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STMN1 as a candidate gene associated with atypical meningioma progression
Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system (CNS) neoplasms [1]. According to the 2007 WHO classification of CNS tumors [2], meningiomas are classified into three grades, I, II, and III. Atypical meningiomas are “intermediate grade” malignancies (WHO grade II) that account for 4.7%–7.2% of meningiomas and are associated with a 29%–52% post-resection recurrence rate [2,3]. Meningioma progression involves partial or complete loss of multiple chromosomes. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 10, 2017 Category: Neurosurgery Authors: Haiyu Liu, Ye Li, Yunbo Li, Lixiang Zhou, Li Bie Source Type: research

Thirty-day non-seizure outcomes following temporal lobectomy for adult epilepsy
Refractory temporal lobe epilepsy (TLE) is the most common cause of pharmacoresistant seizures [1,2]. Temporal lobectomy (TL) is performed after exhausting most other efforts to control refractory TLE. Given that seizure control is the ultimate goal of TL, numerous studies have investigated seizure outcomes after TL in adults [3 –11] and children [12–15]. However, few studies have investigated other (non-seizure) postoperative outcomes after TL, especially using multicenter data. Due to the recognized underutilization of TL for refractory TLE, understanding the full extent of TL complications is paramount in making inf...
Source: Clinical Neurology and Neurosurgery - June 8, 2017 Category: Neurosurgery Authors: Brandon A. Sherrod, Matthew C. Davis, Kristen O. Riley Source Type: research

Severe but reversible neuropathy and encephalopathy due to vitamin E deficiency
Vitamin E deficiency is known to result mainly in a spinocerebellar syndrome and involvement of the peripheral nervous system occurs less commonly. Most cases of vitamin E-deficient ataxic neuropathy reported relate to a genetically-mediated cause through mutation of the alpha-tocopherol transfer protein (TTPA) gene on chromosome 8q13 [1]. Severe subacute adult-onset rapidly disabling neuropathy due to vitamin E deficiency is not to our knowledge reported. Cognitive dysfunction is uncommon in this setting. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 8, 2017 Category: Neurosurgery Authors: Barbara Wysota, Sophia Michael, Fu Liong Hiew, Charlotte Dawson, Yusuf A. Rajabally Tags: Case Report Source Type: research

Evaluation of ALCAM, PECAM-1 and Selectin levels in intracranial meningiomas
Meningiomas are the most common extra-axial brain tumors and constitute almost 30% of all intracranial tumors [1] and arise from the arachnoid cap cells which form the outer layer of the arachnoid mater. Meningiomas show both mesenchymal and epithelial features, which form the basis of their histopathological classification [2]. Generally, these tumors are considered to be benign and slow growing. 20% of meningiomas are currently named as high-grade meningiomas comprising atypical meningiomas (grade-II; 17-18%) and anaplastic meningiomas (grade-III; 1-2%) [3]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 6, 2017 Category: Neurosurgery Authors: Pinar Atukeren, Okan Turk, Karolin Yanar, Rahsan Kemerdere, Sima Sayyahmelli, Bulent Eren, Taner Tanriverdi Source Type: research

Risk factors for postoperative pneumonia after microsurgery for vestibular schwannoma
Vestibular schwannoma (VS) is a rare benign tumour which arises in most cases from the schwann cells of the vestibular part of the eighth cranial nerve [1]. The incidence of VS is estimated to 1.9 per 100,000 per year [2]. Microsurgery is one of the primary current standard options for the treatment of VS [3]. Despite improvements in surgical techniques, intraoperative monitoring and anesthesia, complications continue to occur with considerable incidence [4].It is reported that the overall complication rate for VS surgery is 28.2% [5]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 6, 2017 Category: Neurosurgery Authors: Chenghong Wang, Tengfei Li, Shaozhou Tang, Yuekang Zhang Tags: Full Length Article Source Type: research

A combined cognitive and gait quantification to identify normal pressure hydrocephalus from its mimics: the Geneva ’s protocol
Idiopathic normal pressure hydrocephalus (iNPH) was first described by Salomon Hakim in Bogota in 1957 [1,2] and represents a prevalent neurological conditions in older adults reaching 6% after 80 years [3]. A classic triad of clinical symptoms associating gait, cognitive and urinary disturbances with disproportional ventricular enlargement on brain imaging constitute this reversible condition [4]. Unfortunately, these clinical signs are unspecific and found in various other frequent neurological conditions, such as vascular dementia or Alzheimer ’s disease with comorbid urinary problems (i.e. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 5, 2017 Category: Neurosurgery Authors: Gilles Allali, Magali Laidet, St éphane Armand, Shahan Momjian, Bruno Marques, Arnaud Saj, Frédéric Assal Tags: Full Length Article Source Type: research

A 30-year history of MPAN case from Russia
We present a patient with a complex progressive movement disorder undiagnosed for 30 years until detailed genetic analysis revealed MPAN mutation. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 2, 2017 Category: Neurosurgery Authors: M. Selikhova, E. Fedotova, S. Wiethoff, L.V. Schottlaender, S. Klyushnikov, S.N. Illarioshkin, H. Houlden Tags: Case Report Source Type: research

