Clinical Neurology and Neurosurgery This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Traumatic Subdural Hematoma: Is there a Weekend Effect?
Traumatic subdural hematoma (TSDH) is a surgical emergency. The effect of weekend admission on surgery and in-hospital outcomes in TSDH is not known. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 22, 2017 Category: Neurosurgery Authors: Kavelin Rumalla, Adithi Y. Reddy, Manoj K. Mittal Source Type: research

Calcitonin Gene-related Peptide Monoclonal Antibody for Preventive Treatment of Episodic Migraine: A Meta Analysis
Migraine is a highly prevalent neurological disorder, which may lead to disable and determine the daily activity of patients [1 –4]. Most migraineurs have episodic migraine, defined as headache happen on less than 15days per month according to the International Classification of Headache Disorders (ICHD-II) [5–9]. Preventive treatments, such as valproate, topiramate, propranolol, metoprolol and flunarizine, were effectiv e in episodic migraine [1–3,10]. But most migraineurs might withdraw from the preventive treatment because of the adverse events, caused by the current preventive treatment which were not developed s...
Source: Clinical Neurology and Neurosurgery - January 20, 2017 Category: Neurosurgery Authors: Peiwei Hong, Xintong Wu, Yao Liu Source Type: research

Analysis the causes of radiosurgical failure in intracranial meningiomas treated with radiosurgery
Meningioma is one of the most common tumors of the central nervous system, and accounts for approximately one-third of all intracranial tumors [1]. Treatment options include observation, microsurgical resection, and radiation therapy. Microsurgical resection is generally the mainstay of treatment in meningioma. However, complete resection is not always possible owing to its proximal location to critical structures, such as the optic apparatus and brainstem. Simpson grade 1 resection rates vary from 20% to 90%, depending on the location and size of the tumors [2,3]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 19, 2017 Category: Neurosurgery Authors: Moinay Kim, Young Hyun Cho, Jeong Hoon Kim, Chang Jin Kim, Do Hoon Kwon Source Type: research

Key clinical milestones 15 years and onwards after DBS-STN surgery —A retrospective analysis of patients that underwent surgery between 1993 and 2001
Subthalamic nucleus deep brain stimulation (STN-DBS) is an efficacious treatment for selected individuals with advanced Parkinson's disease (PD) suffering from suboptimal motor control and motor fluctuations despite optimal peroral medication. After successful surgery, STN-DBS improves both motor and some non-motor symptoms and makes possible a reduction of the total dopaminergic medication load [1] thereby reducing pharmacological side effects [2,3]. However, over the years, the underlying disease processes continue unabated and lead to deterioration of non-motor and axial motor functions. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 17, 2017 Category: Neurosurgery Authors: Radu Constantinescu, Barbro Eriksson, Yvonne Jansson, Bo Johnels, Bj örn Holmberg, Thordis Gudmundsdottir, Annika Renck, Peter Berglund, Filip Bergquist Source Type: research

Comment on: Sensory-motor axonal polyneuropathy involving cranial nerves: An uncommon manifestation of disulfiram toxicity (Santos et al., Clin Neurol Neurosurg, 152:12 –15, 2016)
We read with great interest the recently published article by Santos et al. [1] regarding a case of an axonal polyneuropathy after treatment with disulfiram. Because of our continuous research on disulfiram and its side effects we find the issue very interesting and we would like to comment briefly on this report. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 17, 2017 Category: Neurosurgery Authors: Petros N. Karamanakos, Eleftheria S. Panteli Tags: Correspondence Source Type: research

Key clinical milestones 15 years and onwards after DBS-STN surgery − a retrospective analysis of patients that underwent surgery between 1993 and 2001
Subthalamic nucleus deep brain stimulation (STN-DBS) is an efficacious treatment for selected individuals with advanced Parkinson's disease (PD) suffering from suboptimal motor control and motor fluctuations despite optimal peroral medication. After successful surgery, STN-DBS improves both motor and some non-motor symptoms and makes possible a reduction of the total dopaminergic medication load [1] thereby reducing pharmacological side effects [2,3]. However, over the years, the underlying disease processes continue unabated and lead to deterioration of non-motor and axial motor functions. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 17, 2017 Category: Neurosurgery Authors: Radu Constantinescu, Barbro Eriksson, Yvonne Jansson, Bo Johnels, Bj örn Holmberg, Thordis Gudmundsdottir, Annika Renck, Peter Berglund, Filip Bergquist Source Type: research

