAL RESEARCH Source Type: research
Motivations for participation in weight loss clinical trials
SummaryMales are under-represented in weight loss clinical trials, usually comprising fewer than one-quarter of participants. Our study aimed to investigate people's motivations for participating in weight loss trials and determine any relationship with gender. Eighty individuals from an existing registry for weight loss trials were contacted, of whom 24 (9 males, 15 females) agreed to participate in a 20-min semi-structured interview around their expectations and motivations for volunteering. Interviews were audio-recorded and transcribed in Zoom. A transcript of each interview was uploaded into NVivo for preliminary them...
Source: Clinical Obesity - May 30, 2023 Category: Eating Disorders & Weight Management Authors: Alyssa Susanto,
Nicholas R. Fuller,
Samantha Hocking,
Tania Markovic,
Tim Gill Tags: ORIGINAL RESEARCH Source Type: research
Clinical effectiveness of Liraglutide 3.0 mg and impact of weight loss in improving obesity‐related comorbid conditions in King Fahad Medical City, Kingdom of Saudi Arabia: A real‐world experience
SummaryObesity has emerged as one of the most challenging worldwide problems and, if left untreated, can lead to major illnesses and consequences that can impair patients' health The study's objective was to evaluate the effectiveness of Liraglutide 3.0 mg in inducing weight loss and to assess the improvement of obesity-related comorbid conditions among people living with obesity (PwO) in the Kingdom of Saudi Arabia (KSA). A retrospective cohort review of PwO with or without diabetes and taking Liraglutide 3.0 mg in combination with diet and e xercise for weight management was performed and evaluated at King Fahad Med...
Source: Clinical Obesity - May 17, 2023 Category: Eating Disorders & Weight Management Authors: Ali Alshehri,
Nasreen AlFaris,
Abdulhadi M. Al Qahtani,
Mahmoud Shams,
Moataz Yahia Tags: ORIGINAL RESEARCH Source Type: research
Home visits to identify the roles lifestyle and stress play in families of children with obesity
SummaryOne-sixth of Swiss children are affected by overweight, and despite the implementation of an evidence-based multiprofessional approach, there has only been moderate therapeutic success. An unfavourable home environment and psychosocial stresses on the family may impede lifestyle changes. This longitudinal observational study included children with obesity (body mass index [BMI] ≥97th percentile [P.]) or overweight (BMI ≥ 90th P.) with a comorbidity, and who were participating in a regional 12-month multiprofessional group programme (MGP). Two health professionals routinely visited the family home at baseline...
Source: Clinical Obesity - May 16, 2023 Category: Eating Disorders & Weight Management Authors: Ricarda Gmeinder,
Katrin Heldt,
Anneco Dintheer ‐ter Velde,
Dirk Büchter,
Björn Brogle,
Hanna Schmid,
Josef Laimbacher,
Dagmar l'Allemand Tags: ORIGINAL RESEARCH Source Type: research
An exploratory structural equation modelling (ESEM) of the Eating Disorders Examination Questionnaire (EDE ‐Q) in bariatric patients
This study aimed to use exploratory structural equation modelling (ESEM) to estimate the factor structure of the EDE-Q and assess for the additive value of alternative measurement of eating disorder symptoms. Adolescents and adults completed the EDE-Q and a psychiatric evaluation prior to bariatric surgery. Data from 330 participants were analysed using the original four-factor and modified three-factor structure of the EDE-Q using both confirmatory factor analysis (CFA) and exploratory structural equation modelling (ESEM). Age, ethnicity, and body mass index were examined as covariates in the best fitting model, and model...
