Improved wet weight absorption with apraglutide in short bowel syndrome with intestinal failure (SBS-IF) and colon-in-continuity (CIC)
Rationale: SBS-IF is a severe organ failure condition with life-long PS dependence. Glucagon-like peptide-2 (GLP-2) stimulates intestinal adaptation resulting in increased absorptive capacity of nutrients and fluids. Apraglutide (APRA) is a novel long-acting synthetic GLP-2 analog in development for SBS-IF. We performed a pre-defined interim analysis of a phase 2 study in SBS-IF-CiC to investigate the safety and efficacy of 4W APRA treatment based on metabolic balance studies (MBS). (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: A. Verbiest, M.K. Hvistendahl, F. Bolognani, C. Li, O. Khwaja, F. Joly, P.B. Jeppesen, T. Vanuytsel Source Type: research
Sodium depletion and secondary hyperaldosteronism in outpatients with an ileostomy: A cross-sectional study
Rationale: Patients with an ileostomy may experience postoperative electrolyte derangement and dehydration but are presumed to stabilise thereafter. We aimed to investigate the prevalence of sodium depletion in stable outpatients with an ileostomy and applied established methods to estimate their fluid status. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: C.L. Rud, S. Brantlov, J.R. Quist, T.L. Wilkens, J.F. Dahlerup, S. Lal, P.B. Jeppesen, C.L. Hvas Source Type: research
Probiotic-prebiotic usage effects on acute inflammation parameters receiving pelvic radiotherapy patients : A prospective multicentric study
Rationale: Patients using prebiotics or probiotics+probiotics while receiving pelvic radiotherapy were compared with the control group, and their side effects and acute inflammatory responses were examined. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: M. Akmansu, S. Dincer, E.K. Saglam, Z. Akgun Source Type: research
Prediction of clinical outcomes after gastrointestinal surgery in the elderly patients based on a deep learning CT diagnosis model for sarcopenia
In this study,we aimed to construct an automatic model for sarcopenia diagnosis in CT and explore its correlation with clinical outcomes in gastrointestinal surgery. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: R. Liu, Z. Jia, X. Zhou, Y. Wu, Q. Fang, G. Zhu, D. Huang, X. Qian Source Type: research
Malnutrition screening with NRS-2002 prior to assessment as part of glim criteria in patients undergoing major abdominal surgery for gastrointestinal cancer
Rationale: For diagnosing malnutrition GLIM criteria offer a standardised diagnostic pathway. Before assessing malnutrition it is suggested to screen for malnutrition with an implemented screening tool, i.e. the NRS-2002, but data regarding outcome parameters in surgical patients is sparse. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: M. Wobith, A. Weimann Source Type: research
Robot-directed enteral nutritional management in critically ill patients: Results of an RCT
This study evaluated smART+ versus standard care in terms of enteral feeding delivery, gastric residual volume (GRV), and ICU outcomes. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: M. Hellerman Itzahki, I. Kagan, L. Statlender, G. Fishman, I. Bendavid, P. Singer Source Type: research
A switch towards a more sustainable diet for older adults: Implications for protein intake based on a simulation study
Rationale: An adequate amount of good-quality protein (P) is essential to remain fit and healthy at an older age. Animal-based proteins (ABP) are of high quality and provide nearly 60% of the P intake in older adults. It is unclear if an adequate P intake can be achieved when ABP are replaced by vegetarian (Veg) or plant-based (Plant) alternatives. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: J. Borkent, J. Linschooten, A. Roodenburg, M. de van der Schueren Source Type: research
Sex differences in muscle health and amino acid kinetics in older adults with and without mild cognitive impairment
In this study, we examined whether muscle health is more impaired in females than males with MCI, and is related to specific disturbances in amino acid (AA) metabolism. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: S. De Wandel, N.E. Deutz, I. Vaid, G. A. Ten Have, J. Thaden, M.P. Engelen Source Type: research
The impacts of pharmacological drugs on vitamin B6, B9 and B12 intakes and levels among uk adults: National diet and nutrition survey rolling programme (NDNS) (2008 –2017).
This study has assessed the effects of drugs on vitamins B6, B9 and B12 status (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: A. Alsaeedi, S. Welham Source Type: research
Micronutrient supplementation influences the composition and function of the gut microbiome in healthy adults
Rationale: There is evidence suggesting that micronutrients can significantly influence the human gut microbiome1. However, most data derives from animal and in-vitro studies, or from human trials using excessive doses of micronutrients. We studied the effect of multivitamin/multimineral (MVMM) supplementation on gut microbiome and function and how habitual diet can modify these effects. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: S. Mckirdy, A. Koutsos, B. Nichols, J. Havlik, C.R. Chowdhury, K. Gerasimidis Source Type: research
Mitochondria in human white adipose tissue related to body composition
This study aims to evaluate mitochondrial activity and metabolism of human visceral and subcutaneous white AT and their relationship with body mass index (BMI). (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: L. Guerrier, C. Malpuech-Brug ère, O. Bacoeur-Ouzillou, S. Mezher, L. Cassagnes, D. Pezet, J. Gagnière, R. Richard, J. Touron Source Type: research
Visceral adipose tissue and mortality in patients undergoing transcatheter aortic valve implantation
Rationale: The role of visceral adipose tissue (VAT) is still poorly explored in patients undergoing Transcatheter Aortic Valve Implantation (TAVI). We investigated the association between preoperative VAT and 1-year mortality in this setting. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: A. Casirati, A. Somaschini, L. Olivotti, S. Cornara, V. Giachello, M. Astuti, M. Ghione, M. Botta, M. Buscemi, E. Cereda, R. Caccialanza, P. Bellone, S. Cordone Source Type: research
Z-scores of handgrip strength detect people at risk of sarcopenic obesity in younger adults with severe obesity
Rationale: Sarcopenic Obesity (SO) is characterized by excess adiposity and low muscle mass/function. Handgrip (HG) strength is usually performed to detect probable sarcopenia. However, its cut-offs values have been originaly based on geriatric references, so that early muscle functional deficit in the younger adults may be underestimated. We aimed to define which part of the obese population would be “at risk” of SO based on HG strength to prevent SO development and to detect early functional alterations. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: M. Pouget, A. Pinel, A. Mulliez, N. Farigon, E. Gentes, M. Miolanne, M. Picard, C. Guillet, Y. Boirie Source Type: research
Intermittent feeding with an overnight fast increases ketosis and is safe in critically ill children
This study aims to investigate whether an overnight fast enhances the ketosis and is feasible and safe in the Paediatric Intensive Care Unit (PICU). (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: K. Veldscholte, A.B. Cramer, R.C. de Jonge, D. Rizopoulos, K.F. Joosten, S.C. Verbruggen Source Type: research
An open-label, randomised, controlled trial on the benefit of hmb, L-arginine, and L-glutamine beverages and locomotion training as supportive care in the treatment of unresectable advanced hepatocellular carcinoma using lenvatinib: Hello study
In this study, we report a randomised, controlled trial (RCT) on the efficacy of HMB/L-arginine/L-glutamine (HMB/Arg/Gln) and locomotion training as supportive care in the treatment of unresectable advanced HCC with lenvatinib. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: A. Naganuma, F. Makita, R. Sugimoto, M. Kikuchi, K. Furuta, S. Iwamoto, E. Mita, H. Kouno, K. Ario, H. Yatsuhashi, National Hospital Organization Liver Disease Network Group Source Type: research