Stereotactic radiosurgery versus surgical resection for spinal hemangioblastoma: A systematic review
Spinal cord hemangioblastomas are benign vascular tumors accounting for 3% of central nervous system tumors, and comprising 2 –6% of all tumors within the spinal cord [1–3]. Hemangioblastomas arise sporadically in approximately 70–80% of cases, however 20–30% of these lesions are manifestations of von Hippel-Lindau (VHL) disease, a heritable multisystem cancer syndrome [1,3–5]. Hemangioblastomas are the most comm on lesions associated with VHL, and patients with this disease will frequently have multiple spinal cord hemangioblastomas with risk of developing additional tumors throughout their lifetime [2,6]. (Sour...
Source: Clinical Neurology and Neurosurgery - January 17, 2017 Category: Neurosurgery Authors: Kelly J. Bridges, Jerry J. Jaboin, Charlotte D. Kubicky, Khoi D. Than Source Type: research

The role of therapeutic hypothermia in the management of acute spinal cord injury
Acute spinal cord injury (SCI) is a severe and sudden event that carries serious health, financial, social, and quality-of-life burdens. For the 11,000 new cases of SCI every year in the United States, fewer than 5% of the patients with American Spinal Injury Association (ASIA) Grade A injuries ever improve to Grade B, C, or D [1,2]. Although a few potential treatments for this devastating injury exist, such as corticosteroids or decompressive surgery, no therapeutic agent clearly protects against the damage precipitated by acute SCI [3,4]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 16, 2017 Category: Neurosurgery Authors: Nikolay L. Martirosyan, Arpan A. Patel, Alessandro Carotenuto, M.Yashar S Kalani, Michael A. Bohl, Mark C. Preul, Nicholas Theodore Source Type: research

Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma
In the 1920s, Otto Warburg, a German physiologist, discovered that cancer cells, even under aerobic conditions, exhibit active glucose uptake and glycolysis, which has become widely known as the Warburg Effect [1]. Since then, energy metabolism in tumour tissue has become an important research direction for scholars. Abnormal metabolic change is an important feature of malignant tumours, and it also plays an important role in the occurrence and development of the tumour [2 –4]. The study of tumour metabolism may provide new indicators and intervention targets for the diagnosis and treatment of tumours. (Source: Clinical ...
Source: Clinical Neurology and Neurosurgery - January 15, 2017 Category: Neurosurgery Authors: Bo Wang, Wei Wang, ZhiZhong Zhu, XueBin Zhang, Fan Tang, Dong Wang, Xi Liu, XiaoLing Yan, Hao Zhuang Source Type: research

Clinical and genetic features of PKAN patients in a tertiary centre in Turkey
Neurodegeneration with brain iron accumulation (NBIA) represents a wide spectrum of a genetically and clinically heterogeneous group of progressive motor disorders characterised by excessive iron deposition, particularly affecting the basal ganglia [1]. Homozygous or compound heterozygous mutations in pantothenate kinase 2 gene (PANK2) have been implicated in almost half of the cases with NBIA [1 –3]. These mutations are known to lead to pantothenate kinase-associated neurodegeneration (PKAN), which is the most frequently seen subtype of NBIA [1–3]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 14, 2017 Category: Neurosurgery Authors: Nihan Hande Akcakaya, Sibel Ugur Iseri, Birdal Bilir, Esra Battaloglu, Pinar Tekturk, Murat Gultekin, Gokcen Akar, Remzi Yigiter, Hasmet Hanagasi, Recep Alp, Sultan Cagirici, Mefkure Eraksoy, Ugur Ozbek, Zuhal Yapici Source Type: research