Source: Clinical Obesity - May 15, 2023 Category: Eating Disorders & Weight Management Authors: Kayla Costello,
Tom Hildebrandt,
Andreas Michaelides,
Daniel Herron,
Robyn Sysko Tags: ORIGINAL RESEARCH Source Type: research
Issue Information
(Source: Clinical Obesity)
Source: Clinical Obesity - May 4, 2023 Category: Eating Disorders & Weight Management Tags: ISSUE INFORMATION Source Type: research
Impact of specialized obesity management services on the reduction in the use of acute hospital services
This study evaluates the effect of attending a public tertiary obesity service on acute hospital use. This record-linkage study included people aged ≥16 years with severe obesity who attended the Nepean Blue Mountains Family Metabolic Health Service (FMHS), New South Wales, Australia between January 2017, and September 2021. Emergency department (ED) presentations and acute hospital admissions and respective costs in the 1-year and 3-years p re-and-post first FMHS attendance were compared, overall and for adequate attendance (≥5 visits). A total of 640 patients (74% female, 50%<45 years) attended the FMHS, tota...
Source: Clinical Obesity - April 28, 2023 Category: Eating Disorders & Weight Management Authors: Kathryn Williams,
Gabrielle Maston,
Francisco J. Schneuer,
Natasha Nassar Tags: ORIGINAL RESEARCH Source Type: research
Factors associated with choice of behavioural weight loss program by adults with obesity
SummaryWe assessed the preference for two behavioural weight loss programs, Diabetes Prevention Program (DPP) and Healthy Weight for Living (HWL) in adults with obesity. A cross-sectional survey was fielded on the Amazon Mechanical Turk. Eligibility criteria included reporting BMI ≥30 and at least two chronic health conditions. Participants read about the programs, selected their preferred program, and answered follow-up questions. The estimated probability of choosing either program was not significantly different from .5 (N = 1005, 50.8% DPP and 49.2% HWL,p = .61). Participants' expectations about adherence, we...
Source: Clinical Obesity - April 11, 2023 Category: Eating Disorders & Weight Management Authors: Yasaman Jamshidi ‐Naeini,
Susan B. Roberts,
Stephanie Dickinson,
Arthur Owora,
Jon Agley,
Roger S. Zoh,
Xiwei Chen,
David B. Allison Tags: ORIGINAL RESEARCH Source Type: research
Hip arthroscopy versus total hip arthroplasty —A study on patients with obesity above 40 years of age
SummaryPatients older than 40 years with a body-mass-index (BMI)>30 kg/m2, a femoroacetabular-impingement (FAI) and little cartilage damage are a challenge for hip surgeons. Hip-arthroscopy (HAS) or conservative therapy until a total hip arthroplasty (THA) is needed are possible treatments. Our research purpose was to compare the clinical results and complication/reoperation rate after HAS and THA in patients with obesity over 40 years. This retrospective study includes a consecutive series of patients with obesity (BMI>30 kg/m2) who underwent HAS (19 hips) and THA (37 hips) over 40 years of age betwee...
Source: Clinical Obesity - March 16, 2023 Category: Eating Disorders & Weight Management Authors: Richard Niehaus,
Patrick O. Zingg,
Armando Hoch,
Martin Luttenberger,
Rahm Stefan Tags: ORIGINAL RESEARCH Source Type: research
Effect of once ‐weekly subcutaneous semaglutide 2.4 mg on weight‐ and health‐related quality of life in an East Asian population: Patient‐reported outcomes from the STEP 6 trial
SummaryWe assessed the effect of semaglutide 2.4 and 1.7 mg versus placebo on weight-related quality of life (WRQOL) and health-related quality of life (HRQOL) in the STEP 6 trial. Adults from East Asia (body mass index [BMI] ≥27.0 kg/m2 with ≥2 weight-related comorbidities, or ≥35.0 kg/m2 with ≥1 weight-related comorbidity) were randomized 4:1:2:1 to once-weekly subcutaneous semaglutide 2.4 mg or placebo, or semaglutide 1.7 mg or placebo, plus lifestyle intervention for 68 weeks. WRQOL and HRQOL were assessed from baseline to Week 68 using the Impact of Weight on Quality of Life-Lit e Clinical Trials Versi...
Source: Clinical Obesity - March 12, 2023 Category: Eating Disorders & Weight Management Authors: Ronette L. Kolotkin,
Ole Kleist Jeppesen,
James Baker ‐Knight,
Sang Yeoup Lee,
Asako Tokita,
Takashi Kadowaki Tags: ORIGINAL RESEARCH Source Type: research