Intrathecal IgM index correlates with a severe disease course in multiple sclerosis: Clinical and MRI results
Multiple sclerosis (MS) is a chronic autoimmune disease that progresses with axonal losses and demyelination of the central nervous system. The most important tool in the diagnosis of MS is magnetic resonance imaging (MRI), although cerebrospinal fluid (CSF) also provides valuable information. Although CSF findings can provide information about the course of MS as well as assisting with diagnosis, their specificity is limited, despite being an individual marker in several neurological diseases [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 1, 2017 Category: Neurosurgery Authors: Serkan Ozakbas, Bilge Piri Cinar, Pinar Özcelik, Hatice Baser, Gorkem Kosehasanoğullari Source Type: research

The impact of white matter lesions on the cognitive outcome of subthalamic nucleus deep brain stimulation in Parkinson ’s disease
Cognitive decline is a common symptom of Parkinson ’s disease (PD). Mild Cognitive Impairment (MCI) affects about a third of PD patients within the first five years after diagnosis [1]. In the Movement Society Task Force Criteria, PD-MCI is defined as a cognitive decline in the context of PD which is not sufficient to interfere with functional ind ependence [2]. Pure frontal deficits in executive functions may not be generally associated with a higher risk for dementia [3]. Instead, reduced semantic fluency and narrowed visual-constructive functioning indicate the progression from MCI to dementia in PD (PD-D) [4]. (Sourc...
Source: Clinical Neurology and Neurosurgery - May 31, 2017 Category: Neurosurgery Authors: J. Blume, M. Lange, E. Rothenfusser, C. Doenitz, U. Bogdahn, A. Brawanski, J. Schlaier Source Type: research

Tramadol May Increases the Efficacy of Therapeutic Plasma Exchange in Anti-NMDAR Encephalitis
Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis was first described in 2005 in females with ovarian teratomas [1]. The disorder is characterized by altered mental status, psychiatric disorders, and seizures with progression to dyskinesias [1]. In many instances the disorder includes a prodrome which includes headaches, hyperthermia, and in some instances nausea, vomiting, and diarrhea [1]. The most common presenting symptom is usually altered short term memory and many patients present first to psychiatrists due to acute psychosis and agitation [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 31, 2017 Category: Neurosurgery Authors: Bradley A. Dengler, Deanna Kitchen, Ali Seifi Tags: Case Report Source Type: research

A simplified pressure adjustment clinical pathway for programmable valves in NPH patients
Normal pressure hydrocephalus (NPH) occurs insidiously in the later decades of life and presents as a progressive clinical triad of gait disturbance, urinary incontinence, and dementia [1]. Hakim and Adams first proposed CSF diversion as a surgical treatment method for NPH in 1965 [2]. Since then, shunt placement is considered the recommended modality for NPH treatment. As the clinical presentation is variable, the diagnosis of NPH is often not binary and requires thoughtful synthesis of the patient ’s history, physical examination, and radiographic imaging [3]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 30, 2017 Category: Neurosurgery Authors: Tracy S. Ma, Nikhil Sharma, M. Sean Grady Source Type: research

Disability from Pain Directly Correlated with Depression in Parkinson ’s Disease
Patients with Parkinson ’s disease (PD) experience motor, non-motor and neuropsychiatric manifestations that negatively impact their overall quality of life (QoL). PD is a chronic, progressively debilitating neurodegenerative disorder that affects between 0.1%–0.3% individuals and prevalence increasing with age [1]. Th e diagnostic features of PD are tremor, bradykinesia, and rigidity [2]. Non-motor symptoms (NMS) include pain and sensory disturbances, mood disorders including depression and sleep disturbances including Restless Leg Syndrome (RLS) [3–6]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 30, 2017 Category: Neurosurgery Authors: Abdul Qayyum Rana, Nabiha Rehman, Abdul-Rahman M. Qureshi, Aisha Mohammed Tags: Full Length Article Source Type: research

Trends in the incidence of Primary malignant brain tumors in Taiwan and correlation with comorbidities: a population-based study
Brain tumors are a mixed group of primary and metastatic neoplasms that exhibit varying degrees of malignancy. Malignant lesions are relatively uncommon, but their incidence has increased rapidly in highly developed, industrialized countries [1]. Primary malignant brain tumors have drawn wide attention not only because of their poor prognosis, but also for their direct impact on neurologic function, psychological health, and quality of life [2]. Over the past decades, advances in diagnostic methods have revealed a trend toward an increased incidence of brain tumors [3,4]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 25, 2017 Category: Neurosurgery Authors: Ya-Jui Lin, Hsiao-Yean Chiu, Meng-Jiun Chiou, Yin-Cheng Huang, Kuo-Chen Wei, Chang-Fu Kuo, Jun-Te Hsu, Pin-Yuan Chen Tags: Full Length Article Source Type: research

Etiologic classification of ischemic stroke: where do we stand?
Stroke is nowadays one of the major global health problems, comprising 75.2% of deaths and 81.0% of stroke-related disability adjusted life years lost in developing countries [1]. Up to 87% of the global burden of stroke is attributed to ischemic stroke, which is a heterogeneous disorder with more than 100 pathologies implicated in its pathogenesis [2]. Therefore, a reliable and precise etiologic classification of this disease is highly important for both daily clinical practice and research purposes [3 –5]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 23, 2017 Category: Neurosurgery Authors: R ăzvan Alexandru Radu, Elena Oana Terecoasă, Ovidiu Alexandru Băjenaru, Cristina Tiu Source Type: research

Editorial Board
(Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 22, 2017 Category: Neurosurgery Source Type: research