Editorial Commentary: Ceftazidime-Avibactam and Carbapenem-Resistant Enterobacteriaceae: "We're Gonna Need a Bigger Boat"
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Spellberg, B., Bonomo, R. A. Tags: BRIEF REPORTS Source Type: research
Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections
Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Shields, R. K., Potoski, B. A., Haidar, G., Hao, B., Doi, Y., Chen, L., Press, E. G., Kreiswirth, B. N., Clancy, C. J., Nguyen, M. H. Tags: BRIEF REPORTS Source Type: research
Editorial Commentary: Colistin Dosing: Does the Fun Ever Start?
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Pogue, J. M., Ortwine, J. K., Kaye, K. S. Tags: ARTICLES AND COMMENTARIES Source Type: research
The Effectiveness and Safety of High-Dose Colistin: Prospective Cohort Study
Conclusions. In a large cohort, we found no association between high colistin dosing and all-cause mortality. High dosing was associated with more nephrotoxicity. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Benattar, Y. D., Omar, M., Zusman, O., Yahav, D., Zak-Doron, Y., Altunin, S., Elbaz, M., Daitch, V., Granot, M., Leibovici, L., Paul, M. Tags: ARTICLES AND COMMENTARIES Source Type: research
A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug-Drug Interaction
Conclusions. The sponsor elected to terminate this study due to a clearly illustrated drug–drug interaction between FA and RIF, which lowered FA levels to a degree that could influence subject outcomes. Optimization of FA exposure if used in combination with RIF should be a topic of future research.
Clinical Trials Registration. NCT01756924. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Pushkin, R., Iglesias-Ussel, M. D., Keedy, K., MacLauchlin, C., Mould, D. R., Berkowitz, R., Kreuzer, S., Darouiche, R., Oldach, D., Fernandes, P. Tags: ARTICLES AND COMMENTARIES Source Type: research
The Molecular Epidemiology and Antimicrobial Resistance of Neisseria gonorrhoeae in Australia: A Nationwide Cross-Sectional Study, 2012
Conclusions. This large scale epidemiological investigation demonstrated that N. gonorrhoeae infections are dominated by relatively few strain types. The commonest strain types were concentrated in MSM in urban areas and Indigenous heterosexuals in remote areas, and we were able to confirm a resurgent epidemic in heterosexual networks in urban areas. The prevalence of mosaic PBP2 harboring N. gonorrhoeae strains highlight the ability for new N. gonorrhoeae strains to spread and become established across populations. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Trembizki, E., Wand, H., Donovan, B., Chen, M., Fairley, C. K., Freeman, K., Guy, R., Kaldor, J. M., Lahra, M. M., Lawrence, A., Lau, C., Pearson, J., Regan, D. G., Ryder, N., Smith, H., Stevens, K., Su, J.-Y., Ward, J., Whiley, D. M. Tags: ARTICLES AND COMMENTARIES Source Type: research
Viremia and Clinical Presentation in Nicaraguan Patients Infected With Zika Virus, Chikungunya Virus, and Dengue Virus
Conclusions. ZIKV, CHIKV, and DENV result in similar clinical presentations, and coinfections may be relatively common. Our findings illustrate the need for accurate, multiplex diagnostics for patient care and epidemiologic surveillance. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Waggoner, J. J., Gresh, L., Vargas, M. J., Ballesteros, G., Tellez, Y., Soda, K. J., Sahoo, M. K., Nunez, A., Balmaseda, A., Harris, E., Pinsky, B. A. Tags: ARTICLES AND COMMENTARIES Source Type: research
Hepatocellular Carcinoma and Viral Hepatitis in New York City
Conclusions. In NYC, most persons with HCC have viral hepatitis; the majority of viral hepatitis infections are due to HCV. Survival for persons with HCC differs widely by viral hepatitis status. This study highlights the importance of viral hepatitis prevention and treatment and HCC screening. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Moore, M. S., Ivanina, E., Bornschlegel, K., Qiao, B., Schymura, M. J., Laraque, F. Tags: ARTICLES AND COMMENTARIES Source Type: research
Editorial Commentary: Influenza Vaccine Effectiveness: A Glass Both Half Full and Half Empty
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Omer, S. B., Yildirim, I. Tags: ARTICLES AND COMMENTARIES Source Type: research
Are People Living Near Modern Swine Production Facilities at Increased Risk of Influenza Virus Infection?
Conclusions. Our findings suggest that concentrated swine feeding operations amplified transmission of influenza during years in which H1N1 was circulating. This has implications for vaccine strategies targeting swine workers, as well as virologic surveillance in areas with large concentrations of swine. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Lantos, P. M., Hoffman, K., Höhle, M., Anderson, B., Gray, G. C. Tags: ARTICLES AND COMMENTARIES Source Type: research
Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH)
It is important to realize that leishmaniasis guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The IDSA and ASTMH consider adherence to these guidelines to be voluntary, with the ultimate determinations regarding their application to be made by the physician in the light of each patient's individual circumstances. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Aronson, N., Herwaldt, B. L., Libman, M., Pearson, R., Lopez-Velez, R., Weina, P., Carvalho, E. M., Ephros, M., Jeronimo, S., Magill, A. Tags: IDSA GUIDELINE Source Type: research
Passing the Mantle
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Gorbach, S. L. Tags: EDITORIAL Source Type: research
Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH)
It is important to realize that leishmaniasis guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The IDSA and ASTMH consider adherence to these guidelines to be voluntary, with the ultimate determinations regarding their application to be made by the physician in the light of each patient's individual circumstances. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Aronson, N., Herwaldt, B. L., Libman, M., Pearson, R., Lopez-Velez, R., Weina, P., Carvalho, E. M., Ephros, M., Jeronimo, S., Magill, A. Tags: ELECTRONIC ARTICLES Source Type: research
Reviewers
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Tags: ACKNOWLEDGMENTS Source Type: research
In the Literature
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Tags: IN THE LITERATURE Source Type: research