Timing of Anticoagulant Re-Initiation following Intracerebral Hemorrhage in Mechanical Heart Valves: Survey of Neurosurgeons and Thrombosis Experts
While oral anticoagulation is universally recommended among patients with mechanical heart valves (MHVs) [1], there is limited evidence to guide clinicians in managing patients who suffer intracerebral hemorrhage (ICH), a feared complication of anticoagulant treatment estimated to occur at 2-3% per patient-year [2]. In particular, the timing of oral anticoagulant (OAC) re-initiation following stabilization of hemorrhage is challenged by the intricate need to balance the risks of valve thrombosis and ischemic stroke with those of recurrent bleeding. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 13, 2017 Category: Neurosurgery Authors: Fahad AlKherayf, Yan Xu, Harrison Westwick, Ioana Doina Moldovan, Philip S. Wells Source Type: research

Treatment of Brainstem Cavernous Malformations
We have read, with great interest, a recently published article in Clinical Neurology and Neurosurgery by Liu et al. entitled “Gamma knife radiosurgery for brainstem cavernous malformations. [3]” The paper presents a very useful perspective for the treatment of brainstem cavernous malformations (CMs) with Gamma Knife Radiosurgery (GKS). This retrospective cohort analyzed 43 patients with brainstem CMs treated with GKS. Three hemorrhages following GKS were observed within the first 2 years (3.92% annual hemorrhage rate), and 1 hemorrhage was observed after the first 2 years (1.85% annual hemorrhage rate). (Source: Clini...
Source: Clinical Neurology and Neurosurgery - January 13, 2017 Category: Neurosurgery Authors: Aatman Shah, Henry Jung Tags: Editorial Source Type: research

Serum AGR2 as a useful biomarker for pituitary adenomas
Pituitary adenomas (PAs) account for about 15% of intracranial tumors, although autopsy series have found that the incidence of PAs in the general population may be as high as 25% [1]. Many PAs are incidentally found on imaging scans performed for unrelated reasons. PAs are not difficult to diagnose in other suffering from significant hormone hypersecretion, hypothalamic/pituitary dysfunction and visual field compromise due to their large size [2,3]. However, the opposite is true for the patients with PAs that are completely asymptomatic, and are incidentally found on magnetic resonance imaging (MRI) [4] . (Source: Clinica...
Source: Clinical Neurology and Neurosurgery - January 8, 2017 Category: Neurosurgery Authors: Mamatemin Tohti, Junyang Li, Chao Tang, Guodao Wen, Abdukeyum Abdujilil, Parhat Yizim, Chiyuan Ma Source Type: research

Full-endoscopic versus micro-endoscopic and open discectomy: A systematic review and meta-analysis of outcomes and complications
Lumbosacral radiculopathy, with an estimated lifetime prevalence of 3 –5%, often leads to surgical evaluation when conservative management has failed [1,2]. Intervertebral disc herniation is the most common cause of lumbosacral radiculopathy in the working population. Natural history suggests majority of patients will have both resolution of symptoms and radiographi c regression with conservative measures, however many patients experience persistence, progressive symptoms that requires a surgical evaluation [3–5]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 7, 2017 Category: Neurosurgery Authors: Kevin Phan, Joshua Xu, Konrad Schultz, Mohammed Ali Alvi, Victor M. Lu, Panagiotis Kerezoudis, Patrick R. Maloney, Meghan E. Murphy, Ralph J. Mobbs, Mohamad Bydon Source Type: research

An in vitro analysis of the size and shape of cryolesions for facet joint denervation
Lumbar facet joint syndrome (LFJS) is the cause of pain in 15 –54% of patients with low back pain. LFJS was first described by Ghormly in 1933 [1]. Clinically, LFSJ is characterised by a deep dull pain in the lower back, which often radiates into the leg and may be difficult to localise. The pattern of radiation is not radicular unless there is a concomitant nerve root compression. Often, the pain worsens with physical strain and can be provoked by lateral bending and/or hyperextension. Pain can sometimes be elicited by pressure on the affected joint, and neurologic exams are usually normal. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - January 3, 2017 Category: Neurosurgery Authors: T. Wolter, Y. Bozhkov, S.M. Knoeller Source Type: research