Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Algorithm for Predicting Disease Likelihood From a Submaximal Exercise Test
We developed a simplified automated algorithm to interpret noninvasive gas exchange in healthy subjects and patients with heart failure (HF, n = 12), pulmonary arterial hypertension (PAH, n = 11), chronic obstructive lung disease (OLD, n = 16), and restrictive lung disease (RLD, n = 12). They underwent spirometry and thereafter an incremental 3-minute step test where heart rate and SpO2 respiratory gas exchange were obtained. A custom-developed algorithm for each disease pathology was used to interpret outcomes. Each algorithm for HF, PAH, OLD, and RLD was capable of differentiating disease groups (P <...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - July 13, 2017 Category: Respiratory Medicine Authors: Chul-Ho Kim James E Hansen Dean J MacCarter Bruce D Johnson Source Type: research

Legionnaires ’ Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases
Conclusions: We found no specific clinicoradiological characteristics that could differentiate sporadic from epidemic cases of Legionella. Early recognition and high suspicion for Legionnaires’ disease are critical to provide appropriate treatment. Cluster of cases should increase suspicion for an outbreak. (Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine)
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - June 6, 2017 Category: Respiratory Medicine Authors: Hafiz Rizwan Talib Hashmi Lakshmi Saladi Frances Petersen Misbahuddin Khaja Gilda Diaz-Fuentes Source Type: research

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium
Chronic obstructive pulmonary disease (COPD) is one of the major causes of chronic morbidity and mortality worldwide. The development of markers of COPD onset is hampered by the lack of accessibility to the primary target tissue, and there is a need to consider other sample sources as surrogates for biomarker research. Airborne toxicants pass through the nasal epithelium before reaching the lower airways, and the similarity with bronchial histology makes it an attractive surrogate for lower airways. In this work, we describe the transcriptomics findings from the nasal epithelia of subjects enrolled in a clinical study focu...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - June 5, 2017 Category: Respiratory Medicine Authors: Marja Talikka Florian Martin Alain Sewer Gr égory Vuillaume Patrice Leroy Karsta Luettich Nveed Chaudhary Michael J Peck Manuel C Peitsch Julia Hoeng Source Type: research

Nodular Sarcoidosis Masquerading as Cancer
Nodular lung disease is a rare pulmonary manifestation of sarcoidosis and resembles metastatic neoplasm disease. Nodular sarcoidosis is rare, varying from 1.6% to 4% of patients with sarcoidosis. Radiographic nodules measure from 1 to 5 cm in diameter that typically consist of coalescent granulomas. There is limited data on this form of sarcoidosis and its presentation can mimic primary or metastatic pulmonary neoplasms. Nodular sarcoidosis has a favorable prognosis, and resolution can be seen with oral corticosteroids. Herein, we present such a case of nodular pulmonary sarcoidosis with a lung nodule measured up to 6 cm. ...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - April 12, 2017 Category: Respiratory Medicine Authors: Alexander J. Sweidan Navneet K. Singh Alexander. Stein Maged. Tanios Source Type: research

Use of Aminocaproic Acid in Combination With Extracorporeal Membrane Oxygenation in a Case of Leptospirosis Pulmonary Hemorrhage Syndrome
A 32-year-old man presented with a 10-day history of fever, chills, nausea, vomiting, myalgia, nonproductive cough, and worsening dyspnea after freshwater swimming in the Caribbean 1 week prior to presentation. Shortly after arrival at the hospital, the patient developed severe respiratory distress with massive hemoptysis. Based on serologic workup, he was diagnosed with leptospirosis pulmonary hemorrhage syndrome leading to diffuse alveolar hemorrhage, severe hypoxemic respiratory failure, and multiorgan failure. He received appropriate antibiotic coverage along with hemodynamic support with norepinephrine and vasopress...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - March 1, 2017 Category: Respiratory Medicine Authors: Miguel. Pardinas Rodrigo. Mendirichaga Gaurav. Budhrani Rajan. Garg Luis. Rosario Rene. Rico Anthony. Panos Horst. Baier Stefanie. Krick Source Type: research

Natriuretic Peptide and High-Sensitive Troponin T Concentrations Correlate with Effectiveness of Short-Term CPAP in Patients with Obstructive Sleep Apnea and Coronary Artery Disease
The risk of cardiovascular complications is increased in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the most effective way to treat clinically significant OSA. We hypothesized that the concentrations of the cardiac risk markers N-terminal brain natriuretic peptide (NT-proBNP) and high-sensitive troponin T (hs-TropT) correlate with the effectiveness of CPAP therapy in patients with OSA and coexisting coronary artery disease (CAD). Twenty-one patients with severe OSA and coexisting CAD (group 1) and 20 control patients with severe OSA alone (group 2) were treated with CPAP and ...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - December 11, 2016 Category: Respiratory Medicine Authors: Ralf Strehmel Misa Valo Claudius Teupe Source Type: research

The COPD Assessment Test as a Prognostic Marker in Interstitial Lung Disease
The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT), which was developed to measure the health status of patients with COPD, was applied to patients with interstitial lung disease, aiming to examine the CAT as a predictor of outcome. Over a follow-up period of more than one year, 101 consecutive patients with interstitial lung disease were evaluated by the CAT. The CAT scores of 40 in total were categorized into four subsets according to the severity. Patients with higher (more severe) scores exhibited lower forced vital capacity and lung diffusion capacity for carbon monoxide. The survival rate was sign...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - October 29, 2016 Category: Respiratory Medicine Authors: Fujiko Someya Takao Nakagawa Naoki Mugii Source Type: research

Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans
Conclusion: These data suggest that nebulized albuterol improves pulmonary function in healthy humans, while nebulization of both albuterol and saline results in an increase in DM/VC. (Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine)
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - October 11, 2016 Category: Respiratory Medicine Authors: Natalie E. Taylor Sarah E. Baker Thomas P. Olson Sophie Lalande Bruce D. Johnson Eric M. Snyder Source Type: research

Short-Term Pulmonary Rehabilitation for a Female Patient with Chronic Scleroderma under a Single-Case Research Design
Although previously proposed that chronic scleroderma should be cared for clinically and early rehabilitation should be performed in hospital by a chest physical therapist, little evidence is currently available on its benefits. Therefore, this study demonstrated the benefits of short-term pulmonary rehabilitation during hospitalization in a female patient with chronic scleroderma. The aim of rehabilitation was to improve ventilation and gas exchange by using airway clearance, chest mobilization, and breathing-relearning techniques, including strengthening the respiratory system and the muscles of the limbs by using the Br...
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - October 3, 2016 Category: Respiratory Medicine Authors: Jirakrit Leelarungrayub Decha Pinkaew Khanittha Wonglangka Wichai Eungpinichpong Jakkrit Klaphajone Source Type: research

Ultrasound for the Pulmonary Consultant
This article describes major applications of ultrasonography for the pulmonary consultant along with illustrative figures and videos. (Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine)
Source: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine - June 28, 2016 Category: Respiratory Medicine Authors: Astha Chichra Mina Makaryus Parag Chaudhri Mangala Narasimhan Source Type: research