The Burden of Pertussis Hospitalization in HIV-Exposed and HIV-Unexposed South African Infants
Conclusions. Bordetella pertussis contributed to a modest proportion of all-cause respiratory illness hospitalization among black-African children, with a trend for higher incidence among HIV-exposed than HIV-unexposed infants. Maternal vaccination of pregnant women should be considered to reduce the burden of pertussis hospitalization in this population. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Soofie, N., Nunes, M. C., Kgagudi, P., van Niekerk, N., Makgobo, T., Agosti, Y., Hwinya, C., Pathirana, J., Madhi, S. A. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Incidence of Severe and Nonsevere Pertussis Among HIV-Exposed and -Unexposed Zambian Infants Through 14 Weeks of Age: Results From the Southern Africa Mother Infant Pertussis Study (SAMIPS), a Longitudinal Birth Cohort Study
Conclusions. Pertussis is circulating freely among this population of Zambian infants but rarely presents with the classical symptoms of paroxysmal cough, whooping, apnea, and cyanosis. Maternal HIV appears to increase the risk, while lack of effective exposure to DTwP increased the risk. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Gill, C. J., Mwananyanda, L., MacLeod, W., Kwenda, G., Mwale, M., Williams, A. L., Siazeele, K., Yang, Z., Mwansa, J., Thea, D. M. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Epidemiology of Pertussis Among Young Pakistani Infants: A Community-Based Prospective Surveillance Study
Conclusions. In one of the first prospective surveillance studies of infant pertussis in a developing country, we identified a moderate burden of pertussis disease in early infancy in Pakistan. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Omer, S. B., Kazi, A. M., Bednarczyk, R. A., Allen, K. E., Quinn, C. P., Aziz, F., Sial, K., Phadke, V. K., Tondella, M. L., Williams, M. M., Orenstein, W. A., Ali, S. A. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Morbidity and Mortality Due to Bordetella pertussis: A Significant Pathogen in West Africa?
In the absence of specific surveillance platforms for pertussis and availability of suitable diagnostics at the hospital level, reliable data that describe morbidity and mortality from pertussis are difficult to obtain in any setting, as is the case in West Africa. Here, we summarize the available evidence of the burden of pertussis in the region, given historical data, and describe recent and ongoing epidemiological studies that offer opportunities for additional data collection. The available seroepidemiological data provide evidence of ongoing circulation of Bordetella pertussis in the region. Due to the lack of systema...
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Kampmann, B., Mackenzie, G. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Global Childhood Deaths From Pertussis: A Historical Review
Impact of pertussis vaccines on mortality is a key World Health Organization indicator, and trends in mortality rates and age distribution can inform maternal immunization strategies. We systematically reviewed studies reporting pertussis mortality rates (PMRs) per million population, identifying 19 eligible studies. During a prevaccine observation period of ≥50 years in high-income countries (HICs), PMRs reduced in both infants and 1- to 4-year-olds by >80%, along with improvements in living conditions. In studies in low- and middle-income countries (LMICs), PMRs resembled highest prevaccine HIC rates. Postvaccine i...
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Chow, M. Y. K., Khandaker, G., McIntyre, P. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Assessing the Evidence for Maternal Pertussis Immunization: A Report From the Bill & Melinda Gates Foundation Symposium on Pertussis Infant Disease Burden in Low- and Lower-Middle-Income Countries
Implementation of effective interventions has halved maternal and child mortality over the past 2 decades, but less progress has been made in reducing neonatal mortality. Almost 45% of under-5 global mortality now occurs in infants <1 month of age, with approximately 86% of neonatal deaths occurring in low- and lower-middle-income countries (LMICs). As an estimated 23% of neonatal deaths globally are due to infectious causes, maternal immunization (MI) is one intervention that may reduce mortality in the first few months of life, when direct protection often relies on passively transmitted maternal antibodies. Despite a...
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Sobanjo-ter Meulen, A., Duclos, P., McIntyre, P., Lewis, K. D. C., Van Damme, P., O'Brien, K. L., Klugman, K. P. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Pertussis in Young Infants Throughout the World
In typical pertussis in young infants, the child will appear deceptively well; he or she will have coryza, sneezing, and a mild cough. There is no fever. This progresses to gagging, gasping, eye bulging, bradycardia, cyanosis, and vomiting. There is leukocytosis with lymphocytosis and apneic episodes. Deaths relate to leukocytosis, pulmonary hypertension, and pneumonia. The source of pertussis in young infants is most often a family member with cough illness that is not recognized as pertussis. Diagnosis is based on culture/polymerase chain reaction and leukocytosis with lymphocytosis. Treatment depends on macrolide antibi...
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Cherry, J. D. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
The Importance of Persistence
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Plotkin, S. A. Tags: INFANT PERTUSSIS DISEASE BURDEN IN THE CONTEXT OF MATERNAL IMMUNIZATION STRATEGIES Source Type: research
Collignon P et al (Clin Infect Dis 2016; 63: 1087-93)
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Tags: ERRATUM Source Type: research
Reply to Kircher et al
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Humphries, R. M., Hindler, J. A. Tags: CORRESPONDENCE Source Type: research
The Susceptibility Testing Manufacturers Association Presents an Opinion for the Delay of Current Susceptibility Tests
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Kircher, S. M., Cullen, S. K., Killian, S., Zimmer, B. L., Brasso, B. B., for the Susceptibility Testing Manufacturers Association (STMA), Giguere, Luper, Farnham, Knapp Tags: CORRESPONDENCE Source Type: research
Real-Life Use of Isavuconazole in Patients Intolerant to Other Azoles
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Ordaya, E. E., Alangaden, G. J. Tags: CORRESPONDENCE Source Type: research
Reply to Meshnick and Hastings et al
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Phyo, A. P., Ashley, E. A., Anderson, T. J. C., Carrara, V. I., Woodrow, C. J., White, N. J., Nosten, F. Tags: CORRESPONDENCE Source Type: research
Artemisinin Resistance in Southeast Asia
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Meshnick, S. Tags: CORRESPONDENCE Source Type: research
The Importance of Scientific Debate in the Identification, Containment, and Control of Artemisinin Resistance
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Hastings, I. M., Kay, K., Hodel, E. M. Tags: CORRESPONDENCE Source Type: research
